Dasiel Oscar Borroto Escuela

Publikationer
Populärvetenskap och samverkan

Artiklar

Article: MEMBRANES. 2024;14(5):96
Membrane Heteroreceptor Complexes as Second-Order Protein Modulators: A Novel Integrative Mechanism through Allosteric Receptor-Receptor Interactions
Mirchandani-Duque M; Choucri M; Hernandez-Mondragon JC; Crespo-Ramirez M; Perez-Olives C; Ferraro L; Franco R; de la Mora MP; Fuxe K; Borroto-Escuela DO
Article: THE FASEB JOURNAL. 2024;38(7):e23595
Long-term enhancements in antidepressant efficacy and neurogenesis: Effects of intranasal co-administration of neuropeptide Y 1 receptor (NPY1R) and galanin receptor 2 (GALR2) agonists in the ventral hippocampus
Beltran-casanueva R; Hernandez-Garcia A; Serrano-Castro PJ; Sanchez-Perez JA; Barbancho-Fernandez MA; Garcia-Casares N; Fuxe K; Borroto-Escuela DO; Narvaez M
Article: EXPERT OPINION ON THERAPEUTIC TARGETS. 2024;28(4):309-322
Potentiation of antidepressant effects: NPY1R agonist and ketamine synergy enhances TrkB signaling and neurogenesis in the ventral hippocampus
Arrabal-Gomez C; Serrano-Castro P; Sanchez-Perez JA; Garcia-Casares N; Fuxe K; Borroto-Escuela D; Narvaez M
Article: EXPERT OPINION ON THERAPEUTIC TARGETS. 2024;28(4):295-308
Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder
Borroto-Escuela D; Serrano-Castro P; Sanchez-Perez JA; Barbancho-Fernandez MA; Fuxe K; Narvaez M
Article: PROTEIN JOURNAL. 2024;43(2):225-242
In Silico Analyses of Vertebrate G-Protein-Coupled Receptor Fusions United With or Without an Additional Transmembrane Sequence Indicate Classification into Three Groups of Linkers
Kamiya T; Masuko T; Borroto-Escuela DO; Okado H; Nakata H
Article: BEHAVIORAL AND BRAIN FUNCTIONS. 2024;20(1):6
Enhancement of neurogenesis and cognition through intranasal co-delivery of galanin receptor 2 (GALR2) and neuropeptide Y receptor 1 (NPY1R) agonists: a potential pharmacological strategy for cognitive dysfunctions
Sanchez-Varo R; Lopez-Salas A; Beltran-Casanueva R; Diaz-Sanchez E; Alvarez-Contino JE; Barbancho-Fernandez MA; Serrano-Castro P; Fuxe K; Borroto-Escuela DO; Garcia-Casares N; Narvaez M
Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2024;18:1323986
Neuropeptide Y receptor 1 and galanin receptor 2 (NPY1R-GALR2) interactions in the dentate gyrus and their relevance for neurogenesis and cognition
Beltran-Casanueva R; Hernandez-Garcia A; Garcia PDA; Blanco-Reina E; Serrano-Castro P; Garcia-Casares N; Fuxe K; Borroto-Escuela DO; Narvaez M
Article: SCIENTIFIC REPORTS. 2023;13(1):19280
Influence of limb dominance on body and jump asymmetries in elite female handball
Carrasco-Fernandez L; Garcia-Sillero M; Jurado-Castro JM; Borroto-Escuela DO; Garcia-Romero J; Benitez-Porres J
Article: SCIENTIFIC REPORTS. 2023;13(1):11948
Detection, visualization and quantification of protein complexes in human Alzheimer's disease brains using proximity ligation assay
Romero-Fernandez W; Carvajal-Tapia C; Prusky A; Katdare KA; Wang E; Shostak A; Ventura-Antunes L; Harmsen HJ; Lippmann ES; Fuxe K; MacGurn JA; Borroto-Escuela DO; Schrag MS
Article: BIOMEDICINE & PHARMACOTHERAPY. 2023;161:114433
Decreased medial prefrontal cortex activity related to impaired novel object preference task performance following GALR2 and Y1R agonists intranasal infusion
Diaz-Sanchez E; Lopez-Salas A; Mirchandani-Duque M; Alvarez-Contino JE; Sanchez-Perez JA; Fuxe K; Borroto-Escuela DO; Garcia-Casares N; Narvaez M
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(8):7467
5HT1AR-FGFR1 Heteroreceptor Complexes Differently Modulate GIRK Currents in the Dorsal Hippocampus and the Dorsal Raphe Serotonin Nucleus of Control Rats and of a Genetic Rat Model of Depression
Ambrogini P; Lattanzi D; Pagliarini M; Di Palma M; Sartini S; Cuppini R; Fuxe K; Borroto-Escuela DO
Article: PHARMACOLOGICAL REPORTS. 2023;75(2):266-275
Agonistic properties of a series of psychotropic drugs at 5-HT_1A receptors in rat and human brain membranes determined by [³⁵S]GTPγS binding assay
Odagaki Y; Mikami M; Kinoshita M; Meana JJ; Callado LFF; Garcia-Sevilla JA; Borroto-Escuela DO; Fuxe K
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2023;238(2):459-474
GALR2 and Y1R agonists intranasal infusion enhanced adult ventral hippocampal neurogenesis and antidepressant-like effects involving BDNF actions
Erik Alvarez-Contino J; Diaz-Sanchez E; Mirchandani-Duque M; Andres Sanchez-Perez J; Barbancho MA; Lopez-Salas A; Garcia-Casares N; Fuxe K; Borroto-Escuela DO; Narvaez M
Article: FRONTIERS IN PHARMACOLOGY. 2023;14:1251922
Evidence for the existence of facilitatory interactions between the dopamine D2 receptor and the oxytocin receptor in the amygdala of the rat. Relevance for anxiolytic actions
Hernandez-Mondragon JC; Hernandez-Hernandez DA; Crespo-Ramirez M; Prospero-Garcia O; Rocha-Arrieta L; Fuxe K; Borroto-Escuela DO; de la Mora MP
Article: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2023;16:1106765
Combined treatment with Sigma1R and A2AR agonists fails to inhibit cocaine self-administration despite causing strong antagonistic accumbal A2AR-D2R complex interactions: the potential role of astrocytes
Borroto-Escuela DO; Lopez-Salas A; Wydra K; Bartolini M; Zhou Z; Frankowska M; Suder A; Benitez-Porres J; Romero-Fernandez W; Filip M; Fuxe K
Article: MOLECULAR NEUROBIOLOGY. 2022;59(10):5955-5969
The mGlu₅ Receptor Protomer-Mediated Dopamine D₂ Receptor Trans-Inhibition Is Dependent on the Adenosine A_2A Receptor Protomer: Implications for Parkinson's Disease
Romero-Fernandez W; Taura JJ; Crans RAJ; Lopez-Cano M; Fores-Pons R; Narvaez M; Carlsson J; Ciruela F; Fuxe K; Borroto-Escuela DO
Article: BIOMEDICINES. 2022;10(6):1297
Galanin and Neuropeptide Y Interaction Enhances Proliferation of Granule Precursor Cells and Expression of Neuroprotective Factors in the Rat Hippocampus with Consequent Augmented Spatial Memory
Mirchandani-Duque M; Barbancho MA; Lopez-Salas A; Alvarez-Contino JE; Garcia-Casares N; Fuxe K; Borroto-Escuela DO; Narvaez M
