Carmen Gerlach

Om mig
Publikationer
Forskningsbidrag
Populärvetenskap och samverkan

Forskningsbeskrivning

Our research is directed at understanding basic principles and mechanisms
underlying the generation, maintenance and consequences of the heterogeneity
within the T cell immune response, with a special focus on CD8 T cells.
Please see our lab's website [1] for more detailed information.
[1] https://gerlachlab.com/

Artiklar

Article: NATURE IMMUNOLOGY. 2024;25(8):1367-1382

Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8⁺ thymocytes

You Y; Dunst J; Ye K; Sandoz PA; Reinhardt A; Sandrock I; Comet NR; Sarkar RD; Yang E; Duprez E; Agudo J; Brown BD; Utz PJ; Kastenmueller W; Gerlach C; Prinz I; Onfelt B; Kreslavsky T
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2024;54(1):e2350658

The cellular microenvironment regulates CX3CR1 expression on CD8⁺ T cells and the maintenance of CX3CR1⁺ CD8⁺ T cells

Pokharel J; Shryki I; Zwijnenburg AJ; Sandu I; Krumm L; Bekiari C; Avramov V; Heinback R; Lysell J; Eidsmo L; Harris HE; Gerlach C
Article: IMMUNITY. 2023;56(8):1955-1974.e10

Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation

Zwijnenburg AJ; Pokharel J; Varnait R; Zheng W; Hoffer E; Shryki I; Comet NR; Ehrstrom M; Gredmark-Russ S; Eidsmo L; Gerlach C
Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2018;10(10):a029488

Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Natural Killer Cells in Vaccination

Neely HR; Mazo IB; Gerlach C; von Andrian UH
Article: IMMUNITY. 2016;45(6):1270-1284

The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis

Gerlach C; Moseman EA; Loughhead SM; Alvarez D; Zwijnenburg AJ; Waanders L; Garg R; de la Torre JC; von Andrian UH
Article: CELL REPORTS. 2014;9(4):1375-1386

Parallel In Vivo and In Vitro Melanoma RNAi Dropout Screens Reveal Synthetic Lethality between Hypoxia and DNA Damage Response Inhibition

Possik PA; Mueller J; Gerlach C; Kenski JCN; Huang X; Shahrabi A; Krijgsman O; Song J-Y; Smit MA; Gerritsen B; Lieftink C; Kemper K; Michaut M; Beijersbergen RL; Wessels L; Schumacher TN; Peeper DS
Article: SCIENCE. 2013;340(6132):635-639

Heterogeneous Differentiation Patterns of Individual CD8⁺ T Cells

Gerlach C; Rohr JC; Perie L; van Rooij N; van Heijst JWJ; Velds A; Urbanus J; Naik SH; Jacobs H; Beltman JB; de Boer RJ; Schumacher TNM
Article: NATURE. 2013;496(7444):229-232

Diverse and heritable lineage imprinting of early haematopoietic progenitors

Naik SH; Perie L; Swart E; Gerlach C; van Rooij N; de Boer RJ; Schumacher TN
Article: SCIENCE TRANSLATIONAL MEDICINE. 2012;4(158):158ra145

Intravital Microscopy Through an Abdominal Imaging Window Reveals a Pre-Micrometastasis Stage During Liver Metastasis

Ritsma L; Steller EJA; Beerling E; Loomans CJM; Zomer A; Gerlach C; Vrisekoop N; Seinstra D; van Gurp L; Schaefer R; Raats DA; de Graaff A; Schumacher TN; de Koning EJP; Rinkes IHB; Kranenburg O; van Rheenen J
Article: BLOOD. 2012;119(3):798-804

Nab2 regulates secondary CD8⁺ T-cell responses through control of TRAIL expression

Wolkers MC; Gerlach C; Arens R; Janssen EM; Fitzgerald P; Schumacher TN; Medema JP; Green DR; Schoenberger SP
Article: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2011;1217:139-153

