Cesare Patrone
About me
Associate Professor/Senior Lecturer
Researh Group: https://ki.se/en/kisos/the-neurocardiometabol-group
In February 2009 I was recruited to Karolinska Institutet to start up a research group about the neurological complications of type 2 diabetes, with
main focus on stroke. I am responsible for planning, coordinating and executing work in the area of experimental stroke in diabetes.2001-2009: Senior Researcher and Manager at Neuronova AB, Stockholm, Sweden
2000-2001: Postdoctoral Fellow, Karolinska Institutet, Stockholm, Sweden
1998-2000: Postdoctoral Fellow, Uppsala University, Sweden
1998: PhD in Neurobiology, Milano University, Italy
Research grants and awards as PI
1) The Swedish Research Council (Vetenskasprådet); 2022-2025
2) Hjärnfonden 2022
3) Hjärnfonden 2021
4) Diabetesfonden; 2020-2021
5) The Swedish Research Council (Vetenskasprådet); 2018-2021
6) European Foundation for the Study of Diabetes/Sanofi European DiabetesResearch Programme in Macrovascular Complications; 2019
7) Award “Investigator Study IIS” Boehringer Ing. Sweden; 2018
8) Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; 2012-2017
9) Åhlén Stiftelse; 2012-2018
10) O. E. och Edla Johanssons Stiftelse; 2016-2018
11) Magnus Bergvalls Stiftelse; 2011-2016
12) STROKE Riksförbundet; 2018-2020
13) Diabetesfonden; 2014-2015
14) Novo Nordisk Foundation; 2014
15) Syskonen Svensson Stiftelse; 2017
16) European Foundation for the Study of Diabetes; 2013
17) Diabetes Wellness; 2010
18) Stohnes stiftelse; 2010, 2012, 2015
19) STROKE Riksförbundet; 2011-2014
20) European Foundation for the Study of Diabetes; 2009
Courses2018 Assess the structure of examination of projects, Workshop, Karolinska
Institutet2013 Docent in neuroscience, Karolinska Institutet
2011 Course in "Assessment in Higher Education", Karolinska Institutet
2011 Basic Course in Education for University Teachers, Karolinska
Institutet2010 Introductory Doctoral Supervision Course, Karolinska Institutet
2010 Work environment issues and manager responsibilities , Karolinska
Institutet2009 Laboratory Animal Science (FELASA) certificate, Karolinska Institutet
2008 Applied Project Management Courses, Wenell Management AB, Stockholm
2007 Courses in Clinical Trials, Trial Form Support AB, Lund
1998 PhD in Neurobiology, University of Milan, Italy.
1992 University of Milan, Italy, Laurea and M.Sc. Biological Sciences
Research
Stroke and Diabetes
The focus is along two research lines, see also the Research Group at: https://ki.se/en/kisos/the-neurocardiometabol-group- The identification of efficacious preclinical therapies for the treatment of stroke in diabetes.
- The study of the cellular mechanisms at the basis of the neurological complications of diabetes.
Stroke affects several million people worldwide, of which a substantial proportion of cases present in patients suffering from diabetes. Diabetes is
widespread and represents a leading cause of death. About 90 % of the medical and social costs associated with diabetes are dominated by care for macrovascular complications such as stroke. Therefore it is important to identify strategies aimed at prevent stroke in diabetes but also improve
post-stroke outcome in diabetic individuals.- We recently showed that decreasing weight in diabetes to the extent that glucose metabolism is normalized significantly improves stroke recovery: https://news.ki.se/weight-loss-may-repair-the-brain-after-stroke-in-diabetes [1] . The findings have been published in /Cardiovascular Diabetology/
- GLP-1R agonists are commonly used drugs for the treatment of type 2 diabetes. We were the first in 2012 to show that the activation of the glucagon-like receptor 1 (GLP-1R) is neuroprotective against stroke in type 2 diabetic rodents. The findings have been published in /Clinical Science/:https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/22150224/ [2]
- In 2021, we showed that this pharmacological strategy can also improve post-stroke functional recovery. The findings have been published in the British Journal of Pharmacology/https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/33973246/ [3]
- We demonstrated a similar stroke efficacy as for the GLP-1R agonists for another class of clinically used drugs against diabetes called DPP-4 inhibitors. The findings were published in /Diabetes/ in 2012 https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/23209191/ [4] and 2021 https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/32540876/ [5]. See also the press release about the findings 2012 https://news.ki.se/diabetes-drug-may-reduce-brain-damage-after-stroke [6]
- We identified several cellular mechanisms that are induced by diabetes and play a detrimental role in the impairment of stroke recovery. Among the most recent publications are the findings recently published in /Clinical Science /https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/31235555/ [7] and /Acta Neuropathologica Communications /https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/29471869/ [8]
[1] https://news.ki.se/weight-loss-may-repair-the-brain-after-stroke-in-diabetes
[2] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/22150224/
[3] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/33973246/
[4] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/23209191/
[5] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/32540876/
[6] https://news.ki.se/diabetes-drug-may-reduce-brain-damage-after-stroke
[7] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/31235555/
[8] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/29471869/
Teaching
July 2013- ongoing*, Project Coordinator/Examiner in degree projects in medicine, Department of Medical Epidemiology and Biostatistics [1], KI. The
position involves reviewing the students’ work-plan, half time and final thesis, arrange seminars and examine the work.