Article: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. 2022;215:173375
Increased density and antagonistic allosteric interactions in A2AR-D2R heterocomplexes in extinction from cocaine use, lost in cue induced reinstatement of cocaine seeking
Romero-Fernandez W; Wydra K; Borroto-Escuela DOO; Jastrzebska J; Zhou Z; Frankowska M; Filip M; Fuxe K
Article: FRONTIERS IN PHARMACOLOGY. 2022;13:820210
Intranasal Delivery of Galanin 2 and Neuropeptide Y1 Agonists Enhanced Spatial Memory Performance and Neuronal Precursor Cells Proliferation in the Dorsal Hippocampus in Rats
Borroto-Escuela DO; Fores R; Pita M; Barbancho MA; Zamorano-Gonzalez P; Casares NG; Fuxe K; Narvaez M
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2021;236(5):3565-3578
Galanin and neuropeptide Y interactions elicit antidepressant activity linked to neuronal precursor cells of the dentate gyrus in the ventral hippocampus
Borroto-Escuela DO; Pita-Rodriguez M; Fores-Pons R; Barbancho MA; Fuxe K; Narvaez M
Article: NEUROPHARMACOLOGY. 2021;183:108394
Molecular, biochemical and behavioural evidence for a novel oxytocin receptor and serotonin 2C receptor heterocomplex
Chruscicka B; Cowan CSM; Fitzsimons SEW; Borroto-Escuela DO; Druelle CM; Stamou P; Bergmann CA; Dinan TG; Slattery DA; Fuxe K; Cryan JF; Schellekens H
Article: FRONTIERS IN PHARMACOLOGY. 2021;12:627032
The Balance of MU-Opioid, Dopamine D2 and Adenosine A2A Heteroreceptor Complexes in the Ventral Striatal-Pallidal GABA Antireward Neurons May Have a Significant Role in Morphine and Cocaine Use Disorders
Borroto-Escuela DO; Wydra K; Fores-Pons R; Vasudevan L; Romero-Fernandez W; Frankowska M; Ferraro L; Beggiato S; Crespo-Ramirez M; Rivera A; Rocha LL; Perez de la Mora M; Stove C; Filip M; Fuxe K
Article: MECHANISMS OF AGEING AND DEVELOPMENT. 2020;190:111289
Evidence for the existence of A2AR-TrkB heteroreceptor complexes in the dorsal hippocampus of the rat brain: Potential implications of A2AR and TrkB interplay upon ageing
Di Palma M; Sartini S; Lattanzi D; Cuppini R; Pita-Rodriguez M; Diaz-Carmenate Y; Narvaez M; Fuxe K; Borroto-Escuela DO; Ambrogini P
Article: NEUROPHARMACOLOGY. 2020;170:108070
Existence of FGFR1-5-HT1AR heteroreceptor complexes in hippocampal astrocytes. Putative link to 5-HT and FGF2 modulation of hippocampal gamma oscillations
Narvaez M; Andrade-Talavera Y; Valladolid-Acebes I; Fredriksson M; Siegele P; Hernandez-Sosa A; Fisahn A; Fuxe K; Borroto-Escuela DO
Article: PHARMACOLOGICAL REPORTS. 2020;72(2):332-339
Acute cocaine treatment enhances the antagonistic allosteric adenosine A2A-dopamine D2 receptor-receptor interactions in rat dorsal striatum without increasing significantly extracellular dopamine levels
Romero-Fernandez W; Zhou Z; Beggiato S; Wydra K; Filip M; Tanganelli S; Borroto-Escuela DO; Ferraro L; Fuxe K
Article: ONCOGENE. 2020;39(13):2756-2771
Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer
Rebollido-Rios R; Venton G; Sanchez-Redondo S; Iglesias i Felip C; Fournet G; Gonzalez E; Fernandez WR; Escuela DOB; Di Stefano B; Penarroche-Diaz R; Martin G; Ceylan I; Costello R; Perez-Alea M
Article: NEUROTOXICITY RESEARCH. 2020;37(2):433-444
OSU-6162, a Sigma1R Ligand in Low Doses, Can Further Increase the Effects of Cocaine Self-Administration on Accumbal D2R Heteroreceptor Complexes
Borroto-Escuela DO; Romero-Fernandez W; Wydra K; Zhou Z; Suder A; Filip M; Fuxe K
Article: NEUROCHEMICAL RESEARCH. 2020;45(1):5-15
On the G Protein-Coupled Receptor Neuromodulation of the Claustrum
Borroto-Escuela DO; Fuxe K
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(23):6100
A2AR Transmembrane 2 Peptide Administration Disrupts the A2AR-A2AR Homoreceptor but Not the A2AR-D2R Heteroreceptor Complex: Lack of Actions on Rodent Cocaine Self-Administration
Borroto-Escuela DO; Wydra K; Romero-Fernandez W; Zhou Z; Frankowska M; Filip M; Fuxe K
Article: GLIA. 2019;67(12):2410-2423
Potentiation of cannabinoid signaling in microglia by adenosine A_2A receptor antagonists
Franco R; Reyes-Resina I; Aguinaga D; Lillo A; Jimenez J; Raich I; Borroto-Escuela DO; Ferreiro-Vera C; Canela EI; Sanchez de Medina V; del Ser-Badia A; Fuxe K; Saura CA; Navarro G
Article: SCIENTIFIC REPORTS. 2019;9(1):16312
Differential allosteric modulation within dopamine D₂R - neurotensin NTS1R and D₂R - serotonin 5-HT_2AR receptor complexes gives bias to intracellular calcium signalling
Plach M; Schaefer T; Borroto-Escuela DO; Weikert D; Gmeiner P; Fuxe K; Friedland K
Article: TRANSLATIONAL PSYCHIATRY. 2019;9(1):263
Desipramine restores the alterations in circadian entrainment induced by prenatal exposure to glucocorticoids
Spulber S; Conti M; Elberling F; Raciti M; Borroto-Escuela DO; Fuxe K; Ceccatelli S
Article: MOLECULAR NEUROBIOLOGY. 2019;56(10):7045-7055
Acute Cocaine Enhances Dopamine D₂R Recognition and Signaling and Counteracts D₂R Internalization in Sigma1R-D₂R Heteroreceptor Complexes
Borroto-Escuela DO; Narvaez M; Romero-Fernandez W; Pinton L; Wydra K; Filip M; Beggiato S; Tanganelli S; Ferraro L; Fuxe K
Article: BIOMOLECULES. 2019;9(8):368
Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D₂ Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor
Vasudevan L; Borroto-Escuela DO; Huysentruyt J; Fuxe K; Saini DK; Stove C
Article: ACS CHEMICAL NEUROSCIENCE. 2019;10(7):3225-3240
Attenuation of Oxytocin and Serotonin 2A Receptor Signaling through Novel Heteroreceptor Formation
Chruscicka B; Fitzsimons SEW; Borroto-Escuela DO; Druelle C; Stamou P; Nally K; Dinan TG; Cryan JF; Fuxe K; Schellekens H
Article: JOURNAL OF NEURAL TRANSMISSION. 2019;126(4):455-471
Adenosine heteroreceptor complexes in the basal ganglia are implicated in Parkinson's disease and its treatment
Borroto-Escuela DO; Fuxe K
Article: FRONTIERS IN ENDOCRINOLOGY. 2019;10:574
Can Allosteric Receptor-Protein Interactions in Receptor Complexes Be a Molecular Mechanism Involved in Cancer Immune Therapy?
