Bernhard Schmierer

Publikationer
Forskningsbidrag
Populärvetenskap och samverkan

Artiklar

Journal article: CANCERS. 2024;16(13):2437
CRISPR-Cas9 Knockout Screens Identify DNA Damage Response Pathways and BTK as Essential for Cisplatin Response in Diffuse Large B-Cell Lymphoma
Issa II; Due H; Brondum RF; Veeravakaran V; Haraldsdottir H; Sylvester C; Brogaard A; Dhanjal S; Schmierer B; Dybkaer K
Journal article: EJNMMI RADIOPHARMACY AND CHEMISTRY. 2024;9(1):32
Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell model
Durinova A; Smutna L; Barta P; Kamaraj R; Smutny T; Schmierer B; Pavek P; Trejtnar F
Journal article: CANCER RESEARCH. 2024;84(6):2025
Zeb1 downregulation sensitizes pancreatic cancer-associated fibroblasts to killing by oncolytic reovirus through upregulation of the reovirus receptor junction adhesion molecule A
Dam N; Harryvan TJ; Schmierer B; Hawinkels LJAC; Kemp V
Article: NATURE COMMUNICATIONS. 2023;14(1):5024
An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver
Moro CF; Geyer N; Harrizi S; Hamidi Y; Soderqvist S; Kuznyecov D; Tidholm Qvist E; Salmonson Schaad M; Hermann L; Lindberg A; Heuchel RL; Martin-Bernabe A; Dhanjal S; Navis AC; Villard C; del Valle AC; Bozoky L; Sparrelid E; Dirix L; Strell C; Ostman A; Schmierer B; Vermeulen PB; Engstrand J; Bozoky B; Gerling M
Journal article: CANCER RESEARCH. 2023;83(7):3778
Genome-Scale CRISPRa and CRISPRi screening for lncRNA drivers of prostate cancer progression
Weiss S; Lord A; Schmierer B; Rovsing AB; Thomsen EA; Mikkelsen JG; Ulhoi B; Pedersen JS; Borre M; Sorensen KD
Article: FRONTIERS IN ONCOLOGY. 2022;12:852980
Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action
Gubat J; Selvaraju K; Sjoestrand L; Kumar Singh D; Turkina MV; Schmierer B; Sabatier P; Zubarev RA; Linder S; D'Arcy P
Article: ELIFE. 2021;10:e75415
Rapid genome editing by CRISPR-Cas9-POLD3 fusion
Reint G; Li Z; Labun K; Keskitalo S; Soppa I; Mamia K; Tolo E; Szymanska M; Meza-Zepeda LA; Lorenz S; Cieslar-Pobuda A; Hu X; Bordin DL; Staerk J; Valen E; Schmierer B; Varjosalo M; Taipale J; Haapaniemi E
Article: JOURNAL OF CELL SCIENCE. 2019;132(14):jcs234039
TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation
Miller DSJ; Schmierer B; Hill CS
Article: NATURE COMMUNICATIONS. 2018;9(1):3664
Contribution of allelic imbalance to colorectal cancer
Palin K; Pitkanen E; Turunen M; Sahu B; Pihlajamaa P; Kivioja T; Kaasinen E; Valimaki N; Hanninen UA; Cajuso T; Aavikko M; Tuupanen S; Kilpivaara O; van den Berg L; Kondelin J; Tanskanen T; Katainen R; Grau M; Rauanheimo H; Plaketti R-M; Taira A; Sulo P; Hartonen T; Dave K; Schmierer B; Botla S; Sokolova M; Vaharautio A; Gladysz K; Ongen H; Dermitzakis E; Bramsen JB; Orntoft TF; Andersen CL; Ristimaki A; Lepisto A; Renkonen-Sinisalo L; Mecklin J-P; Taipale J; Aaltonen LA
Article: NATURE MEDICINE. 2018;24(7):927-930
CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response
Haapaniemi E; Botla S; Persson J; Schmierer B; Taipale J
Article: MOLECULAR SYSTEMS BIOLOGY. 2017;13(10):945
CRISPR/Cas9 screening using unique molecular identifiers
Schmierer B; Botla SK; Zhang J; Turunen M; Kivioja T; Taipale J
Article: NATURE COMMUNICATIONS. 2015;6:10050
Structural insights into the DNA-binding specificity of E2F family transcription factors
Morgunova E; Yin Y; Jolma A; Dave K; Schmierer B; Popov A; Eremina N; Nilsson L; Taipale J
Article: SCIENCE SIGNALING. 2013;6(305):ra106
Controlling Long-Term Signaling: Receptor Dynamics Determine Attenuation and Refractory Behavior of the TGF-β Pathway
Vizan P; Miller DSJ; Gori I; Das D; Schmierer B; Hill CS
Article: CELL. 2013;154(4):801-813
Transcription Factor Binding in Human Cells Occurs in Dense Clusters Formed around Cohesin Anchor Sites
