Dimitris Kanellis

Om mig
Publikationer
Populärvetenskap och samverkan

Om mig

Bsc Biology, AUTH, Thessaloniki, GR
Msc 'The molecular Basis of Human Diseases', Medical School, UOC, Heraklion, GR
PhD in 'Inflammation-associated Carcinogenesis' IMBB/FORTH, Heraklion, GR

Forskningsbeskrivning

Min forskning syftar till att identifiera och tolka behandlingsrelevanta biologiska mönster i cancer, särskilt de som uppstår genom avvikande posttranskriptionella processer i cancerceller.

Artiklar

Article: NUCLEIC ACIDS RESEARCH. 2024;52(8):4151-4166
Chromatin damage generated by DNA intercalators leads to degradation of RNA Polymerase II
Espinoza JA; Kanellis DC; Saproo S; Leal K; Martinez JF; Bartek J; Lindstrom MS
Article: NATURE COMMUNICATIONS. 2024;15(1):3837
Longitudinal molecular profiling elucidates immunometabolism dynamics in breast cancer
Wang K; Zerdes I; Johansson HJ; Sarhan D; Sun Y; Kanellis DC; Sifakis EG; Mezheyeuski A; Liu X; Loman N; Hedenfalk I; Bergh J; Bartek J; Hatschek T; Lehtio J; Matikas A; Foukakis T
Article: CELL DEATH AND DIFFERENTIATION. 2023;30(7):1666-1678
Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET
Kanellis DC; Zisi A; Skrott Z; Lemmens B; Espinoza JA; Kosar M; Bjorkman A; Li X; Arampatzis S; Bartkova J; Andujar-Sanchez M; Fernandez-Capetillo O; Mistrik M; Lindstrom MS; Bartek J
Article: NEURO-ONCOLOGY. 2023;25(6):1058-1072
Small molecule-mediated disruption of ribosome biogenesis synergizes with FGFR inhibitors to suppress glioma cell growth
Zisi A; Kanellis DC; Moussaud S; Karlsson I; Caren H; Braeutigam L; Bartek J; Lindstrom MS
Article: CELL REPORTS. 2023;42(1):111979
MDC1 maintains active elongation complexes of RNA polymerase II
Pappas G; Munk SHN; Watanabe K; Thomas Q; Gal Z; Gram HH; Lee M; Gomez-Cabello D; Kanellis DC; Olivares-Chauvet P; Larsen DH; Gregersen LH; Maya-Mendoza A; Galanos P; Bartek J
Article: SCIENCE ADVANCES. 2021;7(32):eabf7561
The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output
Kanellis DC; Espinoza JA; Zisi A; Sakkas E; Bartkova J; Katsori A-M; Bostrom J; Dyrskjot L; Broholm H; Altun M; Elsasser SJ; Lindstrom MS; Bartek J
Article: PLOS BIOLOGY. 2021;19(5):e3001263
A chemical screen for modulators of mRNA translation identifies a distinct mechanism of toxicity for sphingosine kinase inhibitors
Corman A; Kanellis DC; Michalska P; Haggblad M; Lafarga V; Bartek J; Carreras-Puigvert J; Fernandez-Capetillo O
Article: GENES & DEVELOPMENT. 2020;34(15-16):1065-1074
Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution
Bjorkman A; Johansen SL; Lin L; Schertzer M; Kanellis DC; Katsori A-M; Christensen ST; Luo Y; Andersen JS; Elsasser SJ; Londono-Vallejo A; Bartek J; Schou KB
Article: CELL DEATH AND DIFFERENTIATION. 2020;27(2):773-789
The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity
Espinoza JA; Zisi A; Kanellis DC; Carreras-Puigvert J; Henriksson M; Huhn D; Watanabe K; Helleday T; Lindstrom MS; Bartek J
Article: ONCOGENE. 2016;35(19):2496-2505
Apolipoprotein A-I inhibits experimental colitis and colitis-propelled carcinogenesis
Gkouskou KK; Ioannou M; Pavlopoulos GA; Georgila K; Siganou A; Nikolaidis G; Kanellis DC; Moore S; Papadakis KA; Kardassis D; Iliopoulos I; McDyer FA; Drakos E; Eliopoulos AG
Article: ONCOGENE. 2015;34(19):2516-2526
Physical and functional interaction of the TPL2 kinase with nucleophosmin
Kanellis DC; Bursac S; Tsichlis PN; Volarevic S; Eliopoulos AG
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(16):E1470-E1479
TPL2 kinase is a suppressor of lung carcinogenesis
Gkirtzimanaki K; Gkouskou KK; Oleksiewicz U; Nikolaidis G; Vyrla D; Liontos M; Pelekanou V; Kanellis DC; Evangelou K; Stathopoulos EN; Field JK; Tsichlis PN; Gorgoulis V; Liloglou T; Eliopoulos AG
Article: JOURNAL OF BIOLOGICAL RESEARCH-THESSALONIKI. 2007;7:41-49
Follow-up of hatchery rotifer cultures with regard to their genetic identity
Papakostas S; De Wolf T; Triantafyllidis A; Vasileiadou K; Kanellis D; Cecconi P; Kappas I; Abatzopoulos TJ

Alla övriga publikationer

Meeting abstract: CANCER RESEARCH. 2024;84(5):pr-002-pr-002
Uncovering novel therapeutic avenues for glioma by exploring the functional interplay of FGFR1, p53, and ribosome biogenesis
Zisi A; Dratkiewicz E; Kanellis DC; Moussaud S; Karlsson I; Caren H; Brautigam L; Bartek J; Lindstrom MS
Letter: LEUKEMIA. 2024;38(3):663-666
The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
Miliara S; Cozzi E; Zhong X; Chan I; Ekwall K; Lehmann S; Lennartsson A; Bartek J; Kanellis DC
Preprint: BIORXIV. 2020
A chemical screen identifies a link between lipid metabolism and mRNA translation
Corman A; Kanellis DC; Häggblad M; Lafarga V; Bartek J; Carreras-Puigvert J; Fernandez-Capetillo O
Conference publication: FEBS JOURNAL. 2013;280:68
Tpl2 interacts with and regulates NPM expression levels under genotoxic stress
Kanellis DC; Tsichlis PN; Eliopoulos AG
Review: CANCER LETTERS. 2011;304(2):80-89
Tp12 kinase signal transduction in inflammation and cancer
Vougioukalaki M; Kanellis DC; Gkouskou K; Eliopoulos AG

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