Borroto-Escuela DO; Fuxe K
Article: PSYCHOPHARMACOLOGY. 2018;235(12):3509-3523
Effects of intra-accumbal or intra-prefrontal cortex microinjections of adenosine 2A receptor ligands on responses to cocaine reward and seeking in rats
Wydra K; Suder A; Frankowska M; Escuela DOB; Fuxe K; Filip M
Article: MOLECULAR NEUROBIOLOGY. 2018;55(8):7038-7048
Disruption of A2AR-D2R Heteroreceptor Complexes After A2AR Transmembrane 5 Peptide Administration Enhances Cocaine Self-Administration in Rats
Borroto-Escuela DO; Wydra K; Li X; Rodriguez D; Carlsson J; Jastrzebska J; Filip M; Fuxe K
Article: PSYCHOPHARMACOLOGY. 2018;235(4):1015-1027
Differential activation of arginine-vasopressin receptor subtypes in the amygdaloid modulation of anxiety in the rat by arginine-vasopressin
Rene Hernandez-Perez O; Crespo-Ramirez M; Cuza-Ferrer Y; Anias-Calderon J; Zhang L; Roldan-Roldan G; Aguilar-Roblero R; Borroto-Escuela DO; Fuxe K; Perez de la Mora M
Article: ONCOTARGET. 2018;9(17):13593-13611
Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors.
Hinz S; Navarro G; Borroto-Escuela D; Seibt BF; Ammon Y-C; de Filippo E; Danish A; Lacher SK; Červinková B; Rafehi M; Fuxe K; Schiedel AC; Franco R; Müller CE
Article: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. 2018;42(2):338-351
Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats
Feltmann K; Borroto-Escuela DO; Ruegg J; Pinton L; de Oliveira Sergio T; Narvaez M; Jimenez-Beristain A; Ekstrom TJ; Fuxe K; Steensland P
Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2018;12:119
A Novel Integrative Mechanism in Anxiolytic Behavior Induced by Galanin 2/Neuropeptide Y Y1 Receptor Interactions on Medial Paracapsular Intercalated Amygdala in Rats
Narvaez M; Borroto-Escuela DO; Santin L; Millon C; Gago B; Flores-Burgess A; Barbancho MA; de la Mora MP; Narvaez JA; Diaz-Cabiale Z; Fuxe K
Article: FRONTIERS IN NEUROSCIENCE. 2018;12:43
Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation
Borroto-Escuela DO; Hinz S; Navarro G; Franco R; Mueller CE; Fuxe K
Article: FRONTIERS IN PHARMACOLOGY. 2018;9:829
Mapping the Interface of a GPCR Dimer: A Structural Model of the A_2A Adenosine and D₂ Dopamine Receptor Heteromer
Borroto-Escuela DO; Rodriguez D; Romero-Fernandez W; Kapla J; Jaiteh M; Ranganathan A; Lazarova T; Fuxe K; Carlsson J
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2018;67:139-151
Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB₁ and CB₂ receptors and relevance for Alzheimer's disease and levodopa-induced dyskinesia
Navarro G; Borroto-Escuela D; Angelats E; Etayo I; Reyes-Resina I; Pulido-Salgado M; Rodriguez-Perez AI; Canela EI; Saura J; Luis Lanciego J; Luis Labandeira-Garcia J; Saura CA; Fuxe K; Franco R
Article: CELLULAR SIGNALLING. 2017;40:116-124
Cocaine modulates allosteric D₂-σ₁ receptor-receptor interactions on dopamine and glutamate nerve terminals from rat striatum
Beggiato S; Borelli AC; Borroto-Escuela D; Corbucci I; Tomasini MC; Marti M; Antonelli T; Tanganelli S; Fuxe K; Ferraro L
Article: ADDICTION BIOLOGY. 2017;22(5):1232-1245
Dopamine D₄ receptor stimulation prevents nigrostriatal dopamine pathway activation by morphine: relevance for drug addiction
Rivera A; Gago B; Suarez-Boomgaard D; Yoshitake T; Roales-Bujan R; Valderrama-Carvajal A; Bilbao A; Medina-Luque J; Diaz-Cabiale Z; Van Craenenbroeck K; Borroto-Escuela DO; Kehr J; Rodriguez de Fonseca F; Santin L; de la Calle A; Fuxe K
Article: ACS OMEGA. 2017;2(8):4779-4789
Existence of Brain 5-HT1A-5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor-Receptor Interactions Regulating 5-HT1A Receptor Recognition
Borroto-Escuela DO; Li X; Tarakanov AO; Savelli D; Narvaez M; Shumilov K; Andrade-Talavera Y; Jimenez-Beristain A; Pomierny B; Diaz-Cabiale Z; Cuppini R; Ambrogini P; Lindskog M; Fuxe K
Article: NEUROPHARMACOLOGY. 2017;118:233-241
Galanin (1-15) enhancement of the behavioral effects of Fluoxetine in the forced swimming test gives a new therapeutic strategy against depression
Flores-Burgess A; Millon C; Gago B; Narvaez M; Borroto-Escuela DO; Mengod G; Angel Narvaez J; Fuxe K; Santin L; Diaz-Cabiale Z
Article: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. 2017;155:24-31
Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1 R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder
Borroto-Escuela DO; Narvaez M; Wydra K; Pintsuk J; Pinton L; Jimenez-Beristain A; Di Palma M; Jastrzebska J; Filip M; Fuxe K
Article: CURRENT OPINION IN PHARMACOLOGY. 2017;32:16-22
Diversity and bias through dopamine D2R heteroreceptor complexes
Borroto-Escuela D; Fuxe K
Article: BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS. 2017;1861(2):235-245
Existence of muscarinic acetylcholine receptor (mAChR) and fibroblast growth factor receptor (FGFR) heteroreceptor complexes and their enhancement of neurite outgrowth in neural hippocampal cultures
Di Liberto V; Borroto-Escuela DO; Frinchi M; Verdi V; Fuxe K; Belluardo N; Mudo G
Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2017;11:309
Disturbances in the FGFR1-5-HT1A Heteroreceptor Complexes in the Raphe-Hippocampal 5-HT System Develop in a Genetic Rat Model of Depression
Borroto-Escuela DO; DuPont CM; Li X; Savelli D; Lattanzi D; Srivastava I; Narvaez M; Di Palma M; Barbieri E; Andrade-Talavera Y; Cuppini R; Odagaki Y; Palkovits M; Ambrogini P; Lindskog M; Fuxe K
Article: JOURNAL OF NEUROCHEMISTRY. 2017;140(2):268-279
A2A-D2 receptor-receptor interaction modulates gliotransmitter release from striatal astrocyte processes
Cervetto C; Venturini A; Passalacqua M; Guidolin D; Genedani S; Fuxe K; Borroto-Esquela DO; Cortelli P; Woods A; Maura G; Marcoli M; Agnati LF
Article: FRONTIERS IN PSYCHIATRY. 2017;8:24
IL1R2, CCR2, and CXCR4 May Form Heteroreceptor Complexes with NMDAR and D2R: Relevance for Schizophrenia
Borroto-Escuela DO; Tarakanov AO; Bechter K; Fuxe K
Article: BRAIN STRUCTURE AND FUNCTION. 2016;221(9):4491-4504