Yan J; Enge M; Whitington T; Dave K; Liu J; Sur I; Schmierer B; Jolma A; Kivioja T; Taipale M; Taipale J
Article: BIOPHYSICAL JOURNAL. 2013;104(12):2595-2606
Dynamical Scenarios for Chromosome Bi-orientation
Zhang T; Oliveira RA; Schmierer B; Novak B
Article: OPEN BIOLOGY. 2011;1(3):110009
Cell cycle commitment in budding yeast emerges from the cooperation of multiple bistable switches
Zhang T; Schmierer B; Novak B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(9):7648-7660
Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor
Yang M; Ge W; Chowdhury R; Claridge TDW; Kramer HB; Schmierer B; McDonough MA; Gong L; Kessler BM; Ratcliffe PJ; Coleman ML; Schofield CJ
Article: INTEGRATIVE BIOLOGY (UNITED KINGDOM). 2011;3(3):197-207
Studying Smad2 intranuclear diffusion dynamics by mathematical modelling of FRAP experiments
Gonzalez-Perez V; Schmierer B; Hill CS; Sear RP
Article: BMC SYSTEMS BIOLOGY. 2010;4:139
Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response - a predictive kinetic model
Schmierer B; Novak B; Schofield CJ
Article: DEVELOPMENT. 2008;135(17):2927-2937
Two highly related regulatory subunits of PP2A exert opposite effects on TGF-β/Activin/Nodal signalling
Batut J; Schmierer B; Cao J; Raftery LA; Hill CS; Howell M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(18):6608-6613
Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system
Schmierer B; Tournier AL; Bates PA; Hill CS
Article: JOURNAL OF CELL SCIENCE. 2006;119(12):2435-2443
Upregulation of chicken p15^INK4b at senescence and in the developing brain
Kim S-H; Rowe J; Fujii H; Jones R; Schmierer B; Kong B-W; Kuchler K; Foster D; Ish-Horowicz D; Peters G
Article: MOLECULAR AND CELLULAR BIOLOGY. 2005;25(22):9845-9858
Kinetic analysis of smad nucleocytoplasmic shuttling reveals a mechanism for transforming growth factor β-dependent nuclear accumulation of Smads
Schmierer B; Hill CS
Article: JOURNAL OF CELL SCIENCE. 2004;117(18):4113-4125
Analysis of Smad nucleocytoplasmic shuttling in living cells
Nicolás FJ; De Bosscher K; Schmierer B; Hill CS
Article: BIOLOGY OF REPRODUCTION. 2004;70(5):1493-1499
Activin A and follicle-stimulating hormone control tight junctions in avian granulosa cells by regulating occludin expression
Schuster MK; Schmierer B; Shkumatava A; Kuchler K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(23):21197-21203
Activin A signaling induces Smad2, but not Smad3, requiring protein kinase A activity in granulosa cells from the avian ovary
Schmierer B; Schuster MK; Shkumatava A; Kuchler K
Article: BIOLOGY OF REPRODUCTION. 2003;68(2):620-627
Activin and follicle-stimulating hormone signaling are required for long-term culture of functionally differentiated primary granulosa cells from the chicken ovary
Schmierer B; Schuster MK; Shkumatava A; Kuchler K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;274(2):542-547
Endothelial cells downregulate expression of the 70 kDa heat shock protein during hypoxia
Oehler R; Schmierer B; Zellner M; Prohaska R; Roth E
Article: THE FASEB JOURNAL. 2000;14(9):1093-1100
Catecholamines up-regulate lipopolysaccharide-induced IL-6 production in human microvascular endothelial cells
Gornikiewicz A; Sautner T; Brostjan C; Schmierer B; Függer R; Roth E; Mühlbacher F; Bergmann M
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Preprint: BIORXIV. 2024
A genome-wide genetic screen identified targets for destabilizing the parasitophorous vacuole of Chlamydia trachomatis
Sait MRB; Jachmann LH; Milivojevic M; Llorente-Sáez C; Dhanjal S; Schumacher F; Henriksson S; Vegesna NVG; Chaban A; Mohanty P; Ölander M; Muraleedharan S; Azadeh SF; Kleuser B; Schmierer B; Sixt BS
Preprint: BIORXIV. 2024
A distinctive tumor compartment in pancreatic lobules defined by nascent stroma and classical tumor cell phenotype
