Florian Rosenberger
Assistant Professor
E-mail: florian.rosenberger@ki.se
Telephone: +46852486619
Visiting address: Solnavägen 9, 17165 Solna
Postal address: C2 Medicinsk biokemi och biofysik, C2 Molekylär metabolism Rosenberger, 171 77 Stockholm
About me
I am an independent group leader harnessing mass spectrometry-based proteomics to trace the molecular origins and consequences of mitochondrial dysfunction.
Research
What happens when mitochondria don't function properly? At the Proteomes of Metabolism lab, we investigate how mitochondria support cellular integrity, adapt to metabolic challenges, and contribute to disease when their function is impaired. Our research focuses particularly on genetically defined mitochondrial disorders. We apply the latest generation of spatial and single-cell proteomics by mass spectrometry, including Deep Visual Proteomics (DVP). This technology enables us to analyze individual cells within their native tissue context, including human biopsies.
Articles
- Article: NATURE COMMUNICATIONS. 2025;16(1):5388Glasgow RIC; Singh V; Pena-Perez L; Wilhalm A; Moedas MF; Moore D; Rosenberger FA; Li X; Atanassov I; Saba M; Cipullo M; Rorbach J; Wedell A; Freyer C; Amunts A; Wredenberg A
- Article: NATURE. 2025;642(8067):484-491Rosenberger FA; Maedler SC; Thorhauge KH; Steigerwald S; Fromme M; Lebedev M; Weiss CAM; Oeller M; Wahle M; Metousis A; Zwiebel M; Schmacke NA; Detlefsen S; Boor P; Fabian O; Frankova S; Krag A; Strnad P; Mann M
- Article: NATURE COMMUNICATIONS. 2024;15(1):10719El Fissi N; Rosenberger FA; Chang K; Wilhalm A; Barton-Owen T; Hansen FM; Golder Z; Alsina D; Wedell A; Mann M; Chinnery PF; Freyer C; Wredenberg A
- Article: NATURE. 2024;635(8040):1001-1009Nordmann TM; Anderton H; Hasegawa A; Schweizer L; Zhang P; Stadler P-C; Sinha A; Metousis A; Rosenberger FA; Zwiebel M; Satoh TK; Anzengruber F; Strauss MT; Tanzer MC; Saito Y; Gong T; Thielert M; Kimura H; Silke N; Rodriguez EH; Restivo G; Nguyen HH; Gross A; Feldmeyer L; Joerg L; Levesque MP; Murray PJ; Ingen-Housz-Oro S; Mund A; Abe R; Silke J; Ji C; French LE; Mann M
- Article: SCIENCE ADVANCES. 2024;10(44):eadp3481Mennuni M; Wilkie SE; Michon P; Alsina D; Filograna R; Lindberg M; Sanin DE; Rosenberger F; Schaaf A; Larsson E; Pearce EL; Larsson N-G
- Journal article: ISCIENCE. 2024;27(9):110620Kabatnik S; Post F; Drici L; Bartels AS; Strauss MT; Zheng X; Madsen GI; Mund A; Rosenberger FA; Moreira J; Mann M
- Article: NATURE METABOLISM. 2024;6(6):1024-1035Jiang S; Yuan T; Rosenberger FA; Mourier A; Dragano NRV; Kremer LS; Rubalcava-Gracia D; Hansen FM; Borg M; Mennuni M; Filograna R; Alsina D; Misic J; Koolmeister C; Papadea P; de Angelis MH; Ren L; Andersson O; Unger A; Bergbrede T; Di Lucrezia R; Wibom R; Zierath JR; Krook A; Giavalisco P; Mann M; Larsson N-G
- Journal article: MOLECULAR & CELLULAR PROTEOMICS. 2023;22(10):100643Nordmann TM; Schweizer L; Metousis A; Thielert M; Rodriguez E; Rahbek-Gjerdrum LM; Stadler P-C; Bzorek M; Mund A; Rosenberger FA; Mann M
- Article: NATURE METHODS. 2023;20(10):1530-1536Rosenberger FA; Thielert M; Strauss MT; Schweizer L; Ammar C; Maedler SC; Metousis A; Skowronek P; Wahle M; Madden K; Gote-Schniering J; Semenova A; Schiller HB; Rodriguez E; Nordmann TM; Mund A; Mann M
- Article: MOLECULAR SYSTEMS BIOLOGY. 2023;19(9):e11503Thielert M; Itang ECM; Ammar C; Rosenberger FA; Bludau I; Schweizer L; Nordmann TM; Skowronek P; Wahle M; Zeng W-F; Zhou X-X; Brunner A-D; Richter S; Levesque MP; Theis FJ; Steger M; Mann M
- Article: NATURE. 2023;617(7961):581-591Shalon D; Culver RN; Grembi JA; Folz J; Treit PV; Shi H; Rosenberger FA; Dethlefsen L; Meng X; Yaffe E; Aranda-Diaz A; Geyer PE; Mueller-Reif JB; Spencer S; Patterson AD; Triadafilopoulos G; Holmes SP; Mann M; Fiehn O; Relman DA; Huang KC
- Article: NATURE COMMUNICATIONS. 2022;13(1):5750Clemente P; Calvo-Garrido J; Pearce SF; Schober FA; Shigematsu M; Siira SJ; Laine I; Spahr H; Steinmetzger C; Petzold K; Kirino Y; Wibom R; Rackham O; Filipovska A; Rorbach J; Freyer C; Wredenberg A
- Article: HUMAN MOLECULAR GENETICS. 2022;31(12):2049-2062Schober FA; Tang JX; Sergeant K; Moedas MF; Zierz CM; Moore D; Smith C; Lewis D; Guha N; Hopton S; Falkous G; Lam A; Pyle A; Poulton J; Gorman GS; Taylor RW; Freyer C; Wredenberg A
- Article: NEUROLOGY-GENETICS. 2021;7(2):e566Bruhn H; Samuelsson K; Schober FA; Engvall M; Lesko N; Wibom R; Nennesmo I; Calvo-Garrido J; Press R; Stranneheim H; Freyer C; Wedell A; Wredenberg A
- Article: HUMAN MUTATION. 2021;42(4):378-384Correia SP; Moedas MF; Naess K; Bruhn H; Maffezzini C; Calvo-Garrido J; Lesko N; Wibom R; Schober FA; Jemt A; Stranneheim H; Freyer C; Wedell A; Wredenberg A
- Article: FRONTIERS IN NEUROLOGY. 2021;12:652590Engvall M; Kawasaki A; Carelli V; Wibom R; Bruhn H; Lesko N; Schober FA; Wredenberg A; Wedell A; Traisk F
- Article: SCIENCE ADVANCES. 2021;7(8):eabf0717Schober FA; Moore D; Atanassov I; Moedas MF; Clemente P; Vegvari A; El Fissi N; Filograna R; Bucher A-L; Hinze Y; The M; Hedman E; Chernogubova E; Begzati A; Wibom R; Jain M; Nilsson R; Kall L; Wedell A; Freyer C; Wredenberg A
- Article: NUCLEIC ACIDS RESEARCH. 2021;49(1):354-370Cipullo M; Pearce SF; Sanchez IGL; Gopalakrishna S; Kruger A; Schober F; Busch JD; Li X; Wredenberg A; Atanassov I; Rorbach J
- Article: METHODS IN MOLECULAR BIOLOGY. 2021;2192:75-87Schober FA; Atanassov I; Freyer C; Wredenberg A
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2021;20:100065Rosenberger FA; Atanassov I; Moore D; Calvo-Garrido J; Moedas MF; Wedell A; Freyer C; Wredenberg A
- Journal article: BIOSPEKTRUM. 2020;26(5):510-515Hengge R; Schober F; Seiffert-Störiko A; Sander J; Störiko A; Heermann R; Mascher T; Herbert M; Thormann K; Kozjak-Pavlovic V; Hantke K; Götz F
