Bethel Tesfai Embaie

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About me

Our research focuses on investigating the cells of neuroblastoma origin and bone marrow metastasis.

PhD Student at Karolinska Institutet, under the supervision of Associate Professor Ninib Baryawno. My thesis focuses on delineating the cellular heterogeneity of neuroblastoma and bone marrow metastases to identify therapeutically targetable vulnerabilities. The aim is to investigate cellular heterogeneity and clonality in neuroblastoma and preclinical models. We further establish ex-vivo organoid models that recapitulate neuroblastoma.

Selected publications

Article: MOLECULAR CANCER. 2024;23(1):180
Joint single-cell genetic and transcriptomic analysis reveal pre-malignant SCP-like subclones in human neuroblastoma
Olsen TK; Otte J; Mei S; Embaie BT; Kameneva P; Cheng H; Gao T; Zachariadis V; Tsea I; Bjorklund A; Kryukov E; Hou Z; Johansson A; Sundstrom E; Martinsson T; Fransson S; Stenman J; Fard SS; Johnsen JI; Kogner P; Adameyko I; Enge M; Kharchenko PV; Baryawno N
Article: JCI INSIGHT. 2024;9(6):e173337
Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic
Mei S; Alchahin AM; Embaie BT; Gavriliuc IM; Verhoeven BM; Zhao T; Li X; Jeffries NE; Pepich A; Sarkar H; Olsen TK; Wickstrom M; Stenman J; Reina-Bedoya O; Kharchenko PV; Saylor PJ; Johnsen JI; Sykes DB; Kogner P; Baryawno N
Article: JCI INSIGHT. 2022;7(17):e153836
DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma
Olsen TK; Dyberg C; Embaie BT; Alchahin A; Milosevic J; Ding J; Otte J; Tummler C; Myrberg IH; Westerhout EM; Koster J; Versteeg R; Ding H-F; Kogner P; Johnsen JI; Sykes DB; Baryawno N
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(49):31386-31397
Capillary leakage provides nutrients and antioxidants for rapid pneumococcal proliferation in influenza-infected lower airways
Sender V; Hentrich K; Pathak A; Ler ATQ; Embaie BT; Lundstrom SL; Gaetani M; Bergstrand J; Nakamoto R; Sham L-T; Widengren J; Normark S; Henriques-Normark B

All other publications

Conference publication: CANCER RESEARCH. 2022;82(12)
Single-cell landscape of the TH-MYCN neuroblastoma mouse model
Embaie BT; Alchahin A; Olsen TK; Sarkar H; Mei S; Baryawno N
Conference publication: PEDIATRIC BLOOD AND CANCER. 2022;69:S226
SCHWANN CELL PRECURSORS IS THE CELL-OF-ORIGIN IN HUMAN NEUROBLASTOMA
Otte J; Olsen T; Mei S; Kameneva P; Embaie BT; Bjorklund A; Johansson A; Sundstrom E; Martinsson T; Fransson S; Stenman J; Cheng H; Zachariadis V; Enge M; Johnsen JI; Kogner P; Adameyko I; Kharchenko P; Baryawno N
Conference publication: PEDIATRIC BLOOD AND CANCER. 2022;69:S229-S230
INVESTIGATING THE INTERACTIONS OF DISTINCT TUMOR SUBPOPULATIONS IN HUMAN NEUROBLASTOMA USING SINGLE-CELL RNASEQ AND NOVEL SPATIAL MULTI-OMICS
Tsea I; Olsen T; Otte J; Mei S; Embaie BT; Kogner P; Johnsen JI; Baryawno N; Fard S
Conference publication: PEDIATRIC BLOOD AND CANCER. 2022;69:S211-S212
SINGLE CELL ANALYSIS OF HUMAN BONE METASTATIC NEUROBLASTOMA UNRAVELS EMERGING IMMUNE CELL POPULATIONS IN THE BONE MARROW
Alchahin A; Embaie BT; Mei S; Verhoeven BM; Olsen T; Kharchenko P; Johnsen JI; Kogner P; Baryawno N
Conference publication: PEDIATRIC BLOOD AND CANCER. 2022;69:S215
SINGLE-CELL TRANSCRIPTOMICS REVEAL TUMOR CELL DIVERSITY IN NEUROBLASTOMA TRANSGENIC MOUSE AND ORGANOID MODELS
Embaie BT; Sarkar H; Alchahin A; Otte J; Olsen T; Mei S; Kharchenko P; Baryawno N
Preprint: BIORXIV. 2021
DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma
Olsen TK; Dyberg C; Embaie B; Alchahin A; Milosevic J; Otte J; Tümmler C; Myrberg IH; Westerhout E; Koster J; Versteeg R; Kogner P; Johnsen JI; Sykes D; Baryawno N
Conference publication: PEDIATRIC BLOOD AND CANCER. 2021;68:S224-S225
Single-Cell Transcriptomic Landscape of Transgenic Mouse Model of Neuroblastoma
Embaie BT; Alchahin A; Olsen T; Mei S; Gavriliuc I; Baryawno N

Grants

SIOP 2024 (International Paediatric Oncology Congress)
Barncancerfonden
1 January 2024 - 31 December 2024
Advances in Neuroblastoma Research (ANR) Meeting 2023
Barncancerfonden
1 January 2023 - 31 December 2023
Educational Course: Bioinformatics Analysis and Visualisation of Medical Genomics Data
Barncancerfonden
1 January 2023 - 31 December 2023
American Association for Cancer Research (AACR) Annual Meeting 2022
Barncancerfonden
1 January 2022 - 31 December 2022

Employments

Clinical Assistant, Department of Women's and Children's Health, Karolinska Institutet, 2025-2025
Phd Student, Department of Women's and Children's Health, Karolinska Institutet, 2021-2024

Degrees and Education

Degree Of Master Of Medical Science 120 Credits, Karolinska Institutet, 2020
Degree Of Bachelor Of Medical Science, Karolinska Institutet, 2018

About me

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