Xu Dawei

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: CANCER CELL INTERNATIONAL. 2024;24(1):127

Comprehensive analyses of the cancer-associated fibroblast subtypes and their score system for prediction of outcomes and immunosuppressive microenvironment in prostate cancer.

Gao Z; Zhang N; An B; Li D; Fang Z; Xu D
Article: BIOMEDICINE & PHARMACOTHERAPY. 2023;169:115863

Irisin protected hemopoietic stem cells and improved outcome of severe bone marrow failure

Li H; Kong D; Zhao Y; Liu X; Xiao F; Li X; Hu J; Chen Y; Li S; Wang B; Chen Y; Jiang Y; Liu X; Feng X; Guo Y; Feng X; Ren J; Wang F; Han Y; Donelan W; Yang L; Xu D; Tang D; Zheng C
Article: BIOLOGY OF SEX DIFFERENCES. 2023;14(1):46

Dyskerin and telomerase RNA component are sex-differentially associated with outcomes and Sunitinib response in patients with clear cell renal cell carcinoma

Yuan H; Qin X; Yang Q; Liu L; Fang Z; Fan Y; Xu D
Article: BIOMEDICINE & PHARMACOTHERAPY. 2023;158:114193

Widespread genomic/molecular alterations of DNA helicases and their clinical/therapeutic implications across human cancer

Qin X; Wang J; Wang X; Huang T; Fang Z; Yan L; Fan Y; Xu D
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1126247

The cuproptosis-associated 11 gene signature as a predictor for outcomes and response to Bacillus Calmette-Guerin and immune checkpoint inhibitor therapies in bladder carcinoma.

Yuan H; Xiu Y; Liu T; Fan Y; Xu D
Article: MOLECULAR ONCOLOGY. 2023;17(1):150-172

Genomic, epigenomic, and transcriptomic signatures for telomerase complex components: a pan-cancer analysis

Wang J; Dai M; Xing X; Wang X; Qin X; Huang T; Fang Z; Fan Y; Xu D
Article: FRONTIERS IN ONCOLOGY. 2023;13:1133902

The chromosomal instability 25 gene signature is identified in clear cell renal cell carcinoma and serves as a predictor for survival and Sunitinib response

Wang C; Qin X; Guo W; Wang J; Liu L; Fang Z; Yuan H; Fan Y; Xu D
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1208223

High DNA methylation age deceleration defines an aggressive phenotype with immunoexclusion environments in endometrial carcinoma

Hao J; Liu T; Xiu Y; Yuan H; Xu D
Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2022;41(1):173

GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma

Fang Z; Zhang N; Yuan X; Xing X; Li X; Qin X; Liu Z; Neo S; Liu C; Kong F; Bjorkholm M; Fan Y; Xu D
Article: BIOMEDICINE & PHARMACOTHERAPY. 2022;149:112796

Synergistic effects of telomerase reverse transcriptase and regulator of telomere elongation helicase 1 on aggressiveness and outcomes in adrenocortical carcinoma

Yuan H; Wu Y; Wang J; Qin X; Huang Y; Yan L; Fana Y; Zedenius J; Juhlin CC; Larsson C; Lui W-O; Xu D
Article: CANCERS. 2022;14(6):1385

Downregulation and Hypermethylation of GABPB1 Is Associated with Aggressive Thyroid Cancer Features

Xing X; Mu N; Yuan X; Wang N; Juhlin CC; Straat K; Larsson C; Neo SY; Xu D
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2022;79(2):110

The association of telomere maintenance and TERT expression with susceptibility to human papillomavirus infection in cervical epithelium

Wang L-N; Wang L; Cheng G; Dai M; Yu Y; Teng G; Zhao J; Xu D
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:971142

The cuproptosis-associated 13 gene signature as a robust predictor for outcome and response to immune- and targeted-therapies in clear cell renal cell carcinoma

Yuan H; Qin X; Wang J; Yang Q; Fan Y; Xu D
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2021;156:106575

Intrinsic 5-lipoxygenase activity regulates migration and adherence of mantle cell lymphoma cells

Xia C; Sadeghi L; Straat K; Merrien M; Wright AP; Sander B; Xu D; Osterborg A; Bjorkholm M; Claesson H-E
Article: CANCERS. 2021;13(19):4827

DNA Methylation Age Drift Is Associated with Poor Outcomes and De-Differentiation in Papillary and Follicular Thyroid Carcinomas

Liu T; Wang J; Xiu Y; Wu Y; Xu D
Article: JOURNAL OF CANCER. 2021;12(13):3853-3861

Regulatory region mutations of TERT, PLEKHS1 and GPR126 genes as urinary biomarkers in upper tract urothelial carcinomas

Xing X; Yuan X; Liu T; Dai M; Fan Y; Liu C; Straat K; Bjorkholm M; Xu D
Article: CANCERS. 2020;12(8):E2133-2133

PLEKHS1 Over-Expression is Associated with Metastases and Poor Outcomes in Papillary Thyroid Carcinoma

Xing X; Mu N; Yuan X; Wang N; Juhlin CC; Straat K; Larsson C; Xu D
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2020;527(2):425-431

JAK2 inhibition in JAK2^V617F-bearing leukemia cells enriches CD34⁺ leukemic stem cells that are abolished by the telomerase inhibitor GRN163L

Dahlstrom J; Xia C; Xing X; Yuan X; Bjorkholm M; Xu D
Article: CELL DEATH AND DIFFERENTIATION. 2020;27(6):1862-1877

GABPA is a master regulator of luminal identity and restrains aggressive diseases in bladder cancer

Guo Y; Yuan X; Li K; Dai M; Zhang L; Wu Y; Sun C; Chen Y; Cheng G; Liu C; Straat K; Kong F; Zhao S; Bjorkholm M; Xu D
Article: ONCOGENE. 2020;39(21):4286-4298

VHL-HIF-2α axis-induced SMYD3 upregulation drives renal cell carcinoma progression via direct trans-activation of EGFR

Liu C; Liu L; Wang K; Li X-F; Ge L-Y; Ma R-Z; Fan Y-D; Li L-C; Liu Z-F; Qiu M; Hao Y-C; Shi Z-F; Xia C-Y; Straat K; Huang Y; Ma L-L; Xu D
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2020;18(1):184

The telomerase gene polymorphisms, but not telomere length, increase susceptibility to primary glomerulonephritis/end stage renal diseases in females

Sun Q; Liu J; Cheng G; Dai M; Liu J; Qi Z; Zhao J; Li W; Kong F; Liu G; Bjorkholm M; Xu D
Article: AGING-US. 2020;12(3):2030-2048

High expression of SMYD3 indicates poor survival outcome and promotes tumour progression through an IGF-1R/AKT/E2F-1 positive feedback loop in bladder cancer

Wang G; Huang Y; Yang F; Tian X; Wang K; Liu L; Fan Y; Li X; Li L; Shi B; Hao Y; Xia C; Nie Q; Xin Y; Shi Z; Ma L; Xu D; Liu C
Article: FRONTIERS IN ONCOLOGY. 2020;10:598872

Hodgkin Lymphoma Monozygotic Triplets Reveal Divergences in DNA Methylation Signatures

Xia C; Olsen TK; Zirakzadeh AA; Almamoun R; Sjoholm LK; Dahlstrom J; Sjoberg J; Claesson H-E; Johnsen JI; Winqvist O; Xu D; Ekstrom TJ; Bjorkholm M; Straat K
Article: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY. 2020;13(8):2123-2129

Patients with benign prostatic hyperplasia show shorter leukocyte telomere length but no association with telomerase gene polymorphisms in Han Chinese males

Cheng G; Dai M; Xin Q; Wang L; Kong F; Xu D
Article: INTERNATIONAL JOURNAL OF MEDICAL SCIENCES. 2020;17(14):2180-2186

Shorter Leukocyte Telomere Length coupled with lower expression of Telomerase Genes in patients with Essential Hypertension

Cheng G; Wang L; Dai M; Wei F; Xu D
Article: EPIGENETICS. 2019;14(12):1224-1233

Telomerase activation in small intestinal neuroendocrine tumours is associated with aberrant TERT promoter methylation, but not hot-spot mutations

Fotouhi O; Ghaderi M; Wang N; Zedenius J; Kjellman M; Xu D; Juhlin CC; Larsson C
Article: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS. 2019;37(5):301.e1-301.e10

The TERT locus genotypes of rs2736100-CC/CA and rs2736098-AA predict shorter survival in renal cell carcinoma

Ma R; Liu C; Lu M; Yuan X; Cheng G; Kong F; Lu J; Straat K; Bjorkholm M; Ma L; Xu D
Article: ONCOGENE. 2019;38(7):965-979

GABPA inhibits invasion/metastasis in papillary thyroid carcinoma by regulating DICER1 expression

Yuan X; Mu N; Wang N; Straat K; Sofiadis A; Guo Y; Stenman A; Li K; Cheng G; Zhang L; Kong F; Ekblad L; Wennerberg J; Nilsson I-L; Juhlin CC; Larsson C; Xu D
Article: CELL DEATH & DISEASE. 2019;10(2):76

ASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells

Wu Y; Li X; Yu J; Bjorkholm M; Xu D
Article: AGING-US. 2018;10(10):3005-3016

Longitudinal changes in leukocyte telomere length and mortality in elderly Swedish men

Yuan X; Kronstrom M; Hellenius M-L; Cederholm T; Xu D; Sjogren P
Article: CANCER LETTERS. 2018;434:33-41

Telomerase reverse transcriptase regulates DNMT3B expression/aberrant DNA methylation phenotype and AKT activation in hepatocellular carcinoma

Yu J; Yuan X; Sjoholm L; Liu T; Kong F; Ekstrom TJ; Bjorkholm M; Xu D
Article: CELL DEATH & DISEASE. 2018;9(9):923

Ectopic hTERT expression facilitates reprograming of fibroblasts derived from patients with Werner syndrome as a WS cellular model

Wang S; Liu Z; Ye Y; Li B; Liu T; Zhang W; Liu G-H; Zhang YA; Qu J; Xu D; Chen Z
Article: CURRENT UROLOGY. 2018;11(3):131-138

Paris Polyphylla-Derived Saponins Inhibit Growth of Bladder Cancer Cells by Inducing Mutant P53 Degradation While Up-Regulating CDKN1A Expression.