Söderqvist S; Viljamaa A; Geyer N; Strell C; Hekmati N; Engstrand J; Sparrelid E; Salmén C; Heuchel R; Zacharouli A; Ghorbani P; Harrizi S; Hamidi Y; Khorosjutina O; Milanova S; Schmierer B; Bozóky B; Moro CF; Gerling M
Book chapter: GENOME EDITING IN DRUG DISCOVERY. 2022;p. 151-164
Sequence Diversification Screens with CRISPR‐Cas9‐Guided Base Editors
Persson J; Schmierer B
Conference publication: CANCER RESEARCH. 2022;82(22):5
Pancreatic cancer comprises co-existing transcriptional states regulated by distinct master regulator programs.
Laise P; Turunen M; Maurer HC; Garcia AC; Elyada E; Schmierer B; Tomassoni L; Worley J; Alvarez MJ; Kesner J; Tan X; Tagore S; Fernandez EC; Wong K; Wang ALE; Ge S; Iuga AC; Griffin AT; Wong W; Manji GA; Notta F; Tuveson DA; Olive KPP; Califano A
Conference publication: MOLECULAR THERAPY. 2022;30(4):267
Rapid Genome Editing by Cas9-POLD3 Fusion
Reint G; Li Z; Labun K; Keskitalo S; Soppa I; Mamia K; Tolo E; Szymanska M; Meza-Zepeda L; Lorenz S; Cieslar-Pobuda A; Hu X; Bordin D; Staerk J; Valen E; Schmierer B; Varjosalo M; Taipale J; Haapaniemi E
Preprint: BIORXIV. 2020
Developmental and MAPK-responsive transcription factors drive distinct malignant subtypes and genetic dependencies in pancreatic cancer
Laise P; Turunen M; Garcia AC; Tomassoni L; Maurer C; Elyada E; Schmierer B; Worley J; Kesner J; Tan X; Fernandez EC; Wong K; Wasko U; Tagore S; Wang A; Ge S; Iuga A; Griffin A; Wong W; Manji G; Alvarez M; Notta F; Tuveson D; Olive K; Califano A
Review: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. 2020;18:2237-2246
Designing custom CRISPR libraries for hypothesis-driven drug target discovery
Iyer VS; Jiang L; Shen Y; Boddul SV; Panda SK; Kasza Z; Schmierer B; Wermeling F
Letter: MOLECULAR SYSTEMS BIOLOGY. 2019;15(8):e9059
Reply to "CRISPR screens are feasible in TP53 wild-type cells"
Haapaniemi E; Botla S; Persson J; Schmierer B; Taipale J
Letter: SCIENCE SIGNALING. 2014;7(344):lc2
Response to comment on "Controlling long-term signaling: Receptor dynamics determine attenuation and refractory behavior of the TGF-β pathway"-Smad2/3 activity does not predict the dynamics of transcription
Vizan P; Miller DSJ; Schmierer B; Hill CS
Book chapter: ENCYCLOPEDIA OF SYSTEMS BIOLOGY. 2013;p. 29
Anoxia
Schmierer B
Book chapter: ENCYCLOPEDIA OF SYSTEMS BIOLOGY. 2013;p. 311-314
Cell Cycle Signaling, Hypoxia
Schmierer B
Book chapter: ENCYCLOPEDIA OF SYSTEMS BIOLOGY. 2013;p. 1055-1056
Ischemic Disease
Schmierer B
Book chapter: ENCYCLOPEDIA OF SYSTEMS BIOLOGY. 2013;p. 1846
Reoxygenation
Schmierer B
Book chapter: ENCYCLOPEDIA OF SYSTEMS BIOLOGY. 2013;p. 1802
PVHL
Schmierer B
Book chapter: ENCYCLOPEDIA OF SYSTEMS BIOLOGY. 2013;p. 434
c-Myc
Schmierer B
Corrigendum: INTEGRATIVE BIOLOGY (UNITED KINGDOM). 2011;3(12):1233
Studying Smad2 intranuclear diffusion dynamics by mathematical modelling of FRAP experiments (vol 3, pg 197, 2011)
Gonzalez-Perez V; Schmierer B; Hill CS; Sear RP
Review: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2007;8(12):970-982
TGFβ-SMAD signal transduction:: molecular specificity and functional flexibility
Schmierer B; Hill CS
Book chapter: SMAD SIGNAL TRANSDUCTION: PROTEINS AND CELL REGULATION. 2006;p. 193-213
Nucleocytoplasmic Shuttling of Smad Proteins
Schmierer B; Hill CS

Forskningsbidrag

Gene Knock Up at the post-transcriptional level to model and treat neurological disease
Swedish Research Council
1 January 2023 - 31 December 2025
Differentiation state instability and clonal selection as escape paths from anticancer therapy
Swedish Research Council
1 January 2021 - 31 December 2023
Mechanism of Smad2/3 nucleocytoplasmic shuttling
FWF Austrian Science Fund
1 June 2004 - 31 May 2006

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