PSF related publications

2024 - 16 publications...

260. tRNA regulation and amino acid usage bias reflect a coordinated metabolic adaptation in Plasmodium falciparum.
Li Q, Vetter L, Veith Y, Christ E, Végvári Á, Sahin C, Ribacke U, Wahlgren M, Ankarklev J, Larsson O, Chun-Leung Chan S
iScience 2024 Nov;27(11):111167

259. LRPPRC and SLIRP synergize to maintain sufficient and orderly mammalian mitochondrial translation.
Rubalcava-Gracia D, Bubb K, Levander F, Burr SP, August AV, Chinnery PF, Koolmeister C, Larsson NG
Nucleic Acids Res 2024 Oct;52(18):11266-11282

258. Mechanism of Two-Component Mono-Oxygenases Involved in Anthracycline 1-Hydroxylation
Wandi BN, Dinis P, Siitonen V, Schneider G, Schnell R, Metsä-Ketelä M. 
ACS Catalysis. 2024;14(16):12359-71:10.1021/acscatal.4c02623.

257. Elucidating microRNA-34a organisation within human Argonaute-2 by dynamic nuclear polarisation-enhanced magic angle spinning NMR.
Dasgupta R, Becker W, Petzold K
Nucleic Acids Res 2024 Oct;52(19):11995-12004

256. Kinetic and structural characterization of NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis.
Scaletti ER, Unterlass JE, Almlöf I, Koolmeister T, Vallin KS, Kapsitidou D, Tsuber V, Helleday T, Stenmark P, Jemth AS
FEBS J 2024 Jun;():

255. The N-terminal SAM domain of the dNTPase SAMHD1 is not required for inhibition by small molecule TH6342.
Dirks C, Bwanika HC, Jemth AS, Zhang SM, Rudd SG
Nucleosides Nucleotides Nucleic Acids 2024 Jun;():1-6

254. Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries.
Akaberi D, Pourghasemi Lati M, Krambrich J, Berger J, Neilsen G, Strandback E, Turunen SP, Wannberg J, Gullberg H, Moche M, Chinthakindi PK, Nyman T, Sarafianos SG, Sandström A, Järhult JD, Sandberg K, Lundkvist Å, Verho O, Lennerstrand J
Antimicrob Agents Chemother 2024 Aug;():e0090924

253. Novel druggable space in human KRAS G13D discovered using structural bioinformatics and a P-loop targeting monoclonal antibody.
Jungholm O, Trkulja C, Moche M, Srinivasa SP, Christakopoulou MN, Davidson M, Reymer A, Jardemark K, Fogaça RL, Ashok A, Jeffries G, Ampah-Korsah H, Strandback E, Andréll J, Nyman T, Nouairia G, Orwar O
Sci Rep 2024 Aug;14(1):19656

252. A hydrophobic groove in secretagogin allows for alternate interactions with SNAP-25 and syntaxin-4 in endocrine tissues.
Szodorai E, Hevesi Z, Wagner L, Hökfelt TGM, Harkany T, Schnell R
Proc Natl Acad Sci U S A 2024 Apr;121(16):e2309211121

251. Structural and Functional Characterization of a Gene Cluster Responsible for Deglycosylation of C-glucosyl Flavonoids and Xanthonoids by Deinococcus aerius.
Furlanetto V, Kalyani DC, Kostelac A, Puc J, Haltrich D, Hällberg BM, Divne C
J Mol Biol 2024 Mar;436(9):168547

250. Tissue-specific RNA Polymerase II promoter-proximal pause release and burst kinetics in a Drosophila embryonic patterning network.
Hunt G, Vaid R, Pirogov S, Pfab A, Ziegenhain C, Sandberg R, Reimegård J, Mannervik M
Genome Biol 2024 Jan;25(1):2

249. Presence of key cholinergic enzymes in human spermatozoa and seminal fluid†.
Thakur B, Hasooni LP, Gera R, Mitra S, Björndahl L, Darreh-Shori T
Biol Reprod 2024 Jan;110(1):63-77

248. Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.
Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG
iScience 2024 Feb;27(2):108907

247. Investigating Protein Binding with the Isothermal Ligand-induced Resolubilization Assay.
Prout-Holm RA, van Walstijn CC, Hitsman A, Rowley MJ, Olsen JE, Page BDG, Frankel A
Chembiochem 2024 Jan;():e202300773

246. Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force.
Smyrlaki I, Fördős F, Rocamonde-Lago I, Wang Y, Shen B, Lentini A, Luca VC, Reinius B, Teixeira AI, Högberg B
Nat Commun 2024 Jan;15(1):465

245. Investigating the anti-cancer potential of pyrimethamine analogues through a modern chemical biology lens.
Brown JI, Persaud R, Iliev P, Karmacharya U, Attarha S, Sahile H, Olsen JE, Hanke D, Idowu T, Frank DA, Frankel A, Williams KC, Page BDG
Eur J Med Chem 2024 Jan;264():115971

2023 - 14 publications

244. Nano-CUT&Tag for multimodal chromatin profiling at single-cell resolution.
Bárcenas-Walls JR, Ansaloni F, Hervé B, Strandback E, Nyman T, Castelo-Branco G, Bartošovič M
Nat Protoc 2023 Dec;():

243. Efficient 3'-pairing renders microRNA targeting less sensitive to mRNA seed accessibility.
Kosek DM, Banijamali E, Becker W, Petzold K, Andersson ER
Nucleic Acids Res 2023 Nov;51(20):11162-11177

242. Ultralight Ultrafast Enzymes.
Zhang X, Meng Z, Beusch CM, Gharibi H, Cheng Q, Lyu H, Di Stefano L, Wang J, Saei AA, Végvári Á, Gaetani M, Zubarev RA
Angew Chem Int Ed Engl 2023 Nov;():e202316488

241. PARP14 is a writer, reader, and eraser of mono-ADP-ribosylation.
Torretta A, Chatzicharalampous C, Ebenwaldner C, Schüler H
J Biol Chem 2023 Sep;299(9):105096

240. Interspecies interaction reduces selection for antibiotic resistance in Escherichia coli.
Nair RR, Andersson DI
Commun Biol 2023 Mar;6(1):331

239. Pseudouridine-Modifying Enzymes SapB and SapH Control Entry into the Pseudouridimycin Biosynthetic Pathway.
Artukka E, Schnell R, Palmu K, Rosenqvist P, Szodorai E, Niemi J, Virta P, Schneider G, Metsä-Ketelä M
ACS Chem Biol 2023 Apr;18(4):794-802

238. Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH.
Schulte T, Panas MD, Han X, Williams L, Kedersha N, Fleck JS, Tan TJC, Dopico XC, Olsson A, Morro AM, Hanke L, Nilvebrant J, Giang KA, Nygren PÅ, Anderson P, Achour A, McInerney GM
Open Biol 2023 May;13(5):220369

237. LolA and LolB from the plant-pathogen Xanthomonas campestris forms a stable heterodimeric complex in the absence of lipoprotein.
Furlanetto V, Divne C
Front Microbiol 2023 ;14():1216799

236. Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A4 Hydrolase.
Teder T, König S, Singh R, Samuelsson B, Werz O, Garscha U, Haeggström JZ
Int J Mol Sci 2023 Apr;24(8):

235. Pathogenic antibody response to glucose-6-phosphate isomerase targets a modified epitope uniquely exposed on joint cartilage.
Li T, Ge C, Krämer A, Sareila O, Leu Agelii M, Johansson L, Forslind K, Lönnblom E, Yang M, Xu B, Li Q, Cheng L, Bergström G, Fernandez G, Kastbom A, Rantapää-Dahlqvist S, Gjertsson I, Holmdahl R
Ann Rheum Dis 2023 Mar;():

234. RNA:RNA interaction in ternary complexes resolved by chemical probing.
Banijamali E, Baronti L, Becker W, Sajkowska-Kozielewicz JJ, Huang T, Palka C, Kosek D, Sweetapple L, Müller J, Stone MD, Andersson ER, Petzold K
RNA 2023 Mar;29(3):317-329

233. A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis.
He Y, Ge C, Moreno-Giró À, Xu B, Beusch CM, Sandor K, Su J, Cheng L, Lönnblom E, Lundqvist C, Slot LM, Tong D, Urbonaviciute V, Liang B, Li T, Lahore GF, Aoun M, Malmström V, Rispens T, Ernfors P, Svensson CI, Scherer HU, Toes REM, Gjertsson I, Ekwall O, Zubarev RA, Holmdahl R
Nat Commun 2023 Feb;14(1):691

232. Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1.
Wallner O, Cázares-Körner A, Scaletti ER, Masuyer G, Bekkhus T, Visnes T, Mamonov K, Ortis F, Lundbäck T, Volkova M, Koolmeister T, Wiita E, Loseva O, Pandey M, Homan E, Benítez-Buelga C, Davies J, Scobie M, Warpman Berglund U, Kalderén C, Stenmark P, Helleday T, Michel M
ChemMedChem 2023 Jan;18(1):e202200310

231. Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity.
Brown JI, Wang P, Wong AYL, Petrova B, Persaud R, Soukhtehzari S, Lopez McDonald M, Hanke D, Christensen J, Iliev P, Wang W, Everton DK, Williams KC, Frank DA, Kanarek N, Page BDG
Metabolites 2023 Jan;13(2):

2022 - 24 publications

230. A Highly Sensitive Method to Efficiently Profile the Histone Modifications of FFPE Samples.
Zhao L, Polavarapu VK, Yadav RP, Xing P, Chen X
Bio Protoc 2022 May;12(10):

229. Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility.
Meijer M, Agirre E, Kabbe M, van Tuijn CA, Heskol A, Zheng C, Mendanha Falcão A, Bartosovic M, Kirby L, Calini D, Johnson MR, Corces MR, Montine TJ, Chen X, Chang HY, Malhotra D, Castelo-Branco G
Neuron 2022 Apr;110(7):1193-1210.e13

228. Rapid adaptive radiation of Darwin's finches depends on ancestral genetic modules.
Rubin CJ, Enbody ED, Dobreva MP, Abzhanov A, Davis BW, Lamichhaney S, Pettersson M, Sendell-Price AT, Sprehn CG, Valle CA, Vasco K, Wallerman O, Grant BR, Grant PR, Andersson L
Sci Adv 2022 Jul;8(27):eabm5982

227. Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples.
Zhang H, Polavarapu VK, Xing P, Zhao M, Mathot L, Zhao L, Rosen G, Swartling FJ, Sjöblom T, Chen X
Genome Res 2022 Jan;32(1):150-161

226. Fidelity varies in the symbiosis between a gutless marine worm and its microbial consortium.
Sato Y, Wippler J, Wentrup C, Ansorge R, Sadowski M, Gruber-Vodicka H, Dubilier N, Kleiner M
Microbiome 2022 Oct;10(1):178

225. FFPE-ATAC: A Highly Sensitive Method for Profiling Chromatin Accessibility in Formalin-Fixed Paraffin-Embedded Samples.
Yadav RP, Polavarapu VK, Xing P, Chen X
Curr Protoc 2022 Aug;2(8):e535

224. Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics.
Pauwels MJ, Xie J, Ceroi A, Balusu S, Castelein J, Van Wonterghem E, Van Imschoot G, Ward A, Menheniott TR, Gustafsson O, Combes F, El Andaloussi S, Sanders NN, Mäger I, Van Hoecke L, Vandenbroucke RE
Biomaterials 2022 Nov;290():121830

223. Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule.
Grinkevich VV, Vema A, Fawkner K, Issaeva N, Andreotti V, Dickinson ER, Hedström E, Spinnler C, Inga A, Larsson LG, Karlén A, Wilhelm M, Barran PE, Okorokov AL, Selivanova G, Zawacka-Pankau JE
Front Mol Biosci 2022 ;9():823195

222. STAT Protein Thermal Shift Assays to Monitor Protein-Inhibitor Interactions.
Iliev P, Hanke D, Page BDG
Chembiochem 2022 Oct;23(20):e202200039

221. Silver nanoparticles with excellent biocompatibility block pseudotyped SARS-CoV-2 in the presence of lung surfactant.
Gupta G, Hamawandi B, Sheward DJ, Murrell B, Hanke L, McInerney G, Blosi M, Costa AL, Toprak MS, Fadeel B
Front Bioeng Biotechnol 2022 ;10():1083232

220. Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action.
Gubat J, Selvaraju K, Sjöstrand L, Kumar Singh D, Turkina MV, Schmierer B, Sabatier P, Zubarev RA, Linder S, D'Arcy P
Front Oncol 2022 ;12():852980

219. Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Bonagas N, Gustafsson NMS, Henriksson M, Marttila P, Gustafsson R, Wiita E, Borhade S, Green AC, Vallin KSA, Sarno A, Svensson R, Göktürk C, Pham T, Jemth AS, Loseva O, Cookson V, Kiweler N, Sandberg L, Rasti A, Unterlass JE, Haraldsson M, Andersson Y, Scaletti ER, Bengtsson C, Paulin CBJ, Sanjiv K, Abdurakhmanov E, Pudelko L, Kunz B, Desroses M, Iliev P, Färnegårdh K, Krämer A, Garg N, Michel M, Häggblad S, Jarvius M, Kalderén C, Jensen AB, Almlöf I, Karsten S, Zhang SM, Häggblad M, Eriksson A, Liu J, Glinghammar B, Nekhotiaeva N, Klingegård F, Koolmeister T, Martens U, Llona-Minguez S, Moulson R, Nordström H, Parrow V, Dahllund L, Sjöberg B, Vargas IL, Vo DD, Wannberg J, Knapp S, Krokan HE, Arvidsson PI, Scobie M, Meiser J, Stenmark P, Berglund UW, Homan EJ, Helleday T
Nat Cancer 2022 Feb;3(2):156-172

218. Enzymatic incorporation of an isotope-labeled adenine into RNA for the study of conformational dynamics by NMR.
Feyrer H, Gurdap CO, Marušič M, Schlagnitweit J, Petzold K
PLoS One 2022 ;17(7):e0264662

217. 14-3-3 Activated Bacterial Exotoxins AexT and ExoT Share Actin and the SH2 Domains of CRK Proteins as Targets for ADP-Ribosylation.
Ebenwaldner C, Hornyak P, García-Saura AG, Torretta A, Anoosheh S, Hofer A, Schüler H
Pathogens 2022 Dec;11(12):

216. Crystal structure of the feruloyl esterase from Lentilactobacillus buchneri reveals a novel homodimeric state.
Kasmaei KM, Kalyani DC, Reichenbach T, Jiménez-Quero A, Vilaplana F, Divne C
Front Microbiol 2022 ;13():1050160

215. Multimodal chromatin profiling using nanobody-based single-cell CUT&Tag.
Bartosovic M, Castelo-Branco G
Nat Biotechnol 2022 Dec;():

214. Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation.
Kissel T, Ge C, Hafkenscheid L, Kwekkeboom JC, Slot LM, Cavallari M, He Y, van Schie KA, Vergroesen RD, Kampstra ASB, Reijm S, Stoeken-Rijsbergen G, Koeleman C, Voortman LM, Heitman LH, Xu B, Pruijn GJM, Wuhrer M, Rispens T, Huizinga TWJ, Scherer HU, Reth M, Holmdahl R, Toes REM
Sci Adv 2022 Feb;8(6):eabm1759

213. Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Michel M, Benítez-Buelga C, Calvo PA, Hanna BMF, Mortusewicz O, Masuyer G, Davies J, Wallner O, Sanjiv K, Albers JJ, Castañeda-Zegarra S, Jemth AS, Visnes T, Sastre-Perona A, Danda AN, Homan EJ, Marimuthu K, Zhenjun Z, Chi CN, Sarno A, Wiita E, von Nicolai C, Komor AJ, Rajagopal V, Müller S, Hank EC, Varga M, Scaletti ER, Pandey M, Karsten S, Haslene-Hox H, Loevenich S, Marttila P, Rasti A, Mamonov K, Ortis F, Schömberg F, Loseva O, Stewart J, D'Arcy-Evans N, Koolmeister T, Henriksson M, Michel D, de Ory A, Acero L, Calvete O, Scobie M, Hertweck C, Vilotijevic I, Kalderén C, Osorio A, Perona R, Stolz A, Stenmark P, Berglund UW, de Vega M, Helleday T
Science 2022 06;376(6600):1471-1476

212. Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals Remdesivir, Ribavirin and Molnupiravir.
Jemth AS, Scaletti ER, Homan E, Stenmark P, Helleday T, Michel M
J Biol Chem 2022 Jun;():102169

211. MYC assembles and stimulates topoisomerases 1 and 2 in a "topoisome".
Das SK, Kuzin V, Cameron DP, Sanford S, Jha RK, Nie Z, Rosello MT, Holewinski R, Andresson T, Wisniewski J, Natsume T, Price DH, Lewis BA, Kouzine F, Levens D, Baranello L
Mol Cell 2022 01;82(1):140-158.e12

210. Antibodies to cartilage oligomeric matrix protein are pathogenic in mice and may be clinically relevant in rheumatoid arthritis.
Ge C, Tong D, Lönnblom E, Liang B, Cai W, Fahlquist-Hagert C, Li T, Kastbom A, Gjertsson I, Dobritzsch D, Holmdahl R
Arthritis Rheumatol 2022 Jan;():

209. Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses.
Luttens A, Gullberg H, Abdurakhmanov E, Vo DD, Akaberi D, Talibov VO, Nekhotiaeva N, Vangeel L, De Jonghe S, Jochmans D, Krambrich J, Tas A, Lundgren B, Gravenfors Y, Craig AJ, Atilaw Y, Sandström A, Moodie LWK, Lundkvist Å, van Hemert MJ, Neyts J, Lennerstrand J, Kihlberg J, Sandberg K, Danielson UH, Carlsson J
J Am Chem Soc 2022 Feb;():

208. Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile Aquifex aeolicus.
Rehling D, Scaletti ER, Rozman Grinberg I, Lundin D, Sahlin M, Hofer A, Sjöberg BM, Stenmark P
Biochemistry 2022 01;61(2):92-106

207. A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo.
Hanke L, Das H, Sheward DJ, Perez Vidakovics L, Urgard E, Moliner-Morro A, Kim C, Karl V, Pankow A, Smith NL, Porebski B, Fernandez-Capetillo O, Sezgin E, Pedersen GK, Coquet JM, Hällberg BM, Murrell B, McInerney GM
Nat Commun 2022 01;13(1):155

2021 - 26 publications

206. FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers.
Zhao L, Xing P, Polavarapu VK, Zhao M, Valero-Martínez B, Dang Y, Maturi N, Mathot L, Neves I, Yildirim I, Swartling FJ, Sjöblom T, Uhrbom L, Chen X
Nucleic Acids Res 2021 Dec;49(21):e125

205. NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487.
Hanna BMF, Michel M, Helleday T, Mortusewicz O
Int J Mol Sci 2021 Apr;22(9):

204. Rational antibody design for undruggable targets using kinetically controlled biomolecular probes.
Trkulja CL, Jungholm O, Davidson M, Jardemark K, Marcus MM, Hägglund J, Karlsson A, Karlsson R, Bruton J, Ivarsson N, Srinivasa SP, Cavallin A, Svensson P, Jeffries GDM, Christakopoulou MN, Reymer A, Ashok A, Willman G, Papadia D, Johnsson E, Orwar O
Sci Adv 2021 Apr;7(16):

203. A multispecies BCO2 beak color polymorphism in the Darwin's finch radiation.
Enbody ED, Sprehn CG, Abzhanov A, Bi H, Dobreva MP, Osborne OG, Rubin CJ, Grant PR, Grant BR, Andersson L
Curr Biol 2021 Dec;31(24):5597-5604.e7

