Cesare Patrone
Senior Lecturer/Clinical Position | Docent
E-mail: cesare.patrone@ki.se
Telephone: +46852487575
Visiting address: Södersjukhuset, Sjukhusbacken 17, 11883 Stockholm
Postal address: S1 Klinisk forskning och utbildning, Södersjukhuset, S1 KI SÖS Forskning Internmedicin, 118 83 Stockholm
About me
- Associate Professor/Senior Lecturer
Researh Group: https://ki.se/en/kisos/the-neurocardiometabol-group
In February 2009 I was recruited to Karolinska Institutet to start up a
research group about the neurological complications of type 2 diabetes, with
main focus on stroke. I am responsible for planning, coordinating and
executing work in the area of experimental stroke in diabetes.
*2001-2009*: Senior Researcher and Manager at Neuronova AB, Stockholm, Sweden
*2000-2001: *Postdoctoral Fellow, Karolinska Institutet, Stockholm, Sweden
*1998-2000:* Postdoctoral Fellow, Uppsala University, Sweden
*1998: *PhD in Neurobiology, Milano University, Italy
Research grants and awards as PI
1) The Swedish Research Council (Vetenskasprådet) - 2022-2025
2) Hjärnfonden 2022
3) Hjärnfonden 2021
4) Diabetesfonden - 2020-2021
5) The Swedish Research Council (Vetenskasprådet) - 2018-2021
6) European Foundation for the Study of Diabetes/Sanofi European Diabetes
Research Programme in Macrovascular Complications - 2019
7) Award “Investigator Study IIS” Boehringer Ing. Sweden - 2018
8) Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse - 2012-2017
9) Åhlén Stiftelse - 2012-2018
10) O. E. och Edla Johanssons Stiftelse - 2016-2018
11) Magnus Bergvalls Stiftelse - 2011-2016
12) STROKE Riksförbundet - 2018-2020
13) Diabetesfonden - 2014-2015
14) Novo Nordisk Foundation - 2014
15) Syskonen Svensson Stiftelse - 2017
16) European Foundation for the Study of Diabetes - 2013
17) Diabetes Wellness - 2010
18) Stohnes stiftelse - 2010, 2012, 2015
19) STROKE Riksförbundet - 2011-2014
20) European Foundation for the Study of Diabetes - 2009
2018 Assess the structure of examination of projects, Workshop, Karolinska
Institutet
2013 Docent in neuroscience, Karolinska Institutet
2011 Course in "Assessment in Higher Education", Karolinska Institutet
2011 Basic Course in Education for University Teachers, Karolinska
Institutet
2010 Introductory Doctoral Supervision Course, Karolinska Institutet
2010 Work environment issues and manager responsibilities , Karolinska
Institutet
2009 Laboratory Animal Science (FELASA) certificate, Karolinska Institutet
2008 Applied Project Management Courses, Wenell Management AB, Stockholm
2007 Courses in Clinical Trials, Trial Form Support AB, Lund
1998 PhD in Neurobiology, University of Milan, Italy.
1992 University of Milan, Italy, Laurea and M.Sc. Biological Sciences
Research
- *Stroke and Diabetes*
The focus is along two research lines, see also the Research Group at:
https://ki.se/en/kisos/the-neurocardiometabol-group
* The identification of efficacious preclinical therapies for the treatment
of stroke in diabetes.
* The study of the cellular mechanisms at the basis of the neurological
complications of diabetes.
Stroke affects several million people worldwide, of which a substantial
proportion of cases present in patients suffering from diabetes. Diabetes is
widespread and represents a leading cause of death. About 90 % of the medical
and social costs associated with diabetes are dominated by care for
macrovascular complications such as stroke. Therefore it is important to
identify strategies aimed at prevent stroke in diabetes but also improve
post-stroke recovery in diabetic individuals.
-We recently showed that decreasing weight in diabetes to the extent that
glucose metabolism is normalized significantly improves stroke recovery:
https://news.ki.se/weight-loss-may-repair-the-brain-after-stroke-in-diabetes.
[1]The findings have been published in /Cardiovascular Diabetology/
-GLP-1R agonists are commonly used drugs for the treatment of type 2
diabetes. We were the first in 2012 to show that the activation of the
glucagon-like receptor 1 (GLP-1R) is neuroprotective against stroke in type 2
diabetic rodents. The findings have been published in /Clinical Science/:
https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/22150224/ [2]
In 2021, we showed that this pharmacological strategy can also improve
post-stroke functional recovery. The findings have been published in the
/British Journal of Pharmacology/
https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/33973246/ [3]
-We demonstrated a similar stroke efficacy as for the GLP-1R agonists for
another class of clinically used drugs against diabetes called DPP-4
inhibitors. The findings were published in /Diabetes/ in
2012 https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/23209191/ [4] and 2021
https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/32540876/ [5].
See also the press release about the findings 2012
https://news.ki.se/diabetes-drug-may-reduce-brain-damage-after-stroke [6]
-We identified several cellular mechanisms that are induced by diabetes and
play a detrimental role in the impairment of stroke recovery. Among the most
recent publications are the findings recently published in /Clinical
Science /https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/31235555/ [7] and
/Acta Neuropathologica Communications
/https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/29471869/ [8]
[1] https://news.ki.se/weight-loss-may-repair-the-brain-after-stroke-in-diabetes
[2] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/22150224/
[3] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/33973246/
[4] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/23209191/
[5] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/32540876/
[6] https://news.ki.se/diabetes-drug-may-reduce-brain-damage-after-stroke
[7] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/31235555/
[8] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/29471869/
Teaching
- *July 2013- ongoing*, Project Coordinator/Examiner in degree projects in
medicine, Department of Medical Epidemiology and Biostatistics [1], KI. The
position involves reviewing the students’ work-plan, half time and final
thesis, arrange seminars and examine the work.