2015- 2020* Visiting Professor (1 week/year), Univ. of Piemonte Orientale, Novara, Italy
[1] http://ki.se/ki/jsp/polopoly.jsp?d=9600&l=en
Articles
- Article: BIOSCIENCE REPORTS. 2024;44(7):BSR20240249Vieira JPP; Karampatsi D; Vercalsteren E; Darsalia V; Patrone C; Duarte JMN
- Journal article: CARDIOVASCULAR DIABETOLOGY. 2024;23(1)Vercalsteren E; Karampatsi D; Buizza C; Nyström T; Klein T; Paul G; Patrone C; Darsalia V
- Article: CARDIOVASCULAR DIABETOLOGY. 2024;23(1):88Vercalsteren E; Karampatsi D; Buizza C; Nyström T; Klein T; Paul G; Patrone C; Darsalia V
- Article: DIABETES. 2023;72(3):405-414Elabi OF; Karampatsi D; Vercalsteren E; Lietzau G; Nystroem T; Klein T; Darsalia V; Patrone C; Paul G
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023Vercalsteren E; Karampatsi D; Dekens D; Letsiou A; Zabala A; Romanitan M; Klein T; Nyström T; Darsalia V; Patrone C
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(4):3989Vercalsteren E; Karampatsi D; Dekens D; Letsiou A; Zabala A; Romanitan M; Klein T; Nystrom T; Darsalia V; Patrone C
- Article: CELLULAR AND MOLECULAR NEUROBIOLOGY. 2022;42(6):1995-2002Lietzau G; Ntika S; Pintana H; Tracy L; Klein T; Nystrom T; Darsalia V; Patrone C; Krizhanovskii C
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2022;179(4):677-694Augestad IL; Dekens D; Karampatsi D; Elabi O; Zabala A; Pintana H; Larsson M; Nystrom T; Paul G; Darsalia V; Patrone C
- Article: CARDIOVASCULAR DIABETOLOGY. 2021;20(1):240Karampatsi D; Zabala A; Wilhelmsson U; Dekens D; Vercalsteren E; Larsson M; Nystrom T; Pekny M; Patrone C; Darsalia V
- Article: CARDIOVASCULAR DIABETOLOGY. 2021;20(1):202Zabala A; Darsalia V; Lind M; Svensson A-M; Franzen S; Eliasson B; Patrone C; Jonsson M; Nystrom T
- Article: BIOSCIENCE REPORTS. 2021;41(6):BSR20210736Hammarlund ME; Darsalia V; Mjornstedt F; Pattanaik B; Mallard C; Rocha-Ferreira E; Patrone C; Johansson ME
- Article: CELLULAR AND MOLECULAR NEUROBIOLOGY. 2021;41(3):591-603Chiazza F; Pintana H; Lietzau G; Nystrom T; Patrone C; Darsalia V
- Article: ACS CHEMICAL NEUROSCIENCE. 2020;11(21):3590-3602Lietzau G; Nystrom T; Wang Z; Darsalia V; Patrone C
- Article: DIABETES. 2020;69(9):1961-1973Augestad IL; Pintana H; Larsson M; Krizhanovskii C; Nystrom T; Klein T; Darsalia V; Patrone C
- Article: NEUROBIOLOGY OF AGING. 2020;89:12-23Lietzau G; Magni G; Kehr J; Yoshitake T; Candeias E; Duarte AI; Pettersson H; Skogsberg J; Abbracchio MP; Klein T; Nystrom T; Ceruti S; Darsalia V; Patrone C
- Article: ALZHEIMERS & DEMENTIA. 2020;16(2):316-325Wang Z; Marseglia A; Shang Y; Dintica C; Patrone C; Xu W
- Article: DIABETES OBESITY & METABOLISM. 2020;22(2):182-190Zabala A; Darsalia V; Holzmann MJ; Franzen S; Svensson A-M; Eliasson B; Patrone C; Nystrom T; Jonsson M
- Article: BIOSCIENCE REPORTS. 2020;40(1):BSR20193156Lundberg M; Curbo S; Bohman H; Agartz I; Ogren S-O; Patrone C; Mansouri S
- Article: ACTA NEUROLOGICA SCANDINAVICA. 2019;140(6):443-448Larsson M; Castren M; Lindstrom V; von Euler M; Patrone C; Wahlgren N; Nathanson D
- Article: CARDIOVASCULAR DIABETOLOGY. 2019;18(1):91Larsson M; Patrone C; von Euler M; Holst JJ; Nathanson D
- Article: CLINICAL SCIENCE. 2019;133(13):1367-1386Pintana H; Lietzau G; Augestad IL; Chiazza F; Nystrom T; Patrone C; Darsalia V
- Journal article: DIABETES. 2018;67Chiazza F; Tammen H; Pintana H; Lietzau G; Collino MS; Nystrom T; Klein T; Darsalia V; Patrone C
- Article: CARDIOVASCULAR DIABETOLOGY. 2018;17(1):60Chiazza F; Tammen H; Pintana H; Lietzau G; Collino M; Nystrom T; Klein T; Darsalia V; Patrone C
- Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2018;6(1):14Lietzau G; Davidsson W; Ostenson C-G; Chiazza F; Nathanson D; Pintana H; Skogsberg J; Klein T; Nystrom T; Darsalia V; Patrone C
- Article: PSYCHONEUROENDOCRINOLOGY. 2017;82:46-50Lietzau G; Darsalia V; Pintana H; Ostenson C-G; Nystrom T; Fisahn A; Patrone C
- Article: PLOS ONE. 2017;12(1):e0170496Mansouri S; Agartz I; Ogren S-O; Patrone C; Lundberg M
- Article: BIOSCIENCE REPORTS. 2016;36(6):e00421Larsson M; Lietzau G; Nathanson D; Ostenson C-G; Mallard C; Johansson ME; Nystrom T; Patrone C; Darsalia V
- Article: PLOS ONE. 2016;11(6):e0156867Mansouri S; Lietzau G; Lundberg M; Nathanson D; Nystrom T; Patrone C
- Article: DIABETES OBESITY & METABOLISM. 2016;18(5):537-541Darsalia V; Larsson M; Lietzau G; Nathanson D; Nystrom T; Klein T; Patrone C
- Article: ONCOTARGET. 2016;7(5):5865-5876Lietzau G; Nystrom T; Ostenson C-G; Darsalia V; Patrone C
- Article: PLOS ONE. 2014;9(8):e103114Darsalia V; Hua S; Larsson M; Mallard C; Nathanson D; Nystroem T; Sjoeholm A; Johansson ME; Patrone C
- Journal article: JOURNAL OF DIABETES & METABOLISM. 2014;5(8)Mansouri S; Darsalia V; Eweida M; Lundberg M; Nathanson D; Patrone C
- Article: JOURNAL OF ALZHEIMERS DISEASE. 2014;41(2):551-560Hussain S; Mansouri S; Sjoholm A; Patrone C; Darsalia V
- Article: REGULATORY PEPTIDES. 2014;190:25-31Darsalia V; Olverling A; Larsson M; Mansouri S; Nathanson D; Nystrom T; Klein T; Sjoholm A; Patrone C
- Journal article: FASEB JOURNAL. 2014;28(S1)Hua S; Darsalia V; Patrone C; Mallard C; Johansson M
- Article: STROKE RESEARCH AND TREATMENT. 2014;2014:747458-7Nathanson D; Patrone C; Nystrom T; von Euler M
- Article: JOURNAL OF NEUROCHEMISTRY. 2013;127(2):209-220Mansouri S; Barde S; Ortsater H; Eweida M; Darsalia V; Langel U; Sjoholm A; Hokfelt T; Patrone C
- Article: DIABETES. 2013;62(4):1289-1296Darsalia V; Ortsater H; Olverling A; Darlof E; Wolbert P; Nystrom T; Klein T; Sjoholm A; Patrone C
- Article: NEUROPEPTIDES. 2013;47(2):133-137Darsalia V; Mansouri S; Wolbert P; Barde S; Sjoholm A; Patrone C
- Article: JOURNAL OF GASTROENTEROLOGY. 2013;48(3):322-332Kappe C; Patrone C; Holst JJ; Zhang Q; Sjoholm A
- Article: JOURNAL OF NEUROINFLAMMATION. 2012;9:276Kappe C; Tracy LM; Patrone C; Iverfeldt K; Sjoholm A
- Journal article: DIABETES. 2012;61:A237Darsalia V; Olverling A; Ortsater H; Klein T; Sjoholm A; Patrone C
- Article: CLINICAL SCIENCE. 2012;122(9-10):473-483Darsalia V; Mansouri S; Ortsater H; Olverling A; Nozadze N; Kappe C; Iverfeldt K; Tracy LM; Grankvist N; Sjoholm A; Patrone C
- Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2012;90(4):759-768Mansouri S; Ortsater H; Gallego OP; Darsalia V; Sjoholm A; Patrone C
- Article: JOURNAL OF PARKINSONS DISEASE. 2011;1(1):49-63Zachrisson O; Zhao M; Andersson A; Dannaeus K; Haggblad JH; Isacson R; Nielsen E; Patrone C; Ronnholm H; Wikstrom L; Delfani K; McCormack AL; Palmer T; Di Monte DA; Hill MP; Lang AMJ; Haegerstrand A
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2011;650(1):249-255Isacson R; Nielsen E; Dannaeus K; Bertilsson G; Patrone C; Zachrisson O; Wikstrom L
- Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2008;86(2):326-338Bertilsson G; Patrone C; Zachrisson O; Andersson A; Dannaeus K; Heidrich J; Kortesmaa J; Mercer A; Nielsen E; Roennholm H; Wikstroem L
- Article: LETTERS IN DRUG DESIGN & DISCOVERY. 2007;4(8):532-539Rapid quantification of neurons and stem/progenitor cells in the adult mouse brain by flow cytometryHellstom NAK; Zachrisson O; Kuhn HG; Patrone C
- Article: MOLECULAR AND CELLULAR BIOLOGY. 2003;23(23):8542-8552Patrone C; Cassel TN; Pettersson K; Piao YS; Cheng GJ; Ciana P; Maggi A; Warner M; Gustafsson J; Nord M
- Article: JOURNAL OF NEUROENDOCRINOLOGY. 2000;12(11):1051-1059Meda C; Vegeto E; Pollio G; Ciana P; Patrone C; Pellicciari C; Maggi A
- Article: ENDOCRINOLOGY. 2000;141(5):1839-1845Patrone C; Pollio G; Vegeto E; Enmark E; de Curtis I; Gustafsson J; Maggi A
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(19):10905-10910Estrogen receptor-dependent regulation of sensory neuron survival in developing dorsal root ganglionPatrone C; Andersson S; Korhonen L; Lindholm D
- Article: NEUROSCIENCE LETTERS. 1999;265(3):207-210Skoglösa Y; Patrone C; Lindholm D
- Journal article: ENDOCRINOLOGY. 1998;12(6):835-841Patrone C
- Article: MOLECULAR ENDOCRINOLOGY. 1998;12(6):835-841Patrone C; Gianazza E; Santagati S; Agrati P; Maggi A
- Article: MOLECULAR ENDOCRINOLOGY. 1997;11(7):938-949Santagati S; Gianazza E; Agrati P; Vegeto E; Patrone C; Pollio G; Maggi A
- Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1997;9(5):1008-1016Agrati P; Ma ZQ; Patrone C; Picotti GB; Pellicciari C; Bondiolotti G; Bottone MG; Maggi A
- Journal article: ENDOCRINOLOGY. 1996;10(5):499-507Patrone C
- Article: MOLECULAR ENDOCRINOLOGY. 1996;10(5):499-507Patrone C; Ma ZQ; Pollio G; Agrati P; Parker MG; Maggi A
- Article: DNA AND CELL BIOLOGY. 1995;14(8):665-671MAGALINI A; FERRARI F; SAVOLDI G; INGRASSIA R; ALBERTINI A; POLLIO G; PATRONE C; MAGGI A; DILORENZO D
- Journal article: PHARMACOLOGICAL RESEARCH. 1995;31:18Maggi A; Santagali S; Vegeto E; Agrati P; Patrone C; Ma ZQ
- Journal article: PHARMACOLOGICAL RESEARCH. 1995;31:69Patrone C; Ma ZQ; Agrati P; Vegeto E; Maggi A
- Journal article: PHARMACOLOGICAL RESEARCH. 1995;31:81Agrati P; Bottone MG; Ma ZQ; Patrone C; Pellicciari C; Maggi A
- Journal article: MOLECULAR ENDOCRINOLOGY. 1994;8(7):910-918MA ZQ; SANTAGATI S; PATRONE C; POLLIO G; VEGETO E; MAGGI A
- Journal article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 1993;47(1-6):207-in8MA ZQ; BONDIOLOTTI GP; OLASMAA M; VIOLANI E; PATRONE C; PICOTTI GB; MAGGI A
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All other publications
- Editorial comment: DIABETES OBESITY & METABOLISM. 2024;26(7):2527-2530Darsalia V; Vercalsteren E; Karampatsi D; Romanitan MO; Mazya MV; Nystrom T; Patrone C
- Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(5):2618Bayassi-Jakowicka M; Lietzau G; Czuba E; Patrone C; Kowianski P
- Conference publication: DIABETOLOGIA. 2021;64(SUPPL 1):4Zabala A; Darsalia V; Lind M; Svensson A-M; Franzen S; Eliasson B; Patrone C; Jonsson M; Nystrom T
- Preprint: RESEARCH SQUARE. 2021Augestad I; Dekens D; Karampatsi D; Elabi O; Zabala A; Pintana H; Larsson M; Nyström T; Paul G; Darsalia V; Patrone C
- Preprint: RESEARCH SQUARE. 2021Lietzau G; Ntika S; Pintana H; Tracy L; Klein T; Nyström T; Darsalia V; Patrone C; Krizhanovskii C
- Review: FRONTIERS IN NEUROLOGY. 2019;10:493Darsalia V; Johansen OE; Lietzau G; Nystrom T; Klein T; Patrone C
- Conference publication: DIABETOLOGIA. 2018;61:S522Lietzau G; Candeias E; Magni G; Kehr J; Yoshitake T; Skogsberg J; Nystrom T; Klein T; Abbracchio MP; Ceruti S; Darsalia V; Patrone C
- Review: NEUROPHARMACOLOGY. 2018;136(Pt B):280-286Darsalia V; Klein T; Nystrom T; Patrone C
- Corrigendum: DIABETES OBESITY & METABOLISM. 2018;20(4):1086Darsalia V; Larsson M; Lietzau G; Nathanson D; Nystrom T; Klein T; Patrone C
- Editorial comment: CARDIOVASCULAR DIABETOLOGY. 2018;17(1):32Darsalia V; Larsson M; Klein T; Patrone C
- Conference publication: DIABETOLOGIA. 2016;59:S282Lietzau G; Ostenson C-G; Nystrom T; Klein T; Darsalia V; Patrone C
- Conference publication: DIABETOLOGIA. 2016;59:S283Darsalia V; Candeias E; Nystrom T; Klein T; Lietzau G; Patrone C
- Conference publication: DIABETOLOGIA. 2015;58:S35Darsalia V; Larsson M; Nathanson D; Drucker DJ; Nystrom T; Klein T; Patrone C
- Conference publication: DIABETOLOGIA. 2015;58:S72GLP-1R activation by exendin-4 prevents neuronal loss in the piriform cortex of type 2 diabetic ratsLietzau G; Darsalia V; Otstenson C-G; Nystrom T; Patrone C
- Review: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2015;35(5):718-723Darsalia V; Larsson M; Nathanson D; Klein T; Nystrom T; Patrone C
- Review: REVIEWS IN ENDOCRINE & METABOLIC DISORDERS. 2014;15(3):233-242Darsalia V; Nathanson D; Nystrom T; Klein T; Sjoholm A; Patrone C
- Editorial comment: LANCET DIABETES & ENDOCRINOLOGY. 2014;2(3):256-262Patrone C; Eriksson O; Lindholm D
- Conference publication: DIABETOLOGIA. 2013;56:S69Darsalia V; Olverling A; Nystrom T; Ortsater H; Rosenbrock H; Sjoholm A; Klein T; Patrone C
- Published conference paper: JOURNAL OF NEUROSCIENCE RESEARCH. 2004;76(2):205-215Mercer A; Rönnholm H; Holmberg J; Lundh H; Heidrich J; Zachrisson O; Ossoinak A; Frisén J; Patrone C
- Addendum: EUROPEAN JOURNAL OF NEUROSCIENCE. 1997;9(7):1552Agrati P; Ma ZQ; Patrone C; Picotti GB; Pellicciari C; Bondiolotti G; Bottone MG; Maggi A
- Book chapter: WOMEN’S HEALTH AND MENOPAUSE: MEDICAL SCIENCE SYMPOSIA SERIES. 1997;p. 209-215Garnier M; Agrati P; Patrone C; Santagati S; Vegeto E; Maggi A
- Book chapter: NEUROCHEMISTRY. 1997;p. 523-528Maggi A; Agrati P; Patrone C; Santagati S; Gamier M; Vegeto E
- Published conference paper: BRAIN RESEARCH BULLETIN. 1997;44(4):519-523Agrati P; Garnier M; Patrone C; Pollio G; Santagati S; Vegeto E; Maggi A
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Grants
