Anna Pasetto

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: GUT. 2025;74(7):1125-1136
Unlocking novel T cell-based immunotherapy for hepatocellular carcinoma through neoantigen-driven T cell receptor isolation
Maravelia P; Yao H; Cai C; Silva DN; Fransson J; Nilsson OB; Lu Y-CW; Micke P; Botling J; Gatto F; Rovesti G; Carlsten M; Sallberg M; Stal P; Jorns C; Buggert M; Pasetto A
Article: HLA. 2025;105(1):e70011
Exploring the Relationship Between Humoral and Cellular T Cell Responses Against SARS-CoV-2 in Exposed Individuals From Emilia Romagna Region and COVID-19 Severity
Mazzotti L; de Souza PB; Azzali I; Angeli D; Nanni O; Sambri V; Semprini S; Bravaccini S; Cerchione C; Gaimari A; Nicolini F; Ancarani V; Martinelli G; Pasetto A; Calderon H; Juan M; Mazza M
Article: MOLECULAR THERAPY. 2024;32(2):540-555
Distinct roles of vaccine-induced SARS-CoV-2-specific neutralizing antibodies and T cells in protection and disease
Yan J; Bangalore CR; Nikouyan N; Appelberg S; Silva DN; Yao H; Pasetto A; Weber F; Weber S; Larsson O; Hoglund U; Bogdanovic G; Grabbe M; Aleman S; Szekely L; Szakos A; Tuvesson O; Gidlund E-K; Cadossi M; Salati S; Tegel H; Hober S; Frelin L; Mirazimi A; Ahlen G; Sallberg M
Article: NPJ PRECISION ONCOLOGY. 2024;8(1):26
Autologous anti-GD2 CAR T cells efficiently target primary human glioblastoma
Chiavelli C; Prapa M; Rovesti G; Silingardi M; Neri G; Pugliese G; Trudu L; Dall'Ora M; Golinelli G; Grisendi G; Vinet J; Bestagno M; Spano C; Papapietro RV; Depenni R; Di Emidio K; Pasetto A; Nascimento Silva D; Feletti A; Berlucchi S; Iaccarino C; Pavesi G; Dominici M
Article: GUT. 2023;72(6):1186-1195
Novel prime-boost immune-based therapy inhibiting both hepatitis B and D virus infections
Burm R; Maravelia P; Ahlen G; Ciesek S; Perez NC; Pasetto A; Urban S; Van Houtte F; Verhoye L; Wedemeyer H; Johansson M; Frelin L; Sallberg M; Meuleman P
Article: CELL REPORTS. 2022;40(5):111153
Cancer genes disfavoring T cell immunity identified via integrated systems approach
Kishton RJ; Patel SJ; Decker AE; Vodnala SK; Cam M; Yamamoto TN; Patel Y; Sukumar M; Yu Z; Ji M; Henning AN; Gurusamy D; Palmer DC; Stefanescu RA; Girvin AT; Lo W; Pasetto A; Malekzadeh P; Deniger DC; Wood KC; Sanjana NE; Restifo NP
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2574:209-219
T-Cell Repertoire Characterization.
Pasetto A; Buggert M
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:896242
Process Development for Adoptive Cell Therapy in Academia: A Pipeline for Clinical-Scale Manufacturing of Multiple TCR-T Cell Products
Silva DN; Chrobok M; Rovesti G; Healy K; Wagner AK; Maravelia P; Gatto F; Mazza M; Mazzotti L; Lohmann V; Chen MS; Sallberg M; Buggert M; Pasetto A
Article: JOURNAL OF INFECTIOUS DISEASES. 2021;223(1):128-138
Blocking Entry of Hepatitis B and D Viruses to Hepatocytes as a Novel Immunotherapy for Treating Chronic Infections
Maravelia P; Frelin L; Ni Y; Perez NC; Ahlen G; Jagya N; Verch G; Verhoye L; Pater L; Johansson M; Pasetto A; Meuleman P; Urban S; Sallberg M
Article: JOURNAL OF IMMUNOTHERAPY. 2021;44(1):1-8
Rapid Identification and Evaluation of Neoantigen-reactive T-Cell Receptors From Single Cells
Paria BC; Levin N; Lowery FJ; Pasetto A; Deniger DC; Parkhurst MR; Yossef R; Kim SP; Florentin M; Ngo LT; Ray S; Krishna S; Robbins PF; Rosenberg SA
