Florian Rosenberger

Articles

Article: NATURE COMMUNICATIONS. 2024;15(1):10719
Preventing excessive autophagy protects from the pathology of mtDNA mutations in Drosophila melanogaster
El Fissi N; Rosenberger FA; Chang K; Wilhalm A; Barton-Owen T; Hansen FM; Golder Z; Alsina D; Wedell A; Mann M; Chinnery PF; Freyer C; Wredenberg A
Journal article: NATURE. 2024;635(8040):1001-1009
Spatial proteomics identifies JAKi as treatment for a lethal skin disease
Nordmann TM; Anderton H; Hasegawa A; Schweizer L; Zhang P; Stadler P-C; Sinha A; Metousis A; Rosenberger FA; Zwiebel M; Satoh TK; Anzengruber F; Strauss MT; Tanzer MC; Saito Y; Gong T; Thielert M; Kimura H; Silke N; Rodriguez EH; Restivo G; Nguyen HH; Gross A; Feldmeyer L; Joerg L; Levesque MP; Murray PJ; Ingen-Housz-Oro S; Mund A; Abe R; Silke J; Ji C; French LE; Mann MAll authors
Journal article: SCIENCE ADVANCES. 2024;10(44):eadp3481
High mitochondrial DNA levels accelerate lung adenocarcinoma progression
Mennuni M; Wilkie SE; Michon P; Alsina D; Filograna R; Lindberg M; Sanin DE; Rosenberger F; Schaaf A; Larsson E; Pearce EL; Larsson N-G
Journal article: ISCIENCE. 2024;27(9):110620
Spatial characterization and stratification of colorectal adenomas by deep visual proteomics.
Kabatnik S; Post F; Drici L; Bartels AS; Strauss MT; Zheng X; Madsen GI; Mund A; Rosenberger FA; Moreira J; Mann M
Article: NATURE METABOLISM. 2024;6(6):1024-1035
Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity
Jiang S; Yuan T; Rosenberger FA; Mourier A; Dragano NRV; Kremer LS; Rubalcava-Gracia D; Hansen FM; Borg M; Mennuni M; Filograna R; Alsina D; Misic J; Koolmeister C; Papadea P; de Angelis MH; Ren L; Andersson O; Unger A; Bergbrede T; Di Lucrezia R; Wibom R; Zierath JR; Krook A; Giavalisco P; Mann M; Larsson N-GAll authors
Journal article: NATURE METHODS. 2023;20(10):1530-1536
Spatial single-cell mass spectrometry defines zonation of the hepatocyte proteome
Rosenberger FA; Thielert M; Strauss MT; Schweizer L; Ammar C; Maedler SC; Metousis A; Skowronek P; Wahle M; Madden K; Gote-Schniering J; Semenova A; Schiller HB; Rodriguez E; Nordmann TM; Mund A; Mann M
Journal article: MOLECULAR & CELLULAR PROTEOMICS. 2023;22(10):100643
A Standardized and Reproducible Workflow for Membrane Glass Slides in Routine Histology and Spatial Proteomics
Nordmann TM; Schweizer L; Metousis A; Thielert M; Rodriguez E; Rahbek-Gjerdrum LM; Stadler P-C; Bzorek M; Mund A; Rosenberger FA; Mann M
Journal article: MOLECULAR SYSTEMS BIOLOGY. 2023;19(9):e11503
Robust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel
Thielert M; Itang ECM; Ammar C; Rosenberger FA; Bludau I; Schweizer L; Nordmann TM; Skowronek P; Wahle M; Zeng W-F; Zhou X-X; Brunner A-D; Richter S; Levesque MP; Theis FJ; Steger M; Mann M
Journal article: NATURE. 2023;617(7961):581-591
Profiling the human intestinal environment under physiological conditions
Shalon D; Culver RN; Grembi JA; Folz J; Treit PV; Shi H; Rosenberger FA; Dethlefsen L; Meng X; Yaffe E; Aranda-Diaz A; Geyer PE; Mueller-Reif JB; Spencer S; Patterson AD; Triadafilopoulos G; Holmes SP; Mann M; Fiehn O; Relman DA; Huang KC
Journal article: NATURE METHODS. 2023;20(3):320-323
Making single-cell proteomics biologically relevant
Rosenberger FA; Thielert M; Mann M
Article: NATURE COMMUNICATIONS. 2022;13(1):5750
ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing
Clemente P; Calvo-Garrido J; Pearce SF; Schober FA; Shigematsu M; Siira SJ; Laine I; Spahr H; Steinmetzger C; Petzold K; Kirino Y; Wibom R; Rackham O; Filipovska A; Rorbach J; Freyer C; Wredenberg A
Article: HUMAN MOLECULAR GENETICS. 2022;31(12):2049-2062
Pathogenic SLC25A26 variants impair SAH transport activity causing mitochondrial disease
Schober FA; Tang JX; Sergeant K; Moedas MF; Zierz CM; Moore D; Smith C; Lewis D; Guha N; Hopton S; Falkous G; Lam A; Pyle A; Poulton J; Gorman GS; Taylor RW; Freyer C; Wredenberg A
Article: NEUROLOGY-GENETICS. 2021;7(2):e566
Novel Mutation m.10372A>G in MT-ND3 Causing Sensorimotor Axonal Polyneuropathy
Bruhn H; Samuelsson K; Schober FA; Engvall M; Lesko N; Wibom R; Nennesmo I; Calvo-Garrido J; Press R; Stranneheim H; Freyer C; Wedell A; Wredenberg A
Article: HUMAN MUTATION. 2021;42(4):378-384
Severe congenital lactic acidosis and hypertrophic cardiomyopathy caused by an intronic variant in NDUFB7
Correia SP; Moedas MF; Naess K; Bruhn H; Maffezzini C; Calvo-Garrido J; Lesko N; Wibom R; Schober FA; Jemt A; Stranneheim H; Freyer C; Wedell A; Wredenberg A
Article: SCIENCE ADVANCES. 2021;7(8):eabf0717
The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters
Schober FA; Moore D; Atanassov I; Moedas MF; Clemente P; Vegvari A; El Fissi N; Filograna R; Bucher A-L; Hinze Y; The M; Hedman E; Chernogubova E; Begzati A; Wibom R; Jain M; Nilsson R; Kall L; Wedell A; Freyer C; Wredenberg A
Article: NUCLEIC ACIDS RESEARCH. 2021;49(1):354-370
Human GTPBP5 is involved in the late stage of mitoribosome large subunit assembly
Cipullo M; Pearce SF; Sanchez IGL; Gopalakrishna S; Kruger A; Schober F; Busch JD; Li X; Wredenberg A; Atanassov I; Rorbach J
Article: METHODS IN MOLECULAR BIOLOGY. 2021;2192:75-87
Quantitative Proteomics in Drosophila with Holidic Stable-Isotope Labeling of Amino Acids in Fruit Flies (SILAF).
Schober FA; Atanassov I; Freyer C; Wredenberg A
Article: MOLECULAR & CELLULAR PROTEOMICS. 2021;20:100065
Stable Isotope Labeling of Amino Acids in Flies (SILAF) Reveals Differential Phosphorylation of Mitochondrial Proteins Upon Loss of OXPHOS Subunits
Rosenberger FA; Atanassov I; Moore D; Calvo-Garrido J; Moedas MF; Wedell A; Freyer C; Wredenberg A
Article: FRONTIERS IN NEUROLOGY. 2021;12:652590
Case Report: A Novel Mutation in the Mitochondrial MT-ND5 Gene Is Associated With Leber Hereditary Optic Neuropathy (LHON)
Engvall M; Kawasaki A; Carelli V; Wibom R; Bruhn H; Lesko N; Schober FA; Wredenberg A; Wedell A; Traisk F
Journal article: BIOSPEKTRUM. 2020;26(5):510-515
Journal Club
Hengge R; Schober F; Seiffert-Störiko A; Sander J; Störiko A; Heermann R; Mascher T; Herbert M; Thormann K; Kozjak-Pavlovic V; Hantke K; Götz F
Article: EMBO MOLECULAR MEDICINE. 2020;12(7):e11659
FBXL4 deficiency increases mitochondrial removal by autophagy
Alsina D; Lytovchenko O; Schab A; Atanassov I; Schober FA; Jiang M; Koolmeister C; Wedell A; Taylor RW; Wredenberg A; Larsson N-G
Article: NUCLEIC ACIDS RESEARCH. 2019;47(17):9386-9399
C6orf203 is an RNA-binding protein involved in mitochondrial protein synthesis
Gopalakrishna S; Pearce SF; Dinan AM; Schober FA; Cipullo M; Spahr H; Khawaja A; Maffezzini C; Freyer C; Wredenberg A; Atanassov I; Firth AE; Rorbach J
Article: PLOS GENETICS. 2019;15(7):e1008240
Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo
Pajak A; Laine I; Clemente P; El-Fissi N; Schober FA; Maffezzini C; Calvo-Garrido J; Wibom R; Filograna R; Dhir A; Wedell A; Freyer C; Wredenberg A
Article: EMBO REPORTS. 2019;20(6):embr201948101
TEFM regulates both transcription elongation and RNA processing in mitochondria
Jiang S; Koolmeister C; Misic J; Siira S; Kuehl I; Ramos ES; Miranda M; Jiang M; Posse V; Lytovchenko O; Atanassov I; Schober FA; Wibom R; Hultenby K; Milenkovic D; Gustafsson CM; Filipovska A; Larsson N-G
Article: STEM CELL REPORTS. 2019;12(4):696-711
SQSTM1/p62-Directed Metabolic Reprogramming Is Essential for Normal Neurodifferentiation
Calvo-Garrido J; Maffezzini C; Schober FA; Clemente P; Uhlin E; Kele M; Stranneheim H; Lesko N; Bruhn H; Svenningsson P; Falk A; Wedell A; Freyer C; Wredenberg A
Article: HUMAN MOLECULAR GENETICS. 2017;26(13):2515-2525
A multi-systemic mitochondrial disorder due to a dominant p.Y955H disease variant in DNA polymerase gamma
Siibak T; Clemente P; Bratic A; Bruhn H; Kauppila TES; Macao B; Schober FA; Lesko N; Wibom R; Naess K; Nennesmo I; Wedell A; Peter B; Freyer C; Falkenberg M; Wredenberg A
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Preprint: BIORXIV. 2024
The mitochondrial methylation potential gates mitoribosome assembly
Glasgow RIC; Singh V; Peña-Pérez L; Wilhalm A; Moedas M; Moore D; Rosenberger F; Li X; Atanassov I; Saba M; Cipullo M; Rorbach J; Wedell A; Freyer C; Amunts A; Wredenberg A
Preprint: BIORXIV. 2024
The proteomic landscape of proteotoxic stress in a fibrogenic liver disease
Rosenberger FA; Mädler SC; Thorhauge KH; Steigerwald S; Fromme M; Lebedev M; Weiss CAM; Oeller M; Wahle M; Zwiebel M; Schmacke NA; Detlefsen S; Boor P; Kaserman J; Wilson A; Fabián O; Fraňková S; Krag AA; Strnad P; Mann M
Preprint: MEDRXIV. 2023
Spatial characterization and stratification of colorectal adenomas by Deep Visual Proteomics
Kabatnik S; Post F; Drici L; Bartels AS; Strauss MT; Zheng X; Madsen GI; Mund A; Rosenberger FA; Moreira JM; Mann M
Doctoral thesis: 2021
Systems biology of mitochondrial dysfunction
Schober F

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