Galanin (1-15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system
Millon C; Flores-Burgess A; Narvaez M; Borroto-Escuela DO; Santin L; Gago B; Angel Narvaez J; Fuxe K; Diaz-Cabiale Z
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2016;1862(11):2075-2085
Signaling in dopamine D2 receptor-oxytocin receptor heterocomplexes and its relevance for the anxiolytic effects of dopamine and oxytocin interactions in the amygdala of the rat
Perez de la Mora M; Perez-Carrera D; Crespo-Ramirez M; Tarakanov A; Fuxe K; Borroto-Escuela DO
Article: BRAIN STRUCTURE AND FUNCTION. 2016;221(8):4129-4139
Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the dentate gyrus are related with antidepressant-like effects
Narvaez M; Borroto-Escuela DO; Millon C; Gago B; Flores-Burgess A; Santin L; Fuxe K; Angel Narvaez J; Diaz-Cabiale Z
Article: LIFE SCIENCES. 2016;167:92-97
Alterations in ventral and dorsal striatal allosteric A2AR-D2R receptor-receptor interactions after amphetamine challenge: Relevance for schizophrenia
Pintsuk J; Borroto-Escuela DO; Lai TKY; Liu F; Fuxe K
Article: CELLULAR SIGNALLING. 2016;28(8):1001-1014
Characterization of the interaction between the dopamine D4 receptor, KLHL12 and β-arrestins
Skieterska K; Shen A; Clarisse D; Rondou P; Borroto-Escuela DO; Lintermans B; Fuxe K; Xiang YK; Van Craenenbroeck K
Article: JOURNAL OF NEUROCHEMISTRY. 2016;138(2):254-264
Functional role of striatal A2A, D2, and mGlu5 receptor interactions in regulating striatopallidal GABA neuronal transmission
Beggiato S; Tomasini MC; Borelli AC; Borroto-Escuela DO; Fuxe K; Antonelli T; Tanganelli S; Ferraro L
Article: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. 2016;144:85-91
Cocaine self-administration differentially affects allosteric A2A-D2 receptor-receptor interactions in the striatum. Relevance for cocaine use disorder
Pintsuk J; Borroto-Escuela DO; Pomierny B; Wydra K; Zaniewska M; Filip M; Fuxe K
Article: REVIEWS IN THE NEUROSCIENCES. 2016;27(1):1-25
Role of iso-receptors in receptor-receptor interactions with a focus on dopamine iso-receptor complexes
Agnati LF; Guidolin D; Cervetto C; Borroto-Escuela DO; Fuxe K
Article: NEUROCHEMICAL RESEARCH. 2015;40(12):2600-2614
Volume Transmission in Central Dopamine and Noradrenaline Neurons and Its Astroglial Targets
Fuxe K; Agnati LF; Marcoli M; Borroto-Escuela DO
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1852(12):2585-2592
The zinc binding receptor GPR39 interacts with 5-HT_1A and GalR₁ to form dynamic heteroreceptor complexes with signaling diversity
Tena-Campos M; Ramon E; Borroto-Escuela DO; Fuxe K; Garriga P
Article: EXPERT OPINION ON INVESTIGATIONAL DRUGS. 2015;24(9):1247-1260
Basimglurant for treatment of major depressive disorder: a novel negative allosteric modulator of metabotropic glutamate receptor 5
Fuxe K; Borroto-Escuela DO
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2015;463(3):180-186
Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression
Borroto-Escuela DO; Perez-Alea M; Narvaez M; Tarakanov AO; Mudo G; Jimenez-Beristain A; Agnati LE; Ciruela F; Belluardo N; Fuxe K
Article: BRAIN STRUCTURE AND FUNCTION. 2015;220(4):2289-2301
Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the amygdala lead to increased anxiolytic actions
Narvaez M; Millon C; Borroto-Escuela D; Flores-Burgess A; Santin L; Parrado C; Gago B; Puigcerver A; Fuxe K; Angel Narvaez J; Diaz-Cabiale Z
Article: PSYCHOPHARMACOLOGY. 2015;232(10):1767-1778
On the role of A_2A and D₂ receptors in control of cocaine and food-seeking behaviors in rats
Wydra K; Suder A; Borroto-Escuela DO; Filip M; Fuxe K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2015;456(1):489-493
Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system
Borroto-Escuela DO; Narvaez M; Perez-Alea M; Tarakanov AO; Jimenez-Beristain A; Mudo G; Agnati LF; Ciruela F; Belluardo N; Fuxe K
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;18(3):pyu064
A Role for Galanin N-Terminal Fragment (1-15) in Anxiety- and Depression-Related Behaviors in Rats
Millon C; Flores-Burgess A; Narvaez M; Borroto-Escuela DO; Santin L; Parrado C; Narvaez JA; Fuxe K; Diaz-Cabiale Z
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2014;452(3):347-353
Preferential activation by galanin 1-15 fragment of the GalR1 protomer of a GalR1-GalR2 heteroreceptor complex
Borroto-Escuela DO; Narvaez M; Di Palma M; Calvo F; Rodriguez D; Millon C; Carlsson J; Agnati LF; Garriga P; Diaz-Cabiale Z; Fuxe K
Article: EUROPEAN JOURNAL OF HISTOCHEMISTRY. 2014;58(3):2400
Dopamine D1 and D2 receptor immunoreactivities in the arcuate-median eminence complex and their link to the tubero-infundibular dopamine neurons
Romero-Fernandez W; Borroto-Escuela DO; Vargas-Barroso V; Narvaez M; Di Palma M; Agnati LF; Sahd JL; Fuxe K
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2014;15(5):8570-8590
The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components
Borroto-Escuela DO; Brito I; Romero-Fernandez W; Di Palma M; Oflijan J; Skieterska K; Duchou J; Van Craenenbroeck K; Suarez-Boomgaard D; Rivera A; Guidolin D; Agnati LF; Fuxe K
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2014;15(1):1481-1498
Dopamine D₄ Receptor Counteracts Morphine-Induced Changes in μ Opioid Receptor Signaling in the Striosomes of the Rat Caudate Putamen
Suarez-Boomgaard D; Gago B; Valderrama-Carvajal A; Roales-Bujan R; Van Craenenbroeck K; Duchou J; Borroto-Escuela DO; Medina-Luque J; de la Calle A; Fuxe K; Rivera A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2014;443(1):278-284
Hallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes
Borroto-Escuela DO; Romero-Fernandez W; Narvaez M; Oflijan J; Agnati LF; Fuxe K
Article: FRONTIERS IN PHYSIOLOGY. 2014;5:370
Potential of caveolae in the therapy of cardiovascular and neurological diseases
Navarro G; Borroto-Escuela DO; Fuxe K; Franco R
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2013;441(2):387-392
Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2
Borroto-Escuela DO; Corrales F; Narvaez M; Oflijan J; Agnati LF; Palkovits M; Fuxe K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2013;435(1):140-146
Dopamine D2 receptor signaling dynamics of dopamine D2-neurotensin 1 receptor heteromers
Borroto-Escuela DO; Ravani A; Tarakanov AO; Brito I; Narvaez M; Romero-Fernandez W; Corrales F; Agnati LF; Tanganelli S; Ferraro L; Fuxe K
Article: JOURNAL OF NEUROCHEMISTRY. 2012;123(3):373-384
Molecular determinants of A2AR-D2R allosterism: role of the intracellular loop 3 of the D2R
Fernandez-Duenas V; Gomez-Soler M; Jacobson KA; Kumar ST; Fuxe K; Borroto-Escuela DO; Ciruela F
Article: BRAIN RESEARCH. 2012;1476:119-131
On the role of volume transmission and receptor-receptor interactions in social behaviour: Focus on central catecholamine and oxytocin neurons
Fuxe K; Borroto-Escuela DO; Romero-Fernandez W; Ciruela F; Manger P; Leo G; Diaz-Cabiale Z; Agnati LF
Article: JOURNAL OF MOLECULAR NEUROSCIENCE. 2012;48(1):154-160
Integrin Triplets of Marine Sponges in Human Brain Receptor Heteromers
Tarakanov AO; Fuxe KG; Borroto-Escuela DO
Article: JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH. 2012;32(4):202-208
Integrin triplets of marine sponges in human D2 receptor heteromers
Tarakanov AO; Fuxe KG; Borroto-Escuela DO
Article: JOURNAL OF NEURAL TRANSMISSION. 2012;119(5):517-523
On the origin of the triplet puzzle of homologies in receptor heteromers: toll-like receptor triplets in different types of receptors
Tarakanov AO; Fuxe KG; Borroto-Escuela DO
Article: EXPERIMENTAL CELL RESEARCH. 2012;318(5):603-613
Microvesicle and tunneling nanotube mediated intercellular transfer of g-protein coupled receptors in cell cultures
Guescini M; Leo G; Genedani S; Carone C; Pederzoli F; Ciruela F; Guidolin D; Stocchi V; Mantuano M; Borroto-Escuela DO; Fuxe K; Agnati LF
Article: JOURNAL OF MOLECULAR NEUROSCIENCE. 2012;46(3):616-621
On the Origin of the Triplet Puzzle of Homologies in Receptor Heteromers: Immunoglobulin Triplets in Different Types of Receptors
Tarakanov AO; Fuxe KG; Borroto-Escuela DO
Article: FRONTIERS IN ENDOCRINOLOGY. 2012;3:127
On the existence and function of galanin receptor heteromers in the central nervous system.
Fuxe K; Borroto-Escuela DO; Romero-Fernandez W; Tarakanov AO; Calvo F; Garriga P; Tena M; Narvaez M; Millón C; Parrado C; Ciruela F; Agnati LF; Narvaez JA; Díaz-Cabiale Z
Article: BIOLOGICAL PSYCHIATRY. 2012;71(1):84-91
Fibroblast Growth Factor Receptor 1-5-Hydroxytryptamine 1A Heteroreceptor Complexes and Their Enhancement of Hippocampal Plasticity
Borroto-Escuela DO; Romero-Fernandez W; Mudo G; Perez-Alea M; Ciruela F; Tarakanov AO; Narvaez M; Di Liberto V; Agnati LF; Belluardo N; Fuxe K
Article: GLYCOBIOLOGY. 2011;21(12):1663-1672
Altered trafficking and unfolded protein response induction as a result of M₃ muscarinic receptor impaired N-glycosylation
Romero-Fernandez W; Borroto-Escuela DO; Alea MP; Garcia-Mesa Y; Garriga P
Article: JOURNAL OF NEUROIMMUNOLOGY. 2011;237(1-2):13-22
Differential expression of muscarinic acetylcholine receptor subtypes in Jurkat cells and their signaling
Perez Alea M; Borroto-Escuela DO; Romero-Fernandez W; Fuxe K; Garriga P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;409(4):764-768
Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family
Romero-Fernandez W; Borroto-Escuela DO; Tarakanov AO; Mudo G; Narvaez M; Perez-Alea M; Agnati LF; Ciruela F; Belluardo N; Fuxe K
Article: BIOTECHNOLOGY PROGRESS. 2011;27(3):838-845
Overproduction of Human M₃ Muscarinic Acetylcholine Receptor: An Approach Toward Structural Studies
Romero-Fernandez W; Garriga P; Borroto-Escuela DO
Article: THE FEBS JOURNAL. 2011;278(8):1333-1344
Dopamine D₄ receptor oligomerization - contribution to receptor biogenesis
Van Craenenbroeck K; Borroto-Escuela DO; Romero-Fernandez W; Skieterska K; Rondou P; Lintermans B; Vanhoenacker P; Fuxe K; Ciruela F; Haegeman G
Article: JOURNAL OF MOLECULAR BIOLOGY. 2011;406(5):687-699
On the Existence of a Possible A_2A-D₂-β-Arrestin2 Complex: A_2A Agonist Modulation of D₂ Agonist-Induced β-Arrestin2 Recruitment
Borroto-Escuela DO; Romero-Fernandez W; Tarakanov AO; Ciruela F; Agnati LF; Fuxe K
Article: JOURNAL OF NEUROSCIENCE METHODS. 2011;195(2):161-169
Muscarinic receptor family interacting proteins: Role in receptor function
Borroto-Escuela DO; Correia PA; Romero-Fernandez W; Narvaez M; Fuxe K; Ciruela F; Garriga P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;404(4):928-934
Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions
Borroto-Escuela DO; Van Craenenbroeck K; Romero-Fernandez W; Guidolin D; Woods AS; Rivera A; Haegeman G; Agnati LF; Tarakanov AO; Fuxe K
Article: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. 2011;28(5):1009-1022
Dissecting the Conserved NPxxY Motif of the M₃ Muscarinic Acetylcholine Receptor: Critical Role of Asp-7.49 for Receptor Signaling and Multiprotein Complex Formation
Borroto-Escuela DO; Romero-Fernandez W; Garcia-Negredo G; Correia PA; Garriga P; Fuxe K; Ciruela F
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;402(4):801-807
Characterization of the A_2AR-D₂R interface Focus on the role of the C-terminal tail and the transmembrane helices
Borroto-Escuela DO; Romero-Fernandez W; Tarakanov AO; Gomez-Soler M; Corrales F; Marcellino D; Narvaez M; Frankowska M; Flajolet M; Heintz N; Agnati LF; Ciruela F; Fuxe K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;401(4):605-610
Dopamine D2 and 5-hydroxytryptamine 5-HT_2A receptors assemble into functionally interacting heteromers
Borroto-Escuela DO; Romero-Fernandez W; Tarakanov AO; Marcellino D; Ciruela F; Agnati LF; Fuxe K
Article: JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH. 2010;30(5):322-330
G protein-coupled receptor oligomerization for what?