202. PARP10 Multi-Site Auto- and Histone MARylation Visualized by Acid-Urea Gel Electrophoresis.
García-Saura AG, Schüler H
Cells 2021 Mar;10(3):

201. A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1.
Yagüe-Capilla M, Rudd SG
J Vis Exp 2021 Apr;(170):

200. MacroGreen, a simple tool for detection of ADP-ribosylated proteins.
García-Saura AG, Herzog LK, Dantuma NP, Schüler H
Commun Biol 2021 Jul;4(1):919

199. Rapid genome editing by CRISPR-Cas9-POLD3 fusion.
Reint G, Li Z, Labun K, Keskitalo S, Soppa I, Mamia K, Tolo E, Szymanska M, Meza-Zepeda LA, Lorenz S, Cieslar-Pobuda A, Hu X, Bordin DL, Staerk J, Valen E, Schmierer B, Varjosalo M, Taipale J, Haapaniemi E
Elife 2021 Dec;10():

198. Practical Aspects of Sample Preparation and Setup of 1H R1ρ Relaxation Dispersion Experiments of RNA.
Feyrer H, Schlagnitweit J, Petzold K
J Vis Exp 2021 Jul;(173):

197. Production of Structured RNA Fragments by In Vitro Transcription and HPLC Purification.
Karlsson H, Feyrer H, Baronti L, Petzold K
Curr Protoc 2021 Jun;1(6):e159

196. Rapid genome editing by CRISPR-Cas9-POLD3 fusion.
Reint G, Li Z, Labun K, Keskitalo S, Soppa I, Mamia K, Tolo E, Szymanska M, Meza-Zepeda LA, Lorenz S, Cieslar-Pobuda A, Hu X, Bordin DL, Staerk J, Valen E, Schmierer B, Varjosalo M, Taipale J, Haapaniemi E
Elife 2021 Dec;10():

195. Genome-wide mapping of G-quadruplex structures with CUT&Tag.
Lyu J, Shao R, Kwong Yung PY, Elsässer SJ
Nucleic Acids Res 2021 Nov;():

194. Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase.
Schriever K, Saenz-Mendez P, Rudraraju RS, Hendrikse NM, Hudson EP, Biundo A, Schnell R, Syrén PO
J Am Chem Soc 2021 03;143(10):3794-3807

193. N-Thio-β-lactams targeting L,D-transpeptidase-2, with activity against drug-resistant strains of Mycobacterium tuberculosis.
Martelli G, Pessatti TB, Steiner EM, Cirillo M, Caso C, Bisognin F, Landreh M, Monte PD, Giacomini D, Schnell R
Cell Chem Biol 2021 Mar;():

192. Crystal structure of a homotrimeric verrucomicrobial exo-β-1,4-mannosidase active in the hindgut of the wood-feeding termite Reticulitermes flavipes.
Kalyani DC, Reichenbach T, Keskitalo MM, Conrad J, Aspeborg H, Divne C
J Struct Biol X 2021 ;5():100048

191. Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
Rehling D, Zhang SM, Jemth AS, Koolmeister T, Throup A, Wallner O, Scaletti E, Moriyama T, Nishii R, Davies J, Desroses M, Rudd SG, Scobie M, Homan E, Berglund UW, Yang JJ, Helleday T, Stenmark P
J Biol Chem ;296():100568

190. NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir.
Zhang SM, Rehling D, Jemth AS, Throup A, Landázuri N, Almlöf I, Göttmann M, Valerie NCK, Borhade SR, Wakchaure P, Page BDG, Desroses M, Homan EJ, Scobie M, Rudd SG, Berglund UW, Söderberg-Nauclér C, Stenmark P, Helleday T
Cell Chem Biol 2021 Dec;28(12):1693-1702.e6

189. Mechanism of Ganglioside Receptor Recognition by Botulinum Neurotoxin Serotype E.
Masuyer G, Davies JR, Stenmark P
Int J Mol Sci 2021 Aug;22(15):

188. FragMAXapp: crystallographic fragment-screening data-analysis and project-management system.
Lima GMA, Jagudin E, Talibov VO, Benz LS, Marullo C, Barthel T, Wollenhaupt J, Weiss MS, Mueller U
Acta Crystallogr D Struct Biol 2021 Jun;77(Pt 6):799-808 

187. Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors.
Akaberi D, Båhlström A, Chinthakindi PK, Nyman T, Sandström A, Järhult JD, Palanisamy N, Lundkvist Å, Lennerstrand J
Antiviral Res 2021 Apr;190():105074

186. Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase.
Schriever K, Saenz-Mendez P, Rudraraju RS, Hendrikse NM, Hudson EP, Biundo A, Schnell R, Syrén PO
J Am Chem Soc 2021 Jan;():

185. A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens.
Vella P, Rudraraju RS, Lundbäck T, Axelsson H, Almqvist H, Vallin M, Schneider G, Schnell R
Bioorg Med Chem 2021 Jan;30():115898

184. A DNA-nanoassembly-based approach to map membrane protein nanoenvironments.
Ambrosetti E, Bernardinelli G, Hoffecker I, Hartmanis L, Kiriako G, de Marco A, Sandberg R, Högberg B, Teixeira AI
Nat Nanotechnol 2021 Jan;16(1):85-95

183. Direct detection of SARS-CoV-2 using non-commercial RT-LAMP reagents on heat-inactivated samples.
Alekseenko A, Barrett D, Pareja-Sanchez Y, Howard RJ, Strandback E, Ampah-Korsah H, et al
Sci Rep 2021 01;11(1):1820

182. A homodimeric bacterial exo-β-1,3-glucanase derived from moose rumen microbiome shows a structural framework similar to yeast exo-β-1,3-glucanases.
Kalyani DC, Reichenbach T, Aspeborg H, Divne C
Enzyme Microb Technol 2021 Feb;143():109723

181. Single-cell CUT&Tag profiles histone modifications and transcription factors in complex tissues.
Bartosovic M, Kabbe M, Castelo-Branco G
Nat Biotechnol 2021 Jul;39(7):825-835

2020 - 24 publications

180. MrpH, a new class of metal-binding adhesin, requires zinc to mediate biofilm formation.
Jiang W, Ubhayasekera W, Breed MC, Norsworthy AN, Serr N, Mobley HLT, Pearson MM, Knight SD
PLoS Pathog 2020 Aug;16(8):e1008707

179. Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring-An Inactive Enzyme with Intact Substrate Binding.
Gustafsson R, Eckhard U, Ye W, Enbody ED, Pettersson M, Jemth P, Andersson L, Selmer M
Biomolecules 2020 Dec;10(12):

178. The application of differential scanning fluorimetry in exploring bisubstrate binding to protein arginine N-methyltransferase 1.
Brown JI, Page BDG, Frankel A
Methods 2020 Mar;175():10-23

177. Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death.
Busker S, Qian W, Haraldsson M, Espinosa B, Johansson L, Attarha S, Kolosenko I, Liu J, Dagnell M, Grandér D, Arnér ESJ, Tamm KP, Page BDG
Sci Adv 2020 Mar;6(12):eaax7945

176. Proton pump inhibitors act with unprecedented potencies as inhibitors of the acetylcholine biosynthesizing enzyme-A plausible missing link for their association with incidence of dementia.
Kumar R, Kumar A, Nordberg A, Långström B, Darreh-Shori T
Alzheimers Dement 2020 Jul;16(7):1031-1042

175. Esomeprazole reduces sperm motility index by targeting the spermic cholinergic machinery: A mechanistic study for the association between use of proton pump inhibitors and reduced sperm motility index.
Kumar A, Kumar R, Flanagan J, Långström B, Björndahl L, Darreh-Shori T
Biochem Pharmacol 2020 Dec;182():114212

174. Defining the proteolytic landscape during enterovirus infection.
Saeed M, Kapell S, Hertz NT, Wu X, Bell K, Ashbrook AW, Mark MT, Zebroski HA, Neal ML, Flodström-Tullberg M, MacDonald MR, Aitchison JD, Molina H, Rice CM
PLoS Pathog 2020 Sep;16(9):e1008927

173. Mitigation of the replication of SARS-CoV-2 by nitric oxide in vitro.
Akaberi D, Krambrich J, Ling J, Luni C, Hedenstierna G, Järhult JD, Lennerstrand J, Lundkvist Å
Redox Biol 2020 Oct;37():101734

172. Arachidonic acid promotes the binding of 5-lipoxygenase on nanodiscs containing 5-lipoxygenase activating protein in the absence of calcium-ions.
Kumar RB, Purhonen P, Hebert H, Jegerschöld C
PLoS One 2020 ;15(7):e0228607

171. An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility.
Navarro C, Lyu J, Katsori AM, Caridha R, Elsässer SJ
Nat Commun 2020 10;11(1):5095

170. Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins.
Nowak K, Rosenthal F, Karlberg T, Bütepage M, Thorsell AG, Dreier B, et al
Nat Commun 2020 10;11(1):5199

169. One-Pot Production of RNA in High Yield and Purity Through Cleaving Tandem Transcripts.
Feyrer H, Munteanu R, Baronti L, Petzold K
Molecules 2020 Mar;25(5):

168. A robust and versatile method for production and purification of large-scale RNA samples for structural biology.
Karlsson H, Baronti L, Petzold K
RNA 2020 08;26(8):1023-1037

167. A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes.
Yuen LH, Dana S, Liu Y, Bloom SI, Thorsell AG, Neri D, Donato AJ, Kireev D, Schüler H, Franzini RM
J Am Chem Soc 2019 04;141(13):5169-5181

166. Development of a chemical probe against NUDT15.
Zhang SM, Desroses M, Hagenkort A, Valerie NCK, Rehling D, Carter M, Wallner O, Koolmeister T, Throup A, Jemth AS, Almlöf I, Loseva O, Lundbäck T, Axelsson H, Regmi S, Sarno A, Krämer A, Pudelko L, Bräutigam L, Rasti A, Göttmann M, Wiita E, Kutzner J, Schaller T, Kalderén C, Cázares-Körner A, Page BDG, Krimpenfort R, Eshtad S, Altun M, Rudd SG, Knapp S, Scobie M, Homan EJ, Berglund UW, Stenmark P, Helleday T
Nat Chem Biol 2020 10;16(10):1120-1128

165. An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.
Hanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, Corcoran M, Achour A, Karlsson Hedestam GB, Hällberg BM, Murrell B, McInerney GM
Nat Commun 2020 09;11(1):4420

164. A ribonucleotide reductase from Clostridium botulinum reveals distinct evolutionary pathways to regulation via the overall activity site.
Martínez-Carranza M, Jonna VR, Lundin D, Sahlin M, Carlson LA, Jemal N, Högbom M, Sjöberg BM, Stenmark P, Hofer A
J Biol Chem 2020 Nov;295(46):15576-15587

163. Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
Škerlová J, Unterlass J, Göttmann M, Marttila P, Homan E, Helleday T, Jemth AS, Stenmark P
J Biol Chem 2020 08;295(33):11656-11668

162. A Transmembrane Crenarchaeal Mannosyltransferase Is Involved in N-Glycan Biosynthesis and Displays an Unexpected Minimal Cellulose-Synthase-like Fold.
Gandini R, Reichenbach T, Spadiut O, Tan TC, Kalyani DC, Divne C
J Mol Biol 2020 07;432(16):4658-4672

161. Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA.
Baronti L, Guzzetti I, Ebrahimi P, Friebe Sandoz S, Steiner E, Schlagnitweit J, Fromm B, Silva L, Fontana C, Chen AA, Petzold K
Nature 2020 07;583(7814):139-144

160. In silico Druggability Assessment of the NUDIX Hydrolase Protein Family as a Workflow for Target Prioritization.
Michel M, Homan EJ, Wiita E, Pedersen K, Almlöf I, Gustavsson AL, Lundbäck T, Helleday T, Warpman Berglund U
Front Chem 2020 ;8():443

159. MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
Scaletti ER, Vallin KS, Bräutigam L, Sarno A, Warpman Berglund U, Helleday T, Stenmark P, Jemth AS
J Biol Chem 2020 04;295(15):4761-4772

158, The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products.
Scaletti E, Claesson M, Helleday T, Jemth AS, Stenmark P
J Mol Biol 2020 02;432(4):1126-1142

157. Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease.
Akaberi D, Chinthakindi PK, Båhlström A, Palanisamy N, Sandström A, Lundkvist Å, Lennerstrand J
J Biomol Struct Dyn 2020 Nov;38(18):5526-5536

2019 - 10 publications

156. Genotyping by low-coverage whole-genome sequencing in intercross pedigrees from outbred founders: a cost-efficient approach.
Zan Y, Payen T, Lillie M, Honaker CF, Siegel PB, Carlborg Ö
Genet Sel Evol 2019 Aug;51(1):44

155. Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients.
Idborg H, Zandian A, Ossipova E, Wigren E, Preger C, Mobarrez F, Checa A, Sohrabian A, Pucholt P, Sandling JK, Fernandes-Cerqueira C, Rönnelid J, Oke V, Grosso G, Kvarnström M, Larsson A, Wheelock CE, Syvänen AC, Rönnblom L, Kultima K, Persson H, Gräslund S, Gunnarsson I, Nilsson P, Svenungsson E, Jakobsson PJ
Front Immunol 2019 ;10():1029

154.  Gas-Phase Collisions with Trimethylamine-N-Oxide Enable Activation-Controlled Protein Ion Charge Reduction.
Kaldmäe M, Österlund N, Lianoudaki D, Sahin C, Bergman P, Nyman T, Kronqvist N, Ilag LL, Allison TM, Marklund EG, Landreh M
J Am Soc Mass Spectrom 2019 Aug;30(8):1385-1388

153. Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.
Nicholls TJ, Spåhr H, Jiang S, Siira SJ, Koolmeister C, Sharma S, Kauppila JHK, Jiang M, Kaever V, Rackham O, Chabes A, Falkenberg M, Filipovska A, Larsson NG, Gustafsson CM
Mol Cell 2019 12;76(5):784-796.e6

152. E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2.
Anandapadamanaban M, Kyriakidis NC, Csizmók V, Wallenhammar A, Espinosa AC, Ahlner A, Round AR, Trewhella J, Moche M, Wahren-Herlenius M, Sunnerhagen M
J Biol Chem 2019 07;294(30):11404-11419

151. Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs.
Scaletti E, Jemth AS, Helleday T, Stenmark P
FEBS Lett 2019 07;593(14):1863-1873

150. Crystal structure of the catalytic domain of the Weissella oryzae botulinum-like toxin.
Košenina S, Masuyer G, Zhang S, Dong M, Stenmark P
FEBS Lett 2019 06;593(12):1403-1410

149. Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana.
Jemth AS, Scaletti E, Carter M, Helleday T, Stenmark P
Biochemistry 2019 02;58(7):887-899

148. Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Ge C, Xu B, Liang B, Lönnblom E, Lundström SL, Zubarev RA, Ayoglu B, Nilsson P, Skogh T, Kastbom A, Malmström V, Klareskog L, Toes REM, Rispens T, Dobritzsch D, Holmdahl R
Arthritis Rheumatol 2019 02;71(2):210-221

147. Cotranslational Folding of a Pentarepeat β-Helix Protein.
Notari L, Martínez-Carranza M, Farías-Rico JA, Stenmark P, von Heijne G
J Mol Biol 2018 12;430(24):5196-5206

2018 - 33 publications

146. Ligation of free HMGB1 to TLR2 in the absence of ligand is negatively regulated by the C-terminal tail domain.
Aucott H, Sowinska A, Harris HE, Lundback P
Mol Med 2018 May;24(1):19

145. Probing the activity of a recombinant Zn2+ -transporting P-type ATPase.
Ravishankar H, Barth A, Andersson M
Biopolymers 2018 Feb;109(2):

144. E. coli HMS174(DE3) is a sustainable alternative to BL21(DE3).
Hausjell J, Weissensteiner J, Molitor C, Halbwirth H, Spadiut O
Microb Cell Fact 2018 Oct;17(1):169

143. Structures of two fimbrial adhesins, AtfE and UcaD, from the uropathogen Proteus mirabilis.
Jiang W, Ubhayasekera W, Pearson MM, Knight SD
Acta Crystallogr D Struct Biol 2018 Nov;74(Pt 11):1053-1062

142. Ligation of free HMGB1 to TLR2 in the absence of ligand is negatively regulated by the C-terminal tail domain.
Aucott H, Sowinska A, Harris HE, Lundback P
Mol Med 2018 May;24(1):19

141b. Correction: APR-246 reactivates mutant p53 by targeting cysteines 124 and 277.
Zhang Q, Bykov VJN, Wiman KG, Zawacka-Pankau J
Cell Death Dis 2019 Oct;10(10):769

141a. APR-246 reactivates mutant p53 by targeting cysteines 124 and 277.
Zhang Q, Bykov VJN, Wiman KG, Zawacka-Pankau J
Cell Death Dis 2018 May;9(5):439

140. PrgB promotes aggregation, biofilm formation, and conjugation through DNA binding and compaction.
Schmitt A, Jiang K, Camacho MI, Jonna VR, Hofer A, Westerlund F, Christie PJ, Berntsson RP
Mol Microbiol 2018 Aug;109(3):291-305

139. 14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface.
Karlberg T, Hornyak P, Pinto AF, Milanova S, Ebrahimi M, Lindberg M, Püllen N, Nordström A, Löverli E, Caraballo R, Wong EV, Näreoja K, Thorsell AG, Elofsson M, De La Cruz EM, Björkegren C, Schüler H
Nat Commun 2018 09;9(1):3785

138. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Page BDG, Valerie NCK, Wright RHG, Wallner O, Isaksson R, Carter M, Rudd SG, Loseva O, Jemth AS, Almlöf I, Font-Mateu J, Llona-Minguez S, Baranczewski P, Jeppsson F, Homan E, Almqvist H, Axelsson H, Regmi S, Gustavsson AL, Lundbäck T, Scobie M, Strömberg K, Stenmark P, Beato M, Helleday T
Nat Commun 2018 01;9(1):250

137. Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins.
Spåhr H, Chia T, Lingford JP, Siira SJ, Cohen SB, Filipovska A, Rackham O
Nat Commun 2018 06;9(1):2212

136. A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.
Ladds MJGW, van Leeuwen IMM, Drummond CJ, Chu S, Healy AR, Popova G, Pastor Fernández A, Mollick T, Darekar S, Sedimbi SK, Nekulova M, Sachweh MCC, Campbell J, Higgins M, Tuck C, Popa M, Safont MM, Gelebart P, Fandalyuk Z, Thompson AM, Svensson R, Gustavsson AL, Johansson L, Färnegårdh K, Yngve U, Saleh A, Haraldsson M, D'Hollander ACA, Franco M, Zhao Y, Håkansson M, Walse B, Larsson K, Peat EM, Pelechano V, Lunec J, Vojtesek B, Carmena M, Earnshaw WC, McCarthy AR, Westwood NJ, Arsenian-Henriksson M, Lane DP, Bhatia R, McCormack E, Laín S
Nat Commun 2018 03;9(1):1107

135. Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.
Visnes T, Cázares-Körner A, Hao W, Wallner O, Masuyer G, Loseva O, Mortusewicz O, Wiita E, Sarno A, Manoilov A, Astorga-Wells J, Jemth AS, Pan L, Sanjiv K, Karsten S, Gokturk C, Grube M, Homan EJ, Hanna BMF, Paulin CBJ, Pham T, Rasti A, Berglund UW, von Nicolai C, Benitez-Buelga C, Koolmeister T, Ivanic D, Iliev P, Scobie M, Krokan HE, Baranczewski P, Artursson P, Altun M, Jensen AJ, Kalderén C, Ba X, Zubarev RA, Stenmark P, Boldogh I, Helleday T
Science 2018 11;362(6416):834-839

134. MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.
Jemth AS, Gustafsson R, Bräutigam L, Henriksson L, Vallin KSA, Sarno A, Almlöf I, Homan E, Rasti A, Warpman Berglund U, Stenmark P, Helleday T
Nucleic Acids Res 2018 11;46(20):10888-10904
133. STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions.
Desroses M, Busker S, Astorga-Wells J, Attarha S, Kolosenko I, Zubarev RA, Helleday T, Grandér D, Page BDG
J Pharm Biomed Anal 2018 Oct;160():80-88

132. Structural and biochemical characterization of the Cutibacterium acnes exo-β-1,4-mannosidase that targets the N-glycan core of host glycoproteins.
Reichenbach T, Kalyani D, Gandini R, Svartström O, Aspeborg H, Divne C
PLoS One 2018 ;13(9):e0204703

131. Structural and Functional Characterization of the BcsG Subunit of the Cellulose Synthase in Salmonella typhimurium.
Sun L, Vella P, Schnell R, Polyakova A, Bourenkov G, Li F, Cimdins A, Schneider TR, Lindqvist Y, Galperin MY, Schneider G, Römling U
J Mol Biol 2018 09;430(18 Pt B):3170-3189

130. A glutaredoxin domain fused to the radical-generating subunit of ribonucleotide reductase (RNR) functions as an efficient RNR reductant.
Rozman Grinberg I, Lundin D, Sahlin M, Crona M, Berggren G, Hofer A, Sjöberg BM
J Biol Chem 2018 10;293(41):15889-15900

129. BtsCI and BseGI display sequence preference in the nucleotides flanking the recognition sequence.
Rosa J, Fernandez-Gonzalez E, Ducani C, Högberg B
PLoS One 2018 ;13(8):e0202057

128. CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response.
Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J
Nat Med 2018 07;24(7):927-930

127. Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14.
Holechek J, Lease R, Thorsell AG, Karlberg T, McCadden C, Grant R, Keen A, Callahan E, Schüler H, Ferraris D
Bioorg Med Chem Lett 2018 06;28(11):2050-2054

126. The structure of the N-terminal module of the cell wall hydrolase RipA and its role in regulating catalytic activity.
Steiner EM, Lyngsø J, Guy JE, Bourenkov G, Lindqvist Y, Schneider TR, Pedersen JS, Schneider G, Schnell R
Proteins 2018 09;86(9):912-923

125. Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding.
Gustafsson R, Zhang S, Masuyer G, Dong M, Stenmark P
Toxins (Basel) 2018 04;10(4):

124. Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima.
Morgunova E, Yin Y, Das PK, Jolma A, Zhu F, Popov A, Xu Y, Nilsson L, Taipale J
Elife 2018 04;7():

123. Structural and functional studies of Spr1654: an essential aminotransferase in teichoic acid biosynthesis in Streptococcus pneumoniae.
Han X, Sun R, Sandalova T, Achour A
Open Biol 2018 04;8(4):

122. Identification of Poly(ADP-Ribose) Polymerase Macrodomain Inhibitors Using an AlphaScreen Protocol.
Ekblad T, Verheugd P, Lindgren AE, Nyman T, Elofsson M, Schüler H
SLAS Discov 2018 04;23(4):353-362

121. The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability.
Hafstrand I, Doorduijn EM, Sun R, Talyzina A, Sluijter M, Pellegrino S, Sandalova T, Duru AD, van Hall T, Achour A
J Immunol 2018 04;200(8):2860-2868

120. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.
Stafford WC, Peng X, Olofsson MH, Zhang X, Luci DK, Lu L, Cheng Q, Trésaugues L, Dexheimer TS, Coussens NP, Augsten M, Ahlzén HM, Orwar O, Östman A, Stone-Elander S, Maloney DJ, Jadhav A, Simeonov A, Linder S, Arnér ESJ
Sci Transl Med 2018 02;10(428):

119. Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit.
Rozman Grinberg I, Lundin D, Hasan M, Crona M, Jonna VR, Loderer C, Sahlin M, Markova N, Borovok I, Berggren G, Hofer A, Logan DT, Sjöberg BM
Elife 2018 02;7():

118. Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold.
Carter M, Jemth AS, Carreras-Puigvert J, Herr P, Martínez Carranza M, Vallin KSA, Throup A, Helleday T, Stenmark P
Structure 2018 02;26(2):295-303.e6

117. Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
Narwal M, Jemth AS, Gustafsson R, Almlöf I, Warpman Berglund U, Helleday T, Stenmark P
Biochemistry 2018 02;57(5):593-603

116. Role of Thiol Reactivity for Targeting Mutant p53.
Zhang Q, Bergman J, Wiman KG, Bykov VJN
Cell Chem Biol 2018 Oct;25(10):1219-1230.e3

115. A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.
Riley AM, Unterlass J, Konieczny V, Taylor CW, Helleday T, Potter BVL
Medchemcomm 2018 Jul;9(7):1105-1113

114. Regulation of Neuronal Na,K-ATPase by Extracellular Scaffolding Proteins.
Liebmann T, Fritz N, Kruusmägi M, Westin L, Bernhem K, Bondar A, Aperia A, Brismar H
Int J Mol Sci 2018 Jul;19(8):

2017 - 25 publications

113. InSiDDe: A Server for Designing Artificial Disordered Proteins.
Schramm A, Lieutaud P, Gianni S, Longhi S, Bignon C
Int J Mol Sci 2017 Dec;19(1):

112b. Correction to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.
Llona-Minguez S, Höglund A, Ghassemian A, Desroses M, Calderón-Montaño JM, Burgos Morón E, Valerie NCK, Wiita E, Almlöf I, Koolmeister T, Mateus A, Cazares-Körner C, Sanjiv K, Homan E, Loseva O, Baranczewski P, Darabi M, Mehdizadeh A, Fayezi S, Jemth AS, Warpman Berglund U, Sigmundsson K, Lundbäck T, Jenmalm Jensen A, Artursson P, Scobie M, Helleday T
J Med Chem 2017 Sep;60(17):7614

112a. Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.
Llona-Minguez S, Höglund A, Ghassemian A, Desroses M, Calderón-Montaño JM, Burgos Morón E, Valerie NCK, Wiita E, Almlöf I, Koolmeister T, Mateus A, Cazares-Körner C, Sanjiv K, Homan E, Loseva O, Baranczewski P, Darabi M, Mehdizadeh A, Fayezi S, Jemth AS, Warpman Berglund U, Sigmundsson K, Lundbäck T, Jenmalm Jensen A, Artursson P, Scobie M, Helleday T
J Med Chem 2017 May;60(10):4279-4292

111. Structure determination of a major facilitator peptide transporter: Inward facing PepTSt from Streptococcus thermophilus crystallized in space group P3121.
Quistgaard EM, Martinez Molledo M, Löw C
PLoS One 2017 ;12(3):e0173126

110. Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1.
Lehmann LC, Hewitt G, Aibara S, Leitner A, Marklund E, Maslen SL, Maturi V, Chen Y, van der Spoel D, Skehel JM, Moustakas A, Boulton SJ, Deindl S
Mol Cell 2017 Dec;68(5):847-859.e7

109. A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family.
Carreras-Puigvert J, Zitnik M, Jemth AS, Carter M, Unterlass JE, Hallström B, Loseva O, Karem Z, Calderón-Montaño JM, Lindskog C, Edqvist PH, Matuszewski DJ, Ait Blal H, Berntsson RPA, Häggblad M, Martens U, Studham M, Lundgren B, Wählby C, Sonnhammer ELL, Lundberg E, Stenmark P, Zupan B, Helleday T
Nat Commun 2017 11;8(1):1541

108. Structural basis for dolichylphosphate mannose biosynthesis.
Gandini R, Reichenbach T, Tan TC, Divne C
Nat Commun 2017 07;8(1):120

107. Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance.
Petrus P, Bialesova L, Checa A, Kerr A, Naz S, Bäckdahl J, Gracia A, Toft S, Dahlman-Wright K, Hedén P, Dahlman I, Wheelock CE, Arner P, Mejhert N, Gao H, Rydén M
J Clin Endocrinol Metab 2018 02;103(2):710-721

106. Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51.
Kumar R, Moche M, Winblad B, Pavlov PF
Sci Rep 2017 10;7(1):14288

105. Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX-type gene cluster.
Gustafsson R, Berntsson RP, Martínez-Carranza M, El Tekle G, Odegrip R, Johnson EA, Stenmark P
FEBS Lett 2017 11;591(22):3781-3792

104. Entirely enzymatic nanofabrication of DNA-protein conjugates.
Bernardinelli G, Högberg B
Nucleic Acids Res 2017 Oct;45(18):e160

103. Profiling of in vitro activities of urea-based inhibitors against cysteine synthases from Mycobacterium tuberculosis.
Brunner K, Steiner EM, Reshma RS, Sriram D, Schnell R, Schneider G
Bioorg Med Chem Lett 2017 10;27(19):4582-4587

102. Capturing LTA4 hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB4 synthesis.
Stsiapanava A, Samuelsson B, Haeggström JZ
Proc Natl Acad Sci U S A 2017 09;114(36):9689-9694

101. Mucin-Inspired Lubrication on Hydrophobic Surfaces.
Käsdorf BT, Weber F, Petrou G, Srivastava V, Crouzier T, Lieleg O
Biomacromolecules 2017 Aug;18(8):2454-2462

100. Investigation of calcium-dependent activity and conformational dynamics of zebra fish 12-lipoxygenase.
Mittal M, Hasan M, Balagunaseelan N, Fauland A, Wheelock C, Rådmark O, Haeggström JZ, Rinaldo-Matthis A
Biochim Biophys Acta Gen Subj 2017 Aug;1861(8):2099-2111

99. Biophysical characterization of the calmodulin-like domain of Plasmodium falciparum calcium dependent protein kinase 3.
Andresen C, Niklasson M, Cassman Eklöf S, Wallner B, Lundström P
PLoS One 2017 ;12(7):e0181721

98. Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Dobritzsch D, Holmdahl R
JCI Insight 2017 Jul;2(13):

97. Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14.
Upton K, Meyers M, Thorsell AG, Karlberg T, Holechek J, Lease R, Schey G, Wolf E, Lucente A, Schüler H, Ferraris D
Bioorg Med Chem Lett 2017 07;27(13):2907-2911

96. Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J
Science 2017 05;356(6337):

95. SnoN Stabilizes the SMAD3/SMAD4 Protein Complex.
Walldén K, Nyman T, Hällberg BM
Sci Rep 2017 04;7():46370

94. Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy.
B Kumar R, Zhu L, Hebert H, Jegerschöld C
J Vis Exp 2017 03;(121):

93. Binding and processing of β-lactam antibiotics by the transpeptidase LdtMt2 from Mycobacterium tuberculosis.
Steiner EM, Schneider G, Schnell R
FEBS J 2017 03;284(5):725-741

92. Characterization of the Ruler Protein Interaction Interface on the Substrate Specificity Switch Protein in the Yersinia Type III Secretion System.
Ho O, Rogne P, Edgren T, Wolf-Watz H, Login FH, Wolf-Watz M
J Biol Chem 2017 02;292(8):3299-3311

91. Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.
Thorsell AG, Ekblad T, Karlberg T, Löw M, Pinto AF, Trésaugues L, Moche M, Cohen MS, Schüler H
J Med Chem 2017 02;60(4):1262-1271

90. Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
Herold N, Rudd SG, Ljungblad L, Sanjiv K, Myrberg IH, Paulin CB, Heshmati Y, Hagenkort A, Kutzner J, Page BD, Calderón-Montaño JM, Loseva O, Jemth AS, Bulli L, Axelsson H, Tesi B, Valerie NC, Höglund A, Bladh J, Wiita E, Sundin M, Uhlin M, Rassidakis G, Heyman M, Tamm KP, Warpman-Berglund U, Walfridsson J, Lehmann S, Grandér D, Lundbäck T, Kogner P, Henter JI, Helleday T, Schaller T
Nat Med 2017 Feb;23(2):256-263

89, Small Molecule Microarray Based Discovery of PARP14 Inhibitors.
Peng B, Thorsell AG, Karlberg T, Schüler H, Yao SQ
Angew Chem Int Ed Engl 2017 01;56(1):248-253

2016 - 27 publications

88. Fuzzy regions in an intrinsically disordered protein impair protein-protein interactions.
Gruet A, Dosnon M, Blocquel D, Brunel J, Gerlier D, Das RK, Bonetti D, Gianni S, Fuxreiter M, Longhi S, Bignon C
FEBS J 2016 Feb;283(4):576-94

87. Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Siitonen V, Selvaraj B, Niiranen L, Lindqvist Y, Schneider G, Metsä-Ketelä M
Proc Natl Acad Sci U S A 2016 May;113(19):5251-6

86. A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice.
Lundbäck P, Lea JD, Sowinska A, