Xu Dawei

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Articles

Article: CANCER CELL INTERNATIONAL. 2024;24(1):127
Comprehensive analyses of the cancer-associated fibroblast subtypes and their score system for prediction of outcomes and immunosuppressive microenvironment in prostate cancer.
Gao Z; Zhang N; An B; Li D; Fang Z; Xu D
Article: BIOMEDICINE & PHARMACOTHERAPY. 2023;169:115863
Irisin protected hemopoietic stem cells and improved outcome of severe bone marrow failure
Li H; Kong D; Zhao Y; Liu X; Xiao F; Li X; Hu J; Chen Y; Li S; Wang B; Chen Y; Jiang Y; Liu X; Feng X; Guo Y; Feng X; Ren J; Wang F; Han Y; Donelan W; Yang L; Xu D; Tang D; Zheng C
Article: BIOLOGY OF SEX DIFFERENCES. 2023;14(1):46
Dyskerin and telomerase RNA component are sex-differentially associated with outcomes and Sunitinib response in patients with clear cell renal cell carcinoma
Yuan H; Qin X; Yang Q; Liu L; Fang Z; Fan Y; Xu D
Article: BIOMEDICINE & PHARMACOTHERAPY. 2023;158:114193
Widespread genomic/molecular alterations of DNA helicases and their clinical/therapeutic implications across human cancer
Qin X; Wang J; Wang X; Huang T; Fang Z; Yan L; Fan Y; Xu D
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1126247
The cuproptosis-associated 11 gene signature as a predictor for outcomes and response to Bacillus Calmette-Guerin and immune checkpoint inhibitor therapies in bladder carcinoma.
Yuan H; Xiu Y; Liu T; Fan Y; Xu D
Article: MOLECULAR ONCOLOGY. 2023;17(1):150-172
Genomic, epigenomic, and transcriptomic signatures for telomerase complex components: a pan-cancer analysis
Wang J; Dai M; Xing X; Wang X; Qin X; Huang T; Fang Z; Fan Y; Xu D
Article: FRONTIERS IN ONCOLOGY. 2023;13:1133902
The chromosomal instability 25 gene signature is identified in clear cell renal cell carcinoma and serves as a predictor for survival and Sunitinib response
Wang C; Qin X; Guo W; Wang J; Liu L; Fang Z; Yuan H; Fan Y; Xu D
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1208223
High DNA methylation age deceleration defines an aggressive phenotype with immunoexclusion environments in endometrial carcinoma
Hao J; Liu T; Xiu Y; Yuan H; Xu D
Article: JOURNAL OF EXPERIMENTAL AND CLINICAL CANCER RESEARCH. 2022;41(1):173
GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma
Fang Z; Zhang N; Yuan X; Xing X; Li X; Qin X; Liu Z; Neo S; Liu C; Kong F; Bjorkholm M; Fan Y; Xu D
Article: BIOMEDICINE & PHARMACOTHERAPY. 2022;149:112796
Synergistic effects of telomerase reverse transcriptase and regulator of telomere elongation helicase 1 on aggressiveness and outcomes in adrenocortical carcinoma
Yuan H; Wu Y; Wang J; Qin X; Huang Y; Yan L; Fana Y; Zedenius J; Juhlin CC; Larsson C; Lui W-O; Xu D
Article: CANCERS. 2022;14(6):1385
Downregulation and Hypermethylation of GABPB1 Is Associated with Aggressive Thyroid Cancer Features
Xing X; Mu N; Yuan X; Wang N; Juhlin CC; Straat K; Larsson C; Neo SY; Xu D
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2022;79(2):110
The association of telomere maintenance and TERT expression with susceptibility to human papillomavirus infection in cervical epithelium
Wang L-N; Wang L; Cheng G; Dai M; Yu Y; Teng G; Zhao J; Xu D
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:971142
The cuproptosis-associated 13 gene signature as a robust predictor for outcome and response to immune- and targeted-therapies in clear cell renal cell carcinoma
Yuan H; Qin X; Wang J; Yang Q; Fan Y; Xu D
Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2021;156:106575
Intrinsic 5-lipoxygenase activity regulates migration and adherence of mantle cell lymphoma cells
Xia C; Sadeghi L; Straat K; Merrien M; Wright AP; Sander B; Xu D; Osterborg A; Bjorkholm M; Claesson H-E
Article: CANCERS. 2021;13(19):4827
DNA Methylation Age Drift Is Associated with Poor Outcomes and De-Differentiation in Papillary and Follicular Thyroid Carcinomas
Liu T; Wang J; Xiu Y; Wu Y; Xu D
Article: JOURNAL OF CANCER. 2021;12(13):3853-3861
Regulatory region mutations of TERT, PLEKHS1 and GPR126 genes as urinary biomarkers in upper tract urothelial carcinomas
Xing X; Yuan X; Liu T; Dai M; Fan Y; Liu C; Straat K; Bjorkholm M; Xu D
Article: CANCERS. 2020;12(8):E2133-2133
PLEKHS1 Over-Expression is Associated with Metastases and Poor Outcomes in Papillary Thyroid Carcinoma
Xing X; Mu N; Yuan X; Wang N; Juhlin CC; Straat K; Larsson C; Xu D
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2020;527(2):425-431
JAK2 inhibition in JAK2^V617F-bearing leukemia cells enriches CD34⁺ leukemic stem cells that are abolished by the telomerase inhibitor GRN163L
Dahlstrom J; Xia C; Xing X; Yuan X; Bjorkholm M; Xu D
Article: CELL DEATH AND DIFFERENTIATION. 2020;27(6):1862-1877
GABPA is a master regulator of luminal identity and restrains aggressive diseases in bladder cancer
Guo Y; Yuan X; Li K; Dai M; Zhang L; Wu Y; Sun C; Chen Y; Cheng G; Liu C; Straat K; Kong F; Zhao S; Bjorkholm M; Xu D
Article: ONCOGENE. 2020;39(21):4286-4298
VHL-HIF-2α axis-induced SMYD3 upregulation drives renal cell carcinoma progression via direct trans-activation of EGFR
Liu C; Liu L; Wang K; Li X-F; Ge L-Y; Ma R-Z; Fan Y-D; Li L-C; Liu Z-F; Qiu M; Hao Y-C; Shi Z-F; Xia C-Y; Straat K; Huang Y; Ma L-L; Xu D
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2020;18(1):184
The telomerase gene polymorphisms, but not telomere length, increase susceptibility to primary glomerulonephritis/end stage renal diseases in females
Sun Q; Liu J; Cheng G; Dai M; Liu J; Qi Z; Zhao J; Li W; Kong F; Liu G; Bjorkholm M; Xu D
Article: AGING. 2020;12(3):2030-2048
High expression of SMYD3 indicates poor survival outcome and promotes tumour progression through an IGF-1R/AKT/E2F-1 positive feedback loop in bladder cancer
Wang G; Huang Y; Yang F; Tian X; Wang K; Liu L; Fan Y; Li X; Li L; Shi B; Hao Y; Xia C; Nie Q; Xin Y; Shi Z; Ma L; Xu D; Liu C
Article: FRONTIERS IN ONCOLOGY. 2020;10:598872
Hodgkin Lymphoma Monozygotic Triplets Reveal Divergences in DNA Methylation Signatures
Xia C; Olsen TK; Zirakzadeh AA; Almamoun R; Sjoholm LK; Dahlstrom J; Sjoberg J; Claesson H-E; Johnsen JI; Winqvist O; Xu D; Ekstrom TJ; Bjorkholm M; Straat K
Article: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY. 2020;13(8):2123-2129
Patients with benign prostatic hyperplasia show shorter leukocyte telomere length but no association with telomerase gene polymorphisms in Han Chinese males
Cheng G; Dai M; Xin Q; Wang L; Kong F; Xu D
Article: INTERNATIONAL JOURNAL OF MEDICAL SCIENCES. 2020;17(14):2180-2186
Shorter Leukocyte Telomere Length coupled with lower expression of Telomerase Genes in patients with Essential Hypertension
Cheng G; Wang L; Dai M; Wei F; Xu D
Article: EPIGENETICS. 2019;14(12):1224-1233
Telomerase activation in small intestinal neuroendocrine tumours is associated with aberrant TERT promoter methylation, but not hot-spot mutations
Fotouhi O; Ghaderi M; Wang N; Zedenius J; Kjellman M; Xu D; Juhlin CC; Larsson C
Article: UROLOGIC ONCOLOGY: SEMINARS AND ORIGINAL INVESTIGATIONS. 2019;37(5):301.e1-301.e10
The TERT locus genotypes of rs2736100-CC/CA and rs2736098-AA predict shorter survival in renal cell carcinoma
Ma R; Liu C; Lu M; Yuan X; Cheng G; Kong F; Lu J; Straat K; Bjorkholm M; Ma L; Xu D
Article: ONCOGENE. 2019;38(7):965-979
GABPA inhibits invasion/metastasis in papillary thyroid carcinoma by regulating DICER1 expression
Yuan X; Mu N; Wang N; Straat K; Sofiadis A; Guo Y; Stenman A; Li K; Cheng G; Zhang L; Kong F; Ekblad L; Wennerberg J; Nilsson I-L; Juhlin CC; Larsson C; Xu D
Article: CELL DEATH AND DISEASE. 2019;10(2):76
ASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells
Wu Y; Li X; Yu J; Bjorkholm M; Xu D
Article: AGING. 2018;10(10):3005-3016
Longitudinal changes in leukocyte telomere length and mortality in elderly Swedish men
Yuan X; Kronstrom M; Hellenius M-L; Cederholm T; Xu D; Sjogren P
Article: CANCER LETTERS. 2018;434:33-41
Telomerase reverse transcriptase regulates DNMT3B expression/aberrant DNA methylation phenotype and AKT activation in hepatocellular carcinoma
Yu J; Yuan X; Sjoholm L; Liu T; Kong F; Ekstrom TJ; Bjorkholm M; Xu D
Article: CELL DEATH AND DISEASE. 2018;9(9):923
Ectopic hTERT expression facilitates reprograming of fibroblasts derived from patients with Werner syndrome as a WS cellular model
Wang S; Liu Z; Ye Y; Li B; Liu T; Zhang W; Liu G-H; Zhang YA; Qu J; Xu D; Chen Z
Article: CURRENT UROLOGY. 2018;11(3):131-138
Paris Polyphylla-Derived Saponins Inhibit Growth of Bladder Cancer Cells by Inducing Mutant P53 Degradation While Up-Regulating CDKN1A Expression.
Guo Y; Liu Z; Li K; Cao G; Sun C; Cheng G; Zhang D; Peng W; Liu J; Qi Y; Zhang L; Wang P; Chen Y; Lin Z; Guan Y; Zhang J; Wen J; Wang F; Kong F; Xu D; Zhao S
Article: ANNALS OF HEMATOLOGY. 2018;97(1):63-72
MYC-dependent downregulation of telomerase by FLT3 inhibitors is required for their therapeutic efficacy on acute myeloid leukemia
Zhang X; Li B; Yu J; Dahlstrom J; Anh NT; Bjorkhom M; Xu D
Article: ONCOLOGIST. 2017;22(10):1178-1188
TERT Promoter Hypermethylation in Gastrointestinal Cancer: A Potential Stool Biomarker
Liu L; Liu C; Fotouhi O; Fan Y; Wang K; Xia C; Shi B; Zhang G; Wang K; Kong F; Larsson C; Hu S; Xu D
Article: EBIOMEDICINE. 2017;21:104-116
Histone Chaperone ASF1A Predicts Poor Outcomes for Patients With Gastrointestinal Cancer and Drives Cancer Progression by Stimulating Transcription of β-Catenin Target Genes
Liang X; Yuan X; Yu J; Wu Y; Li K; Sun C; Li S; Shen L; Kong F; Jia J; Bjorkholm M; Xu D
Article: CANCER RESEARCH. 2017;77(9):2534-2547
WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT^high Prostate Cancer Stem Cells
Zhang K; Guo Y; Wang X; Zhao H; Ji Z; Cheng C; Li L; Fang Y; Xu D; Zhu HH; Gao W-Q
Article: ONCOTARGET. 2017;8(14):23120-23129
The TERT promoter mutation incidence is modified by germline TERT rs2736098 and rs2736100 polymorphisms in hepatocellular carcinoma
Yuan X; Cheng G; Yu J; Zheng S; Sun C; Sun Q; Li K; Lin Z; Liu T; Li P; Xu Y; Kong F; Bjorkholm M; Xu D
Article: CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY. 2017;8(3):e79
Association Between the Telomerase rs2736098_ TT Genotype and a Lower Risk of Chronic Hepatitis B and Cirrhosis in Chinese Males
Cheng G; Yuan X; Wang F; Sun Q; Xin Q; Li K; Sun C; Lin Z; Luan Y; Xu Y; Li P; Kong F; Xu D
Article: THE FASEB JOURNAL. 2017;31(2):491-504
Human 15-lipoxygenase-1 is a regulator of dendritic-cell spreading and podosome formation
Han H; Liang X; Ekberg M; Kritikou JS; Brunnstrom A; Pelcman B; Matl M; Miao X; Andersson M; Yuan X; Schain F; Parvin S; Melin E; Sjoberg J; Xu D; Westerberg LS; Bjorkholm M; Claesson H-E
Article: ANNALS OF HEMATOLOGY. 2016;95(11):1825-1832
TERT rs2736100 genotypes are associated with differential risk of myeloproliferative neoplasms in Swedish and Chinese male patient populations
Dahlstrom J; Liu T; Yuan X; Saft L; Ghaderi M; Wei YB; Lavebratt C; Li P; Zheng C; Bjorkholm M; Xu D
Article: ONCOTARGET. 2016;7(22):31972-31979
The association between the TERT rs2736100 AC genotype and reduced risk of upper tract urothelial carcinomas in a Han Chinese population
Yuan X; Meng Y; Li P; Ge N; Kong F; Yang L; Bjorkholm M; Zhao S; Xu D
Article: ONCOTARGET. 2016;7(18):25826-25835
The genetic difference between Western and Chinese urothelial cell carcinomas: infrequent FGFR3 mutation in Han Chinese patients
Yuan X; Liu C; Wang K; Liu L; Liu T; Ge N; Kong F; Yang L; Bjorkholm M; Fan Y; Zhao S; Xu D
Article: ONCOTARGET. 2016;7(16):21332-21346
Genetic and epigenetic background and protein expression profiles in relation to telomerase activation in medullary thyroid carcinoma
Wang N; Kjellin H; Sofiadis A; Fotouhi O; Juhlin CC; Backdahl M; Zedenius J; Xu D; Lehtio J; Larsson C
Article: ONCOTARGET. 2015;6(35):38079-38092
Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells
Ci X; Li B; Ma X; Kong F; Zheng C; Bjorkholm M; Jia J; Xu D
Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2015;121(Pt A):122-130
Early growth response gene (EGR)-1 regulates leukotriene D4-induced cytokine transcription in Hodgkin lymphoma cells
Han H; Xue-Franzen Y; Miao X; Nagy E; Li N; Xu D; Sjoberg J; Bjorkholm M; Claesson H-E
Article: ONCOTARGET. 2015;6(7):4888-4900
The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression
Zhang X; Li B; de Jonge N; Bjorkholm M; Xu D
Article: ONCOLOGIST. 2015;20(3):263-269
TERT Promoter Mutations and TERT mRNA but Not FGFR3 Mutations Are Urinary Biomarkers in Han Chinese Patients With Urothelial Bladder Cancer
Wang K; Liu T; Liu C; Meng Y; Yuan X; Liu L; Ge N; Liu J; Wang C; Ren H; Yan K; Hu S; Xu Z; Fan Y; Xu D
Article: ONCOTARGET. 2014;5(23):12428-12439
TERT promoter mutations are associated with distant metastases in upper tract urothelial carcinomas and serve as urinary biomarkers detected by a sensitive castPCR
Wang K; Liu T; Ge N; Liu L; Yuan X; Liu J; Kong F; Wang C; Ren H; Yan K; Hu S; Xu Z; Bjrkholm M; Fan Y; Zhao S; Liu C; Xu D
Article: ONCOTARGET. 2014;5(20):10048-10057
TERT promoter mutations and gene amplification: Promoting TERT expression in Merkel cell carcinoma
Xie H; Liu T; Wang N; Bjornhagen V; Hoog A; Larsson C; Lui W-O; Xu D
Article: ONCOGENE. 2014;33(42):4978-4984
The age- and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomas
Liu T; Wang N; Cao J; Sofiadis A; Dinets A; Zedenius J; Larsson C; Xu D
Article: CANCER. 2014;120(19):2965-2979
TERT Promoter Mutation as an Early Genetic Event Activating Telomerase in Follicular Thyroid Adenoma (FTA) and Atypical FTA
Wang N; Liu T; Sofiadis A; Juhlin CC; Zedenius J; Hoog A; Larsson C; Xu D
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2014;99(8):E1571-E1579
Telomerase-Dependent and Independent Telomere Maintenance and its Clinical Implications in Medullary Thyroid Carcinoma
Wang N; Xu D; Sofiadis A; Hoog A; Vukojevic V; Backdahl M; Zedenius J; Larsson C
Article: ENDOCRINE-RELATED CANCER. 2014;21(3):427-434
The activating TERT promoter mutation C228T is recurrent in subsets of adrenal tumors
Liu T; Brown TC; Juhlin CC; Andreasson A; Wang N; Backdahl M; Healy JM; Prasad ML; Korah R; Carling T; Xu D; Larsson C
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2014;12:135
Laminin 411 acts as a potent inducer of umbilical cord mesenchymal stem cell differentiation into insulin-producing cells
Qu H; Liu X; Ni Y; Jiang Y; Feng X; Xiao J; Guo Y; Kong D; Li A; Li X; Zhuang X; Wang Z; Wang Y; Chang Y; Chen S; Kong F; Zhang X; Zhao S; Sun Y; Xu D; Wang D; Zheng C
Article: ONCOTARGET. 2014;5(7):1829-1836
TERT promoter mutations in renal cell carcinomas and upper tract urothelial carcinomas
Wang K; Liu T; Liu L; Liu J; Liu C; Wang C; Ge N; Ren H; Yan K; Hu S; Bjorkholm M; Fan Y; Xu D
Article: PLOS ONE. 2014;9(4):e94442
Promoter Polymorphism in the Serotonin Transporter ( 5-HTT) Gene Is Significantly Associated with Leukocyte Telomere Length in Han Chinese
Li P; Liu T; Liu J; Zhang Q; Lou F; Kong F; Cheng G; Bjorkholm M; Zheng C; Xu D
Article: PLOS ONE. 2014;9(1):e85085
Interleukin-4-Mediated 15-Lipoxygenase-1 Trans-Activation Requires UTX Recruitment and H3K27me3 Demethylation at the Promoter in A549 Cells
Han H; Xu D; Liu C; Claesson H-E; Bjorkholm M; Sjoberg J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2013;442(1-2):112-115
Differential shortening rate of telomere length in the development of human fetus
Cheng G; Kong F; Luan Y; Sun C; Wang J; Zhang L; Jiang B; Qi T; Zhao J; Zheng C; Xu D
Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2013;105(22):1719-1728
SMYD3 as an Oncogenic Driver in Prostate Cancer by Stimulation of Androgen Receptor Transcription
Liu C; Wang C; Wang K; Liu L; Shen Q; Yan K; Sun X; Chen J; Liu J; Ren H; Liu H; Xu Z; Hu S; Xu D; Fan Y
Article: ONCOGENE. 2013;32(36):4203-4213
Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells
Liu Z; Li Q; Li K; Chen L; Li W; Hou M; Liu T; Yang J; Lindvall C; Bjorkholm M; Jia J; Xu D
Article: BRITISH JOURNAL OF CANCER. 2013;108(11):2272-2280
Telomerase reverse transcriptase inhibition stimulates cyclooxygenase 2 expression in cancer cells and synergizes with celecoxib to exert anti-cancer effects
Liu T; Liang X; Li B; Bjorkholm M; Jia J; Xu D
Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY. 2012;44(9):1531-1540
Telomere dysfunction induced by chemotherapeutic agents and radiation in normal human cells
Li P; Hou M; Lou F; Bjorkholm M; Xu D
Article: GENETICS AND MOLECULAR RESEARCH. 2012;11(1):370-378
Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma
Chen XF; Cai S; Chen QG; Ni ZH; Tang JH; Xu DW; Wang XB
Article: EXPERIMENTAL CELL RESEARCH. 2012;318(3):169-176
Epigenetic and transcriptional control of the 15-lipoxygenase-1 gene in a Hodgkin lymphoma cell line
Liu C; Schain F; Han H; Xu D; Andersson-Sand H; Forsell P; Claesson H-E; Bjorkholm M; Sjoberg J
Article: PLOS ONE. 2012;7(12):e52703
Transcriptional Regulation of 15-Lipoxygenase Expression by Histone H3 Lysine 4 Methylation/Demethylation
Liu C; Xu D; Han H; Fan Y; Schain F; Xu Z; Claesson H-E; Bjorkholm M; Sjoberg J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;416(3-4):372-378
Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer
Li W; Zhao L; Zang W; Liu Z; Chen L; Liu T; Xu D; Jia J
Article: JOURNAL OF PATHOLOGY. 2011;225(2):203-211
Activation of telomerase by seminal plasma in malignant and normal cervical epithelial cells
Liu L; Liu C; Lou F; Zhang G; Wang X; Fan Y; Yan K; Wang K; Xu Z; Hu S; Bjorkholm M; Xu D
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;407(3):599-604
Premature senescence of T cells in long-term survivors of renal transplantation
Li P; Tian C; Ge N; Wang H; Liu L; Lou F; Bjorkholm M; Xu D
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2010;30(12):2604-2610
Nuclear Factor κB-Mediated Transactivation of Telomerase Prevents Intimal Smooth Muscle Cell From Replicative Senescence During Vascular Repair
Bu D-X; Johansson ME; Ren J; Xu D-W; Johnson FB; Edfeldt K; Yan Z-Q
Article: MOLECULAR CANCER. 2010;9:132
Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer
Li W; Zeng J; Li Q; Zhao L; Liu T; Bjorkholm M; Jia J; Xu D
Article: GASTROENTEROLOGY. 2010;138(3):981-992
The Histone Demethylase RBP2 Is Overexpressed in Gastric Cancer and Its Inhibition Triggers Senescence of Cancer Cells
Zeng J; Ge Z; Wang L; Li Q; Wang N; Bjorkholm M; Jia J; Xu D
Article: THE FASEB JOURNAL. 2010;24(2):579-586
Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase
Ge Z; Li W; Wang N; Liu C; Zhu Q; Bjorkholm M; Gruber A; Xu D
Article: JOURNAL OF PATHOLOGY. 2009;218(4):419-427
FoxM1 is up-regulated in gastric cancer and its inhibition leads to cellular senescence, partially dependent on p27^kip1
Zeng J; Wang L; Li Q; Li W; Bjorkholm M; Jia J; Xu D
Article: AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2009;297(1):L196-L203
15-Lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells
Liu C; Xu D; Liu L; Schain F; Brunnstrom A; Bjorkholm M; Claesson H-E; Sjoberg J
Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2009;101(7):488-497
Activation of Telomerase by Human Cytomegalovirus
Straat K; Liu C; Rahbar A; Zhu Q; Liu L; Wolmer-Solberg N; Lou F; Liu Z; Shen J; Jia J; Kyo S; Bjoerkholm M; Sjoberg J; Soederberg-Naucler C; Xu D
Article: CLINICAL LYMPHOMA AND MYELOMA. 2008;8(6):340-347
Differential Expression of Cysteinyl Leukotriene Receptor 1 and 15-Lipoxygenase-1 in Non-Hodgkin Lymphomas
Schain F; Schain D; Mahshid Y; Liu C; Porwit A; Xu D; Claesson H-E; Sundstrom C; Bjorkholm M; Sjoberg J
Article: INTERNATIONAL JOURNAL OF CANCER. 2008;123(10):2285-2293
Evidence for a pathophysiological role of cysteinyl leukotrienes in classical Hodgkin lymphoma
Schain F; Tryselius Y; Sjoberg J; Porwit A; Backman L; Malec M; Xu D; Vockerodt M; Baumforth KRN; Wei W; Murray PG; Bjorkholm M; Claesson H-E
Article: CLINICAL CANCER RESEARCH. 2008;14(12):3722-3728
CIP2A is overexpressed in gastric cancer and its depletion leads to impaired clonogenicity, senescence, or differentiation of tumor cells
Li W; Ge Z; Liu C; Liu Z; Bjorkholm M; Jia J; Xu D
Article: CANCER LETTERS. 2008;260(1-2):28-36
Expression of the full-length telomerase reverse transcriptase (hTERT) transcript in both malignant and normal gastric tissues
Li W; Li L; Liu Z; Liu C; Liu Z; Straat K; Bjorkholm M; Jia J; Xu D
Article: PLOS ONE. 2008;3(1):e1446
Lysine-Specific Demethylase 1 (LSD1) Is Required for the Transcriptional Repression of the Telomerase Reverse Transcriptase (hTERT) Gene
Zhu Q; Liu C; Ge Z; Fang X; Zhang X; Straat K; Bjorkholm M; Xu D
Article: MOLECULAR CANCER RESEARCH. 2007;5(8):793-800
The opposing effect of hypoxia-inducible factor-2α on expression of telomerase reverse transcriptase
Lou F; Chen X; Jalink M; Zhu Q; Ge N; Zhao S; Fang X; Fan Y; Bjoerkholm M; Liu Z; Xu D
Article: CANCER RESEARCH. 2007;67(6):2626-2631
The telomerase reverse transcriptase (hTERT) gene is a direct target of the histone methyltransferase SMYD3
Liu C; Fang X; Ge Z; Jalink M; Kyo S; Bjorkhom M; Gruber A; Sjoberg J; Xu D
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;353(4):999-1003
Human normal T lymphocytes and lymphoid cell lines do express alternative splicing variants of human telomerase reverse transcriptase (hTERT) mRNA
Jalink M; Ge Z; Liu C; Bjorkholm M; Gruber A; Xu D
Article: BRITISH JOURNAL OF CANCER. 2006;94(11):1658-1662
Nucleostemin mRNA is expressed in both normal and malignant renal tissues
Fan Y; Liu Z; Zhao S; Lou F; Nilsson S; Ekman P; Xu D; Fang X
Article: INTERNATIONAL JOURNAL OF CANCER. 2006;118(10):2485-2489
Switch to full-length of XAF1 mRNA expression in prostate cancer cells by the DNA methylation inhibitor
Fang XL; Liu ZX; Fan YD; Zheng CY; Nilson S; Egevad L; Ekman P; Xu DW
Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(1):230-237
Mitogen-activated protein kinase cascade-mediated histone H3 phosphorylation is critical for telornerase reverse transcriptase expression/telomerase activation induced by proliferation
Ge Z; Liu C; Björkholm M; Gruber A; Xu DW
Article: INTERNATIONAL JOURNAL OF CANCER. 2005;116(3):395-400
hTERT gene copy number is not associated with hTERT RNA expression or telomerase activity in colorectal cancer
Palmqvist R; Zhang AJ; Xu DW; Golovleva F; Norrback KF; Gruber A; Öberg Å; Stenling R; Roos G
Article: CLINICAL CANCER RESEARCH. 2005;11(12):4331-4337
Differential expression of full-length telomerase reverse transcriptase mRNA and telomerase activity between normal and malignant renal tissues
Fan YD; Liu ZX; Fang XL; Ge Z; Ge N; Jia Y; Sun P; Lou FL; Björkholm M; Gruber A; Ekman P; Xu DW
Article: INTERNATIONAL JOURNAL OF CANCER. 2005;113(2):284-289
Epstein-Barr virus latent membrane 2A (LMP2A) down-regulates telomerase reverse transcriptase (hTERT) in epithelial cell lines
Chen F; Liu C; Lindvall C; Xu DW; Ernberg I
Article: ONCOGENE. 2004;23(44):7441-7447
Telomere attrition predominantly occurs in precursor lesions during in vivo carcinogenic process of the uterine cervix
Zhang AJ; Wang JL; Zheng BY; Fang XL; Ångström T; Liu C; Li XD; Erlandsson F; Björkholm M; Nordenskjörd M; Gruber A; Wallin KL; Xu DW
Article: ONCOLOGY REPORTS. 2004;12(3):523-526
Enhanced sensitivity of prostate cancer DU145 cells to cisplatinum by 5-aza-2′-deoxycytidine
Fang XL; Zheng CY; Liu ZX; Ekman P; Xu DW
Article: EXPERIMENTAL CELL RESEARCH. 2004;297(1):61-67
Transcriptional regulation of 15-lipoxygenase expression by promoter methylation
Liu C; Xu DW; Sjöberg J; Forsell P; Björkholm M; Claesson HE
Article: METHODS IN MOLECULAR BIOLOGY. 2004;287:87-97
Inhibition of histone deacetylases.
Liu C; Xu D
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2003;72(4):940-948
Deletion of the telomerase reverse transcriptase gene and haploinsufficiency of telomere maintenance in Cri du chat syndrome
Zhang AJ; Zheng CY; Hou M; Lindvall C; Li KJ; Erlandsson F; Björkholm M; Gruber A; Blennow E; Xu DW
Article: MODERN PATHOLOGY. 2003;16(3):246-255
Ki-67 and hTERT expression can aid in the distinction between malignant and benign pheochromocytoma and paraganglioma
Elder EE; Xu D; Höög A; Enberg U; Pisa P; Gruber A; Larsson C; Bäckdahl M
Article: LEUKEMIA RESEARCH. 2003;27(2):183-191
Different effects of metabolic inhibitors and cyclosporin A on daunorubicin transport in leukemia cells from patients with AML
Knaust E; Porwit-MacDonald A; Gruber A; Xu DW; Peterson C
Article: GENES CHROMOSOMES AND CANCER. 2002;34(3):269-275
Amplification of the telomerase reverse transcriptase (hTERT) gene in cervical carcinomas
Zhang AJ; Zheng CY; Hou M; Lindvall C; Wallin KL; Ångström T; Yang XY; Hellström AC; Blennow E; Björkholm M; Zetterberg A; Gruber A; Xu DW
Article: EXPERIMENTAL CELL RESEARCH. 2002;274(1):25-34
The histone deacetylase inhibitor trichostatin a derepresses the telomerase reverse transcriptase (hTERT) gene in human cells
Hou M; Wang XB; Popov N; Zhang AJ; Zhao XY; Zhou R; Zetterberg A; Björkholm M; Henriksson M; Gruber A; Xu DW
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(1):53-60
Expression of CTLA-4 by human monocytes
Wang XB; Giscombe R; Yan Z; Heiden T; Xu D; Lefvert AK
Article: INTERNATIONAL JOURNAL OF CANCER. 2001;94(3):407-413
Immature dendritic cells kill ovarian carcinoma cells by a Fas/FasL pathway, enabling them to sensitize tumor-specific CTLs
Yang RC; Xu DW; Zhang AJ; Gruber A
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2001;113(2):339-346
Pharmacological basis for cladribine resistance in a human acute T lymphoblastic leukaemia cell line selected for resistance to etoposide
Lotfi K; Månsson E; Chandra J; Wang YY; Xu DW; Knaust E; Spasokoukotskaja T; Liliemark E; Eriksson S; Albertioni F
Article: HAEMATOLOGICA. 2001;86(4):386-393
Telomerase activity in relation to pro- and anti-apoptotic protein expression in high grade non-Hodgkin's lymphomas
MacNamara B; Xu DW; Wang WH; Chen ZG; Hou M; Mazur J; Gruber A; Porwit-MacDonald A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(7):3826-3831
Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells
Xu DW; Popov N; Hou M; Wang Q; Björkholm M; Gruber A; Menkel AR; Henriksson M
Article: BRITISH JOURNAL OF CANCER. 2001;84(5):621-625
Telomerase activity in plasma cell dyscrasias
Xu D; Zheng C; Bergenbrant S; Holm G; Björkholm M; Yi Q; Gruber A
Journal article: BLOOD. 2000;96(13):4313-4318
Interferon α down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells
Xu D; Erickson S; Szeps M; Gruber A; Sangfelt O; Einhorn S; Pisa P; Grandér D
Article: BLOOD. 2000;96(13):4313-4318
Interferon or down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells
Xu DW; Erickson S; Szeps M; Gruber A; Sangfelt O; Einhorn S; Pisa P; Grandér D
Article: CANCER RESEARCH. 2000;60(22):6230-6235
Frequent amplification of the Telomerase Reverse Transcriptase gene in human tumors
Zhang AJ; Zheng CY; Lindvall C; Hou M; Ekedahl J; Lewensohn R; Yan ZQ; Yang XY; Henriksson M; Blennow E; Nordenskjöld M; Zetterberg A; Björkholm M; Gruber A; Xu DW
Article: ONCOGENE. 2000;19(45):5123-5133
Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells
Xu DW; Wang Q; Gruber A; Björkholm M; Chen ZG; Zaid A; Selivanova G; Peterson C; Wiman KG; Pisa P
Article: JOURNAL OF CLINICAL ONCOLOGY. 2000;18(9):1837-1844
P-glycoprotein inhibitor valspodar (PSC 833) increases the intracellular concentrations of daunorubicin in vivo in patients with p-glycoprotein-positive acute myeloid leukemia
Tidefelt U; Liliemark J; Gruber A; Liliemark E; Sundman-Engberg B; Juliusson G; Stenke L; Elmhorn-Rosenborg A; Möllgård L; Lehman S; Xu D; Covelli A; Gustavsson B; Paul C
Article: HAEMATOLOGICA. 2000;85(2):124-132
Heterogeneity of isolated mononuclear cells from patients with acute myeloid leukemia affects cellular accumulation and efflux of daunorubicin
Knaust E; Porwit-MacDonald A; Gruber A; Xu DW; Peterson C
Article: BRITISH JOURNAL OF HAEMATOLOGY. 1999;106(3):627-633
High levels of lung resistance related protein mRNA in leukaemic cells from patients with acute myelogenous leukaemia are associated with inferior response to chemotherapy and prior treatment with mitoxantrone
Xu DW; Areström I; Virtala R; Pisa P; Peterson C; Gruber A
Article: BRITISH JOURNAL OF CANCER. 1999;80(8):1156-1161
Suppression of telomerase reverse transcriptase (hTERT) expression in differentiated HL-60 cells:: regulatory mechanisms
Xu D; Gruber A; Björkholm M; Peterson C; Pisa P
Article: LEUKEMIA AND LYMPHOMA. 1999;32(3-4):309-316
Intraclonal heterogeneity in the in vitro daunorubicin-induced apoptosis in acute myeloid leukemia
Palucka KA; Knaust E; Xu DW; Macnamara B; Porwit-MacDonald A; Gruber A; Peterson C; Björkholm M; Pisa P
Article: BRITISH JOURNAL OF HAEMATOLOGY. 1998;102(5):1367-1375
Telomerase activity and the expression of telomerase components in acute myelogenous leukaemia
Xu DW; Gruber A; Peterson C; Pisa P
Article: BRITISH JOURNAL OF CANCER. 1998;77(11):1732-1736
Multidrug resistance phenotype in leukaemic cells from patients with acute myelocytic leukaemia can be detected with ⁹⁹Tc^m-MIBI
Gruber A; Areström I; Xu D; Liliemark J; Larsson SA; Jacobsson H
Article: LEUKEMIA. 1996;10(8):1354-1357
Suppression of telomerase activity in HL60 cells after treatment with differentiating agents
Xu D; Gruber A; Peterson C; Pisa P
Article: BRITISH JOURNAL OF HAEMATOLOGY. 1996;92(4):847-854
Levels of mdr1 and mrp mRNA in leukaemic cell populations from patients with acute myelocytic leukaemia are heterogenous and inversely correlated to cellular daunorubicin accumulation
Xu D; Knaust E; Pisa P; Palucka K; Lundeberg J; Arestrom I; Peterson C; Gruber A
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All other publications

Review: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(11):e1111
Thyroid carcinoma-featured telomerase activation and telomere maintenance: Biology and translational/clinical significance
Yuan X; Yuan H; Zhang N; Liu T; Xu D
Review: FRONTIERS IN IMMUNOLOGY. 2022;13:1071390
TERT promoter mutations and methylation for telomerase activation in urothelial carcinomas: New mechanistic insights and clinical significance
Liu T; Li S; Xia C; Xu D
Review: CANCER LETTERS. 2020;493:1-9
TERT promoter mutations and GABP transcription factors in carcinogenesis: More foes than friends
Yuan X; Dai M; Xu D
Review: ANNALS OF TRANSLATIONAL MEDICINE. 2020;8(19):1244
Telomerase reverse transcriptase promoter mutations in thyroid carcinomas: implications in precision oncology-a narrative review
Yuan X; Liu T; Xu D
Review: CURRENT TOPICS IN MEDICINAL CHEMISTRY. 2020;20(6):410-432
Telomere-related Markers for Cancer
Yuan X; Dai M; Xu D
Review: ONCOGENE. 2019;38(34):6172-6183
Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players
Yuan X; Larsson C; Xu D
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(13):E3338-3338
Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking with Epigenetics
Yuan X; Xu D
Review: GENES. 2016;7(7):E38-38
Cancer-Specific Telomerase Reverse Transcriptase (TERT) Promoter Mutations: Biological and Clinical Implications
Liu T; Yuan X; Xu D
Letter: HAEMATOLOGICA. 2015;100(10):e402-e405
Dysregulation of shelterin factors coupled with telomere shortening in Philadelphia chromosome negative myeloproliferative neoplasms
Dahlstrom J; Zhang X; Ghaderi M; Hultcrantz M; Bjorkholm M; Xu D
Letter: ENDOCRINE-RELATED CANCER. 2015;22(3):L9-L11
TERT promoter mutations are rare in parathyroid tumors
Haglund F; Juhlin CC; Brown T; Ghaderi M; Liu T; Stenman A; Dinets A; Prasad M; Korah R; Xu D; Carling T; Larsson C
Letter: LEUKEMIA. 2014;28(8):1751-1754
Genomic analysis of the clonal origin and evolution of acute promyelocytic leukemia in a unique patient with a very late (17 years) relapse
Zhang X; Zhang Q; Dahlstrom J; Tran AN; Yang B; Gu Z; Ghaderi M; Porwit A; Jia J; Derolf A; Xu D; Bjorkholm M
Review: SCIENCE CHINA LIFE SCIENCES. 2014;57(6):564-570
Telomerase as a "stemness" enzyme
Kong F; Zheng C; Xu D
Letter: GENE. 2014;540(2):266-267
The absence of TERT promoter mutations in primary gastric cancer
Liu T; Liang X; Bjoerkholm M; Jia J; Xu D
Corrigendum: PLOS ONE. 2014;9(2):e91499
Interleukin-4-Mediated 15-Lipoxygenase-1 Trans-Activation Requires UTX Recruitment and H3K27me3 Demethylation at the Promoter in A549 Cells (vol 9, e85085, 2014)
Han H; Xu D; Liu C; Claesson H-E; Bjoerkholm M
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2008;9(1):44
UNCOVERING NF-κB ACTIVATION AND FUNCTION IN INTIMAL DEVELOPMENT
Bu D; Xu D; Hansson G; Yan Z
Published conference paper: CANCER RESEARCH. 2003;63(8):1743-1747
Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling:: Activation of the Epiregulin gene
Lindvall C; Hou M; Komurasaki T; Zheng CY; Henriksson M; Sedivy JM; Björkholm M; Teh BT; Nordenskjöld M; Xu DW
Published conference paper: CLINICAL CHEMISTRY. 2001;47(3):519-524
Real-time quantitative telomeric repeat amplification protocol assay for the detection of telomerase activity
Hou M; Xu DW; Björkholm M; Gruber A
Thesis / dissertation: 1999
Telomerase activity and its regulation in malignant hematopoietic cells
Xu, Dawei
Conference publication: BLOOD. 1995;86(10):2727
Telomerase is expressed in CD34+ hematopoietic cells from normal human umbilical cord blood, adult peripheral blood and bone marrow.
Xu D; Palucka AK; Peterson C; Bjorkholm M; Gruber A; Pisa P

Employments

Principal Researcher, Department of Medicine, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2006
Doctor Of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 1999

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