*2015- 2020* Visiting Professor (1 week/year), Univ. of Piemonte Orientale,
Novara, Italy
[1] http://ki.se/ki/jsp/polopoly.jsp?d=9600& - amp
- l=en
Articles
- Article: BIOSCIENCE REPORTS. 2024;44(7):BSR20240249
- Article: CARDIOVASCULAR DIABETOLOGY. 2024;23(1):88
- Article: DIABETES. 2023;72(3):405-414
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(4):3989
- Article: CELLULAR AND MOLECULAR NEUROBIOLOGY. 2022;42(6):1995-2002
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2022;179(4):677-694
- Article: CARDIOVASCULAR DIABETOLOGY. 2021;20(1):240
- Article: CARDIOVASCULAR DIABETOLOGY. 2021;20(1):202
- Article: BIOSCIENCE REPORTS. 2021;41(6):BSR20210736
- Article: CELLULAR AND MOLECULAR NEUROBIOLOGY. 2021;41(3):591-603
- Article: ACS CHEMICAL NEUROSCIENCE. 2020;11(21):3590-3602
- Article: DIABETES. 2020;69(9):1961-1973
- Article: NEUROBIOLOGY OF AGING. 2020;89:12-23
- Article: DIABETES, OBESITY AND METABOLISM. 2020;22(2):182-190
- Article: ALZHEIMER'S AND DEMENTIA. 2020;16(2):316-325
- Article: BIOSCIENCE REPORTS. 2020;40(1):BSR20193156
- Article: ACTA NEUROLOGICA SCANDINAVICA. 2019;140(6):443-448
- Article: CARDIOVASCULAR DIABETOLOGY. 2019;18(1):91
- Article: CLINICAL SCIENCE. 2019;133(13):1367-1386
- Article: CARDIOVASCULAR DIABETOLOGY. 2018;17(1):60
- Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2018;6(1):14
- Article: PSYCHONEUROENDOCRINOLOGY. 2017;82:46-50
- Article: PLOS ONE. 2017;12(1):e0170496
- Article: BIOSCIENCE REPORTS. 2016;36(6):e00421
- Article: DIABETES, OBESITY AND METABOLISM. 2016;18(5):537-541
- Article: ONCOTARGET. 2016;7(5):5865-5876
- Article: PLOS ONE. 2016;11(6):e0156867
- Article: JOURNAL OF ALZHEIMER'S DISEASE. 2014;41(2):551-560
- Article: REGULATORY PEPTIDES. 2014;190:25-31
- Article: STROKE RESEARCH AND TREATMENT. 2014;2014:747458-7
- Article: PLOS ONE. 2014;9(8):e103114
- Article: JOURNAL OF NEUROCHEMISTRY. 2013;127(2):209-220
- Article: NEUROPEPTIDES. 2013;47(2):133-137
- Article: DIABETES. 2013;62(4):1289-1296
- Article: JOURNAL OF GASTROENTEROLOGY. 2013;48(3):322-332
- Article: JOURNAL OF NEUROINFLAMMATION. 2012;9:276
- Article: CLINICAL SCIENCE. 2012;122(9-10):473-483
- Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2012;90(4):759-768
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2011;650(1):249-255
- Article: JOURNAL OF PARKINSON’S DISEASE. 2011;1(1):49-63
- Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2008;86(2):326-338
- Article: LETTERS IN DRUG DESIGN AND DISCOVERY. 2007;4(8):532-539
- Article: MOLECULAR AND CELLULAR BIOLOGY. 2003;23(23):8542-8552
- Article: JOURNAL OF NEUROENDOCRINOLOGY. 2000;12(11):1051-1059
- Article: ENDOCRINOLOGY. 2000;141(5):1839-1845
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(19):10905-10910
- Article: NEUROSCIENCE LETTERS. 1999;265(3):207-210
- Article: MOLECULAR ENDOCRINOLOGY. 1998;12(6):835-841
- Article: MOLECULAR ENDOCRINOLOGY. 1997;11(7):938-949
- Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1997;9(5):1008-1016
- Article: MOLECULAR ENDOCRINOLOGY. 1996;10(5):499-507
- Article: DNA AND CELL BIOLOGY. 1995;14(8):665-671
- Show more
All other publications
- Editorial comment: DIABETES, OBESITY AND METABOLISM. 2024;26(7):2527-2530
- Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(5):2618
- Review: FRONTIERS IN NEUROLOGY. 2019;10:493
- Review: NEUROPHARMACOLOGY. 2018;136(Pt B):280-286
- Corrigendum: DIABETES, OBESITY AND METABOLISM. 2018;20(4):1086
- Editorial comment: CARDIOVASCULAR DIABETOLOGY. 2018;17(1):32
- Review: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2015;35(5):718-723
- Review: REVIEWS IN ENDOCRINE AND METABOLIC DISORDERS. 2014;15(3):233-242
- Editorial comment: THE LANCET DIABETES AND ENDOCRINOLOGY. 2014;2(3):256-262
- Published conference paper: JOURNAL OF NEUROSCIENCE RESEARCH. 2004;76(2):205-215
- Addendum: EUROPEAN JOURNAL OF NEUROSCIENCE. 1997;9(7):1552
- Published conference paper: BRAIN RESEARCH BULLETIN. 1997;44(4):519-523
Employments
- Senior Lecturer/Clinical Position, Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, 2018-
Degrees and Education
- Docent, Karolinska Institutet, 2013