Carmen Gerlach
Principal Researcher
E-mail: carmen.gerlach@ki.se
Visiting address: Cmm, L8:03, Karolinska Universitetssjukhuset, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Reuma Gerlach C, 171 77 Stockholm
Research
- Our research is directed at understanding basic principles and mechanisms
underlying the generation, maintenance and consequences of the heterogeneity
within the T cell immune response, with a special focus on CD8 T cells.
Please see our lab's website [1] for more detailed information.
[1] https://gerlachlab.com/
Articles
- Article: NATURE IMMUNOLOGY. 2024;25(8):1367-1382You Y; Dunst J; Ye K; Sandoz PA; Reinhardt A; Sandrock I; Comet NR; Sarkar RD; Yang E; Duprez E; Agudo J; Brown BD; Utz PJ; Kastenmueller W; Gerlach C; Prinz I; Onfelt B; Kreslavsky T
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2024;54(1):e2350658Pokharel J; Shryki I; Zwijnenburg AJ; Sandu I; Krumm L; Bekiari C; Avramov V; Heinback R; Lysell J; Eidsmo L; Harris HE; Gerlach C
- Article: IMMUNITY. 2023;56(8):1955-1974.e10Zwijnenburg AJ; Pokharel J; Varnait R; Zheng W; Hoffer E; Shryki I; Comet NR; Ehrstrom M; Gredmark-Russ S; Eidsmo L; Gerlach C
- Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2018;10(10):a029488Neely HR; Mazo IB; Gerlach C; von Andrian UH
- Article: IMMUNITY. 2016;45(6):1270-1284Gerlach C; Moseman EA; Loughhead SM; Alvarez D; Zwijnenburg AJ; Waanders L; Garg R; de la Torre JC; von Andrian UH
- Article: CELL REPORTS. 2014;9(4):1375-1386Possik PA; Mueller J; Gerlach C; Kenski JCN; Huang X; Shahrabi A; Krijgsman O; Song J-Y; Smit MA; Gerritsen B; Lieftink C; Kemper K; Michaut M; Beijersbergen RL; Wessels L; Schumacher TN; Peeper DS
- Article: SCIENCE. 2013;340(6132):635-639Gerlach C; Rohr JC; Perie L; van Rooij N; van Heijst JWJ; Velds A; Urbanus J; Naik SH; Jacobs H; Beltman JB; de Boer RJ; Schumacher TNM
- Article: NATURE. 2013;496(7444):229-232Naik SH; Perie L; Swart E; Gerlach C; van Rooij N; de Boer RJ; Schumacher TN
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2012;4(158):158ra145Ritsma L; Steller EJA; Beerling E; Loomans CJM; Zomer A; Gerlach C; Vrisekoop N; Seinstra D; van Gurp L; Schaefer R; Raats DA; de Graaff A; Schumacher TN; de Koning EJP; Rinkes IHB; Kranenburg O; van Rheenen J
- Article: BLOOD. 2012;119(3):798-804Wolkers MC; Gerlach C; Arens R; Janssen EM; Fitzgerald P; Schumacher TN; Medema JP; Green DR; Schoenberger SP
- Article: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2011;1217:139-153Gerlach C; van Heijst JWJ; Schumacher TNM
- Article: IMMUNITY. 2010;32(6):754-765Wensveen FM; van Gisbergen KPJM; Derks IAM; Gerlach C; Schumacher TN; van Lier RAW; Eldering E
- Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(6):1235-1246Gerlach C; van Heijst JWJ; Swart E; Sie D; Armstrong N; Kerkhoven RM; Zehn D; Bevan MJ; Schepers K; Schumacher TNM
- Article: SCIENCE. 2009;325(5945):1265-1269van Heijst JWJ; Gerlach C; Swart E; Sie D; Nunes-Alves C; Kerkhoven RM; Arens R; Correia-Neves M; Schepers K; Schumacher TNM
- Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2008;205(10):2309-2318Schepers K; Swart E; van Heijst JWJ; Gerlach C; Castrucci M; Sie D; Heimerikx M; Velds A; Kerkhoven RM; Arens R; Schumacher TNM
All other publications
- Editorial comment: TRENDS IN IMMUNOLOGY. 2025;46(7):505-507Come NR; Gerlach C
- Editorial comment: NATURE REVIEWS IMMUNOLOGY. 2023;23(9):544Borsa M; Gerlach C
- Editorial comment: CELL REPORTS. 2023;42(5):112548Pokharel J; Gerlach C
- Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2023;53(3):e2250305van Gisbergen KPJM; Gerlach C
- Editorial comment: IMMUNITY. 2021;54(10):2169-2171Ordovas-Montanes J; Gerlach C; Moraes-Vieira P; Vento-Tormo R; Zhang C; Jurado KA
- Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2020;92(6):e12983Al Khabouri S; Gerlach C
- Editorial comment: IMMUNITY. 2019;50(5):1119-1121Zwijnenburg AJ; Gerlach C
- Editorial comment: TRENDS IN IMMUNOLOGY. 2018;39(3):170-172Eidsmo L; Gerlach C
- Editorial comment: CELL. 2015;161(4):702-704Gerlach C; Loughhead SM; von Andrian UH
- Review: TRENDS IN IMMUNOLOGY. 2014;35(4):170-177Rohr JC; Gerlach C; Kok L; Schumacher TN
- Editorial comment: CELL. 2013;154(4):720-722Gerlach C; Thiriot A; von Andrian UH
- Review: NATURE REVIEWS IMMUNOLOGY. 2010;10(9):621-631Schumacher TNM; Gerlach C; van Heijst JWJ
Grants
- Swedish Research Council1 January 2024 - 31 December 2028Cancer is the second most common cause of death in Sweden. Recent breakthroughs in cancer therapy, e.g. check-point blockade and chimeric antigen receptor (CAR) T cells, highlight the potency of the immune system in controlling and eradicating cancer, but also its limitations in combating many forms of solid tumors. Major efforts are needed to better target cancer and enhance the homing, persistence and function of effector immune cells, requiring close collaboration between basic and clinical scientists. Our goal is to create a vibrant multidisciplinary center that bridges expert knowledge in the biology of cytotoxic lymphocytes – immune cells that kill cancer cells – with that of good manufacturing practice compliant production and adoptive cell therapy in the clinic. Thereby, we will foster innovative new adoptive cell therapies focused on tumor-directed lymphocytes. A major emphasis will be on recruiting and supporting outstanding young principal investigators as well as postdoctoral researchers dedicated to engineering of lymphocytes for cellular therapy of cancer. We will also establish a program for internationally leading visiting scholars to invigorate discussions and innovation within our unique research constellation. Scholars will also contribute to teaching of workshops and graduate courses. Altogether, our efforts aim to expand competence and create an international leading platform within a rapidly developing field of living drugs against cancer.