The descent of memory T cells

Gerlach C; van Heijst JWJ; Schumacher TNM
Article: IMMUNITY. 2010;32(6):754-765

Apoptosis Threshold Set by Noxa and Mcl-1 after T Cell Activation Regulates Competitive Selection of High-Affinity Clones

Wensveen FM; van Gisbergen KPJM; Derks IAM; Gerlach C; Schumacher TN; van Lier RAW; Eldering E
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(6):1235-1246

One naive T cell, multiple fates in CD8⁺ T cell differentiation

Gerlach C; van Heijst JWJ; Swart E; Sie D; Armstrong N; Kerkhoven RM; Zehn D; Bevan MJ; Schepers K; Schumacher TNM
Article: SCIENCE. 2009;325(5945):1265-1269

Recruitment of Antigen-Specific CD8⁺ T Cells in Response to Infection Is Markedly Efficient

van Heijst JWJ; Gerlach C; Swart E; Sie D; Nunes-Alves C; Kerkhoven RM; Arens R; Correia-Neves M; Schepers K; Schumacher TNM
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2008;205(10):2309-2318

Dissecting T cell lineage relationships by cellular barcoding

Schepers K; Swart E; van Heijst JWJ; Gerlach C; Castrucci M; Sie D; Heimerikx M; Velds A; Kerkhoven RM; Arens R; Schumacher TNM

Alla övriga publikationer

Editorial comment: NATURE REVIEWS IMMUNOLOGY. 2023;23(9):544

Heterologous immunity: innate function of memory CD4⁺ T cells

Borsa M; Gerlach C
Editorial comment: CELL REPORTS. 2023;42(5):112548

Linking asymmetric cell division, CD8⁺ T cell fate, and signal strength

Pokharel J; Gerlach C
Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2023;53(3):e2250305

No-shows in T-cell responses are frequent for clones of low T-cell receptor affinity

van Gisbergen KPJM; Gerlach C
Editorial comment: IMMUNITY. 2021;54(10):2169-2171

Navigating COVID-19: Starting a lab during the pandemic

Ordovas-Montanes J; Gerlach C; Moraes-Vieira P; Vento-Tormo R; Zhang C; Jurado KA
Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2020;92(6):e12983

T cell fate mapping and lineage tracing technologies probing clonal aspects underlying the generation of CD8 T cell subsets

Al Khabouri S; Gerlach C
Editorial comment: IMMUNITY. 2019;50(5):1119-1121

Exploiting Allelic Variation in CD8⁺ T Cells

Zwijnenburg AJ; Gerlach C
Editorial comment: TRENDS IN IMMUNOLOGY. 2018;39(3):167-170

TrendsTalk

Gerlach C
Editorial comment: TRENDS IN IMMUNOLOGY. 2018;39(3):170-172

Heavy Water Shedding Light on Antigen-Specific T Cell Responses

Eidsmo L; Gerlach C
Corrigendum: TRENDS IN IMMUNOLOGY. 2018;39(5):434

Carmen Gerlach (vol 39, pg 167, 2018)

Gerlach C
Editorial comment: CELL. 2015;161(4):702-704

Figuring Fact from Fiction: Unbiased Polling of Memory T Cells

Gerlach C; Loughhead SM; von Andrian UH
Review: TRENDS IN IMMUNOLOGY. 2014;35(4):170-177

Single cell behavior in T cell differentiation

Rohr JC; Gerlach C; Kok L; Schumacher TN
Editorial comment: CELL. 2013;154(4):720-722

Of Origins and Pedigrees: Lineage Tracing of Dendritic Cells

Gerlach C; Thiriot A; von Andrian UH
Review: NATURE REVIEWS IMMUNOLOGY. 2010;10(9):621-631

Mapping the life histories of T cells

Schumacher TNM; Gerlach C; van Heijst JWJ

Forskningsbidrag

Center for Cellular Cancer Therapy (C3T)

Swedish Research Council

1 January 2024 - 31 December 2028

Forskningsbeskrivning

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