Ciruela F; Vallano A; Arnau JM; Sanchez S; Borroto-Escuela DO; Agnati LF; Fuxe K; Fernandez-Duenas V
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2010;1803(7):813-825
The M₅ muscarinic acetylcholine receptor third intracellular loop regulates receptor function and oligomerization
Borroto-Escuela DO; Garcia-Negredo G; Garriga P; Fuxe K; Ciruela F
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;394(1):222-227
A serine point mutation in the adenosine A_2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D₂R
Borroto-Escuela DO; Marcellino D; Narvaez M; Flajolet M; Heintz N; Agnati L; Ciruela F; Fuxe K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;393(4):767-772
Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization
Borroto-Escuela DO; Narvaez M; Marcellino D; Parrado C; Angel Narvaez J; Tarakanov AO; Agnati LF; Diaz-Cabiale Z; Fuxe K
Article: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. 2010;25(4-5):397-408
Impaired M₃ Muscarinic Acetylcholine Receptor Signal Transduction Through Blockade of Binding of Multiple Proteins to its Third Intracellular Loop
Borroto-Escuela DO; Correia PA; Perez Alea M; Narvaez M; Garriga P; Fuxe K; Ciruela F
Article: JOURNAL OF MICROBIOLOGICAL METHODS. 2006;65(1):187-193
Vectors and P64k gene targeting for tandem affinity purification in Neisseria meningitidis
Escuela DOB; Alea MP; Fernandez WR; Gil DB
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Editorial comment: NEUROPSYCHOPHARMACOLOGY. 2024;50(1):326-327
Advancement in human neuroimaging based on proximity ligation assay in brain disease
Borroto-Escuela DO; Fuxe K
Editorial comment: FRONTIERS IN PHARMACOLOGY. 2024;15:1426351
Editorial: Substance use disorder: above and beyond addiction
Kumar J; Mohamed W; Borroto-Escuela DO; Sangu M; Rashid R; Isa MFM; Shanmugam PK
Review: FRONTIERS IN CELLULAR NEUROSCIENCE. 2024;18:1398862
Understanding electrical and chemical transmission in the brain
Borroto-Escuela DO; Gonzalez-Cristo E; Ochoa-Torres V; Serra-Rojas EM; Ambrogini P; Arroyo-Garcia LE; Fuxe K
Preprint: RES SQ. 2023;RES SQ
Detection, Visualization and Quantification of Protein Complexes in Human Alzheimer's Disease Brains using Proximity Ligation Assay.
Romero-Fernandez W; Carvajal-Tapia C; Prusky A; Katdare K; Wang E; Shostak A; Ventura-Antunes L; Harmsen H; Lippmann E; Borroto-Escuela D; MacGurn J; Fuxe K; Schrag M
Editorial comment: NEURAL REGENERATION RESEARCH. 2022;17(10):2211-2212
The integrative role of G protein-coupled receptor heterocomplexes in Parkinson's disease
Borroto-Escuela DO; Fuxe K
Review: CELLS. 2022;11(11):1826
Dysfunctional Heteroreceptor Complexes as Novel Targets for the Treatment of Major Depressive and Anxiety Disorders
Perez de la Mora M; Borroto-Escuela DO; Crespo-Ramirez M; Rejon-Orantes JDC; Palacios-Lagunas DA; Martinez-Mata MK; Sanchez-Luna D; Tesoro-Cruz E; Fuxe K
Review: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2022;15:1055344
The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: potential relevance for brain and behavior
Borroto-Escuela DO; Cuesta-Marti C; Lopez-Salas A; Crespo-Ramirez M; Tesoro-Cruz E; Palacios-Lagunas DA; de la Mora MP; Schellekens H; Fuxe K; Chrukicka-Smaga B
Corrigendum: PHARMACOLOGICAL REPORTS. 2021;73(5):1484
The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons (vol 73, pg 1096, 2021)
Borroto-Escuela DO; Ferraro L; Beggiato S; Narvaez M; Fores-Pons R; Alvarez-Contino JE; Wydra K; Frankowska M; Bader M; Filip M; Fuxe K
Review: PHARMACOLOGICAL REPORTS. 2021;73(4):1096-1108
The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons
Borroto-Escuela DO; Ferraro L; Beggiato S; Narvaez M; Fores-Pons R; Alvarez-Contino JE; Wydra K; Frankowska M; Bader M; Filip M; Fuxe K
Review: CELLS. 2021;10(8):1902
Serotonin Heteroreceptor Complexes and Their Integration of Signals in Neurons and Astroglia-Relevance for Mental Diseases
Borroto-Escuela DO; Ambrogini P; Narvaez M; Di Liberto V; Beggiato S; Ferraro L; Fores-Pons R; Alvarez-Contino JE; Lopez-Salas A; Mudo G; Diaz-Cabiale Z; Fuxe K
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(4):1927
The Role of Central Serotonin Neurons and 5-HT Heteroreceptor Complexes in the Pathophysiology of Depression: A Historical Perspective and Future Prospects
Borroto-Escuela DO; Ambrogini P; Chruscicka B; Lindskog M; Crespo-Ramirez M; Hernandez-Mondragon JC; Perez de la Mora M; Schellekens H; Fuxe K
Editorial comment: FRONTIERS IN PHARMACOLOGY. 2021;12:654426
Adenosine and Kynurenic Acid Interactions: Possible Relevance for Schizophrenia Treatment?
