Bethel Tesfai Embaie

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Min avhandling fokuserade på att kartlägga den cellulära heterogeniteten i neuroblastom och benmärgsmetastaser för att identifiera möjliga behandlingsmål. Genom att använda enkelcellsekvensering och ex vivo-organoid modeller studerade vi sjukdomens cellulära och transkriptionella mångfald samt testade nya behandlingsstrategier.

Utvalda publikationer

Article: CANCER RESEARCH. 2025;85(6):1015-1034
Comparative Single-Cell Transcriptomics of Human Neuroblastoma and Preclinical Models Reveals Conservation of an Adrenergic Cell State
Embaie BT; Sarkar H; Alchahin AM; Otte J; Olsen TK; Tummler C; Kameneva P; Artemov AV; Akkuratova N; Adameyko I; Stukenborg J-B; Wickstrom M; Kogner P; Johnsen JI; Mei S; Kharchenko PV; Baryawno N
Article: MOLECULAR CANCER. 2024;23(1):180
Joint single-cell genetic and transcriptomic analysis reveal pre-malignant SCP-like subclones in human neuroblastoma
Olsen TK; Otte J; Mei S; Embaie BT; Kameneva P; Cheng H; Gao T; Zachariadis V; Tsea I; Bjorklund A; Kryukov E; Hou Z; Johansson A; Sundstrom E; Martinsson T; Fransson S; Stenman J; Fard SS; Johnsen JI; Kogner P; Adameyko I; Enge M; Kharchenko PV; Baryawno N
Article: JCI INSIGHT. 2024;9(6):e173337
Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic
Mei S; Alchahin AM; Embaie BT; Gavriliuc IM; Verhoeven BM; Zhao T; Li X; Jeffries NE; Pepich A; Sarkar H; Olsen TK; Wickstrom M; Stenman J; Reina-Bedoya O; Kharchenko PV; Saylor PJ; Johnsen JI; Sykes DB; Kogner P; Baryawno N
Article: JCI INSIGHT. 2022;7(17):e153836
DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma
Olsen TK; Dyberg C; Embaie BT; Alchahin A; Milosevic J; Ding J; Otte J; Tummler C; Myrberg IH; Westerhout EM; Koster J; Versteeg R; Ding H-F; Kogner P; Johnsen JI; Sykes DB; Baryawno N
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(49):31386-31397
Capillary leakage provides nutrients and antioxidants for rapid pneumococcal proliferation in influenza-infected lower airways
Sender V; Hentrich K; Pathak A; Ler ATQ; Embaie BT; Lundstrom SL; Gaetani M; Bergstrand J; Nakamoto R; Sham L-T; Widengren J; Normark S; Henriques-Normark B

Alla övriga publikationer

Doctoral thesis: 2025
Delineating cellular heterogeneity of neuroblastoma for identifying therapeutically targetable vulnerabilities
Embaie BT
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S226
SCHWANN CELL PRECURSORS IS THE CELL-OF-ORIGIN IN HUMAN NEUROBLASTOMA
Otte J; Olsen T; Mei S; Kameneva P; Embaie BT; Bjorklund A; Johansson A; Sundstrom E; Martinsson T; Fransson S; Stenman J; Cheng H; Zachariadis V; Enge M; Johnsen JI; Kogner P; Adameyko I; Kharchenko P; Baryawno N
Conference publication: CANCER RESEARCH. 2022;82(12)
Single-cell landscape of the TH-MYCN neuroblastoma mouse model
Embaie BT; Alchahin A; Olsen TK; Sarkar H; Mei S; Baryawno N
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S211-S212
SINGLE CELL ANALYSIS OF HUMAN BONE METASTATIC NEUROBLASTOMA UNRAVELS EMERGING IMMUNE CELL POPULATIONS IN THE BONE MARROW
Alchahin A; Embaie BT; Mei S; Verhoeven BM; Olsen T; Kharchenko P; Johnsen JI; Kogner P; Baryawno N
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S215
SINGLE-CELL TRANSCRIPTOMICS REVEAL TUMOR CELL DIVERSITY IN NEUROBLASTOMA TRANSGENIC MOUSE AND ORGANOID MODELS
Embaie BT; Sarkar H; Alchahin A; Otte J; Olsen T; Mei S; Kharchenko P; Baryawno N
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S229-S230
INVESTIGATING THE INTERACTIONS OF DISTINCT TUMOR SUBPOPULATIONS IN HUMAN NEUROBLASTOMA USING SINGLE-CELL RNASEQ AND NOVEL SPATIAL MULTI-OMICS
Tsea I; Olsen T; Otte J; Mei S; Embaie BT; Kogner P; Johnsen JI; Baryawno N; Fard S
Conference publication: PEDIATRIC BLOOD & CANCER. 2021;68:S224-S225
Single-Cell Transcriptomic Landscape of Transgenic Mouse Model of Neuroblastoma
Embaie BT; Alchahin A; Olsen T; Mei S; Gavriliuc I; Baryawno N

Forskningsbidrag

SIOP 2024 (International Paediatric Oncology Congress)
Barncancerfonden
1 January 2024 - 31 December 2024
Advances in Neuroblastoma Research (ANR) Meeting 2023
Barncancerfonden
1 January 2023 - 31 December 2023
Educational Course: Bioinformatics Analysis and Visualisation of Medical Genomics Data
Barncancerfonden
1 January 2023 - 31 December 2023
American Association for Cancer Research (AACR) Annual Meeting 2022
Barncancerfonden
1 January 2022 - 31 December 2022

Examina och utbildning

PhD, Medicinsk Vetenskap, Delineating cellular heterogeneity of neuroblastoma for identifying therapeutically targetable vulnerabilities, Institutionen för kvinnors och barns hälsa (KBH), Karolinska Institutet, 2025
Medicine Masterexamen, Karolinska Institutet, 2020
Medicine Kandidatexamen, Karolinska Institutet, 2018

Om mig

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Forskningsbidrag

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI