Cesare Patrone

Cesare Patrone

Lektor/Klinisk Anställning | Docent
E-postadress: cesare.patrone@ki.se
Telefon: +46852487575
Besöksadress: Södersjukhuset, Sjukhusbacken 17, 11883 Stockholm
Postadress: S1 Klinisk forskning och utbildning, Södersjukhuset, S1 KI SÖS Forskning Internmedicin, 118 83 Stockholm

Om mig

  • Associate Professor/Senior Lecturer

    Researh Group: https://ki.se/en/kisos/the-neurocardiometabol-group

    In February 2009 I was recruited to Karolinska Institutet to start up a 
    research group about the neurological complications of type 2 diabetes, with
    main focus on stroke. I am responsible for planning, coordinating and
    executing work in the area of experimental stroke in diabetes.

    *2001-2009*: Senior Researcher and Manager at Neuronova AB, Stockholm, Sweden

    *2000-2001: *Postdoctoral Fellow, Karolinska Institutet, Stockholm, Sweden

    *1998-2000:* Postdoctoral Fellow, Uppsala University, Sweden

    *1998: *PhD in Neurobiology, Milano University, Italy

    Research grants and awards as PI 


    1) The Swedish Research Council (Vetenskasprådet); 2022-2025


    2) Hjärnfonden 2022


    3) Hjärnfonden 2021


    4) Diabetesfonden; 2020-2021


    5) The Swedish Research Council (Vetenskasprådet); 2018-2021


    6) European Foundation for the Study of Diabetes/Sanofi European DiabetesResearch Programme in Macrovascular Complications; 2019

     
    7) Award “Investigator Study IIS” Boehringer Ing. Sweden; 2018


    8) Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; 2012-2017

     
    9) Åhlén Stiftelse; 2012-2018


    10) O. E. och Edla Johanssons Stiftelse; 2016-2018

     
    11) Magnus Bergvalls Stiftelse; 2011-2016

     
    12) STROKE Riksförbundet; 2018-2020

     
    13) Diabetesfonden; 2014-2015


    14) Novo Nordisk Foundation; 2014


    15) Syskonen Svensson Stiftelse; 2017

     
    16) European Foundation for the Study of Diabetes; 2013

     
    17) Diabetes Wellness; 2010


    18) Stohnes stiftelse; 2010, 2012, 2015

     
    19) STROKE Riksförbundet; 2011-2014

     
    20) European Foundation for the Study of Diabetes; 2009


    Courses

    2018 Assess the structure of examination of projects, Workshop, Karolinska 
    Institutet

    2013 Docent in neuroscience, Karolinska Institutet

    2011 Course in "Assessment in Higher Education", Karolinska Institutet

    2011 Basic Course in Education for University Teachers, Karolinska 
    Institutet

    2010 Introductory Doctoral Supervision Course, Karolinska Institutet

    2010 Work environment issues and manager responsibilities , Karolinska 
    Institutet

    2009 Laboratory Animal Science (FELASA) certificate, Karolinska Institutet

    2008 Applied Project Management Courses, Wenell Management AB, Stockholm

    2007 Courses in Clinical Trials, Trial Form Support AB, Lund

    1998 PhD in Neurobiology, University of Milan, Italy.

    1992 University of Milan, Italy, Laurea and M.Sc. Biological Sciences

Forskningsbeskrivning

Undervisning

  • July 2013- ongoing*, Project Coordinator/Examiner in degree projects in medicine, Department of Medical Epidemiology and Biostatistics [1], KI. The 
    position involves reviewing the students’ work-plan, half time and final thesis, arrange seminars and examine the work.

     
    2015- 2020* Visiting Professor (1 week/year), Univ. of Piemonte Orientale, Novara, Italy
    [1] http://ki.se/ki/jsp/polopoly.jsp?d=9600&;amp;l=en

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Swedish Research Council
    1 January 2023 - 31 December 2025
    AimType 2 diabetic (T2D) and elderly people have severe/persistent post-stroke disabilities and the causal mechanisms are unknown. Insulin resistance (IR), which is a hallmark of T2D, also afflicts up to 50% of non-diabetic elderly people (prediabetic). IR has been associated to poor stroke outcome. However, if the pharmacological targeting of IR improves stroke recovery is unknown and will be addressed in this experimental project.Project organisation/time plan/methodsThe project’s duration is 3 years. Most of the activities will take place at the PI’s lab where validated IR (aging- and high sucrose-induced), and stroke (middle cerebral artery occlusion) mouse models plus lab facilities are in place. One post-doc and one PhD student will perform the experiments. Stroke and T2D expertise is provided by co-PIs Dr Vladimer Darsalia and Prof Thomas Nyström. The cellular studies are in collaboration with Profs Gesine Paul (Lund Univ) and Milos Pekny (Gothenburg Univ).Relevance/ImplementationT2D and aging impair stroke recovery. Since T2D is reaching epidemic dimensions, the elderly population continues to grow, and both conditions are strong stroke risk factors, this creates a social burden with rising medical need. Positive results of this project will be important to develop new therapies targeting IR, in the preventive perspective to limit stroke sequelae in two of the largest populations at stroke risk. This could have remarkable implications for an enormous group of people.
  • Swedish Research Council
    1 December 2022 - 30 November 2025
    The purpose of this project is to utilize our genomewide association study (GWAS) of abdominal subcutaneous adipose tissue (SAT) phenotypes and enhancer map to couple risk-alleles for central obesity and type 2 diabetes (T2D) to adipose phenotypes and functional elements of the genome. The GENiAL cohort comprises n~930 adults that have undergone SAT biopsy and detailed characterization of adipose morphology and metabolism. We will complete a GWAS of basal and insulin stimulated lipogenesis in GENiAL. By in silico analyses we will evaluate whether lipogenesis-associated alleles influence the risk of developing central obesity or T2D. Next, we will map overlap between enhancers and their RNA (eRNA), and alleles associated with adipocyte lipogenesis, number, size or lipolysis in GENiAL. Finally, significant alleles, enhancers, and genes identified in the above analyses will be evaluated for impact on adipocytes in vitro. The first gene to study is RREB1 where we have identified an allele associated with fewer fat cells and increased risk of T2D. Candidate genes will undergo screening by siRNA mediated knockdown in human adipose derived stem cells, and eRNA by antisense knockdown. Allelic specific effects can subsequently be studied by Lentivirus transfection or CRISPR/Cas9.This project can lead to the identification of novel targets for treating obesity and T2D, and to increase the informativeness of genetic risk scores that can be used to guide treatment decisions in T2D.
  • Swedish Heart-Lung Foundation
    1 January 2020 - 31 December 2022
  • GLUCAGON-LIKE PEPTIDE 1 ACTIVATION AGAINST STROKE IN DIABETES: FROM THE PRECLINICAL TO THE CLINICAL PHASE
    Novo Nordisk Foundation
    1 January 2014 - 1 January 2015

Anställningar

  • Lektor/Klinisk Anställning, Klinisk forskning och utbildning, Södersjukhuset, Karolinska Institutet, 2018-

Examina och utbildning

  • Docent, Neurovetenskap, Karolinska Institutet, 2013

Nyheter från KI

Kalenderhändelser från KI