Dawei Xu | Karolinska Institutet

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2026;24(1):497
DKC1: a robust prognostic factor and potential therapeutic target in multiple myeloma
Sun C; Cheng L; Li A; Han Y; Wang Y; Xiao J; Guo Y; Zhang W; Sun L; Xu D; Kong D; Jiang Y; Zheng C
Article: FRONTIERS IN IMMUNOLOGY. 2025;16:1585647
Glycan dysregulation as one of major metabolic subtypes is associated with TERC overexpression and poor outcomes in cervical cancer
Dong Y; Zhang X; Zhao J; Hou Q; Yu Y; Wu Y; Shi X; Wang L; Xu D
Article: CELL DEATH & DISEASE. 2025;16(1):618
The ETS transcription factor GABPA inhibits bladder cancer aggressiveness by repressing extracellular matrix deposition and mechanotransduction signaling
Dai M; Yuan X; Sun C; Han R; Bjorkholm M; Kong F; Zhao S; Xu D
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2025;13:1592135
Comprehensive analyses of telomerase component DKC1 and its association with clinical, molecular and immune landscapes in uterine corpus endometrial carcinoma
Sun C; Liu X; Liu T; Fan C; Jiang Y; Li B; Yuan H; Zheng C; Xu D
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2024;22(1):1049
Maternal infection of SARS-CoV-2 during the first and second trimesters leads to newborn telomere shortening
Wang L; Zhang J; Liu F; Shi Q; Gao F; Li J; Liu Y; Kong F; Xu D
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2024;174:106871
Expression and putative biological roles of lipoxygenases and leukotriene receptors in leukemia and lymphoma
Claesson H-E; Sjoberg J; Xu D; Bjorkholm M
Article: CANCER CELL INTERNATIONAL. 2024;24(1):127
Comprehensive analyses of the cancer-associated fibroblast subtypes and their score system for prediction of outcomes and immunosuppressive microenvironment in prostate cancer
Gao Z; Zhang N; An B; Li D; Fang Z; Xu D
Article: BIOMEDICINE & PHARMACOTHERAPY. 2023;169:115863
Irisin protected hemopoietic stem cells and improved outcome of severe bone marrow failure
Li H; Kong D; Zhao Y; Liu X; Xiao F; Li X; Hu J; Chen Y; Li S; Wang B; Chen Y; Jiang Y; Liu X; Feng X; Guo Y; Feng X; Ren J; Wang F; Han Y; Donelan W; Yang L; Xu D; Tang D; Zheng C
Article: BIOLOGY OF SEX DIFFERENCES. 2023;14(1):46
Dyskerin and telomerase RNA component are sex-differentially associated with outcomes and Sunitinib response in patients with clear cell renal cell carcinoma
Yuan H; Qin X; Yang Q; Liu L; Fang Z; Fan Y; Xu D
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1208223
High DNA methylation age deceleration defines an aggressive phenotype with immunoexclusion environments in endometrial carcinoma
Hao J; Liu T; Xiu Y; Yuan H; Xu D
Article: FRONTIERS IN ONCOLOGY. 2023;13:1133902
The chromosomal instability 25 gene signature is identified in clear cell renal cell carcinoma and serves as a predictor for survival and Sunitinib response
Wang C; Qin X; Guo W; Wang J; Liu L; Fang Z; Yuan H; Fan Y; Xu D
Article: BIOMEDICINE & PHARMACOTHERAPY. 2023;158:114193
Widespread genomic/molecular alterations of DNA helicases and their clinical/therapeutic implications across human cancer
Qin X; Wang J; Wang X; Huang T; Fang Z; Yan L; Fan Y; Xu D
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1126247
The cuproptosis-associated 11 gene signature as a predictor for outcomes and response to Bacillus Calmette-Guerin and immune checkpoint inhibitor therapies in bladder carcinoma.
Yuan H; Xiu Y; Liu T; Fan Y; Xu D
Article: MOLECULAR ONCOLOGY. 2023;17(1):150-172
Genomic, epigenomic, and transcriptomic signatures for telomerase complex components: a pan-cancer analysis
Wang J; Dai M; Xing X; Wang X; Qin X; Huang T; Fang Z; Fan Y; Xu D
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:971142
The cuproptosis-associated 13 gene signature as a robust predictor for outcome and response to immune- and targeted-therapies in clear cell renal cell carcinoma
Yuan H; Qin X; Wang J; Yang Q; Fan Y; Xu D
Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2022;41(1):173
GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma
Fang Z; Zhang N; Yuan X; Xing X; Li X; Qin X; Liu Z; Neo S; Liu C; Kong F; Bjorkholm M; Fan Y; Xu D
Article: BIOMEDICINE & PHARMACOTHERAPY. 2022;149:112796
Synergistic effects of telomerase reverse transcriptase and regulator of telomere elongation helicase 1 on aggressiveness and outcomes in adrenocortical carcinoma
Yuan H; Wu Y; Wang J; Qin X; Huang Y; Yan L; Fana Y; Zedenius J; Juhlin CC; Larsson C; Lui W-O; Xu D
Article: CANCERS. 2022;14(6):1385
Downregulation and Hypermethylation of GABPB1 Is Associated with Aggressive Thyroid Cancer Features
Xing X; Mu N; Yuan X; Wang N; Juhlin CC; Straat K; Larsson C; Neo SY; Xu D
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2022;79(2):110
The association of telomere maintenance and TERT expression with susceptibility to human papillomavirus infection in cervical epithelium
Wang L-N; Wang L; Cheng G; Dai M; Yu Y; Teng G; Zhao J; Xu D
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2021;156:106575
Intrinsic 5-lipoxygenase activity regulates migration and adherence of mantle cell lymphoma cells
Xia C; Sadeghi L; Straat K; Merrien M; Wright AP; Sander B; Xu D; Osterborg A; Bjorkholm M; Claesson H-E
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Alla övriga publikationer

