Arne Östman

Publikationer
CV
Populärvetenskap och samverkan

Utvalda publikationer

Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2023;115(1):71-82
Fibroblast subsets in non-small cell lung cancer: Associations with survival, mutations, and immune features
Pellinen T; Paavolainen L; Martin-Bernabe A; Araujo RP; Strell C; Mezheyeuski A; Backman M; La Fleur L; Bruck O; Sjolund J; Holmberg E; Valimaki K; Brunnstrom H; Botling J; Moreno-Ruiz P; Kallioniemi O; Micke P; Ostman A
Article: CLINICAL CANCER RESEARCH. 2021;27(12):3469-3477
High PDGFRb Expression Predicts Resistance to Radiotherapy in DCIS within the SweDCIS Randomized Trial
Strell C; Folkvaljon D; Holmberg E; Schiza A; Thurfjell V; Karlsson P; Bergh J; Bremer T; Akslen LA; Warnberg F; Ostman A
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2019;111(9):983-995
Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ
Strell C; Paulsson J; Jin S-B; Tobin NP; Mezheyeuski A; Roswall P; Mutgan C; Mitsios N; Johansson H; Wickberg SM; Svedlund J; Nilsson M; Hall P; Mulder J; Radisky DC; Pietras K; Bergh J; Lendahl U; Warnberg F; Ostman A
Article: CLINICAL CANCER RESEARCH. 2019;25(12):3702-3717
A Novel ACKR2-Dependent Role of Fibroblast-Derived CXCL14 in Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer
Sjoberg E; Meyrath M; Milde L; Herrera M; Lovrot J; Hagerstrand D; Frings O; Bartish M; Rolny C; Sonnhammer E; Andy CE; Augsten M; Ostman A
Article: CANCER RESEARCH. 2014;74(13):3408-3417
Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15
Bruzzese F; Hagglof C; Leone A; Sjoberg E; Roca MS; Kiflemariam S; Sjoblom T; Hammarsten P; Egevad L; Bergh A; Ostman A; Budillon A; Augsten M
Article: CANCER RESEARCH. 2014;74(11):2999-3010
Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties
Augsten M; Sjoberg E; Frings O; Vorrink SU; Frijhoff J; Olsson E; Borg A; Ostman A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(33):13398-13403
Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling
Dagnell M; Frijhoff J; Pader I; Augsten M; Boivin B; Xu J; Mandal PK; Tonks NK; Hellberg C; Conrad M; Arner ESJ; Ostman A
Article: CANCER RESEARCH. 2013;73(7):2139-2149
Distinct Effects of Ligand-Induced PDGFRα and PDGFRβ Signaling in the Human Rhabdomyosarcoma Tumor Cell and Stroma Cell Compartments
Ehnman M; Missiaglia E; Folestad E; Selfe J; Strell C; Thway K; Brodin B; Pietras K; Shipley J; Ostman A; Eriksson U
Article: CANCER RESEARCH. 2013;73(4):1287-1297
STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer
Pena C; Virtudes Cespedes M; Lindh MB; Kiflemariam S; Mezheyeuski A; Edqvist P-H; Hagglof C; Birgisson H; Bojmar L; Jirstrom K; Sandstrom P; Olsson E; Veerla S; Gallardo A; Sjoblom T; Chang AC-M; Reddel RR; Mangues R; Augsten M; Ostman A
Journal article: NATURE MEDICINE. 2012;18(9):1332-1334
The tumor microenvironment controls drug sensitivity
Ostman A

Artiklar

Article: CELL COMMUNICATION AND SIGNALING. 2025;23(1):184
Myogenic IGFBP5 levels in rhabdomyosarcoma are nourished by mesenchymal stromal cells and regulate growth arrest and apoptosis
Zhang Y; Katkhada K; Meng LZ; Zhao B; Tong S; Chaabane W; Kallai A; Tobin NP; Ostman A; Mega A; Ehnman M
Article: GYNECOLOGIC ONCOLOGY. 2025;193:148-155
High prevalence of FAP plus cancer-associated fibroblasts predicts poor outcome in patients with high-grade serous ovarian cancer with high CD8 T-cell density
Corvigno S; Fernebro J; Severin-Karisson J; Mezheieusky A; Martin-Bernabe A; Fuente LMDL; Westbom-Fremer S; Carlson JW; Klein C; Kannisto P; Hedenfalk I; Malander S; Ostma A; Dahlstrand H
Article: UPSALA JOURNAL OF MEDICAL SCIENCES. 2024;129:e10710
Interactions between cancer-associated fibroblasts and T-cells: functional crosstalk with targeting and biomarker potential
Milosevic V; Ostman A
Article: FRONTIERS IN IMMUNOLOGY. 2024;15:1325191
Development of 42 marker panel for in-depth study of cancer associated fibroblast niches in breast cancer using imaging mass cytometry
Rogenes H; Finne K; Winge I; Akslen LA; Ostman A; Milosevic V
Article: MABS. 2023;15(1):2223750
A PDGFRB- and CD40-targeting bispecific AffiMab induces stroma-targeted immune cell activation
Mega A; Mebrahtu A; Aniander G; Ryer E; Skold A; Sandegren A; Rydin EB; Rockberg J; Ostman A; Frejd FY
Article: CELL REPORTS. 2023;42(12):113507
Report VEGF-C-expressing TAMs rewire the metastatic fate of breast cancer cells
Banerjee K; Kerzel T; Bekkhus T; Ferreira SDS; Wallmann T; Wallerius M; Landwehr L-S; Agardy DA; Schauer N; Malmerfeldt A; Bergh J; Bartish M; Hartman J; Ostman A; Squadrito ML; Rolny C
Journal article: FRONTIERS IN IMMUNOLOGY. 2023;14:1283186
Biomarkers in the era of cancer immunotherapy: zooming in from the periphery to the tumor microenvironment
Charo J; Gomes B; Pietras K; Ostman A
Article: NATURE COMMUNICATIONS. 2023;14(1):5024
An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver
Moro CF; Geyer N; Harrizi S; Hamidi Y; Soderqvist S; Kuznyecov D; Tidholm Qvist E; Salmonson Schaad M; Hermann L; Lindberg A; Heuchel RL; Martin-Bernabe A; Dhanjal S; Navis AC; Villard C; del Valle AC; Bozoky L; Sparrelid E; Dirix L; Strell C; Ostman A; Schmierer B; Vermeulen PB; Engstrand J; Bozoky B; Gerling M
Article: BLOOD. 2023;142(1):73-89
Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option
Dolinska M; Cai H; Mansson A; Shen J; Xiao P; Bouderlique T; Li X; Leonard E; Chang M; Gao Y; Medina JP; Kondo M; Sandhow L; Johansson A-SF; Deneberg S; Soederlund S; Jaedersten M; Ungerstedt J; Tobiasson M; Ostman A; Mustjoki S; Stenke L; Le Blanc K; Hellstroem-Lindberg E; Lehmann S; Ekblom M; Olsson-Stroemberg U; Sigvarosson M; Qian H
Article: BREAST CANCER RESEARCH AND TREATMENT. 2023;200(2):293-304
Vessel size as a marker of survival in estrogen receptor positive breast cancer
Milosevic V; Edelmann RJ; Winge I; Strell C; Mezheyeuski A; Knutsvik G; Askeland C; Wik E; Akslen LA; Ostman A
Article: BIOLOGICAL IMAGING. 2023;3:e6
Visualization and quality control tools for large-scale multiplex tissue analysis in TissUUmaps3.