Guo Y; Liu Z; Li K; Cao G; Sun C; Cheng G; Zhang D; Peng W; Liu J; Qi Y; Zhang L; Wang P; Chen Y; Lin Z; Guan Y; Zhang J; Wen J; Wang F; Kong F; Xu D; Zhao S
Article: ANNALS OF HEMATOLOGY. 2018;97(1):63-72

MYC-dependent downregulation of telomerase by FLT3 inhibitors is required for their therapeutic efficacy on acute myeloid leukemia

Zhang X; Li B; Yu J; Dahlstrom J; Anh NT; Bjorkhom M; Xu D
Article: ONCOLOGIST. 2017;22(10):1178-1188

TERT Promoter Hypermethylation in Gastrointestinal Cancer: A Potential Stool Biomarker

Liu L; Liu C; Fotouhi O; Fan Y; Wang K; Xia C; Shi B; Zhang G; Wang K; Kong F; Larsson C; Hu S; Xu D
Article: EBIOMEDICINE. 2017;21:104-116

Histone Chaperone ASF1A Predicts Poor Outcomes for Patients With Gastrointestinal Cancer and Drives Cancer Progression by Stimulating Transcription of β-Catenin Target Genes

Liang X; Yuan X; Yu J; Wu Y; Li K; Sun C; Li S; Shen L; Kong F; Jia J; Bjorkholm M; Xu D
Article: CANCER RESEARCH. 2017;77(9):2534-2547

WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT^high Prostate Cancer Stem Cells

Zhang K; Guo Y; Wang X; Zhao H; Ji Z; Cheng C; Li L; Fang Y; Xu D; Zhu HH; Gao W-Q
Article: ONCOTARGET. 2017;8(14):23120-23129

The TERT promoter mutation incidence is modified by germline TERT rs2736098 and rs2736100 polymorphisms in hepatocellular carcinoma

Yuan X; Cheng G; Yu J; Zheng S; Sun C; Sun Q; Li K; Lin Z; Liu T; Li P; Xu Y; Kong F; Bjorkholm M; Xu D
Article: CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY. 2017;8(3):e79

Association Between the Telomerase rs2736098_ TT Genotype and a Lower Risk of Chronic Hepatitis B and Cirrhosis in Chinese Males

Cheng G; Yuan X; Wang F; Sun Q; Xin Q; Li K; Sun C; Lin Z; Luan Y; Xu Y; Li P; Kong F; Xu D
Article: FASEB JOURNAL. 2017;31(2):491-504

Human 15-lipoxygenase-1 is a regulator of dendritic-cell spreading and podosome formation

Han H; Liang X; Ekberg M; Kritikou JS; Brunnstrom A; Pelcman B; Matl M; Miao X; Andersson M; Yuan X; Schain F; Parvin S; Melin E; Sjoberg J; Xu D; Westerberg LS; Bjorkholm M; Claesson H-E
Article: ANNALS OF HEMATOLOGY. 2016;95(11):1825-1832

TERT rs2736100 genotypes are associated with differential risk of myeloproliferative neoplasms in Swedish and Chinese male patient populations

Dahlstrom J; Liu T; Yuan X; Saft L; Ghaderi M; Wei YB; Lavebratt C; Li P; Zheng C; Bjorkholm M; Xu D
Article: ONCOTARGET. 2016;7(22):31972-31979

The association between the TERT rs2736100 AC genotype and reduced risk of upper tract urothelial carcinomas in a Han Chinese population

Yuan X; Meng Y; Li P; Ge N; Kong F; Yang L; Bjorkholm M; Zhao S; Xu D
Article: ONCOTARGET. 2016;7(18):25826-25835

The genetic difference between Western and Chinese urothelial cell carcinomas: infrequent FGFR3 mutation in Han Chinese patients

Yuan X; Liu C; Wang K; Liu L; Liu T; Ge N; Kong F; Yang L; Bjorkholm M; Fan Y; Zhao S; Xu D
Article: ONCOTARGET. 2016;7(16):21332-21346

Genetic and epigenetic background and protein expression profiles in relation to telomerase activation in medullary thyroid carcinoma

Wang N; Kjellin H; Sofiadis A; Fotouhi O; Juhlin CC; Backdahl M; Zedenius J; Xu D; Lehtio J; Larsson C
Article: ONCOTARGET. 2015;6(35):38079-38092

Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells

Ci X; Li B; Ma X; Kong F; Zheng C; Bjorkholm M; Jia J; Xu D
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2015;121(Pt A):122-130

Early growth response gene (EGR)-1 regulates leukotriene D4-induced cytokine transcription in Hodgkin lymphoma cells

Han H; Xue-Franzen Y; Miao X; Nagy E; Li N; Xu D; Sjoberg J; Bjorkholm M; Claesson H-E
Article: ONCOTARGET. 2015;6(7):4888-4900

The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression

Zhang X; Li B; de Jonge N; Bjorkholm M; Xu D
Article: ONCOLOGIST. 2015;20(3):263-269

TERT Promoter Mutations and TERT mRNA but Not FGFR3 Mutations Are Urinary Biomarkers in Han Chinese Patients With Urothelial Bladder Cancer

Wang K; Liu T; Liu C; Meng Y; Yuan X; Liu L; Ge N; Liu J; Wang C; Ren H; Yan K; Hu S; Xu Z; Fan Y; Xu D
Article: ONCOTARGET. 2014;5(23):12428-12439

TERT promoter mutations are associated with distant metastases in upper tract urothelial carcinomas and serve as urinary biomarkers detected by a sensitive castPCR

Wang K; Liu T; Ge N; Liu L; Yuan X; Liu J; Kong F; Wang C; Ren H; Yan K; Hu S; Xu Z; Bjrkholm M; Fan Y; Zhao S; Liu C; Xu D
Article: ONCOTARGET. 2014;5(20):10048-10057

TERT promoter mutations and gene amplification: Promoting TERT expression in Merkel cell carcinoma

Xie H; Liu T; Wang N; Bjornhagen V; Hoog A; Larsson C; Lui W-O; Xu D
Article: ONCOGENE. 2014;33(42):4978-4984

The age- and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomas

Liu T; Wang N; Cao J; Sofiadis A; Dinets A; Zedenius J; Larsson C; Xu D
Article: CANCER. 2014;120(19):2965-2979

TERT Promoter Mutation as an Early Genetic Event Activating Telomerase in Follicular Thyroid Adenoma (FTA) and Atypical FTA

Wang N; Liu T; Sofiadis A; Juhlin CC; Zedenius J; Hoog A; Larsson C; Xu D
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2014;99(8):E1571-E1579

Telomerase-Dependent and Independent Telomere Maintenance and its Clinical Implications in Medullary Thyroid Carcinoma

Wang N; Xu D; Sofiadis A; Hoog A; Vukojevic V; Backdahl M; Zedenius J; Larsson C
Article: ENDOCRINE-RELATED CANCER. 2014;21(3):427-434

The activating TERT promoter mutation C228T is recurrent in subsets of adrenal tumors

Liu T; Brown TC; Juhlin CC; Andreasson A; Wang N; Backdahl M; Healy JM; Prasad ML; Korah R; Carling T; Xu D; Larsson C
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2014;12:135

Laminin 411 acts as a potent inducer of umbilical cord mesenchymal stem cell differentiation into insulin-producing cells

Qu H; Liu X; Ni Y; Jiang Y; Feng X; Xiao J; Guo Y; Kong D; Li A; Li X; Zhuang X; Wang Z; Wang Y; Chang Y; Chen S; Kong F; Zhang X; Zhao S; Sun Y; Xu D; Wang D; Zheng C
Article: ONCOTARGET. 2014;5(7):1829-1836

TERT promoter mutations in renal cell carcinomas and upper tract urothelial carcinomas

Wang K; Liu T; Liu L; Liu J; Liu C; Wang C; Ge N; Ren H; Yan K; Hu S; Bjorkholm M; Fan Y; Xu D
Article: PLOS ONE. 2014;9(4):e94442

Promoter Polymorphism in the Serotonin Transporter ( 5-HTT) Gene Is Significantly Associated with Leukocyte Telomere Length in Han Chinese

Li P; Liu T; Liu J; Zhang Q; Lou F; Kong F; Cheng G; Bjorkholm M; Zheng C; Xu D
Article: PLOS ONE. 2014;9(1):e85085

Interleukin-4-Mediated 15-Lipoxygenase-1 Trans-Activation Requires UTX Recruitment and H3K27me3 Demethylation at the Promoter in A549 Cells

Han H; Xu D; Liu C; Claesson H-E; Bjorkholm M; Sjoberg J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2013;442(1-2):112-115

Differential shortening rate of telomere length in the development of human fetus

Cheng G; Kong F; Luan Y; Sun C; Wang J; Zhang L; Jiang B; Qi T; Zhao J; Zheng C; Xu D
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2013;105(22):1719-1728

SMYD3 as an Oncogenic Driver in Prostate Cancer by Stimulation of Androgen Receptor Transcription

Liu C; Wang C; Wang K; Liu L; Shen Q; Yan K; Sun X; Chen J; Liu J; Ren H; Liu H; Xu Z; Hu S; Xu D; Fan Y
Article: ONCOGENE. 2013;32(36):4203-4213

Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells

Liu Z; Li Q; Li K; Chen L; Li W; Hou M; Liu T; Yang J; Lindvall C; Bjorkholm M; Jia J; Xu D
Article: BRITISH JOURNAL OF CANCER. 2013;108(11):2272-2280

Telomerase reverse transcriptase inhibition stimulates cyclooxygenase 2 expression in cancer cells and synergizes with celecoxib to exert anti-cancer effects

Liu T; Liang X; Li B; Bjorkholm M; Jia J; Xu D
Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2012;44(9):1531-1540

Telomere dysfunction induced by chemotherapeutic agents and radiation in normal human cells

Li P; Hou M; Lou F; Bjorkholm M; Xu D
Article: GENETICS AND MOLECULAR RESEARCH. 2012;11(1):370-378

Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma

Chen XF; Cai S; Chen QG; Ni ZH; Tang JH; Xu DW; Wang XB
Article: EXPERIMENTAL CELL RESEARCH. 2012;318(3):169-176

Epigenetic and transcriptional control of the 15-lipoxygenase-1 gene in a Hodgkin lymphoma cell line

Liu C; Schain F; Han H; Xu D; Andersson-Sand H; Forsell P; Claesson H-E; Bjorkholm M; Sjoberg J
Article: PLOS ONE. 2012;7(12):e52703

Transcriptional Regulation of 15-Lipoxygenase Expression by Histone H3 Lysine 4 Methylation/Demethylation

Liu C; Xu D; Han H; Fan Y; Schain F; Xu Z; Claesson H-E; Bjorkholm M; Sjoberg J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;416(3-4):372-378

Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer

Li W; Zhao L; Zang W; Liu Z; Chen L; Liu T; Xu D; Jia J
Article: JOURNAL OF PATHOLOGY. 2011;225(2):203-211

Activation of telomerase by seminal plasma in malignant and normal cervical epithelial cells

Liu L; Liu C; Lou F; Zhang G; Wang X; Fan Y; Yan K; Wang K; Xu Z; Hu S; Bjorkholm M; Xu D
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;407(3):599-604

Premature senescence of T cells in long-term survivors of renal transplantation

Li P; Tian C; Ge N; Wang H; Liu L; Lou F; Bjorkholm M; Xu D
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2010;30(12):2604-2610

Nuclear Factor κB-Mediated Transactivation of Telomerase Prevents Intimal Smooth Muscle Cell From Replicative Senescence During Vascular Repair

Bu D-X; Johansson ME; Ren J; Xu D-W; Johnson FB; Edfeldt K; Yan Z-Q
Article: MOLECULAR CANCER. 2010;9:132

Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer

Li W; Zeng J; Li Q; Zhao L; Liu T; Bjorkholm M; Jia J; Xu D
Article: GASTROENTEROLOGY. 2010;138(3):981-992

The Histone Demethylase RBP2 Is Overexpressed in Gastric Cancer and Its Inhibition Triggers Senescence of Cancer Cells

Zeng J; Ge Z; Wang L; Li Q; Wang N; Bjorkholm M; Jia J; Xu D
Article: FASEB JOURNAL. 2010;24(2):579-586

Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase

Ge Z; Li W; Wang N; Liu C; Zhu Q; Bjorkholm M; Gruber A; Xu D
Article: JOURNAL OF PATHOLOGY. 2009;218(4):419-427

FoxM1 is up-regulated in gastric cancer and its inhibition leads to cellular senescence, partially dependent on p27^kip1

Zeng J; Wang L; Li Q; Li W; Bjorkholm M; Jia J; Xu D
Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2009;297(1):L196-L203

15-Lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells

Liu C; Xu D; Liu L; Schain F; Brunnstrom A; Bjorkholm M; Claesson H-E; Sjoberg J
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2009;101(7):488-497

Activation of Telomerase by Human Cytomegalovirus

Straat K; Liu C; Rahbar A; Zhu Q; Liu L; Wolmer-Solberg N; Lou F; Liu Z; Shen J; Jia J; Kyo S; Bjoerkholm M; Sjoberg J; Soederberg-Naucler C; Xu D
Article: CLINICAL LYMPHOMA AND MYELOMA. 2008;8(6):340-347

Differential Expression of Cysteinyl Leukotriene Receptor 1 and 15-Lipoxygenase-1 in Non-Hodgkin Lymphomas

Schain F; Schain D; Mahshid Y; Liu C; Porwit A; Xu D; Claesson H-E; Sundstrom C; Bjorkholm M; Sjoberg J
Article: INTERNATIONAL JOURNAL OF CANCER. 2008;123(10):2285-2293

Evidence for a pathophysiological role of cysteinyl leukotrienes in classical Hodgkin lymphoma

Schain F; Tryselius Y; Sjoberg J; Porwit A; Backman L; Malec M; Xu D; Vockerodt M; Baumforth KRN; Wei W; Murray PG; Bjorkholm M; Claesson H-E
Article: CLINICAL CANCER RESEARCH. 2008;14(12):3722-3728

CIP2A is overexpressed in gastric cancer and its depletion leads to impaired clonogenicity, senescence, or differentiation of tumor cells

Li W; Ge Z; Liu C; Liu Z; Bjorkholm M; Jia J; Xu D
Article: CANCER LETTERS. 2008;260(1-2):28-36

Expression of the full-length telomerase reverse transcriptase (hTERT) transcript in both malignant and normal gastric tissues

Li W; Li L; Liu Z; Liu C; Liu Z; Straat K; Bjorkholm M; Jia J; Xu D
Article: PLOS ONE. 2008;3(1):e1446

Lysine-Specific Demethylase 1 (LSD1) Is Required for the Transcriptional Repression of the Telomerase Reverse Transcriptase (hTERT) Gene

Zhu Q; Liu C; Ge Z; Fang X; Zhang X; Straat K; Bjorkholm M; Xu D
Article: MOLECULAR CANCER RESEARCH. 2007;5(8):793-800

The opposing effect of hypoxia-inducible factor-2α on expression of telomerase reverse transcriptase

Lou F; Chen X; Jalink M; Zhu Q; Ge N; Zhao S; Fang X; Fan Y; Bjoerkholm M; Liu Z; Xu D
Article: CANCER RESEARCH. 2007;67(6):2626-2631

The telomerase reverse transcriptase (hTERT) gene is a direct target of the histone methyltransferase SMYD3

Liu C; Fang X; Ge Z; Jalink M; Kyo S; Bjorkhom M; Gruber A; Sjoberg J; Xu D
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;353(4):999-1003

Human normal T lymphocytes and lymphoid cell lines do express alternative splicing variants of human telomerase reverse transcriptase (hTERT) mRNA

Jalink M; Ge Z; Liu C; Bjorkholm M; Gruber A; Xu D
Article: BRITISH JOURNAL OF CANCER. 2006;94(11):1658-1662

Nucleostemin mRNA is expressed in both normal and malignant renal tissues

Fan Y; Liu Z; Zhao S; Lou F; Nilsson S; Ekman P; Xu D; Fang X
Article: INTERNATIONAL JOURNAL OF CANCER. 2006;118(10):2485-2489

Switch to full-length of XAF1 mRNA expression in prostate cancer cells by the DNA methylation inhibitor

Fang XL; Liu ZX; Fan YD; Zheng CY; Nilson S; Egevad L; Ekman P; Xu DW
Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(1):230-237

Mitogen-activated protein kinase cascade-mediated histone H3 phosphorylation is critical for telornerase reverse transcriptase expression/telomerase activation induced by proliferation

Ge Z; Liu C; Björkholm M; Gruber A; Xu DW
Article: INTERNATIONAL JOURNAL OF CANCER. 2005;116(3):395-400

hTERT gene copy number is not associated with hTERT RNA expression or telomerase activity in colorectal cancer

Palmqvist R; Zhang AJ; Xu DW; Golovleva F; Norrback KF; Gruber A; Öberg Å; Stenling R; Roos G
Article: CLINICAL CANCER RESEARCH. 2005;11(12):4331-4337

Differential expression of full-length telomerase reverse transcriptase mRNA and telomerase activity between normal and malignant renal tissues

Fan YD; Liu ZX; Fang XL; Ge Z; Ge N; Jia Y; Sun P; Lou FL; Björkholm M; Gruber A; Ekman P; Xu DW
Article: INTERNATIONAL JOURNAL OF CANCER. 2005;113(2):284-289

Epstein-Barr virus latent membrane 2A (LMP2A) down-regulates telomerase reverse transcriptase (hTERT) in epithelial cell lines

Chen F; Liu C; Lindvall C; Xu DW; Ernberg I
Article: ONCOGENE. 2004;23(44):7441-7447

Telomere attrition predominantly occurs in precursor lesions during in vivo carcinogenic process of the uterine cervix

Zhang AJ; Wang JL; Zheng BY; Fang XL; Ångström T; Liu C; Li XD; Erlandsson F; Björkholm M; Nordenskjörd M; Gruber A; Wallin KL; Xu DW
Article: ONCOLOGY REPORTS. 2004;12(3):523-526

Enhanced sensitivity of prostate cancer DU145 cells to cisplatinum by 5-aza-2′-deoxycytidine

Fang XL; Zheng CY; Liu ZX; Ekman P; Xu DW
Article: EXPERIMENTAL CELL RESEARCH. 2004;297(1):61-67

Transcriptional regulation of 15-lipoxygenase expression by promoter methylation

Liu C; Xu DW; Sjöberg J; Forsell P; Björkholm M; Claesson HE
Article: METHODS IN MOLECULAR BIOLOGY. 2004;287:87-97

Inhibition of histone deacetylases.

Liu C; Xu D
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2003;72(4):940-948

Deletion of the telomerase reverse transcriptase gene and haploinsufficiency of telomere maintenance in Cri du chat syndrome

Zhang AJ; Zheng CY; Hou M; Lindvall C; Li KJ; Erlandsson F; Björkholm M; Gruber A; Blennow E; Xu DW
Article: MODERN PATHOLOGY. 2003;16(3):246-255

Ki-67 and hTERT expression can aid in the distinction between malignant and benign pheochromocytoma and paraganglioma

Elder EE; Xu D; Höög A; Enberg U; Pisa P; Gruber A; Larsson C; Bäckdahl M
Article: LEUKEMIA RESEARCH. 2003;27(2):183-191

Different effects of metabolic inhibitors and cyclosporin A on daunorubicin transport in leukemia cells from patients with AML

Knaust E; Porwit-MacDonald A; Gruber A; Xu DW; Peterson C
Article: GENES CHROMOSOMES & CANCER. 2002;34(3):269-275

Amplification of the telomerase reverse transcriptase (hTERT) gene in cervical carcinomas

Zhang AJ; Zheng CY; Hou M; Lindvall C; Wallin KL; Ångström T; Yang XY; Hellström AC; Blennow E; Björkholm M; Zetterberg A; Gruber A; Xu DW
Article: EXPERIMENTAL CELL RESEARCH. 2002;274(1):25-34

The histone deacetylase inhibitor trichostatin a derepresses the telomerase reverse transcriptase (hTERT) gene in human cells

Hou M; Wang XB; Popov N; Zhang AJ; Zhao XY; Zhou R; Zetterberg A; Björkholm M; Henriksson M; Gruber A; Xu DW
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(1):53-60

Expression of CTLA-4 by human monocytes

Wang XB; Giscombe R; Yan Z; Heiden T; Xu D; Lefvert AK
Article: INTERNATIONAL JOURNAL OF CANCER. 2001;94(3):407-413

Immature dendritic cells kill ovarian carcinoma cells by a Fas/FasL pathway, enabling them to sensitize tumor-specific CTLs

Yang RC; Xu DW; Zhang AJ; Gruber A
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2001;113(2):339-346

Pharmacological basis for cladribine resistance in a human acute T lymphoblastic leukaemia cell line selected for resistance to etoposide

Lotfi K; Månsson E; Chandra J; Wang YY; Xu DW; Knaust E; Spasokoukotskaja T; Liliemark E; Eriksson S; Albertioni F
Article: HAEMATOLOGICA. 2001;86(4):386-393

Telomerase activity in relation to pro- and anti-apoptotic protein expression in high grade non-Hodgkin's lymphomas

MacNamara B; Xu DW; Wang WH; Chen ZG; Hou M; Mazur J; Gruber A; Porwit-MacDonald A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(7):3826-3831

Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells

Xu DW; Popov N; Hou M; Wang Q; Björkholm M; Gruber A; Menkel AR; Henriksson M
Article: BRITISH JOURNAL OF CANCER. 2001;84(5):621-625

Telomerase activity in plasma cell dyscrasias

Xu D; Zheng C; Bergenbrant S; Holm G; Björkholm M; Yi Q; Gruber A
Journal article: BLOOD. 2000;96(13):4313-4318

Interferon α down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells

Xu D; Erickson S; Szeps M; Gruber A; Sangfelt O; Einhorn S; Pisa P; Grandér D
Article: BLOOD. 2000;96(13):4313-4318

Interferon or down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells

Xu DW; Erickson S; Szeps M; Gruber A; Sangfelt O; Einhorn S; Pisa P; Grandér D
Article: CANCER RESEARCH. 2000;60(22):6230-6235

Frequent amplification of the Telomerase Reverse Transcriptase gene in human tumors

Zhang AJ; Zheng CY; Lindvall C; Hou M; Ekedahl J; Lewensohn R; Yan ZQ; Yang XY; Henriksson M; Blennow E; Nordenskjöld M; Zetterberg A; Björkholm M; Gruber A; Xu DW
Article: ONCOGENE. 2000;19(45):5123-5133

Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells

Xu DW; Wang Q; Gruber A; Björkholm M; Chen ZG; Zaid A; Selivanova G; Peterson C; Wiman KG; Pisa P
Article: JOURNAL OF CLINICAL ONCOLOGY. 2000;18(9):1837-1844

P-glycoprotein inhibitor valspodar (PSC 833) increases the intracellular concentrations of daunorubicin in vivo in patients with p-glycoprotein-positive acute myeloid leukemia

Tidefelt U; Liliemark J; Gruber A; Liliemark E; Sundman-Engberg B; Juliusson G; Stenke L; Elmhorn-Rosenborg A; Möllgård L; Lehman S; Xu D; Covelli A; Gustavsson B; Paul C
Article: HAEMATOLOGICA. 2000;85(2):124-132

Heterogeneity of isolated mononuclear cells from patients with acute myeloid leukemia affects cellular accumulation and efflux of daunorubicin

Knaust E; Porwit-MacDonald A; Gruber A; Xu DW; Peterson C
Article: BRITISH JOURNAL OF HAEMATOLOGY. 1999;106(3):627-633

High levels of lung resistance related protein mRNA in leukaemic cells from patients with acute myelogenous leukaemia are associated with inferior response to chemotherapy and prior treatment with mitoxantrone

Xu DW; Areström I; Virtala R; Pisa P; Peterson C; Gruber A
Article: BRITISH JOURNAL OF CANCER. 1999;80(8):1156-1161

Suppression of telomerase reverse transcriptase (hTERT) expression in differentiated HL-60 cells:: regulatory mechanisms

Xu D; Gruber A; Björkholm M; Peterson C; Pisa P
Article: LEUKEMIA & LYMPHOMA. 1999;32(3-4):309-316

Intraclonal heterogeneity in the in vitro daunorubicin-induced apoptosis in acute myeloid leukemia

Palucka KA; Knaust E; Xu DW; Macnamara B; Porwit-MacDonald A; Gruber A; Peterson C; Björkholm M; Pisa P
Article: BRITISH JOURNAL OF HAEMATOLOGY. 1998;102(5):1367-1375

Telomerase activity and the expression of telomerase components in acute myelogenous leukaemia

Xu DW; Gruber A; Peterson C; Pisa P
Article: BRITISH JOURNAL OF CANCER. 1998;77(11):1732-1736

Multidrug resistance phenotype in leukaemic cells from patients with acute myelocytic leukaemia can be detected with ⁹⁹Tc^m-MIBI

Gruber A; Areström I; Xu D; Liliemark J; Larsson SA; Jacobsson H
Article: LEUKEMIA. 1996;10(8):1354-1357

