Erik Norberg

Erik Norberg

Affiliated to Research | Docent
Telephone: +46852487170
Visiting address: Solnavägen 9, Biomedicum C5, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Signalvägar för proteinnedbrytning, 171 77 Stockholm

About me

  • *2019*-present: /Assoc. Professor/ of Metabolism (Docent), Karolinska Inst.
    *2014*-*2018*: /Asst. Professor/, Karolinska Inst.
    *2011*-*2013*: /PostDoc/ at Dana-Farber Cancer Institute, Harvard Medical
    School, Boston, USA.
    *2011*: /Ph.D./ Karolinska Institute, Stockholm, Sweden.
    *2006*: /MSc/. Stockholm Research School in Molecular Life Science.
    *2005*: /MSc./ Uppsala University, Uppsala, Sweden.
    1) Dimitris N Chorafas Prize - for best Ph.D. thesis at the Karolinska
    Institute 2011.
    2) The Lennart Philipson Award 2015 - Awarded biannuallly to one researcher
    at the Karolinska Institute.

Research

  • We are mainly focusing on the following overarching topics:
    *1.* Metabolic Adaptations to Oncogenes and Tumor Suppressors.
    *2.* Metabolic Signal Transduction.
    *3.* Molecular Regulators of Metabolic Heterogeneity
    /*Research Group ' Cellular Metabolism: */
    Vitaly Kaminsky, PhD, Senior Researcher.
    Elena Kochetkova, PhD, PostDoc,
    Boxi Zhang, PhD, PostDoc.
    Lyudmila Krassikova, PhD, PostDoc.
    Divya Nagarajan, PhD, PostDoc.
    Vagelis Samakidis, MSc, Lab technician.
    Anastasiia Krasko, MSc student.
    Alumni:
    Dawn E Comstock, MD-PhD student, Harvard Medical School.
    Yiwei Ai, MD, research student
    Dominique Smith, Masters student, Uppsala University.
    Wirood Aldjezani, Masters Student, Uppsala University.
    /*Select Original Publications:*/
    *1.* The deubiquitinase JOSD2 is a positive regulator of glucose metabolism.
    Krassikova L, Zhang B, Nagarajan D, Queiroz AL, Kacal M, Samakidis E,
    Vakifahmetoglu-Norberg H, * Norberg E.* /Cell Death Differ/. 2020 Oct 20. doi:
    10.1038/s41418-020-00639-1. Online ahead of print.
    />
  • News:
    https://news.ki.se/newly-discovered-mechanism-controls-cancer-cell-growth-and-metabolism?_ga=2.70076304.168021435.1603384257-969318966.1587422954
    /
    *2.* Ambroise G, Yu TT, Zhang B, Kacal M, Hao Y, Queiroz AL, Ouchida AT,
    Lindskog C, *Norberg E#, * Vakifahmetoglu-Norberg H#. Systematic analysis
    reveals a functional role for STAMBPL1 in the epithelial-mesenchymal
    transition process across multiple carcinomas. /British Journal of Cancer/.
    2020 Sep
  • 123(7):1164-1177. *# co-corresponding author*
    *3.* Zhang B, Zheng A, Hydbring P, Ambroise G, Ouchida AT, Goiny M,
    Vakifahmetoglu-Norberg, H, *Norberg E*. PHGDH Defines a metabolic subtype in
    lung adenocarcinomas with poor prognosis. /Cell Reports /2017 Jun
    13
  • 19(11):2289-2303.
    />
  • Selected as 'Issue Highlight' by Cell Reports./
    *4.* Eriksson M, Ambroise G, Ouchida AT, Queiroz AL, Smith D, Gimenez-Cassina
    A, Iwanicki MP, Muller PA, *Norberg E#*, Vakifahmetoglu-Norberg H#. The
    effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism.
    /Mol Cell Biol./ 2017 Nov 28
  • 37(24) * # Co-corresponding author.*
    />
  • Selected for the Cover volume 37, issue 24./
    *5.* Zhang B, Tornmalm J, Widengren J, Vakifahmetoglu-Norberg H, *Norberg E*.
    Characterization of the Role of the Malate Dehydrogenases to Lung Tumor Cell
    Survival. /Journal of Cancer/ 2017
  • 8(11):2088-2096.
    /*Select Collaboration papers: */
    *1. *Quantitative proteomic analysis of temporal lysosomal proteome and the
    impact of the KFERQ-like motif and LAMP2A in lysosomal targeting. [1] Kacal
    M, Zhang B, Hao Y, *Norberg E*, Vakifahmetoglu-Norberg H /Autophagy 2021 /Jan
    14. doi: 10.1080/15548627.2021.1876343. [Online ahead of print.]
    *2. *Targetome analysis of chaperone-mediated autophagy in cancer cells.
    [2]Hao Y, Kacal M, Ouchida AT, Zhang B, *Norberg E*, Vakifahmetoglu-Norberg
    H. /Autophagy 2019 09
  • 15(9):1558-1571/
    /*Select Reviews/Editorials: */
    1. Queiroz AL, Vakifahmetoglu-Norberg H, *Norberg E*. Resistant to Targeted
    Therapy - Aim for Metabolic Liabilities. /Theranostics/ 2018
  • 8(7):
    2061-2063.
    2. Vakifahmetoglu-Norberg H, Ouchida A, *Norberg E*. The role of Mitochondria
    in Metabolism and Cell Death. /Biochem Biophys Res Commun./ (2017) Jan
    15
  • 482(3):426-431
    />
  • As of July/August 2017, this Review received enough citations to place it
    in the top 1% of the academic field of Biology &
  • Biochemistry (Web of
    Science)./
    3. Stanley I, Ribeiro S, Gimenez-Cassina A, * Norberg E*, Danial NN. Changing
    appetites: The adaptive advantages of fuel choice./ Trends in Cell Biology./
    2014 Feb
  • 24(2):118-27
    /*Open Positions:*/
    2 Master of Science Project (start 2021)
    1 PhD student position available from end of 2021 or begining of 2022.
    1 PostDoc positions available. start 2021
    [1] https://pubmed.ncbi.nlm.nih.gov/33446043
    [2] https://pubmed.ncbi.nlm.nih.gov/30821613

Articles

All other publications

  • Preprint: BIORXIV. 2024;BIORXIV
    Centeno D; Farsinejad S; Kochetkova E; Volpari T; Gladych-Macioszek A; Klupczynska-Gabryszak A; Polotaye T; Greenberg M; Kung D; Hyde E; Alshehri S; Pavlovic T; Sullivan W; Plewa S; Vakifahmetoglu-Norberg H; Monsma FJ; Muller PAJ; Matysiak J; Zaborowski M; DiFeo A; Norberg E; Martin LA; Iwanicki M
  • Preprint: BIORXIV. 2022
    Zhou X; Shi Y; Shirokova V; Kochetkova E; Becirovic T; Zhang B; Kaminskyy VO; Lindskog C; Hydbring P; Ekman S; Genander M; Norberg E; Vakifahmetoglu-Norberg H
  • Review: FRONTIERS IN ONCOLOGY. 2020;10:607149
    Shi Y; Norberg E; Vakifahmetoglu-Norberg H
  • Editorial comment: THERANOSTICS. 2018;8(7):2061-2063
    Queiroz AL; Vakifahmetoglu-Norberg H; Norberg E
  • Review: AUTOPHAGY. 2016;12(1):1-222
    Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Arozena AA; Adachi H; Adams CM; Adams PD; Adeli K; Adhihetty PJ; Adler SG; Agam G; Agarwal R; Aghi MK; Agnello M; Agostinis P; Aguilar PV; Aguirre-Ghiso J; Airoldi EM; Ait-Si-Ali S; Akematsu T; Akporiaye ET; Al-Rubeai M; Albaiceta GM; Albanese C; Albani D; Albert ML; Aldudo J; Alguel H; Alirezaei M; Alloza I; Almasan A; Almonte-Beceril M; Alnemri ES; Alonso C; Altan-Bonnet N; Altieri DC; Alvarez S; Alvarez-Erviti L; Alves S; Amadoro G; Amano A; Amantini C; Ambrosio S; Amelio I; Amer AO; Amessou M; Amon A; An Z; Anania FA; Andersen SU; Andley UP; Andreadi CK; Andrieu-Abadie N; Anel A; Ann DK; Anoopkumar-Dukie S; Antonioli M; Aoki H; Apostolova N; Aquila S; Aquilano K; Araki K; Arama E; Aranda A; Araya J; Arcaro A; Arias E; Arimoto H; Ariosa AR; Armstrong JL; Arnould T; Arsov I; Asanuma K; Askanas V; Asselin E; Atarashi R; Atherton SS; Atkin JD; Attardi LD; Auberger P; Auburger G; Aurelian L; Autelli R; Avagliano L; Avantaggiati ML; 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  • Review: TRENDS IN CELL BIOLOGY. 2014;24(2):118-127
    Stanley IA; Ribeiro SM; Gimenez-Cassina A; Norberg E; Danial NN
  • Corrigendum: FREE RADICAL BIOLOGY AND MEDICINE. 2013;65:895-896
    Dong L-F; Jameson VJA; Tilly D; Prochazka L; Rohlena J; Valis K; Truksa J; Zobalova R; Mandavian E; Kluckova K; Stantic M; Stursa J; Freeman R; Witting PK; Norberg E; Goodwin J; Salvatore BA; Novotna J; Turanek J; Ledvina M; Hozak P; Zhivotovsky B; Coster MJ; Ralph SJ; Smith RAJ; Neuzil J
  • Review: CELL DEATH AND DIFFERENTIATION. 2009;16(8):1075-1082
    Ott M; Norberg E; Zhivotovsky B; Orrenius S

Employments

  • Affiliated to Research, Department of Physiology and Pharmacology, Karolinska Institutet, 2024-2026
  • Principal Researcher, Department of Physiology and Pharmacology, Karolinska Institutet, 2021-2024

Degrees and Education

  • Docent, Karolinska Institutet, 2019
  • Degree Of Doctor Of Philosophy, Institute of Environmental Medicine, Karolinska Institutet, 2011

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