Behanova A; Avenel C; Andersson A; Chelebian E; Klemm A; Wik L; Östman A; Wählby C
Article: CYTOMETRY PART B-CLINICAL CYTOMETRY. 2021;99(12):1176-1186
Machine learning for cell classification and neighborhood analysis in glioma tissue
Solorzano L; Wik L; Olsson Bontell T; Wang Y; Klemm AH; Ofverstedt J; Jakola AS; Ostman A; Wahlby C
Article: JOURNAL OF PATHOLOGY CLINICAL RESEARCH. 2021;7(5):482-494
High tumor cell platelet-derived growth factor receptor beta expression is associated with shorter survival in malignant pleural epithelioid mesothelioma
Ollila H; Paajanen J; Wolff H; Ilonen I; Sutinen E; Valimaki K; ostman A; Anttila S; Kettunen E; Rasanen J; Kallioniemi O; Myllarniemi M; Mayranpaa MI; Pellinen T
Article: CANCERS. 2021;13(13):3151
High Density of NRF2 Expression in Malignant Cells Is Associated with Increased Risk of CNS Metastasis in Early-Stage NSCLC
Tsakonas G; Martin-Bernabe A; Rounis K; Moreno-Ruiz P; Botling J; De Petris L; Ylipaa A; Mezheyeuski A; Micke P; Ostman A; Ekman S
Article: BREAST CANCER RESEARCH AND TREATMENT. 2021;187(1):45-55
Prognostic and predictive impact of stroma cells defined by PDGFRb expression in early breast cancer: results from the randomized SweBCG91RT trial
Strell C; Stenmark Tullberg A; Jetne Edelmann R; Akslen LA; Malmstrom P; Ferno M; Holmberg E; Ostman A; Karlsson P
Article: LUNG CANCER. 2021;155:10-19
Stromal FAP is an independent poor prognosis marker in non-small cell lung adenocarcinoma and associated with p53 mutation
Moreno-Ruiz P; Corvigno S; te Grootenhuis NC; La Fleur L; Backman M; Strell C; Mezheyeuski A; Hoelzlwimmer G; Klein C; Botling J; Micke P; Ostman A
Article: CANCERS. 2021;13(5):1175
CD11c-CD8 Spatial Cross Presentation: A Novel Approach to Link Immune Surveillance and Patient Survival in Soft Tissue Sarcoma
Su Y; Tsagkozis P; Papakonstantinou A; Tobin NP; Gultekin O; Malmerfelt A; Ingelshed K; Neo SY; Lundquist J; Chaabane W; Nisancioglu MH; Leiss LW; Ostman A; Bergh J; Sedimbi S; Lehti K; Lundqvist A; Stragliotto CL; Haglund F; Ehnman M
Article: GYNECOLOGIC ONCOLOGY. 2020;159(3):860-868
High density of stroma-localized CD11c-positive macrophages is associated with longer overall survival in high-grade serous ovarian cancer
Corvigno S; Mezheyeuski A; De La Fuente LM; Westbom-Freme S; Carlson JW; Fernebro J; Avall-Lundqvist E; Kannisto P; Hedenfalk I; Malander S; Rolny C; Dahlstrand H; Ostman A
Article: CANCERS. 2020;12(11):E3238-3238
Prognostic Interactions between FAP plus Fibroblasts and CD8a+T Cells in Colon Cancer
Herrera M; Mezheyeuski A; Villabona L; Corvigno S; Strell C; Klein C; Holzlwimmer G; Glimelius B; Masucci G; Sjoblom T; Ostman A
Article: ELIFE. 2020;9:e59996
Cytotoxic T-cells mediate exercise-induced reductions in tumor growth
Rundqvist H; Velica P; Barbieri L; Gameiro PA; Bargiela D; Gojkovic M; Mijwel S; Reitzner SM; Wulliman D; Ahlstedt E; Ule J; Ostman A; Johnson RS
Article: CELL DEATH DISCOVERY. 2020;6(1):42
Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells
Cheteh EH; Sarne V; Ceder S; Bianchi J; Augsten M; Rundqvist H; Egevad L; Ostman A; Wiman KG
Article: GLIA. 2020;68(5):979-988
Platelet-derived growth factor receptor α/glial fibrillary acidic protein expressing peritumoral astrocytes associate with shorter median overall survival in glioblastoma patients
Leiss L; Mega A; Bontell TO; Nister M; Smits A; Corvigno S; Rahman MA; Enger PO; Miletic H; Ostman A
Article: GLIA. 2020;68(2):316-327
Astrocytes enhance glioblastoma growth
Mega A; Nilsen MH; Leiss LW; Tobin NP; Miletic H; Sleire L; Strell C; Nelander S; Krona C; Hagerstrand D; Enger PO; Nister M; Ostman A
Article: SCIENTIFIC REPORTS. 2020;10(1):281
Fibroblasts in urothelial bladder cancer define stroma phenotypes that are associated with clinical outcome
Mezheyeuski A; Segersten U; Leiss LW; Malmstrom P-U; Hatina J; Ostman A; Strell C
Article: SCIENCE ADVANCES. 2019;5(9):eaax2770
ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer
Kuninty PR; Bansal R; De Geus SWL; Mardhian DF; Schnittert J; van Baarlen J; Storm G; Bijlsma MF; van Laarhoven HW; Metselaar JM; Kuppen PJK; Vahrmeijer AL; Ostman A; Sier CFM; Prakash J
Article: PROSTATE. 2019;79(13):1505-1513
Fibroblast as a critical stromal cell type determining prognosis in prostate cancer
Blom S; Erickson A; Ostman A; Rannikko A; Mirtti T; Kallioniemi O; Pellinen T
Article: BRITISH JOURNAL OF CANCER. 2019;121(4):303-311
Stroma-normalised vessel density predicts benefit from adjuvant fluorouracil-based chemotherapy in patients with stage II/III colon cancer
Mezheyeuski A; Hrynchyk I; Herrera M; Karlberg M; Osterman E; Ragnhammar P; Edler D; Portyanko A; Ponten F; Sjoblom T; Glimelius B; Ostman A
Article: SCIENTIFIC REPORTS. 2019;9(1):10163
Differential prognostic impact of platelet-derived growth factor receptor expression in NSCLC
Kilvaer TK; Rakaee M; Hellevik T; Vik J; De Petris L; Donnem T; Strell C; Ostman A; Busund L-TR; Martinez-Zubiaurre I
Article: FASEB JOURNAL. 2019;33(5):6609-6621
Integrin 11 in pancreatic stellate cells regulates tumor stroma interaction in pancreatic cancer
Schnittert J; Bansal R; Mardhian DF; van Baarlen J; Ostman A; Prakash J
Article: BRITISH JOURNAL OF CANCER. 2018;119(7):840-846
A minority-group of renal cell cancer patients with high infiltration of CD20+B-cells is associated with poor prognosis
Sjoberg E; Frodin M; Lovrot J; Mezheyeuski A; Johansson M; Harmenberg U; Egevad L; Sandstrom P; Ostman A
Article: VIRCHOWS ARCHIV. 2018;472(3):395-405
Treatment-related survival associations of claudin-2 expression in fibroblasts of colorectal cancer
Mezheyeuski A; Strell C; Hrynchyk I; Guren TK; Dragomir A; Doroshenko T; Pashkova O; Gorgun J; Ruksha K; Pfeiffer P; Kure EH; Sorbye H; Edler D; Martling A; Glimelius B; Ostman A; Portyanko A
Article: SCIENCE TRANSLATIONAL MEDICINE. 2018;10(428):eaaf7444
Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy
Stafford WC; Peng X; Olofsson MH; Zhang X; Luci DK; Lu L; Cheng Q; Tresaugues L; Dexheimer TS; Coussens NP; Augsten M; Ahlzen H-SM; Orwar O; Ostman A; Stone-Elander S; Maloney DJ; Jadhav A; Simeonov A; Linder S; Arner ESJ
Article: PLOS ONE. 2018;13(2):e0192157
Tissue analyses reveal a potential immune-adjuvant function of FAP-1 positive fibroblasts in non-small cell lung cancer
Kilvaer TK; Rakaee M; Hellevik T; Ostman A; Strell C; Bremnes RM; Busund L-T; Donnem T; Martinez-Zubiaurre I
Article: NATURE BIOMEDICAL ENGINEERING. 2017;1(10):796-806
Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity
Tanaka N; Kanatani S; Tomer R; Sahlgren C; Kronqvist P; Kaczynska D; Louhivuori L; Kis L; Lindh C; Mitura P; Stepulak A; Corvigno S; Hartman J; Micke P; Mezheyeuski A; Strell C; Carlson JW; Moro CF; Dahlstrand H; Ostman A; Matsumoto K; Wiklund P; Oya M; Miyakawa A; Deisseroth K; Uhlen P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2017;292(35):14371-14380
Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H₂O₂ exposure
Dagnell M; Pace PE; Cheng Q; Frijhoff J; Ostman A; Arner ESJ; Hampton MB; Winterbourn CC
Article: JOURNAL OF PATHOLOGY CLINICAL RESEARCH. 2017;3(3):214-224
Multi-parametric profiling of renal cell, colorectal, and ovarian cancer identifies tumour-type-specific stroma phenotypes and a novel vascular biomarker
Corvigno S; Frodin M; Wisman GBA; Nijman HW; Van der Zee AGJ; Jirstrom K; Nodin B; Hrynchyk I; Edler D; Ragnhammar P; Johansson M; Dahlstrand H; Mezheyeuski A; Ostman A
Article: BRITISH JOURNAL OF CANCER. 2017;117(1):65-77
Stroma-regulated HMGA2 is an independent prognostic marker in PDAC and AAC
Strell C; Norberg KJ; Mezheyeuski A; Schnittert J; Kuninty PR; Moro CF; Paulsson J; Schultz NA; Calatayud D; Lohr JM; Frings O; Verbeke CS; Heuchel RL; Prakash J; Johansen JS; Ostman A
Article: CELL DEATH & DISEASE. 2017;8(6):e2848
Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death
Cheteh EH; Augsten M; Rundqvist H; Bianchi J; Sarne V; Egevad L; Bykov VJN; Ostman A; Wiman KG
Article: BRITISH JOURNAL OF CANCER. 2017;116(2):195-201
Perivascular PDGFR-β is an independent marker for prognosis in renal cell carcinoma
Frodin M; Mezheyeuski A; Corvigno S; Harmenberg U; Sandstrom P; Egevad L; Johansson M; Ostman A
Article: JOURNAL OF PATHOLOGY CLINICAL RESEARCH. 2017;3(1):38-43
High expression of stromal PDGFRβ is associated with reduced benefit of tamoxifen in breast cancer
Paulsson J; Ryden L; Strell C; Frings O; Tobin NP; Fornander T; Bergh J; Landberg G; Stal O; Ostman A
Article: SCIENTIFIC REPORTS. 2016;6:36149
Image analysis-derived metrics of histomorphological complexity predicts prognosis and treatment response in stage II-III colon cancer
Mezheyeuski A; Hrynchyk I; Karlberg M; Portyanko A; Egevad L; Ragnhammar P; Edler D; Glimelius B; Ostman A
Article: NATURE IMMUNOLOGY. 2016;17(11):1282-1290
Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype
Shen X; Burguillos MA; Osman AM; Frijhoff J; Carrillo-Jimenez A; Kanatani S; Augsten M; Saidi D; Rodhe J; Kavanagh E; Rongvaux A; Rraklli V; Nyman U; Holmberg J; Ostman A; Flavell RA; Barragan A; Venero JL; Blomgren K; Joseph B
Article: ONCOTARGET. 2016;7(27):41948-41958
Survival-associated heterogeneity of marker-defined perivascular cells in colorectal cancer
Mezheyeuski A; Lindh MB; Guren TK; Dragomir A; Pfeiffer P; Kure EH; Ikdahl T; Skovlund E; Corvigno S; Strell C; Pietras K; Ponten F; Mulder J; Qvortrup C; Portyanko A; Tveit KM; Glimelius B; Sorbye H; Ostman A
Article: BREAST CANCER RESEARCH AND TREATMENT. 2016;158(2):253-261
Amount of stroma is associated with mammographic density and stromal expression of oestrogen receptor in normal breast tissues
Gabrielson M; Chiesa F; Paulsson J; Strell C; Behmer C; Ronnow K; Czene K; Ostman A; Hall P
Article: CANCER RESEARCH. 2016;76(11):3166-3178
Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages
Wallerius M; Wallmann T; Bartish M; Ostling J; Mezheyeuski A; Tobin NP; Nygren E; Pangigadde P; Pellegrini P; Squadrito ML; Ponten F; Hartman J; Bergh J; DeMilito A; De Palma M; Ostman A; Andersson J; Rolny C
Article: CLINICAL CANCER RESEARCH. 2016;22(10):2417-2426
An Endothelial Gene Signature Score Predicts Poor Outcome in Patients with Endocrine-Treated, Low Genomic Grade Breast Tumors
Tobin NP; Wennmalm K; Lindstrom LS; Foukakis T; He L; Genove G; Ostman A; Landberg G; Betsholtz C; Bergh J
Article: BRITISH JOURNAL OF CANCER. 2016;114(10):1117-1124
Expression of the chemokine CXCL14 in the tumour stroma is an independent marker of survival in breast cancer
Sjoberg E; Augsten M; Bergh J; Jirstrom K; Ostman A
Article: ONCOTARGET. 2016;7(14):18573-18584
Markers of fibroblast-rich tumor stroma and perivascular cells in serous ovarian cancer: Inter- and intra-patient heterogeneity and impact on survival
Corvigno S; Wisman GBA; Mezheyeuski A; van der Zee AGJ; Nijman HW; Avall-Lundqvist E; Ostman A; Dahlstrand H
Article: ONCOTARGET. 2016;7(13):16396-16408
MicroRNA-199a and-214 as potential therapeutic targets in pancreatic stellate cells in pancreatic tumor
Kuninty PR; Bojmar L; Tjomsland V; Larsson M; Storm G; Ostman A; Sandstrom P; Prakash J
Article: FEBS OPEN BIO. 2016;6(3):179-189
Inhibition of Src homology 2 domain-containing phosphatase 1 increases insulin sensitivity in high-fat diet-induced insulin-resistant mice
Krueger J; Wellnhofer E; Meyborg H; Stawowy P; Ostman A; Kintscher U; Kappert K
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2015;107(10):djv209
Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells
Hong J; Tobin NP; Rundqvist H; Li T; Lavergne M; Garcia-Ibanez Y; Qin H; Paulsson J; Zeitelhofer M; Adzemovic MZ; Nilsson I; Roswall P; Hartman J; Johnson RS; Ostman A; Bergh J; Poljakovic M; Genove G
Article: HISTOLOGY AND HISTOPATHOLOGY. 2015;30(10):1203-1211
