Axel Abelein
Assistant Professor | Docent
E-mail: axel.abelein@ki.se
Visiting address: Blickagången 16, Neo, Flemingsberg, 14152 Hudding
Postal address: H7 Medicin, Huddinge, H7 CeRM Abelein, 171 77 Stockholm
Research
- My research concerns protein self-assembly related to neurodegenerative
diseases with the focus on characterization of protein structure and
molecular mechanisms of self-assembly. The studies in our lab include a
broad range of different techniques within biophysics, protein
biochemistry and biomedicine. My current research focuses on the
aggregation mechanisms of amyloid-β peptide (Aβ) fibril formation,
associated to Alzheimer’s disease and inhibition mechanisms by the
BRICHOS domain, a chaperone-like protein that is potential candidate to be
implemented in Alzheimer’s disease treatment. Furthermore, another research
line is the development of new expression and purification protocols for
aggregation-prone proteins using a spider silk-derived solubility tag, where
one possible application is the generation of new biomaterials.
Please visit our group homepage for more information:
https://ki.se/en/bionut/laboratory-for-protein-misfolding-and-assembly
Selected publications
- Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2025;147(27):23504-23518Morman C; Leppert A; Pizzirusso G; Zheng Z; Sun X; Kumar R; Biverstal H; Landreh M; Johansson J; Arroyo-Garcia LE; Luo J; Chen G; Abelein A
- Article: PROTEIN SCIENCE. 2024;33(8):e5091Adam L; Kumar R; Arroyo-Garcia LE; Molenkamp WH; Nowak JS; Klute H; Farzadfard A; Alkenayeh R; Nielsen J; Biverstal H; Otzen DE; Johansson J; Abelein A
- Journal article: NATURE COMMUNICATIONS. 2024;15(1):965Kumar R; Le Marchand T; Adam L; Bobrovs R; Chen G; Fridmanis J; Kronqvist N; Biverstål H; Jaudzems K; Johansson J; Pintacuda G; Abelein A
- Article: NATURE COMMUNICATIONS. 2024;15(1):965Kumar R; Le Marchand T; Adam L; Bobrovs R; Chen G; Fridmanis J; Kronqvist N; Biverstal H; Jaudzems K; Johansson J; Pintacuda G; Abelein A
- Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(8):1503-1511Kumar R; Arroyo-Garcia LE; Manchanda S; Adam L; Pizzirusso G; Biverstal H; Nilsson P; Fisahn A; Johansson J; Abelein A
- Article: MOLECULAR THERAPY. 2023;31(2):487-502Manchanda S; Galan-Acosta L; Abelein A; Tambaro S; Chen G; Nilsson P; Johansson J
- Article: JACS AU. 2022;2(11):2571-2584Abelein A; Ciofi-Baffoni S; Morman C; Kumar R; Giachetti A; Piccioli M; Biverstal H
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(21):7224-7234Wallin C; Jarvet J; Biverstal H; Warmlander S; Danielsson J; Graslund A; Abelein A
- Article: COMMUNICATIONS BIOLOGY. 2020;3(1):32Chen G; Andrade-Talavera Y; Tambaro S; Leppert A; Nilsson HE; Zhong X; Landreh M; Nilsson P; Hebert H; Biverstal H; Fisahn A; Abelein A; Johansson J
- Article: NATURE COMMUNICATIONS. 2017;8(1):2081Chen G; Abelein A; Nilsson HE; Leppert A; Andrade-Talavera Y; Tambaro S; Hemmingsson L; Roshan F; Landreh M; Biverstal H; Koeck PJB; Presto J; Hebert H; Fisahn A; Johansson J
- Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2016;138(21):6893-6902Abelein A; Jarvet J; Barth A; Graslund A; Danielsson J
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(17):5407-5412Abelein A; Graslund A; Danielsson J
Articles
- Article: SCIENCE ADVANCES. 2025;11(24):eads7525Jin Z; Olsen WP; Moerman C; Leppert A; Kumar R; Mollebjerg A; Nielsen LG; Moshynets OV; Frasinyuk MS; Elosua JY; Ferreira D; Abelein A; Landreh M; Knight SD; Johansson J; Otzen DE; Chen G
- Article: PROTEIN SCIENCE. 2024;33(7):e5063Chen G; Wang Y; Zheng Z; Jiang W; Leppert A; Zhong X; Belorusova A; Siegal G; Jegerschold C; Koeck PJB; Abelein A; Hebert H; Knight SD; Johansson J
- Journal article: BIOPHYSICAL JOURNAL. 2024;123(3):413a-414aMorman C; Leppert A; Johansson J; Luo J; Abelein A
- Article: COMMUNICATIONS BIOLOGY. 2023;6(1):497Chen G; Leppert A; Poska H; Nilsson HE; Alvira CP; Zhong X; Koeck P; Jegerschold C; Abelein A; Hebert H; Johansson J
- Article: RSC CHEMICAL BIOLOGY. 2022;3(11):1342-1358Chen G; Andrade-Talavera Y; Zhong X; Hassan S; Biverstal H; Poska H; Abelein A; Leppert A; Kronqvist N; Rising A; Hebert H; Koeck PJB; Fisahn A; Johansson J
- Article: ACS CHEMICAL BIOLOGY. 2022;17(8):2201-2211Zhong X; Kumar R; Wang Y; Biverstal H; Jegerschoeld CI; Koeck PJB; Johansson J; Abelein A; Chen G
- Article: NATURE COMMUNICATIONS. 2022;13(1):4695Arndt T; Jaudzems K; Shilkova O; Francis J; Johansson M; Laity PR; Sahin C; Chatterjee U; Kronqvist N; Barajas-Ledesma E; Kumar R; Chen G; Stromberg R; Abelein A; Langton M; Landreh M; Barth A; Holland C; Johansson J; Rising A
- Article: EMBO REPORTS. 2022;23(7):e54405Brackhan M; Calza G; Lundgren K; Bascunana P; Bruning T; Soliymani R; Kumar R; Abelein A; Baumann M; Lalowski M; Pahnke J
- Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2022;10(1):96Jiang R; Smailovic U; Haytural H; Tijms BM; Li H; Haret RM; Shevchenko G; Chen G; Abelein A; Gobom J; Frykman S; Sekiguchi M; Fujioka R; Watamura N; Sasaguri H; Nystrom S; Hammarstrom P; Saido TC; Jelic V; Syvanen S; Zetterberg H; Winblad B; Bergquist J; Visser PJ; Nilsson P
- Article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:878303Jiang R; Shimozawa M; Mayer J; Tambaro S; Kumar R; Abelein A; Winblad B; Bogdanovic N; Nilsson P
- Article: STRUCTURE. 2022;30(5):733-742.e7Kaldmae M; Vosselman T; Zhong X; Lama D; Chen G; Saluri M; Kronqvist N; Siau JW; Ng AS; Ghadessy FJ; Sabatier P; Vojtesek B; Sarr M; Sahin C; Osterlund N; Ilag LL; Vaananen VA; Sedimbi S; Arsenian-Henriksson M; Zubarev RA; Nilsson L; Koeck PJB; Rising A; Abelein A; Fritz N; Johansson J; Lane DP; Landreh M
- Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2021;198:113996Tigro H; Kronqvist N; Abelein A; Galan-Acosta L; Chen G; Landreh M; Lyashkov A; Aon MA; Ferrucci L; Shimmo R; Johansson J; Moaddel R
- Article: BIOCHEMISTRY. 2021;60(9):678-688Leppert A; Tiiman A; Kronqvist N; Landreh M; Abelein A; Vukojevic V; Johansson J
- Article: SCIENTIFIC REPORTS. 2020;10(1):21765Biverstal H; Kumar R; Schellhaus AK; Sarr M; Dantuma NP; Abelein A; Johansson J
- Article: FEBS JOURNAL. 2020;287(13):2823-2833Kaldmae M; Leppert A; Chen G; Sarr M; Sahin C; Nordling K; Kronqvist N; Gonzalvo-Ulla M; Fritz N; Abelein A; Lain S; Biverstal H; Jornvall H; Lane DP; Rising A; Johansson J; Landreh M
- Article: SCIENTIFIC REPORTS. 2020;10(1):235Abelein A; Chen G; Kitoka K; Aleksis R; Oleskovs F; Sarr M; Landreh M; Pahnke J; Nordling K; Kronqvist N; Jaudzems K; Rising A; Johansson J; Biverstal H
- Article: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY. 2016;38:183-193Wallin C; Kulkarni YS; Abelein A; Jarvet J; Liao Q; Strodel B; Olsson L; Luo J; Abrahams JP; Sholts SB; Roos PM; Kamerlin SCL; Graslund A; Warmlander SKTS
- Article: BIOCHEMICAL JOURNAL. 2016;473(20):3683-3704Poska H; Haslbeck M; Kurudenkandy FR; Hermansson E; Chen G; Kostallas G; Abelein A; Biverstal H; Crux S; Fisahn A; Presto J; Johansson J
- Journal article: BIOPHYSICAL JOURNAL. 2015;108(2):64aGraslund A; Abelein A; Danielsson J
- Journal article: BIOPHYSICAL JOURNAL. 2014;106(2):39aAbelein A; Kaspersen JD; Nielsen SB; Jensen GV; Christiansen G; Pedersen JS; Danielsson J; Otzen DE; Graslund A
- Article: CHEMBIOCHEM. 2013;14(14):1692-1704Warmlander S; Tiiman A; Abelein A; Luo J; Jarvet J; Soderberg KL; Danielsson J; Graslund A
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2013;288(32):23518-23528Abelein A; Kaspersen JD; Nielsen SB; Jensen GV; Christiansen G; Pedersen JS; Danielsson J; Otzen DE; Graslund A
- Article: FEBS LETTERS. 2012;586(22):3991-3995Abelein A; Lang L; Lendel C; Graslund A; Danielsson J
- Journal article: BIOPHYSICAL JOURNAL. 2012;102(3):441aAbelein A; Bolognesi B; Dobson CM; Graslund A; Lendel C
- Article: BIOCHEMISTRY. 2012;51(1):126-137Abelein A; Bolognesi B; Dobson CM; Graslund A; Lendel C