Beggiato S; Zuccarini M; Cassano T; Borroto-Escuela DO; Di Iorio P; Schwarcz R; Fuxe K; Ferraro L
Editorial comment: FRONTIERS IN PHARMACOLOGY. 2021;12:781381
Molecular Integration in Adenosine Heteroreceptor Complexes Through Allosteric and De-Phosphorylation (STEP) Mechanisms and its Role in Brain Disease
Borroto-Escuela DO; Ferraro L; Fuxe K
Review: NEUROSCIENCE. 2020;439:301-318
Conventional and Novel Pharmacological Approaches to Treat Dopamine-Related Disorders: Focus on Parkinson's Disease and Schizophrenia
de la Mora MP; Hernandez-Mondragon C; Crespo-Ramierz M; Rejon-Orantes J; Borroto-Escuela DO; Fuxe K
Review: CELLS. 2020;9(6):1372
Adenosine A_2AReceptors in Substance Use Disorders: A Focus on Cocaine
Wydra K; Gawlinski D; Gawlinska K; Frankowska M; Borroto-Escuela DO; Fuxe K; Filip M
Review: CELLS. 2020;9(5):1077
Multiple Adenosine-Dopamine (A2A-D2 Like) Heteroreceptor Complexes in the Brain and Their Role in Schizophrenia
Borroto-Escuela DO; Ferraro L; Narvaez M; Tanganelli S; Beggiato S; Liu F; Rivera A; Fuxe K
Editorial comment: NEUROPHARMACOLOGY. 2019;152:1-3
Understanding receptor heteromerization and its allosteric integration of signals
Fuxe K; Borroto-Escuela DO
Review: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2019;12:230
Oligomeric Receptor Complexes and Their Allosteric Receptor-Receptor Interactions in the Plasma Membrane Represent a New Biological Principle for Integration of Signals in the CNS
Borroto-Escuela DO; Fuxe K
Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2018;39(12):1008-1020
A2AR-D2R Heteroreceptor Complexes in Cocaine Reward and Addiction
Borroto-Escuela DO; Wydra K; Filip M; Fuxe K
Review: PHARMACOLOGICAL REPORTS. 2018;70(5):936-950
Glutamate heteroreceptor complexes in the brain
Borroto-Escuela DO; Tarakanov AO; Brito I; Fuxe K
Review: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2018;366(3):519-526
Dopamine D₂ Receptor Supersensitivity as a Spectrum of Neurotoxicity and Status in Psychiatric Disorders
Kostrzewa RM; Wydra K; Filip M; Crawford CA; McDougall SA; Brown RW; Borroto-Escuela DO; Fuxe K; Gainetdinov RR
Review: MOLECULES. 2018;23(6):1341
Receptor-Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment
Borroto-Escuela DO; Narvaez M; Ambrogini P; Ferraro L; Brito I; Romero-Fernandez W; Andrade-Talavera Y; Flores-Burgess A; Millon C; Gago B; Angel Narvaez J; Odagaki Y; Palkovits M; Diaz-Cabiale Z; Fuxe K
Review: FRONTIERS IN SYNAPTIC NEUROSCIENCE. 2018;10:20
Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors
Borroto-Escuela DO; De la Mora MP; Manger P; Narvaez M; Beggiato S; Crespo-Ramirez M; Navarro G; Wydra K; Diaz-Cabiale Z; Rivera A; Ferraro L; Tanganelli S; Filip G; Franco R; Fuxe K
Review: NEUROPEPTIDES. 2017;64:39-45
The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours
Millon C; Flores-Burgess A; Narvaez M; Borroto-Escuela DO; Gago B; Santin L; Castilla-Ortega E; Angel Narvaez J; Fuxe K; Diaz-Cabiale Z
Review: FRONTIERS IN CELLULAR NEUROSCIENCE. 2017;11:37
Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease
Borroto-Escuela DO; Carlsson J; Ambrogini P; Narvaez M; Wydra K; Tarakanov AO; Li X; Millon C; Ferraro L; Cuppini R; Tanganelli S; Liu F; Filip M; Diaz-Cabiale Z; Fuxe K
Review: NEURAL REGENERATION RESEARCH. 2016;11(8):1220-1223
Volume transmission and receptor-receptor interactions in heteroreceptor complexes: understanding the role of new concepts for brain communication
Fuxe K; Borroto-Escuela DO
Review: NEUROPHARMACOLOGY. 2016;104:161-168
Purinergic signaling in Parkinson's disease. Relevance for treatment
Navarro G; Borroto-Escuela DO; Fuxe K; Franco R
Review: THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY. 2016;6(2):77-94
Multiple D2 heteroreceptor complexes: new targets for treatment of schizophrenia
Borroto-Escuela DO; Pintsuk J; Schaefer T; Friedland K; Ferraro L; Tanganelli S; Liu F; Fuxe K
Review: NEURAL PLASTICITY. 2016;2016:4827268-12
Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes
Borroto-Escuela DO; Wydra K; Pintsuk J; Narvaez M; Corrales F; Zaniewska M; Agnati LF; Franco R; Tanganelli S; Ferraro L; Filip M; Fuxe K
Review: TRENDS IN NEUROSCIENCES. 2016;39(1):5-15
FGFR1-5-HT1A Heteroreceptor Complexes: Implications for Understanding and Treating Major Depression
Borroto-Escuela DO; Tarakanov AO; Fuxe K
Editorial comment: NEUROPSYCHOPHARMACOLOGY. 2016;41(1):380-382
Heteroreceptor Complexes and their Allosteric Receptor-Receptor Interactions as a Novel Biological Principle for Integration of Communication in the CNS: Targets for Drug Development
Fuxe K; Borroto-Escuela DO
Review: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON. BIOLOGICAL SCIENCES. 2015;370(1672):20140183
The role of transmitter diffusion and flow versus extracellular vesicles in volume transmission in the brain neural-glial networks
Borroto-Escuela DO; Agnati LF; Bechter K; Jansson A; Tarakanov AO; Fuxe K
Review: EXPERT OPINION ON THERAPEUTIC TARGETS. 2015;19(3):377-398
Dopamine heteroreceptor complexes as therapeutic targets in Parkinson's disease
Fuxe K; Guidolin D; Agnati LF; Borroto-Escuela DO
Review: EXPERT OPINION ON THERAPEUTIC TARGETS. 2015;19(2):265-283
G-protein-coupled receptor type A heteromers as an emerging therapeutic target
Guidolin D; Agnati LF; Marcoli M; Borroto-Escuela DO; Fuxe K
Review: JOURNAL OF NEURAL TRANSMISSION. 2014;121(12):1431-1449
Information handling by the brain: proposal of a new "paradigm" involving the roamer type of volume transmission and the tunneling nanotube type of wiring transmission
Agnati LF; Guidolin D; Maura G; Marcoli M; Leo G; Carone C; De Caro R; Genedani S; Borroto-Escuela DO; Fuxe K
Editorial comment: CURRENT PROTEIN AND PEPTIDE SCIENCE. 2014;15(7):647
Understanding the Role of Heteroreceptor Complexes in the Central Nervous System
Fuxe K; Borroto-Escuela D; Fisone G; Agnati LF; Tanganelli S
Review: CURRENT PROTEIN AND PEPTIDE SCIENCE. 2014;15(7):659-665
Role of Dimerization in Dopamine D₄ Receptor Biogenesis
Van Craenenbroeck K; Borroto-Escuela DO; Skieterska K; Duchou J; Romero-Fernandez W; Fuxe K
Review: CURRENT PROTEIN AND PEPTIDE SCIENCE. 2014;15(7):703-718