Inter- and intra-tumoral relationships between vasculature characteristics, GLUT1 and budding in colorectal carcinoma
Mezheyeuski A; Nerovnya A; Bich T; Tur G; Ostman A; Portyanko A
Article: NEURO-ONCOLOGY. 2015;17(7):953-964
Preclinical evaluation of dasatinib alone and in combination with cabozantinib for the treatment of diffuse intrinsic pontine glioma
Truffaux N; Philippe C; Paulsson J; Andreiuolo F; Guerrini-Rousseau L; Cornilleau G; Le Dret L; Richon C; Lacroix L; Puget S; Geoerger B; Vassal G; Oestman A; Grill J
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2015;757:59-67
SIRT1 inhibition in pancreatic cancer models: Contrasting effects in vitro and in vivo
Oon CE; Strell C; Yeong KY; Ostman A; Prakash J
Article: ANTIOXIDANTS & REDOX SIGNALING. 2015;22(11):938-950
Knockout of Mitochondrial Thioredoxin Reductase Stabilizes Prolyl Hydroxylase 2 and Inhibits Tumor Growth and Tumor-Derived Angiogenesis
Hellfritsch J; Kirsch J; Schneider M; Fluege T; Wortmann M; Frijhoff J; Dagnell M; Fey T; Esposito I; Koelle P; Pogoda K; Angeli JPF; Ingold I; Kuhlencordt P; Ostman A; Pohl U; Conrad M; Beck H
Article: MOLECULAR METABOLISM. 2015;4(4):325-336
Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout mice
Krueger J; Brachs S; Trappiel M; Kintscher U; Meyborg H; Wellnhofer E; Thoene-Reineke C; Stawowy P; Ostman A; Birkenfeld AL; Boehmer FD; Kappert K
Article: BRITISH JOURNAL OF CANCER. 2014;111(11):2091-2102
microRNA expression signatures of gastrointestinal stromal tumours: associations with imatinib resistance and patient outcome
Akcakaya P; Caramuta S; Ahlen J; Ghaderi M; Berglund E; Ostman A; Branstrom R; Larsson C; Lui W-O
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2014;92(9):983-994
Inhibition of protein tyrosine phosphatases enhances cerebral collateral growth in rats
Buschmann I; Hackbusch D; Gatzke N; Duelsner A; Trappiel M; Dagnell M; Ostman A; van Huijsduijnen RH; Kappert K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2014;450(4):1600-1605
Effects of epigenetic modificators in combination with small molecule inhibitors of receptor tyrosine kinases on medulloblastoma growth
Marino A-M; Frijhoff J; Calero R; Baryawno N; Ostman A; Johnsen JI
Journal article: SEMINARS IN CANCER BIOLOGY. 2014;25:1-2
Cancer-associated fibroblasts: Recent developments and emerging challenges
Ostman A
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2014;68:268-277
The mitochondrial reactive oxygen species regulator p66Shc controls PDGF-induced signaling and migration through protein tyrosine phosphatase oxidation
Frijhoff J; Dagnell M; Augsten M; Beltrami E; Giorgio M; Ostman A
Journal article: JOURNAL OF INTERNAL MEDICINE. 2013;274(2):102-104
Breast cancer biology and the future of tailored therapies
Bergh J; Hall P; Ostman A; Toftgard R
Article: CELL COMMUNICATION AND SIGNALING. 2013;11:49
Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice
Krueger J; Trappiel M; Dagnell M; Stawowy P; Meyborg H; Boehm C; Bhanot S; Ostman A; Kintscher U; Kappert K
Article: PLOS ONE. 2013;8(7):e67579
Effect of Acute Exercise on Prostate Cancer Cell Growth
Rundqvist H; Augsten M; Stromberg A; Rullman E; Mijwel S; Kharaziha P; Panaretakis T; Gustafsson T; Ostman A
Journal article: EXPERIMENTAL CELL RESEARCH. 2013;319(11):1595
Introduction to tumor-stroma interactions
Ostman A; Pietras K
Article: AMERICAN JOURNAL OF PATHOLOGY. 2013;182(6):2037-2047
Prognostic Significance in Breast Cancer of a Gene Signature Capturing Stromal PDGF Signaling
Frings O; Augsten M; Tobin NP; Carlson J; Paulsson J; Pena C; Olsson E; Veerla S; Bergh J; Ostman A; Sonnhammer ELL
Article: HISTOCHEMISTRY AND CELL BIOLOGY. 2012;138(6):847-860
Expression of the E-cadherin repressors Snail, Slug and Zeb1 in urothelial carcinoma of the urinary bladder: relation to stromal fibroblast activation and invasive behaviour of carcinoma cells
Schulte J; Weidig M; Balzer P; Richter P; Franz M; Junker K; Gajda M; Friedrich K; Wunderlich H; Ostman A; Petersen I; Berndt A
Article: INTERNATIONAL JOURNAL OF CANCER. 2012;131(10):2264-2273
CD99 is a novel prognostic stromal marker in non-small cell lung cancer
Edlund K; Lindskog C; Saito A; Berglund A; Ponten F; Goransson-Kultima H; Isaksson A; Jirstrom K; Planck M; Johansson L; Lambe M; Holmberg L; Nyberg F; Ekman S; Bergqvist M; Landelius P; Lamberg K; Botling J; Ostman A; Micke P
Article: MOLECULAR CANCER THERAPEUTICS. 2012;11(11):2419-2428
Selective Targeting of Interferon γ to Stromal Fibroblasts and Pericytes as a Novel Therapeutic Approach to Inhibit Angiogenesis and Tumor Growth
Bansal R; Tomar T; Ostman A; Poelstra K; Prakash J
Article: MOLECULAR CANCER RESEARCH. 2012;10(9):1158-1168
Cancer-Associated Fibroblasts Induce Matrix Metalloproteinase-Mediated Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma Cells
Johansson A-C; Ansell A; Jerhammar F; Lindh MB; Grenman R; Munck-Wikland E; Ostman A; Roberg K
Article: BLOOD. 2012;119(19):4499-4511
Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/PTPRJ
Godfrey R; Arora D; Bauer R; Stopp S; Mueller JP; Heinrich T; Boehmer S-A; Dagnell M; Schnetzke U; Scholl S; Ostman A; Boehmer F-D
Article: NEOPLASMA. 2012;59(6):719-727
Fibroblast-dependent regulation of the stem cell properties of cancer cells
Weiland A; Roswall P; Hatzihristidis TC; Pietras K; Ostman A; Strell C
Article: NEURO-ONCOLOGY. 2011;13(11):1178-1191
Identification of a SOX2-dependent subset of tumor- and sphere-forming glioblastoma cells with a distinct tyrosine kinase inhibitor sensitivity profile
Hagerstrand D; He X; Lindh MB; Hoefs S; Hesselager G; Ostman A; Nister M
Article: CELL. 2011;146(5):826-840
Global Proteomic Assessment of the Classical Protein-Tyrosine Phosphatome and "Redoxome''
Karisch R; Fernandez M; Taylor P; Virtanen C; St-Germain JR; Jin LL; Harris IS; Mori J; Mak TW; Senis YA; Ostman A; Moran MF; Neel BG
Article: CELLULAR SIGNALLING. 2011;23(5):820-826
Hypoxia followed by re-oxygenation induces oxidation of tyrosine phosphatases
Sandin A; Dagnell M; Gonon A; Pernow J; Stangl V; Aspenstrom P; Kappert K; Ostman A
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2011;183(8):1092-1102
Hypoxia Enhances Platelet-derived Growth Factor Signaling in the Pulmonary Vasculature by Down-Regulation of Protein Tyrosine Phosphatases
ten Freyhaus H; Dagnell M; Leuchs M; Vantler M; Berghausen EM; Caglayan E; Weissmann N; Dahal BK; Schermuly RT; Oestman A; Kappert K; Rosenkranz S
Article: INTERNATIONAL JOURNAL OF CANCER. 2011;128(8):1981-1988
Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma
Paulsson J; Lindh MB; Jarvius M; Puputti M; Nister M; Nupponen NN; Paulus W; Soderberg O; Dresemann G; von Deimling A; Joensuu H; Ostman A; Hasselblatt M
Article: SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY. 2011;45(1):39-45
GAD1 is a biomarker for benign and malignant prostatic tissue
Jaraj SJ; Augsten M; Haggarth L; Wester K; Ponten F; Ostman A; Egevad L
Article: SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY. 2011;45(1):60-67
Diagnostic biomarkers of prostate cancer
Haggarth L; Hagglof C; Jaraj SJ; Wester K; Ponten F; Ostman A; Egevad L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(36):15774-15779
12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases
Conrad M; Sandin A; Foerster H; Seiler A; Frijhoff J; Dagnell M; Bornkamm GW; Radmark O; van Huijsduijnen RH; Aspenstrom P; Boehmer F; Ostman A
Article: NEURO-ONCOLOGY. 2010;12(9):967-975
PI3K/PTEN/Akt pathway status affects the sensitivity of high-grade glioma cell cultures to the insulin-like growth factor-1 receptor inhibitor NVP-AEW541
Hagerstrand D; Lindh MB; Pena C; Garcia-Echeverria C; Nister M; Hofmann F; Ostman A
Article: ANTI-CANCER DRUGS. 2010;21(8):759-765
Chimeric tyrosine kinase-HDAC inhibitors as antiproliferative agents
Uecker A; Sicker M; Beckers T; Mahboobi S; Hagerstrand D; Ostman A; Bohmer F-D
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(34):26417-26430
Differential Up-regulation of MAP Kinase Phosphatases MKP3/DUSP6 and DUSP5 by Ets2 and c-Jun Converge in the Control of the Growth Arrest Versus Proliferation Response of MCF-7 Breast Cancer Cells to Phorbol Ester
Nunes-Xavier CE; Tarrega C; Cejudo-Marin R; Frijhoff J; Sandin A; Ostman A; Pulido R
Article: PLOS ONE. 2010;5(5):e10747
Stromal PDGFRβ Expression in Prostate Tumors and Non-Malignant Prostate Tissue Predicts Prostate Cancer Survival
Hagglof C; Hammarsten P; Josefsson A; Stattin P; Paulsson J; Bergh A; Ostman A
Article: CANCER RESEARCH. 2010;70(7):2644-2654
Forkhead Box F1 Regulates Tumor-Promoting Properties of Cancer-Associated Fibroblasts in Lung Cancer
Saito R-A; Micke P; Paulsson J; Augsten M; Pena C; Jonsson P; Botling J; Edlund K; Johansson L; Carlsson P; Jirstrom K; Miyazono K; Ostman A
Article: CANCER MICROENVIRONMENT. 2010;3(1):167-176
A Digest on the Role of the Tumor Microenvironment in Gastrointestinal Cancers
Augsten M; Hagglof C; Pena C; Ostman A
Article: AMERICAN JOURNAL OF PATHOLOGY. 2009;175(4):1631-1637
Platelet-Derived Growth Factor Receptor Expression and Activation in Choroid Plexus Tumors
Koos B; Paulsson J; Jarvius M; Sanchez BC; Wrede B; Mertsch S; Jeibmann A; Kruse A; Peters O; Wolff JEA; Galla H-J; Soderberg O; Paulus W; Ostman A; Hasselblatt M
Article: AMERICAN JOURNAL OF PATHOLOGY. 2009;175(1):334-341
Prognostic Significance of Stromal Platelet-Derived Growth Factor β-Receptor Expression in Human Breast Cancer
Paulsson J; Sjoblom T; Micke P; Ponten F; Landberg G; Heldin C-H; Bergh J; Brennan DJ; Jirstrom K; Ostman A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;382(4):678-684
Regulation of tyrosine phosphatases in the adventitia during vascular remodelling
Micke P; Hackbusch D; Mercan S; Stawowy P; Tsuprykov O; Unger T; Ostman A; Kappert K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(9):3414-3419
CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth
Augsten M; Hagglof C; Olsson E; Stolz C; Tsagozis P; Levchenko T; Frederick MJ; Borg A; Micke P; Egevad L; Ostman A
Article: INTERNATIONAL JOURNAL OF CANCER. 2009;124(5):1227-1234
Metronomic scheduling of imatinib abrogates clonogenicity of neuroblastoma cells and enhances their susceptibility to selected chemotherapeutic drugs in vitro and in vivo
Paimberg E; Johnsen JI; Paulsson J; Gleissman H; Wickstrom M; Edgren M; Ostman A; Kogner P; Lindskog M
Journal article: NATURE MEDICINE. 2009;15(3):237-238
Stromal signature identifies basal breast cancers
Wennmalm K; Ostman A; Bergh J
Article: ARCHIVES OF DERMATOLOGICAL RESEARCH. 2008;300(9):505-516
Regeneration of human epidermis on acellular dermis is impeded by small-molecule inhibitors of EGF receptor tyrosine kinase
Forsberg S; Ostman A; Rollman O
Article: NUCLEIC ACIDS RESEARCH. 2008;36(13):4443-4453
The structure of the 5′-end of the protein-tyrosine phosphatase PTPRJ mRNA reveals a novel mechanism for translation attenuation
Karagyozov L; Godfrey R; Boehmer S-A; Petermann A; Hoelters S; Ostman A; Boehmer F-D
Article: CIRCULATION RESEARCH. 2008;103(2):149-158
Redox-sensitive signaling by angiotensin II involves oxidative inactivation and blunted phosphorylation of protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells from SHR
Tabet F; Schiffrin EL; Callera GE; He Y; Yao G; Ostman A; Kappert K; Tonks NK; Touyz RM
Article: INTERNATIONAL JOURNAL OF CANCER. 2008;122(7):1548-1556
The effects of tumor-derived platelet-derived growth factor on vascular morphology and function in vivo revealed by susceptibility MRI
Robinson SP; Ludwig C; Paulsson J; Oestman A
Article: BRITISH JOURNAL OF DERMATOLOGY. 2008;158(3):527-538
Expression profiling of microdissected cell populations selected from basal cells in normal epidermis and basal cell carcinoma
Asplund A; Bjorklund MG; Sundquist C; Stromberg S; Edlund K; Oestman A; Nilsson P; Ponten F; Lundeberg J
Article: MODERN PATHOLOGY. 2008;21(3):265-270
Platelet-derived growth factor receptor expression and amplification in choroid plexus carcinomas
Nupponen NN; Paulsson J; Jeibmann A; Wrede B; Tanner M; Wolff JEA; Paulus W; Ostman A; Hasselblatt M
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2008;19(2):281-289
PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis
Eitner F; Buecher E; van Roeyen C; Kunter U; Rong S; Seikrit C; Villa L; Boor P; Fredriksson L; Bakstrom G; Eriksson U; Ostman A; Floege J; Ostendorf T
Article: NEURO-ONCOLOGY. 2008;10(1):2-9
Gene expression analyses of grade II gliomas and identification of rPTPβ/ζ as a candidate oligodendroglioma marker
Haegerstrand D; Smits A; Eriksson A; Sigurclarclottir S; Olofsson T; Hartman M; Nister M; Kalimo H; Oetman A
Article: JOURNAL OF ENDODONTICS. 2008;34(1):14-21
Profiling of radicular cyst and odontogenic keratocyst cytokine production suggests common growth mechanisms
Hayashi M; Ohshima T; Ohshima M; Yamaguchi Y; Miyata H; Takeichi O; Ogiso B; Ito K; Ostman A; Otsuka K
Article: INTERNATIONAL JOURNAL OF CANCER. 2007;121(12):2606-2614
Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling
Hasumi Y; Klosowska-Wardega A; Furuhashi M; Ostman A; Heldin C-H; Hellberg C
Article: MOLECULAR & CELLULAR PROTEOMICS. 2007;6(9):1500-1509
In situ detection of phosphorylated platelet-derived growth factor receptor β using a generalized proximity ligation method
Jarvius M; Paulsson J; Weibrecht I; Leuchowius K-J; Andersson A-C; Wahlby C; Gullberg M; Botling J; Sjoblom T; Markova B; Ostman A; Landegren U; Soderberg O
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2007;43(1):100-110
Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2
Weibrecht I; Boehmer S-A; Dagnell M; Kappert K; Ostman A; Boehmer F-D
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2007;127(6):1516-1523
In situ identification of genes regulated specifically in fibroblasts of human basal cell carcinoma
Micke P; Kappert K; Ohshima M; Sundquist C; Scheidl S; Linclahl P; Heldin C-H; Botlinl L; Ponten F; Ostman A
Article: FASEB JOURNAL. 2007;21(2):523-534
Dynamic changes in the expression of DEP-1 and other PDGF receptor-antagonizing PTPs during onset and termination of neointima formation
Kappert K; Paulsson J; Sparwel J; Leppanen O; Hellberg C; Ostman A; Micke P
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2006;26(12):2644-2651
Antioxidants relieve phosphatase inhibition and reduce PDGF signaling in cultured VSMCs and in restenosis
Kappert K; Sparwel J; Sandin A; Seiler A; Siebolts U; Leppanen O; Rosenkranz S; Ostman A
Article: JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 2006;43(4):383-392
Highly active antiretroviral therapy attenuates re-endothelialization and alters neointima formation in the rat carotid artery after balloon injury
Kappert K; Leppanen O; Paulsson J; Furuhashi M; Carlsson M-A; Heldin C-H; Fatkenheuer G; Rosenkranz S; Ostman A
Article: MOLECULAR BIOLOGY OF THE CELL. 2006;17(11):4846-4855
Loss of T-cell protein tyrosine phosphatase induces recycling of the platelet-derived growth factor (PDGF) β-receptor but not the PDGF α-receptor
Karlsson S; Kowanetz K; Sandin A; Persson C; Ostman A; Heldin C-H; Hellberg C
Article: ONCOGENE. 2006;25(47):6319-6324
DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients
Balavenkatraman KK; Jandt E; Friedrich K; Kautenburger T; Pool-Zobel BL; Ostman A; Boehmer FD
Article: ONCOGENE. 2006;25(35):4913-4922
Characterization of an imatinib-sensitive subset of high-grade human glioma cultures
Hagerstrand D; Hesselager G; Achterberg S; Bolin UW; Kowanetz M; Kastemar M; Heldin C-H; Isaksson A; Nister M; Ostman A
Article: LABORATORY INVESTIGATION. 2006;86(2):202-211
Biobanking of fresh frozen tissue: RNA is stable in nonfixed surgical specimens
Micke P; Ohshima M; Tahmasebpoor S; Ren ZP; Östman A; Pontén F; Botling J
Article: CANCER RESEARCH. 2005;65(17):7824-7831
Effect of platelet-derived growth factor receptor-β inhibition with STI571 on radioimmunotherapy
Baranowska-Kortylewicz J; Abe M; Pietras K; Kortylewicz ZP; Kurizaki T; Nearman J; Paulsson J; Mosley RL; Enke CA; Östman A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(11):10298-10304
Differential oxidation of protein-tyrosine phosphatases
Groen A; Lemeer S; van der Wijk T; Overvoorde J; Heck AJR; Ostman A; Barford D; Slijper M; den Hertog J
Article: METHODS. 2005;35(1):37-43
An antibody-based method for monitoring in vivo oxidation of protein tyrosine phosphatases
Persson C; Kappert K; Engström U; Östman A; Sjöblom T
Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2004;45(7):2075-2082
c-Kit-dependent growth of uveal melanoma cells: A potential therapeutic target?
All-Ericsson C; Girnita L; Müller-Brunotte A; Brodin B; Seregard S; Östman A; Larsson O
Article: CANCER RESEARCH. 2004;64(8):2725-2733
Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate
Furuhashi M; Sjöblom T; Abramsson A; Ellingsen J; Micke P; Li H; Bergsten-Folestad E; Eriksson U; Heuchel R; Betsholtz C; Heldin CH; Östman A
Article: CIRCULATION. 2004;109(9):1140-1146
Oral imatinib mesylate (STI571/Gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits
Leppänen O; Rutanen J; Hiltunen MO; Rissanen TT; Turunen MP; Sjöblom T; Brüggen J; Bäckström G; Carlsson M; Buchdunger E; Bergqvist D; Alitalo K; Heldin CH; Östman A; Ylä-Herttuala S
Article: MOLECULAR AND CELLULAR BIOLOGY. 2004;24(5):2190-2201
Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.
Persson C; Sävenhed C; Bourdeau A; Tremblay ML; Markova B; Böhmer FD; Haj FG; Neel BG; Elson A; Heldin C-H; Rönnstrand L; Ostman A; Hellberg C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(7):1886-1891
Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases.
Persson C; Sjöblom T; Groen A; Kappert K; Engström U; Hellman U; Heldin C-H; den Hertog J; Ostman A
Article: EUROPEAN JOURNAL OF CANCER. 2004;40(2):267-274
Smad2 suppresses the growth of Mv1Lu cells subcutaneously inoculated in mice.
Sjöblom T; Yakymovych I; Heldin C-H; Ostman A; Souchelnytskyi S
Article: JOURNAL OF PATHOLOGY. 2004;202(1):130-138
A fluid cover medium provides superior morphology and preserves RNA integrity in tissue sections for laser microdissection and pressure catapulting.
Micke P; Bjørnsen T; Scheidl S; Strömberg S; Demoulin J-B; Ponten F; Ostman A; Lindahl P; Busch C
Article: AMBIO. 2003;32(8):495-501
Evaluation of environmental monitoring strategies.
Rönnbäck B-I; Nordberg M-L; Olsson A; Ostman A
Article: CLINICAL CANCER RESEARCH. 2003;9(10 Pt 1):3779-3787
STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake.
Pietras K; Stumm M; Hubert M; Buchdunger E; Rubin K; Heldin C-H; McSheehy P; Wartmann M; Ostman A
Article: GENES & DEVELOPMENT. 2003;17(15):1835-1840
Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall.
Lindblom P; Gerhardt H; Liebner S; Abramsson A; Enge M; Hellstrom M; Backstrom G; Fredriksson S; Landegren U; Nystrom HC; Bergstrom G; Dejana E; Ostman A; Lindahl P; Betsholtz C
Article: AMERICAN JOURNAL OF PATHOLOGY. 2003;163(2):673-682
Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy
Pontén A; Li XR; Thorén P; Aase K; Sjöblom T; Östman A; Eriksson U
Article: ONCOGENE. 2003;22(27):4175-4185
The protein-tyrosine phosphatase DEP-1 modulates growth factor-stimulated cell migration and cell-matrix adhesion.
Jandt E; Denner K; Kovalenko M; Ostman A; Böhmer F-D
Article: CANCER CELL. 2003;3(5):439-443
PDGF receptors as cancer drug targets.
Pietras K; Sjöblom T; Rubin K; Heldin C-H; Ostman A
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2003;120(5):742-749
Platelet derived growth factor (PDGF) responsive epidermis formed from human keratinocytes transduced with the PDGF beta receptor gene.
Rollman O; Jensen UB; Ostman A; Bolund L; Gústafsdóttir SM; Jensen TG
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2003;11(9):2007-2018
Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit.
Gazit A; Yee K; Uecker A; Böhmer F-D; Sjöblom T; Ostman A; Waltenberger J; Golomb G; Banai S; Heinrich MC; Levitzki A
Article: FASEB JOURNAL. 2002;16(12):1575-1583
Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-αα and -αβ receptors
Cao RH; Bråkenhielm E; Li XR; Pietras K; Widenfalk J; Östman A; Eriksson U; Cao YH
Article: CANCER RESEARCH. 2002;62(19):5476-5484
Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy.
Pietras K; Rubin K; Sjöblom T; Buchdunger E; Sjöquist M; Heldin C-H; Ostman A
Article: NATURE BIOTECHNOLOGY. 2002;20(5):473-477
Protein detection using proximity-dependent DNA ligation assays.
Fredriksson S; Gullberg M; Jarvius J; Olsson C; Pietras K; Gústafsdóttir SM; Ostman A; Landegren U
Article: FEBS LETTERS. 2002;517(1-3):27-31
Primary sequence determinants responsible for site-selective dephosphorylation of the PDGF beta-receptor by the receptor-like protein tyrosine phosphatase DEP-1.
Persson C; Engström U; Mowbray SL; Ostman A
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2002;398(2):284-290
New members of the platelet-derived growth factor family of mitogens
Heldin CH; Eriksson U; Östman A
Article: ONCOGENE. 2001;20(37):5219-5224
An extracellular ligand increases the specific activity of the receptor-like protein tyrosine phosphatase DEP-1.
Sörby M; Sandström J; Ostman A
Article: CANCER RESEARCH. 2001;61(15):5778-5783
Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis
Sjöblom T; Shimizu A; O'Brien KP; Pietras K; Dal Cin P; Buchdunger E; Dumanski JP; Östman A; Heldin CH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(30):27749-27752
Ligand stimulation reduces platelet-derived growth factor beta-receptor susceptibility to tyrosine dephosphorylation.
Shimizu A; Persson C; Heldin CH; Ostman A
Article: NATURE CELL BIOLOGY. 2001;3(5):512-516
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.
Bergsten E; Uutela M; Li X; Pietras K; Ostman A; Heldin CH; Alitalo K; Eriksson U
Article: CANCER RESEARCH. 2001;61(7):2929-2934
Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors.
Pietras K; Ostman A; Sjöquist M; Buchdunger E; Reed RK; Heldin CH; Rubin K
Article: CANCER RESEARCH. 2000;60(23):6723-6729
Antiangiogenic effects of latent antithrombin through perturbed cell-matrix interactions and apoptosis of endothelial cells.
Larsson H; Sjöblom T; Dixelius J; Ostman A; Ylinenjärvi K; Björk I; Claesson-Welsh L
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2000;20(11):E89-E95
Intimal hyperplasia recurs after removal of PDGF-AB and -BB inhibition in the rat carotid artery injury model.
Leppänen O; Janjic N; Carlsson MA; Pietras K; Levin M; Vargeese C; Green LS; Bergqvist D; Ostman A; Heldin CH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(21):16219-16226
Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1.
Kovalenko M; Denner K; Sandström J; Persson C; Gross S; Jandt E; Vilella R; Böhmer F; Ostman A
Article: NATURE CELL BIOLOGY. 2000;2(5):302-309
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
Li X; Pontén A; Aase K; Karlsson L; Abramsson A; Uutela M; Bäckström G; Hellström M; Boström H; Li H; Soriano P; Betsholtz C; Heldin CH; Alitalo K; Ostman A; Eriksson U
Article: BIOCHEMISTRY. 2000;39(9):2370-2375
Predimerization of recombinant platelet-derived growth factor receptor extracellular domains increases antagonistic potency.
Leppänen O; Miyazawa K; Bäckström G; Pietras K; Sjöblom T; Heldin CH; Ostman A
Article: INTERNATIONAL JOURNAL OF CANCER. 2000;85(3):398-406
Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells.
Uhrbom L; Hesselager G; Ostman A; Nistér M; Westermark B
Article: ONCOGENE. 1999;18(50):7055-7062
Characterization of the chronic myelomonocytic leukemia associated TEL-PDGF beta R fusion protein.
Sjöblom T; Boureux A; Rönnstrand L; Heldin CH; Ghysdael J; Ostman A
Article: CANCER RESEARCH. 1999;59(15):3719-3723
The dermatofibrosarcoma protuberans-associated collagen type Iα1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB
Shimizu A; O'Brien KP; Sjöblom T; Pietras K; Buchdunger E; Collins VP; Heldin CH; Dumanski JP; Östman A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(39):25495-25502
Role of immunoglobulin-like domains 2-4 of the platelet-derived growth factor alpha-receptor in ligand-receptor complex assembly.
Miyazawa K; Bäckström G; Leppänen O; Persson C; Wernstedt C; Hellman U; Heldin CH; Ostman A
Article: CANCER RESEARCH. 1997;57(24):5598-5604
Cell scattering and migration induced by autocrine transforming growth factor alpha in human glioma cells in vitro.
El-Obeid A; Bongcam-Rudloff E; Sörby M; Ostman A; Nistér M; Westermark B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(37):23317-23322
Identification of a 190-kDa vascular endothelial growth factor 165 cell surface binding protein on a human glioma cell line.
Omura T; Miyazawa K; Ostman A; Heldin CH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(19):12676-12682
Immunoglobulin-like domain 4-mediated receptor-receptor interactions contribute to platelet-derived growth factor-induced receptor dimerization.
Omura T; Heldin CH; Ostman A
Article: INTERNATIONAL JOURNAL OF CANCER. 1996;68(6):802-809
Production of cell-associated PDGF-AA by a human sarcoma cell line: evidence for a latent autocrine effect.
Afrakhte M; Nistér M; Ostman A; Westermark B; Paulsson Y
Article: BIOCHEMISTRY. 1996;35(45):14413-14424
Inhibitory DNA ligands to platelet-derived growth factor B-chain.
Green LS; Jellinek D; Jenison R; Ostman A; Heldin CH; Janjic N
Article: FEBS LETTERS. 1996;385(3):181-184
Identification of three amino acid residues in the B-chain of platelet-derived growth factor with different importance for binding to PDGF alpha- and beta-receptors.
Kreysing J; Ostman A; van de Poll M; Bäckström G; Heldin CH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(18):10963-10966
Protein-tyrosine phosphatase-mediated decrease of epidermal growth factor and platelet-derived growth factor receptor tyrosine phosphorylation in high cell density cultures.
Sörby M; Ostman A
Article: GROWTH FACTORS. 1995;12(2):159-164
Involvement of loop 2 of platelet-derived growth factor-AA and -BB in receptor binding.
Andersson M; Ostman A; Kreysing J; Bäckström G; Van de Poll M; Heldin CH
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The diverse and complex roles of atypical chemokine receptors in cancer: From molecular biology to clinical relevance and therapy
Sjoberg E; Meyrath M; Chevigne A; Ostman A; Augsten M; Szpakowska M
Review: TRENDS IN CANCER. 2018;4(12):838-848
Microvascular Mural Cells in Cancer
Ostman A; Corvigno S
Corrigendum: NATURE BIOMEDICAL ENGINEERING. 2018;2(1):48
Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity (vol 1, pg 796, 2017)
Tanaka N; Kanatani S; Tomer R; Sahlgren C; Kronqvist P; Kaczynska D; Louhivuori L; Kis L; Lindh C; Mitura P; Stepulak A; Corvigno S; Hartman J; Micke P; Mezheyeuski A; Strell C; Carlson JW; Moro CF; Dahlstrand H; Ostman A; Matsumoto K; Wiklund P; Oya M; Miyakawa A; Deisseroth K; Uhlen P
Review: ADVANCED DRUG DELIVERY REVIEWS. 2017;121:117-123
PDGF receptors in tumor stroma: Biological effects and associations with prognosis and response to treatment
Ostman A
Review: ANTIOXIDANTS & REDOX SIGNALING. 2014;20(13):1994-2010
Regulation of Protein Tyrosine Phosphatase Oxidation in Cell Adhesion and Migration
Frijhoff J; Dagnell M; Godfrey R; Ostman A
Review: EXPERT OPINION ON INVESTIGATIONAL DRUGS. 2014;23(2):211-226
Therapeutic targeting of platelet-derived growth factor receptors in solid tumors
Ehnman M; Oestman A
Review: FUTURE ONCOLOGY. 2014;10(9):1695-1708
PDGF receptors in tumor biology: prognostic and predictive potential
Paulsson J; Ehnman M; Ostman A
Review: FEBS JOURNAL. 2013;280(2):413-431
Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis
Boehmer F; Szedlacsek S; Tabernero L; Ostman A; den Hertog J
Review: UPSALA JOURNAL OF MEDICAL SCIENCES. 2012;117(2):187-195
Fibroblasts-a key host cell type in tumor initiation, progression, and metastasis
Strell C; Rundqvist H; Ostman A
Review: JOURNAL OF BIOCHEMISTRY. 2011;150(4):345-356
Regulation of protein tyrosine phosphatases by reversible oxidation
Ostman A; Frijhoff J; Sandin A; Boehmer F-D
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1324-1331
Hallmarks of cancer: Interactions with the tumor stroma
Pietras K; Ostman A
Review: LAKARTIDNINGEN. 2010;107(16):1066-1070
[Intensive search for agents that knock out tumor growth].
Ostman A
Review: RECENT RESULTS IN CANCER RESEARCH. 2010;180:103-114
PDGF and vessel maturation.
Hellberg C; Ostman A; Heldin C-H
Review: CURRENT OPINION IN GENETICS & DEVELOPMENT. 2009;19(1):67-73
Cancer-associated fibroblasts and tumor growth - bystanders turning into key players
Oestman A; Augsten M
Review: FEBS JOURNAL. 2008;275(5):831-847
Protein tyrosine phosphatases: regulatory mechanisms.
den Hertog J; Ostman A; Böhmer F-D
Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2007;97:247-274
PDGF receptors as targets in tumor treatment
Ostman A; Heldin C-H
Review: NATURE REVIEWS CANCER. 2006;6(4):307-320
Protein-tyrosine phosphatases and cancer
Östman A; Hellberg C; Böhmer FD
Review: EXPERT OPINION ON THERAPEUTIC TARGETS. 2005;9(6):1217-1233
Exploring the tumour environment: cancer-associated fibroblasts as targets in cancer therapy
Micke P; Östman A
Review: CARDIOVASCULAR RESEARCH. 2005;65(3):587-598
Tyrosine phosphatases in vessel wall signaling
Kappert K; Peters KG; Böhmer FD; Östman A
Review: METHODS IN MOLECULAR BIOLOGY. 2005;293:151-166
Laser-assisted cell microdissection using the PALM system.
Micke P; Ostman A; Lundeberg J; Ponten F
Review: NATURE REVIEWS CANCER. 2004;4(10):806-813
High interstitial fluid pressure -: An obstacle in cancer therapy
Heldin CH; Rubin K; Pietras K; Östman A
Published conference paper: LUNG CANCER. 2004;45 Suppl 2:S163-S175
Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?
Micke P; Ostman A
Review: CYTOKINE & GROWTH FACTOR REVIEWS. 2004;15(4):275-286
PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma
Östman A
Review: TRENDS IN CELL BIOLOGY. 2001;11(6):258-266
Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases.
Ostman A; Böhmer FD
Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2001;80:1-38
Involvement of platelet-derived growth factor in disease: development of specific antagonists.
Ostman A; Heldin CH
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1998;1378(1):F79-113
Signal transduction via platelet-derived growth factor receptors.
Heldin CH; Ostman A; Rönnstrand L
Review: CYTOKINE & GROWTH FACTOR REVIEWS. 1996;7(1):3-10
Ligand-induced dimerization of growth factor receptors: variations on the theme.
Heldin CH; Ostman A
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Professor, Senior, Onkologi-Patologi, Karolinska Institutet, 2025-2026
Professor, Onkologi-Patologi, Karolinska Institutet, 2006-2025

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