Article: JOURNAL OF CLINICAL INVESTIGATION. 2019;129(11):4992-5004
Recognition of human gastrointestinal cancer neoantigens by circulating PD-1⁺ lymphocytes
Gros A; Tran E; Parkhurst MR; Ilyas S; Pasetto A; Groh EM; Robbins PF; Yossef R; Garcia-Garijo A; Fajardo CA; Prickett TD; Jia L; Gartner JJ; Ray S; Ngo L; Wunderllich JR; Yang JC; Rosenberg SA
Article: CANCER DISCOVERY. 2019;9(8):1022-1035
Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers
Parkhurst MR; Robbins PF; Tran E; Prickett TD; Gartner JJ; Jia L; Ivey G; Li YF; El-Gamil M; Lalani A; Crystal JS; Sachs A; Groh E; Ray S; Ngo LT; Kivitz S; Pasetto A; Yossef R; Lowery FJ; Goff SL; Lo W; Cafri G; Deniger DC; Malekzadeh P; Ahmadzadeh M; Wunderlich JR; Somerville RPT; Rosenberg SA
Article: CANCER IMMUNOLOGY RESEARCH. 2019;7(4):534-543
Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer
Lo W; Parkhurst M; Robbins PF; Tran E; Lu Y-C; Jia L; Gartner JJ; Pasetto A; Deniger D; Malekzadeh P; Shelton TE; Prickett T; Ray S; Kivitz S; Paria BC; Kriley I; Schrump DS; Rosenberg SA
Article: JOURNAL OF CLINICAL INVESTIGATION. 2019;129(3):1109-1114
Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers
Malekzadeh P; Pasetto A; Robbins PF; Parkhurst MR; Paria BC; Jia L; Gartner JJ; Hill V; Yu Z; Restifo NP; Sachs A; Iran E; Lo W; Somerville RPT; Rosenberg SA; Deniger DC
Article: NATURE COMMUNICATIONS. 2019;10(1):449
Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients
Cafri G; Yossef R; Pasetto A; Deniger DC; Lu Y-C; Parkhurst M; Gartner JJ; Jia L; Ray S; Ngo LT; Jafferji M; Sachs A; Prickett T; Robbins PF; Rosenberg SA
Article: SCIENCE IMMUNOLOGY. 2019;4(31):eaao4310
Tumor-infiltrating human CD4⁺ regulatory T cells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity
Ahmadzadeh M; Pasetto A; Jia L; Deniger DC; Stevanovic S; Robbins PF; Rosenberg SA
Article: CLINICAL CANCER RESEARCH. 2018;24(22):5562-5573
T-cell Responses to TP53 "Hotspot" Mutations and Unique Neoantigens Expressed by Human Ovarian Cancers
Deniger DC; Pasetto A; Robbins PF; Gartner JJ; Prickett TD; Paria BC; Malekzadeh P; Jia L; Yossef R; Langhan MM; Wunderlich JR; Danforth DN; Somerville RPT; Rosenberg SA
Article: JCI INSIGHT. 2018;3(19):122467
Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy
Yossef R; Tran E; Deniger DC; Gros A; Pasetto A; Parkhurst MR; Gartner JJ; Prickett TD; Cafri G; Robbins PF; Rosenberg SA
Article: NATURE MEDICINE. 2018;24(6):724-730
Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer
Zacharakis N; Chinnasamy H; Black M; Xu H; Lu Y-C; Zheng Z; Pasetto A; Langhan M; Shelton T; Prickett T; Gartner J; Jia L; Trebska-McGowan K; Somerville RP; Robbins PF; Rosenberg SA; Goff SL; Feldman SA
Article: CLINICAL CANCER RESEARCH. 2017;23(10):2491-2505
Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression
Parkhurst M; Gros A; Pasetto A; Prickett T; Crystal JS; Robbins P; Rosenberg SA
Article: JOURNAL OF VIROLOGY. 2017;91(9):e00010-e00017
Hepatitis C Virus-Specific T Cell Receptor mRNA-Engineered Human T Cells: Impact of Antigen Specificity on Functional Properties
Balasiddaiah A; Davanian H; Aleman S; Pasetto A; Frelin L; Sallberg M; Lohmann V; Koh S; Bertoletti A; Chen M
Article: SCIENCE. 2017;356(6334):200-205
Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer
Stevanovic S; Pasetto A; Helman SR; Gartner JJ; Prickett TD; Howie B; Robins HS; Robbins PF; Klebanoff CA; Rosenberg SA; Hinrichs CS
Article: CLINICAL CANCER RESEARCH. 2017;23(2):351-362
A Pilot Trial of the Combination of Vemurafenib with Adoptive Cell Therapy in Patients with Metastatic Melanoma
Deniger DC; Kwong MLM; Pasetto A; Dudley ME; Wunderlich JR; Langhan MM; Lee C-CR; Rosenberg SA
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2016;375(23):2255-2262
T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer
Tran E; Robbins PF; Lu Y-C; Prickett TD; Gartner JJ; Jia L; Pasetto A; Zheng Z; Ray S; Groh EM; Kriley IR; Rosenberg SA
Article: CANCER IMMUNOLOGY RESEARCH. 2016;4(9):734-743
Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor
Pasetto A; Gros A; Robbins PF; Deniger DC; Prickett TD; Matus-Nicodemos R; Douek DC; Howie B; Robins H; Parkhurst MR; Gartner J; Trebska-McGowan K; Crystal JS; Rosenberg SA
Article: CANCER IMMUNOLOGY RESEARCH. 2016;4(8):669-678
Durable Complete Response from Metastatic Melanoma after Transfer of Autologous T Cells Recognizing 10 Mutated Tumor Antigens
Prickett TD; Crystal JS; Cohen CJ; Pasetto A; Parkhurst MR; Gartner JJ; Yao X; Wang R; Gros A; Li YF; El-Gamil M; Trebska-McGowan K; Rosenberg SA; Robbins PF
Article: MOLECULAR THERAPY. 2016;24(6):1078-1089
Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System
Deniger DC; Pasetto A; Tran E; Parkhurst MR; Cohen CJ; Robbins PF; Cooper LJN; Rosenberg SA
Article: NATURE MEDICINE. 2016;22(4):433-438
Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients
Gros A; Parkhurst MR; Tran E; Pasetto A; Robbins PF; Ilyas S; Prickett TD; Gartner JJ; Crystal JS; Roberts IM; Trebska-McGowan K; Wunderlich JR; Yang JC; Rosenberg SA
Article: JOURNAL OF IMMUNOLOGY. 2013;190(3):1113-1124
A Synthetic Codon-Optimized Hepatitis C Virus Nonstructural 5A DNA Vaccine Primes Polyfunctional CD8⁺ T Cell Responses in Wild-Type and NS5A-Transgenic Mice
Holmstrom F; Pasetto A; Nahr V; Brass A; Kriegs M; Hildt E; Broderick KE; Chen M; Ahlen G; Frelin L
Article: PLOS ONE. 2013;8(6):e65964
The Adjuvant Activity of Alphavirus Replicons Is Enhanced by Incorporating the Microbial Molecule Flagellin into the Replicon
Knudsen ML; Johansson DX; Kostic L; Nordstron EKL; Tegerstedt K; Pasetto A; Applequist SE; Ljungberg K; Sirard J-C; Liljestrom P
Article: JOURNAL OF IMMUNOLOGY. 2012;189(9):4510-4519
TCR-Redirected Human T Cells Inhibit Hepatitis C Virus Replication: Hepatotoxic Potential Is Linked to Antigen Specificity and Functional Avidity
Pasetto A; Frelin L; Aleman S; Holmstrom F; Brass A; Ahlen G; Brenndorfer ED; Lohmann V; Bartenschlager R; Sallberg M; Bertoletti A; Chen M
Article: JOURNAL OF GENERAL VIROLOGY. 2012;93(Pt 2):247-258
Generation of T-cell receptors targeting a genetically stable and immunodominant cytotoxic T-lymphocyte epitope within hepatitis C virus non-structural protein 3
Pasetto A; Frelin L; Brass A; Yasmeen A; Koh S; Lohmann V; Bartenschlager R; Magalhaes I; Maeurer M; Sallberg M; Chen M
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Anställningar

Forskningsspecialist, Laboratoriemedicin, Karolinska Institutet, 2022-

Examina och utbildning

Medicine Doktorsexamen, Institutionen för odontologi, Karolinska Institutet, 2012

Artiklar

Anställningar

Examina och utbildning

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