"Neuro-Semeiotics" and "Free-Energy Minimization" Suggest a Unified Perspective for Integrative Brain Actions: Focus on Receptor Heteromers and Roamer Type of Volume Transmission
Agnati LF; Guidolin D; Marcoli M; Genedani S; Borroto-Escuela D; Maura G; Fuxe K
Review: CURRENT PROTEIN AND PEPTIDE SCIENCE. 2014;15(7):648-658
G-Protein-Coupled Receptors Oligomerization: Emerging Signaling Units and New Opportunities for Drug Design
Tena-Campos M; Ramon E; Rivera D; Borroto-Escuela DO; Romero-Fernandez W; Fuxe K; Garriga P
Review: CURRENT PROTEIN AND PEPTIDE SCIENCE. 2014;15(7):681-690
Neurotensin NTS1-Dopamine D2 Receptor-Receptor Interactions in Putative Receptor Heteromers: Relevance for Parkinson's Disease and Schizophrenia
Ferraro L; Beggiato S; Borroto-Escuela DO; Ravani L; O'Connor WT; Tomasini MC; Borelli AC; Agnati LF; Antonelli T; Tanganelli S; Fuxe K
Editorial comment: EXPERT REVIEW OF NEUROTHERAPEUTICS. 2014;14(7):719-721
The impact of receptor-receptor interactions in heteroreceptor complexes on brain plasticity
Fuxe K; Agnati LF; Borroto-Escuela DO
Review: NEUROPSYCHOPHARMACOLOGY. 2014;39(1):131-155
Moonlighting Proteins and Protein-Protein Interactions as Neurotherapeutic Targets in the G Protein-Coupled Receptor Field
Fuxe K; Borroto-Escuela DO; Romero-Fernandez W; Palkovits M; Tarakanov AO; Ciruela F; Agnati LF
Review: FRONTIERS IN ENDOCRINOLOGY. 2014;5:71
Diversity and bias through receptor-receptor interactions in GPCR heteroreceptor complexes. Focus on examples from dopamine D2 receptor heteromerization
Fuxe K; Tarakanov A; Romero Fernandez W; Ferraro L; Tanganelli S; Filip M; Agnati LF; Garriga P; Diaz-Cabiale Z; Borroto-Escuela DO
Review: PROGRESS IN BRAIN RESEARCH. 2014;211:113-139
Dopamine D2 heteroreceptor complexes and their receptor-receptor interactions in ventral striatum: novel targets for antipsychotic drugs
Fuxe K; Borroto-Escuela DO; Tarakanov AO; Romero-Fernandez W; Ferraro L; Tanganelli S; Perez-Alea M; Di Palma M; Agnati LF
Editorial comment: MOLECULAR PSYCHIATRY. 2013;18(8):849-850
Evidence for the existence of dopamine d2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor-receptor interactions
Romero-Fernandez W; Borroto-Escuela DO; Agnati LF; Fuxe K
Editorial comment: CHINESE JOURNAL OF INTEGRATIVE MEDICINE. 2013;19(5):323-329
Volume transmission and its different forms in the central nervous system
Fuxe K; Borroto-Escuela DO; Romero-Fernandez W; Zhang W-B; Agnati LF
Review: CURRENT PROTEIN AND PEPTIDE SCIENCE. 2013;14(2):141-160
A New Interpretative Paradigm for Conformational Protein Diseases
Agnati LF; Guidolin D; Woods AS; Ciruela F; Carone C; Vallelunga A; Escuela DOB; Genedani S; Fuxe K
Review: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. 2013;2013:563716-17
On the G-Protein-Coupled Receptor Heteromers and Their Allosteric Receptor-Receptor Interactions in the Central Nervous System: Focus on Their Role in Pain Modulation
Borroto-Escuela DO; Romero-Fernandez W; Rivera A; Van Craenenbroeck K; Tarakanov AO; Agnati LF; Fuxe K
Review: METHODS IN CELL BIOLOGY. 2013;117:141-164
Bioluminescence Resonance Energy Transfer Methods to Study G Protein-Coupled Receptor-Receptor Tyrosine Kinase Heteroreceptor Complexes
Borroto-Escuela DO; Flajolet M; Agnati LF; Greengard P; Fuxe K
Review: METHODS IN ENZYMOLOGY. 2013;521:281-294
G Protein-Coupled Receptor Heterodimerization in the Brain
Borroto-Escuela DO; Romero-Fernandez W; Garriga P; Ciruela F; Narvaez M; Tarakanov AO; Palkovits M; Agnati LF; Fuxe K
Review: BRAIN RESEARCH. 2012;1476:86-95
G protein-coupled receptor oligomerization and brain integration: Focus on adenosinergic transmission
Ciruela F; Fernandez-Duenas V; Llorente J; Borroto-Escuela D; Cuffi ML; Carbonell L; Sanchez S; Agnati LF; Fuxe K; Tasca CI
Review: BRAIN RESEARCH. 2012;1476:38-57
Possible genetic and epigenetic links between human inner speech, schizophrenia and altruism
Agnati LF; Barlow P; Ghidoni R; Borroto-Escuela DO; Guidolin D; Fuxe K
Review: METHODS. 2012;57(4):467-472
Fluorescence resonance energy transfer-based technologies in the study of protein-protein interactions at the cell surface
Fernandez-Duenas V; Llorente J; Gandia J; Borroto-Escuela DO; Agnati LF; Tasca CI; Fuxe K; Ciruela F
Review: CURRENT MEDICINAL CHEMISTRY. 2012;19(3):356-363
GPCR Heteromers and their Allosteric Receptor-Receptor Interactions
Fuxe K; Borroto-Escuela DO; Marcellino D; Romero-Fernandez W; Frankowska M; Guidolin D; Filip M; Ferraro L; Woods AS; Tarakanov A; Ciruela F; Agnati LF; Tanganelli S
Review: CURRENT DRUG TARGETS. 2012;13(1):53-71
Muscarinic Acetylcholine Receptor-Interacting Proteins (mAChRIPs): Targeting the Receptorsome
Borroto-Escuela DO; Agnati LF; Fuxe K; Ciruela F
Review: FRONTIERS IN PHYSIOLOGY. 2012;3:136
Extrasynaptic neurotransmission in the modulation of brain function. Focus on the striatal neuronal-glial networks
Fuxe K; Borroto-Escuela DO; Romero-Fernandez W; Diaz-Cabiale Z; Rivera A; Ferraro L; Tanganelli S; Tarakanov AO; Garriga P; Angel Narvaez J; Ciruela F; Guescini M; Agnati LF
Review: IUBMB LIFE. 2011;63(7):463-472
Moonlighting Characteristics of G Protein-coupled Receptors: Focus on Receptor Heteromers and Relevance for Neurodegeneration
Borroto-Escuela DO; Tarakanov AO; Guidolin D; Ciruela F; Agnati LF; Fuxe K
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2011;1808(5):1245-1255
Adenosine receptor containing oligomers: Their role in the control of dopamine and glutamate neurotransmission in the brain
Ciruela F; Gomez-Soler M; Guidolin D; Borroto-Escuela DO; Agnati LF; Fuxe K; Fernandez-Duenas V
Review: JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH. 2010;30(5):272-283
The changing world of G protein-coupled receptors: from monomers to dimers and receptor mosaics with allosteric receptor-receptor interactions
Fuxe K; Marcellino D; Borroto-Escuela DO; Frankowska M; Ferraro L; Guidolin D; Ciruela F; Agnati LF
Review: CNS NEUROSCIENCE & THERAPEUTICS. 2010;16(3):e18-e42
Adenosine-Dopamine Interactions in the Pathophysiology and Treatment of CNS Disorders
Fuxe K; Marcellino D; Borroto-Escuela DO; Guescini M; Fernandez-Duenas V; Tanganelli S; Rivera A; Ciruela F; Agnati LF
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