Review: FRONTIERS IN IMMUNOLOGY. 2023;13:1071390
TERT promoter mutations and methylation for telomerase activation in urothelial carcinomas: New mechanistic insights and clinical significance
Liu T; Li S; Xia C; Xu D
Review: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(11):e1111
Thyroid carcinoma-featured telomerase activation and telomere maintenance: Biology and translational/clinical significance
Yuan X; Yuan H; Zhang N; Liu T; Xu D
Review: CANCER LETTERS. 2020;493:1-9
TERT promoter mutations and GABP transcription factors in carcinogenesis: More foes than friends
Yuan X; Dai M; Xu D
Review: ANNALS OF TRANSLATIONAL MEDICINE. 2020;8(19):1244
Telomerase reverse transcriptase promoter mutations in thyroid carcinomas: implications in precision oncology-a narrative review
Yuan X; Liu T; Xu D
Review: CURRENT TOPICS IN MEDICINAL CHEMISTRY. 2020;20(6):410-432
Telomere-related Markers for Cancer
Yuan X; Dai M; Xu D
Review: ONCOGENE. 2019;38(34):6172-6183
Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players
Yuan X; Larsson C; Xu D
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(13):E3338-3338
Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking with Epigenetics
Yuan X; Xu D
Review: GENES. 2016;7(7):E38-38
Cancer-Specific Telomerase Reverse Transcriptase (TERT) Promoter Mutations: Biological and Clinical Implications
Liu T; Yuan X; Xu D
Letter: HAEMATOLOGICA. 2015;100(10):e402-e405
Dysregulation of shelterin factors coupled with telomere shortening in Philadelphia chromosome negative myeloproliferative neoplasms
Dahlstrom J; Zhang X; Ghaderi M; Hultcrantz M; Bjorkholm M; Xu D
Letter: ENDOCRINE-RELATED CANCER. 2015;22(3):L9-L11
TERT promoter mutations are rare in parathyroid tumors
Haglund F; Juhlin CC; Brown T; Ghaderi M; Liu T; Stenman A; Dinets A; Prasad M; Korah R; Xu D; Carling T; Larsson C
Letter: LEUKEMIA. 2014;28(8):1751-1754
Genomic analysis of the clonal origin and evolution of acute promyelocytic leukemia in a unique patient with a very late (17 years) relapse
Zhang X; Zhang Q; Dahlstrom J; Tran AN; Yang B; Gu Z; Ghaderi M; Porwit A; Jia J; Derolf A; Xu D; Bjorkholm M
Review: SCIENCE CHINA-LIFE SCIENCES. 2014;57(6):564-570
Telomerase as a "stemness" enzyme
Kong F; Zheng C; Xu D
Letter: GENE. 2014;540(2):266-267
The absence of TERT promoter mutations in primary gastric cancer
Liu T; Liang X; Bjoerkholm M; Jia J; Xu D
Corrigendum: PLOS ONE. 2014;9(2):e91499
Interleukin-4-Mediated 15-Lipoxygenase-1 Trans-Activation Requires UTX Recruitment and H3K27me3 Demethylation at the Promoter in A549 Cells (vol 9, e85085, 2014)
Han H; Xu D; Liu C; Claesson H-E; Bjoerkholm M
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2008;9(1):44
UNCOVERING NF-κB ACTIVATION AND FUNCTION IN INTIMAL DEVELOPMENT
Bu D; Xu D; Hansson G; Yan Z
Published conference paper: CANCER RESEARCH. 2003;63(8):1743-1747
Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling:: Activation of the Epiregulin gene
Lindvall C; Hou M; Komurasaki T; Zheng CY; Henriksson M; Sedivy JM; Björkholm M; Teh BT; Nordenskjöld M; Xu DW
Published conference paper: CLINICAL CHEMISTRY. 2001;47(3):519-524
Real-time quantitative telomeric repeat amplification protocol assay for the detection of telomerase activity
Hou M; Xu DW; Björkholm M; Gruber A
Doctoral thesis: 1999
Telomerase activity and its regulation in malignant hematopoietic cells
Xu D
Conference publication: BLOOD. 1995;86(10):2727
Telomerase is expressed in CD34+ hematopoietic cells from normal human umbilical cord blood, adult peripheral blood and bone marrow.
Xu D; Palucka AK; Peterson C; Bjorkholm M; Gruber A; Pisa P

Anställningar

Senior Forskare, Medicin, Solna, Karolinska Institutet, 2022-

Examina och utbildning

Docent, Experimentell medicin, Karolinska Institutet, 2006
MEDICINE DOKTORSEXAMEN, Institutionen för medicin, Solna, Karolinska Institutet, 1999

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