- Swedish Research Council1 January 2023 - 31 December 2025AimType 2 diabetic (T2D) and elderly people have severe/persistent post-stroke disabilities and the causal mechanisms are unknown. Insulin resistance (IR), which is a hallmark of T2D, also afflicts up to 50% of non-diabetic elderly people (prediabetic). IR has been associated to poor stroke outcome. However, if the pharmacological targeting of IR improves stroke recovery is unknown and will be addressed in this experimental project.Project organisation/time plan/methodsThe project’s duration is 3 years. Most of the activities will take place at the PI’s lab where validated IR (aging- and high sucrose-induced), and stroke (middle cerebral artery occlusion) mouse models plus lab facilities are in place. One post-doc and one PhD student will perform the experiments. Stroke and T2D expertise is provided by co-PIs Dr Vladimer Darsalia and Prof Thomas Nyström. The cellular studies are in collaboration with Profs Gesine Paul (Lund Univ) and Milos Pekny (Gothenburg Univ).Relevance/ImplementationT2D and aging impair stroke recovery. Since T2D is reaching epidemic dimensions, the elderly population continues to grow, and both conditions are strong stroke risk factors, this creates a social burden with rising medical need. Positive results of this project will be important to develop new therapies targeting IR, in the preventive perspective to limit stroke sequelae in two of the largest populations at stroke risk. This could have remarkable implications for an enormous group of people.
- Swedish Research Council1 December 2022 - 30 November 2025The purpose of this project is to utilize our genomewide association study (GWAS) of abdominal subcutaneous adipose tissue (SAT) phenotypes and enhancer map to couple risk-alleles for central obesity and type 2 diabetes (T2D) to adipose phenotypes and functional elements of the genome. The GENiAL cohort comprises n~930 adults that have undergone SAT biopsy and detailed characterization of adipose morphology and metabolism. We will complete a GWAS of basal and insulin stimulated lipogenesis in GENiAL. By in silico analyses we will evaluate whether lipogenesis-associated alleles influence the risk of developing central obesity or T2D. Next, we will map overlap between enhancers and their RNA (eRNA), and alleles associated with adipocyte lipogenesis, number, size or lipolysis in GENiAL. Finally, significant alleles, enhancers, and genes identified in the above analyses will be evaluated for impact on adipocytes in vitro. The first gene to study is RREB1 where we have identified an allele associated with fewer fat cells and increased risk of T2D. Candidate genes will undergo screening by siRNA mediated knockdown in human adipose derived stem cells, and eRNA by antisense knockdown. Allelic specific effects can subsequently be studied by Lentivirus transfection or CRISPR/Cas9.This project can lead to the identification of novel targets for treating obesity and T2D, and to increase the informativeness of genetic risk scores that can be used to guide treatment decisions in T2D.
- Swedish Heart-Lung Foundation1 January 2020 - 31 December 2022
- Swedish Research Council1 January 2019 - 31 December 2021
- GLUCAGON-LIKE PEPTIDE 1 ACTIVATION AGAINST STROKE IN DIABETES: FROM THE PRECLINICAL TO THE CLINICAL PHASENovo Nordisk Foundation1 January 2014 - 1 January 2015
Employments
- Senior Lecturer/Clinical Position, Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, 2018-
Degrees and Education
- Docent, Karolinska Institutet, 2013