Axel Abelein
Assistant Professor | Docent
E-mail: axel.abelein@ki.se
Visiting address: Blickagången 16, Neo, Flemingsberg, 14152 Hudding
Postal address: H7 Medicin, Huddinge, H7 BioNut Abelein, 171 77 Stockholm
Research
- My research concerns protein self-assembly related to neurodegenerative
diseases with the focus on characterization of protein structure and
molecular mechanisms of self-assembly. The studies in our lab include a
broad range of different techniques within biophysics, protein
biochemistry and biomedicine. My current research focuses on the
aggregation mechanisms of amyloid-β peptide (Aβ) fibril formation,
associated to Alzheimer’s disease and inhibition mechanisms by the
BRICHOS domain, a chaperone-like protein that is potential candidate to be
implemented in Alzheimer’s disease treatment. Furthermore, another research
line is the development of new expression and purification protocols for
aggregation-prone proteins using a spider silk-derived solubility tag, where
one possible application is the generation of new biomaterials.
Please visit our group homepage for more information:
https://ki.se/en/bionut/laboratory-for-protein-misfolding-and-assembly
Selected publications
- Article: PROTEIN SCIENCE. 2024;33(8):e5091
- Journal article: NATURE COMMUNICATIONS. 2024;15(1):965
- Article: NATURE COMMUNICATIONS. 2024;15(1):965
- Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(8):1503-1511
- Article: MOLECULAR THERAPY. 2023;31(2):487-502
- Article: JACS AU. 2022;2(11):2571-2584
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(21):7224-7234
- Article: COMMUNICATIONS BIOLOGY. 2020;3(1):32
- Article: NATURE COMMUNICATIONS. 2017;8(1):2081
- Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2016;138(21):6893-6902
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(17):5407-5412
Articles
- Article: PROTEIN SCIENCE. 2024;33(7):e5063
- Journal article: BIOPHYSICAL JOURNAL. 2024;123(3):413a-414a
- Article: COMMUNICATIONS BIOLOGY. 2023;6(1):497
- Article: RSC CHEMICAL BIOLOGY. 2022;3(11):1342-1358
- Article: ACS CHEMICAL BIOLOGY. 2022;17(8):2201-2211
- Article: NATURE COMMUNICATIONS. 2022;13(1):4695
- Article: EMBO REPORTS. 2022;23(7):e54405
- Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2022;10(1):96
- Article: STRUCTURE. 2022;30(5):733-742.e7
- Article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:878303
- Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2021;198:113996
- Article: BIOCHEMISTRY. 2021;60(9):678-688
- Article: SCIENTIFIC REPORTS. 2020;10(1):21765
- Article: THE FEBS JOURNAL. 2020;287(13):2823-2833
- Article: SCIENTIFIC REPORTS. 2020;10(1):235
- Article: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY. 2016;38:183-193
- Article: BIOCHEMICAL JOURNAL. 2016;473(20):3683-3704
- Journal article: BIOPHYSICAL JOURNAL. 2015;108(2):64a
- Article: CHEMBIOCHEM. 2013;14(14):1692-1704
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2013;288(32):23518-23528
- Article: FEBS LETTERS. 2012;586(22):3991-3995
- Article: BIOCHEMISTRY. 2012;51(1):126-137
- Journal article: BIOPHYSICAL JOURNAL. 2012;102(3):441a
- Show more
All other publications
- Review: ACCOUNTS OF CHEMICAL RESEARCH. 2023;56(19):2653-2663
- Review: PROTEIN SCIENCE. 2023;32(6):e4645
- Review: RSC MEDICINAL CHEMISTRY. 2023;14(5):848-857
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S96
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S97
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S189
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S168
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S89
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S54
- Review: FRONTIERS IN MOLECULAR BIOSCIENCES. 2023;10:1193458
- Conference publication: ALZHEIMER'S AND DEMENTIA. 2021;17(S5)
- Conference publication: PROTEIN SCIENCE. 2017;26:31-32
- Review: JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2014;19(4-5):623-634
- Corrigendum: FEBS LETTERS. 2013;587(9):1452
Grants
- Swedish Research Council1 January 2024 - 31 December 2027
- Development of novel protein-based biomaterials for sustainable water purification from heavy metalsSwedish Research Council for Environment Agricultural Sciences and Spatial Planning1 January 2021 - 31 December 2024
Employments
- Assistant Professor, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2025
Degrees and Education
- Docent, Karolinska Institutet, 2024