- Article: EMBO MOLECULAR MEDICINE. 2020;12(7):e11659Alsina D; Lytovchenko O; Schab A; Atanassov I; Schober FA; Jiang M; Koolmeister C; Wedell A; Taylor RW; Wredenberg A; Larsson N-G
- Article: NUCLEIC ACIDS RESEARCH. 2019;47(17):9386-9399Gopalakrishna S; Pearce SF; Dinan AM; Schober FA; Cipullo M; Spahr H; Khawaja A; Maffezzini C; Freyer C; Wredenberg A; Atanassov I; Firth AE; Rorbach J
- Article: PLOS GENETICS. 2019;15(7):e1008240Pajak A; Laine I; Clemente P; El-Fissi N; Schober FA; Maffezzini C; Calvo-Garrido J; Wibom R; Filograna R; Dhir A; Wedell A; Freyer C; Wredenberg A
- Article: EMBO REPORTS. 2019;20(6):e48101Jiang S; Koolmeister C; Misic J; Siira S; Kuehl I; Ramos ES; Miranda M; Jiang M; Posse V; Lytovchenko O; Atanassov I; Schober FA; Wibom R; Hultenby K; Milenkovic D; Gustafsson CM; Filipovska A; Larsson N-G
- Article: STEM CELL REPORTS. 2019;12(4):696-711Calvo-Garrido J; Maffezzini C; Schober FA; Clemente P; Uhlin E; Kele M; Stranneheim H; Lesko N; Bruhn H; Svenningsson P; Falk A; Wedell A; Freyer C; Wredenberg A
- Article: HUMAN MOLECULAR GENETICS. 2017;26(13):2515-2525Siibak T; Clemente P; Bratic A; Bruhn H; Kauppila TES; Macao B; Schober FA; Lesko N; Wibom R; Naess K; Nennesmo I; Wedell A; Peter B; Freyer C; Falkenberg M; Wredenberg A
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All other publications
- Preprint: BIORXIV. 2025Oliinyk D; Heymann T; Henneberg L; Bardziukova A; Thielert M; Kjærgaard J; Vasconez S; Oeller M; Rodriguez E; Rosenberger F; Mann M
- Preprint: BIORXIV. 2025;BIORXIVWeiss CAM; Brown LA; Miranda L; Pellizzoni P; Ben-Moshe S; Steigerwald S; Remmert K; Hernandez J; Borgwardt K; Rosenberger FA; Porat-Shliom N; Mann M
- Preprint: BIORXIV. 2025Ammar C; Thielert M; Weiss C; Rodriguez E; Strauss M; Rosenberger F; Zeng W-F; Mann M
- Preprint: BIORXIV. 2024Glasgow RIC; Singh V; Peña-Pérez L; Wilhalm A; Moedas M; Moore D; Rosenberger F; Li X; Atanassov I; Saba M; Cipullo M; Rorbach J; Wedell A; Freyer C; Amunts A; Wredenberg A
- Preprint: BIORXIV. 2024Rosenberger F; Mädler S; Holtz Thorhauge K; Steigerwald S; Fromme M; Lebedev M; Weiss C; Oeller M; Wahle M; Zwiebel M; Schmacke N; Detlefsen S; Boor P; Kaserman J; Wilson A; Fabián O; Fraňková S; Krag A; Strnad P; Mann M
- Preprint: MEDRXIV. 2023Kabatnik S; Post F; Drici L; Snejbjerg Bartels A; Strauss M; Zheng X; Madsen GI; Mund A; Rosenberger F; Moreira JMA; Mann M
- Editorial comment: NATURE METHODS. 2023;20(3):320-323Rosenberger FA; Thielert M; Mann M
Grants
- Starting GrantSwedish Research Council
- Starting GrantSwedish Society for Medical Research
- MBB Frontier GrantKarolinska Institutet
- Assistant Professor positionKarolinska Institutet
- Alpha-1 Hepatocyte Dynamics: A Single-Cell and Spatial Proteomics StudyAlpha-1 Foundation
Employments
- Assistant Professor, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2025-2030
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2021
- Degree Of Master Of Medical Science 120 Credits, Karolinska Institutet, 2015