- Show more
All other publications
- Preprint: BIORXIV. 2023Adam L; Kumar R; Arroyo-Garcia LE; Molenkamp WH; Nowak JS; Klute H; Farzadfard A; Alkenayeh R; Nielsen J; Biverstål H; Otzen DE; Johansson J; Abelein A
- Review: ACCOUNTS OF CHEMICAL RESEARCH. 2023;56(19):2653-2663Abelein A
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S54Abelein A; Kumar R; Le Marchand T; Adam L; Chen G; Fridmanis J; Kronqvist N; Biverstal H; Jaudzems K; Johansson J; Pintacuda G
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S168Adam L; Kumar R; Molenkamp W; Alkenayeh R; Biverstal H; Johansson J; Abelein A
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S96Exploring the potential of the Bri2 BRICHOS domain as a drug-carrier for lysosomal storage disordersMolenkamp W; Kronqvist N; Johansson J; Abelein A
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S89Kumar R; Garcia LEA; Manchanda S; Adam L; Pizzirusso G; Biverstal H; Nilsson P; Fisahn A; Johansson J; Abelein A
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S97Morman C; Leppert A; Johansson J; Luo J; Abelein A
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S189Klute H; Adam L; Molenkamp W; Kumar R; Johansson J; Abelein A
- Review: PROTEIN SCIENCE. 2023;32(6):e4645Leppert A; Poska H; Landreh M; Abelein A; Chen G; Johansson J
- Review: RSC MEDICINAL CHEMISTRY. 2023;14(5):848-857Abelein A; Johansson J
- Review: FRONTIERS IN MOLECULAR BIOSCIENCES. 2023;10:1193458Pena-Bautista C; Kumar R; Baquero M; Johansson J; Chafer-Pericas C; Abelein A; Ferreira D
- Conference publication: ALZHEIMERS & DEMENTIA. 2021;17(S5)Jiang R; Smailovic U; Haytural H; Haret RM; Shevchenko G; Tijms B; Gobom J; Abelein A; Johansson J; Zetterberg H; Winblad B; Frykman S; Jelic V; Bergquist J; Visser PJ; Nilsson P
- Conference publication: PROTEIN SCIENCE. 2017;26:31-32Chen G; Abelein A; Leppert A; Tambaro S; Biverstal H; Presto J; Johansson J
- Review: JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2014;19(4-5):623-634Abelein A; Abrahams JP; Danielsson J; Graslund A; Jarvet J; Luo J; Tiiman A; Warmlander SKTS
- Corrigendum: FEBS LETTERS. 2013;587(9):1452Abelein A; Lang L; Lendel C; Graslund A; Danielsson J
Grants
- Swedish Research Council1 January 2024 - 31 December 2027Protein misfolding has been identified as the underlying molecular process found in several devastating neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease (AD/PD). Based on the aggregation behavior, the surface of AD and PD-associated amyloid fibrils has been suggested to act as a catalyzer for self-replication and generation of toxic oligomers. Specifically tailored molecular chaperones, such as the BRICHOS protein domain, were shown to bind to the amyloid fibrils and break this autocatalytic cycle, possibly by blocking specific aggregation hotspots on the fibrils surface.Here, we aim to elucidate structural features of these catalytic sites from diverse in vitro and in vivo-derived amyloid fibrils using an integrated approach of high-resolution techniques. This information will provide a detailed understanding of the generic molecular mechanisms of chaperone-amyloid interactions, which will open the possibility to specifically target aggregation hotspots by designer chaperones or other drugs. Other goals are to explore the potential of BRICHOS to transport biologic drugs over the blood-brain barrier (BBB), and to determine the seeding activity of samples from patients suffering from different neurodegenerative disorders, which could establish new diagnostic tools.
- Development of novel protein-based biomaterials for sustainable water purification from heavy metalsSwedish Research Council for Environment Agricultural Sciences and Spatial Planning1 January 2021 - 31 December 2024
Employments
- Assistant Professor, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2026
Degrees and Education
- Docent, Karolinska Institutet, 2024