Laboratory for protein misfolding and assembly
We work on the behavior of proteins under physiological and pathological conditions. One focus is to understand what makes certain proteins misfold and aggregate into amyloids in association with severe human diseases and to find ways to counteract these phenomena as an approach to treat neurodegenerative diseases, in particular Alzheimer´s, lung disease and cancer. We also want to understand the underlying molecular mechanisms to create biotechnological tools and novel biomaterials.
Our research aims to develop novel therapeutics based on detailed studies of protein structures and mechanisms of action.
We aim to understand amyloid formation in order to treat neurodegenerative disorders and to develop new protein-based biomaterials.
Our main research interests centre around the understanding of how molecular chaperones interfere with different types of protein aggregation and alleviate relevant toxicities for developing novel treatments, in particular against cancer and neurodegenerative diseases.
The major research line in my lab is spectroscopic and biophysical studies of amyloids to elucidate structure, function and assemblies.
Our research covers the area of developmental and metabolic biology. Specifically, we aim to understand:
1. Cellular dynamics that drive the formation of the intervertebral disc during embryonic development;
2. Cellular plasticity and diversity of adipose tissue in response to dietary intervention and temperature changes.