Florian Rosenberger
Biträdande Lektor
E-postadress: florian.rosenberger@ki.se
Telefon: +46852486619
Besöksadress: Solnavägen 9, 17165 Solna
Postadress: C2 Medicinsk biokemi och biofysik, C2 Molekylär metabolism Rosenberger, 171 77 Stockholm
Om mig
Jag är forskargruppsledare och använder masspektrometri-baserad proteomik för att spåra de molekylära orsakerna till och konsekvenserna av mitokondriell dysfunktion.
Forskningsbeskrivning
Vad händer när cellens ”kraftverk”, mitokondrierna, inte fungerar som de ska? Vid Proteomes of Metabolism-labbet undersöker vi hur mitokondrier bidrar till cellulär integritet, anpassar sig till metabola utmaningar och orsakar sjukdom när deras funktion är nedsatt. Vår forskning fokuserar särskilt på genetiskt definierade mitokondriella sjukdomar. Vi använder den senaste generationen av spatial och singelcellbaserad proteomik med masspektrometri, inklusive Deep Visual Proteomics (DVP). Denna teknik gör det möjligt för oss att analysera enskilda celler i deras naturliga vävnadskontext, inklusive humana biopsier.
Artiklar
- Article: NATURE COMMUNICATIONS. 2025;16(1):5388Glasgow RIC; Singh V; Pena-Perez L; Wilhalm A; Moedas MF; Moore D; Rosenberger FA; Li X; Atanassov I; Saba M; Cipullo M; Rorbach J; Wedell A; Freyer C; Amunts A; Wredenberg A
- Article: NATURE. 2025;642(8067):484-491Rosenberger FA; Maedler SC; Thorhauge KH; Steigerwald S; Fromme M; Lebedev M; Weiss CAM; Oeller M; Wahle M; Metousis A; Zwiebel M; Schmacke NA; Detlefsen S; Boor P; Fabian O; Frankova S; Krag A; Strnad P; Mann M
- Article: NATURE COMMUNICATIONS. 2024;15(1):10719El Fissi N; Rosenberger FA; Chang K; Wilhalm A; Barton-Owen T; Hansen FM; Golder Z; Alsina D; Wedell A; Mann M; Chinnery PF; Freyer C; Wredenberg A
- Article: NATURE. 2024;635(8040):1001-1009Nordmann TM; Anderton H; Hasegawa A; Schweizer L; Zhang P; Stadler P-C; Sinha A; Metousis A; Rosenberger FA; Zwiebel M; Satoh TK; Anzengruber F; Strauss MT; Tanzer MC; Saito Y; Gong T; Thielert M; Kimura H; Silke N; Rodriguez EH; Restivo G; Nguyen HH; Gross A; Feldmeyer L; Joerg L; Levesque MP; Murray PJ; Ingen-Housz-Oro S; Mund A; Abe R; Silke J; Ji C; French LE; Mann M
- Article: SCIENCE ADVANCES. 2024;10(44):eadp3481Mennuni M; Wilkie SE; Michon P; Alsina D; Filograna R; Lindberg M; Sanin DE; Rosenberger F; Schaaf A; Larsson E; Pearce EL; Larsson N-G
- Journal article: ISCIENCE. 2024;27(9):110620Kabatnik S; Post F; Drici L; Bartels AS; Strauss MT; Zheng X; Madsen GI; Mund A; Rosenberger FA; Moreira J; Mann M
- Article: NATURE METABOLISM. 2024;6(6):1024-1035Jiang S; Yuan T; Rosenberger FA; Mourier A; Dragano NRV; Kremer LS; Rubalcava-Gracia D; Hansen FM; Borg M; Mennuni M; Filograna R; Alsina D; Misic J; Koolmeister C; Papadea P; de Angelis MH; Ren L; Andersson O; Unger A; Bergbrede T; Di Lucrezia R; Wibom R; Zierath JR; Krook A; Giavalisco P; Mann M; Larsson N-G
- Journal article: MOLECULAR & CELLULAR PROTEOMICS. 2023;22(10):100643Nordmann TM; Schweizer L; Metousis A; Thielert M; Rodriguez E; Rahbek-Gjerdrum LM; Stadler P-C; Bzorek M; Mund A; Rosenberger FA; Mann M
- Article: NATURE METHODS. 2023;20(10):1530-1536Rosenberger FA; Thielert M; Strauss MT; Schweizer L; Ammar C; Maedler SC; Metousis A; Skowronek P; Wahle M; Madden K; Gote-Schniering J; Semenova A; Schiller HB; Rodriguez E; Nordmann TM; Mund A; Mann M
- Article: MOLECULAR SYSTEMS BIOLOGY. 2023;19(9):e11503Thielert M; Itang ECM; Ammar C; Rosenberger FA; Bludau I; Schweizer L; Nordmann TM; Skowronek P; Wahle M; Zeng W-F; Zhou X-X; Brunner A-D; Richter S; Levesque MP; Theis FJ; Steger M; Mann M
- Article: NATURE. 2023;617(7961):581-591Shalon D; Culver RN; Grembi JA; Folz J; Treit PV; Shi H; Rosenberger FA; Dethlefsen L; Meng X; Yaffe E; Aranda-Diaz A; Geyer PE; Mueller-Reif JB; Spencer S; Patterson AD; Triadafilopoulos G; Holmes SP; Mann M; Fiehn O; Relman DA; Huang KC
- Article: NATURE COMMUNICATIONS. 2022;13(1):5750Clemente P; Calvo-Garrido J; Pearce SF; Schober FA; Shigematsu M; Siira SJ; Laine I; Spahr H; Steinmetzger C; Petzold K; Kirino Y; Wibom R; Rackham O; Filipovska A; Rorbach J; Freyer C; Wredenberg A
- Article: HUMAN MOLECULAR GENETICS. 2022;31(12):2049-2062Schober FA; Tang JX; Sergeant K; Moedas MF; Zierz CM; Moore D; Smith C; Lewis D; Guha N; Hopton S; Falkous G; Lam A; Pyle A; Poulton J; Gorman GS; Taylor RW; Freyer C; Wredenberg A
- Article: NEUROLOGY-GENETICS. 2021;7(2):e566Bruhn H; Samuelsson K; Schober FA; Engvall M; Lesko N; Wibom R; Nennesmo I; Calvo-Garrido J; Press R; Stranneheim H; Freyer C; Wedell A; Wredenberg A
- Article: HUMAN MUTATION. 2021;42(4):378-384Correia SP; Moedas MF; Naess K; Bruhn H; Maffezzini C; Calvo-Garrido J; Lesko N; Wibom R; Schober FA; Jemt A; Stranneheim H; Freyer C; Wedell A; Wredenberg A
- Article: FRONTIERS IN NEUROLOGY. 2021;12:652590Engvall M; Kawasaki A; Carelli V; Wibom R; Bruhn H; Lesko N; Schober FA; Wredenberg A; Wedell A; Traisk F
- Article: SCIENCE ADVANCES. 2021;7(8):eabf0717Schober FA; Moore D; Atanassov I; Moedas MF; Clemente P; Vegvari A; El Fissi N; Filograna R; Bucher A-L; Hinze Y; The M; Hedman E; Chernogubova E; Begzati A; Wibom R; Jain M; Nilsson R; Kall L; Wedell A; Freyer C; Wredenberg A
- Article: NUCLEIC ACIDS RESEARCH. 2021;49(1):354-370Cipullo M; Pearce SF; Sanchez IGL; Gopalakrishna S; Kruger A; Schober F; Busch JD; Li X; Wredenberg A; Atanassov I; Rorbach J
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2021;20:100065Rosenberger FA; Atanassov I; Moore D; Calvo-Garrido J; Moedas MF; Wedell A; Freyer C; Wredenberg A
- Article: METHODS IN MOLECULAR BIOLOGY. 2021;2192:75-87Schober FA; Atanassov I; Freyer C; Wredenberg A
- Journal article: BIOSPEKTRUM. 2020;26(5):510-515Hengge R; Schober F; Seiffert-Störiko A; Sander J; Störiko A; Heermann R; Mascher T; Herbert M; Thormann K; Kozjak-Pavlovic V; Hantke K; Götz F
- Article: EMBO MOLECULAR MEDICINE. 2020;12(7):e11659Alsina D; Lytovchenko O; Schab A; Atanassov I; Schober FA; Jiang M; Koolmeister C; Wedell A; Taylor RW; Wredenberg A; Larsson N-G
- Article: NUCLEIC ACIDS RESEARCH. 2019;47(17):9386-9399Gopalakrishna S; Pearce SF; Dinan AM; Schober FA; Cipullo M; Spahr H; Khawaja A; Maffezzini C; Freyer C; Wredenberg A; Atanassov I; Firth AE; Rorbach J
- Article: PLOS GENETICS. 2019;15(7):e1008240Pajak A; Laine I; Clemente P; El-Fissi N; Schober FA; Maffezzini C; Calvo-Garrido J; Wibom R; Filograna R; Dhir A; Wedell A; Freyer C; Wredenberg A
- Article: EMBO REPORTS. 2019;20(6):e48101Jiang S; Koolmeister C; Misic J; Siira S; Kuehl I; Ramos ES; Miranda M; Jiang M; Posse V; Lytovchenko O; Atanassov I; Schober FA; Wibom R; Hultenby K; Milenkovic D; Gustafsson CM; Filipovska A; Larsson N-G
- Article: STEM CELL REPORTS. 2019;12(4):696-711Calvo-Garrido J; Maffezzini C; Schober FA; Clemente P; Uhlin E; Kele M; Stranneheim H; Lesko N; Bruhn H; Svenningsson P; Falk A; Wedell A; Freyer C; Wredenberg A
- Article: HUMAN MOLECULAR GENETICS. 2017;26(13):2515-2525Siibak T; Clemente P; Bratic A; Bruhn H; Kauppila TES; Macao B; Schober FA; Lesko N; Wibom R; Naess K; Nennesmo I; Wedell A; Peter B; Freyer C; Falkenberg M; Wredenberg A
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Alla övriga publikationer
- Preprint: BIORXIV. 2025Oliinyk D; Heymann T; Henneberg L; Bardziukova A; Thielert M; Kjærgaard J; Vasconez S; Oeller M; Rodriguez E; Rosenberger F; Mann M
- Preprint: BIORXIV. 2025;BIORXIVWeiss CAM; Brown LA; Miranda L; Pellizzoni P; Ben-Moshe S; Steigerwald S; Remmert K; Hernandez J; Borgwardt K; Rosenberger FA; Porat-Shliom N; Mann M
- Preprint: BIORXIV. 2025Ammar C; Thielert M; Weiss C; Rodriguez E; Strauss M; Rosenberger F; Zeng W-F; Mann M
- Preprint: BIORXIV. 2024Glasgow RIC; Singh V; Peña-Pérez L; Wilhalm A; Moedas M; Moore D; Rosenberger F; Li X; Atanassov I; Saba M; Cipullo M; Rorbach J; Wedell A; Freyer C; Amunts A; Wredenberg A
- Preprint: BIORXIV. 2024Rosenberger F; Mädler S; Holtz Thorhauge K; Steigerwald S; Fromme M; Lebedev M; Weiss C; Oeller M; Wahle M; Zwiebel M; Schmacke N; Detlefsen S; Boor P; Kaserman J; Wilson A; Fabián O; Fraňková S; Krag A; Strnad P; Mann M
- Preprint: MEDRXIV. 2023Kabatnik S; Post F; Drici L; Snejbjerg Bartels A; Strauss M; Zheng X; Madsen GI; Mund A; Rosenberger F; Moreira JMA; Mann M
- Editorial comment: NATURE METHODS. 2023;20(3):320-323Rosenberger FA; Thielert M; Mann M
Forskningsbidrag
- EtableringsbidragVetenskapsrådet
- EtableringsbidragSvensk Sällskap för Medicinsk Forskning (SSMF)
- MBB Frontier GrantKarolinska Institutet
- Biträdande LektorKarolinska Institutet
- Alpha-1 Hepatocyte Dynamics: A Single-Cell and Spatial Proteomics StudyAlpha-1 Foundation
Anställningar
- Biträdande Lektor, Medicinsk biokemi och biofysik, Karolinska Institutet, 2025-2030
Examina och utbildning
- Medicine Doktorsexamen, Institutionen för molekylär medicin och kirurgi, Karolinska Institutet, 2021
- Medicine Masterexamen, Karolinska Institutet, 2015