Suppression of telomerase activity in HL60 cells after treatment with differentiating agents

Xu D; Gruber A; Peterson C; Pisa P
Article: BRITISH JOURNAL OF HAEMATOLOGY. 1996;92(4):847-854

Levels of mdr1 and mrp mRNA in leukaemic cell populations from patients with acute myelocytic leukaemia are heterogenous and inversely correlated to cellular daunorubicin accumulation

Xu D; Knaust E; Pisa P; Palucka K; Lundeberg J; Arestrom I; Peterson C; Gruber A
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Review: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(11):e1111

Thyroid carcinoma-featured telomerase activation and telomere maintenance: Biology and translational/clinical significance

Yuan X; Yuan H; Zhang N; Liu T; Xu D
Review: FRONTIERS IN IMMUNOLOGY. 2022;13:1071390

TERT promoter mutations and methylation for telomerase activation in urothelial carcinomas: New mechanistic insights and clinical significance

Liu T; Li S; Xia C; Xu D
Review: CANCER LETTERS. 2020;493:1-9

TERT promoter mutations and GABP transcription factors in carcinogenesis: More foes than friends

Yuan X; Dai M; Xu D
Review: ANNALS OF TRANSLATIONAL MEDICINE. 2020;8(19):1244

Telomerase reverse transcriptase promoter mutations in thyroid carcinomas: implications in precision oncology-a narrative review

Yuan X; Liu T; Xu D
Review: CURRENT TOPICS IN MEDICINAL CHEMISTRY. 2020;20(6):410-432

Telomere-related Markers for Cancer

Yuan X; Dai M; Xu D
Review: ONCOGENE. 2019;38(34):6172-6183

Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players

Yuan X; Larsson C; Xu D
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(13):E3338-3338

Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking with Epigenetics

Yuan X; Xu D
Review: GENES. 2016;7(7):E38-38

Cancer-Specific Telomerase Reverse Transcriptase (TERT) Promoter Mutations: Biological and Clinical Implications

Liu T; Yuan X; Xu D
Letter: HAEMATOLOGICA. 2015;100(10):E402-E405

Dysregulation of shelterin factors coupled with telomere shortening in Philadelphia chromosome negative myeloproliferative neoplasms

Dahlstrom J; Zhang X; Ghaderi M; Hultcrantz M; Bjorkholm M; Xu D
Letter: ENDOCRINE-RELATED CANCER. 2015;22(3):L9-L11

TERT promoter mutations are rare in parathyroid tumors

Haglund F; Juhlin CC; Brown T; Ghaderi M; Liu T; Stenman A; Dinets A; Prasad M; Korah R; Xu D; Carling T; Larsson C
Letter: LEUKEMIA. 2014;28(8):1751-1754

Genomic analysis of the clonal origin and evolution of acute promyelocytic leukemia in a unique patient with a very late (17 years) relapse

Zhang X; Zhang Q; Dahlstrom J; Tran AN; Yang B; Gu Z; Ghaderi M; Porwit A; Jia J; Derolf A; Xu D; Bjorkholm M
Review: SCIENCE CHINA-LIFE SCIENCES. 2014;57(6):564-570

Telomerase as a "stemness" enzyme

Kong F; Zheng C; Xu D
Letter: GENE. 2014;540(2):266-267

The absence of TERT promoter mutations in primary gastric cancer

Liu T; Liang X; Bjoerkholm M; Jia J; Xu D
Corrigendum: PLOS ONE. 2014;9(2):e91499

Interleukin-4-Mediated 15-Lipoxygenase-1 Trans-Activation Requires UTX Recruitment and H3K27me3 Demethylation at the Promoter in A549 Cells (vol 9, e85085, 2014)

Han H; Xu D; Liu C; Claesson H-E; Bjoerkholm M
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2008;9(1):44

UNCOVERING NF-κB ACTIVATION AND FUNCTION IN INTIMAL DEVELOPMENT

Bu D; Xu D; Hansson G; Yan Z
Published conference paper: CANCER RESEARCH. 2003;63(8):1743-1747

Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling:: Activation of the Epiregulin gene

Lindvall C; Hou M; Komurasaki T; Zheng CY; Henriksson M; Sedivy JM; Björkholm M; Teh BT; Nordenskjöld M; Xu DW
Published conference paper: CLINICAL CHEMISTRY. 2001;47(3):519-524

Real-time quantitative telomeric repeat amplification protocol assay for the detection of telomerase activity

Hou M; Xu DW; Björkholm M; Gruber A
Conference publication: BLOOD. 1995;86(10):2727

Telomerase is expressed in CD34+ hematopoietic cells from normal human umbilical cord blood, adult peripheral blood and bone marrow.

Xu D; Palucka AK; Peterson C; Bjorkholm M; Gruber A; Pisa P

Anställningar

Senior Forskare, Medicin, Solna, Karolinska Institutet, 2022-

Examina och utbildning

Docent, Experimentell medicin, Karolinska Institutet, 2006
MEDICINE DOKTORSEXAMEN, Institutionen för medicin, Solna, Karolinska Institutet, 1999

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Anställningar

Examina och utbildning

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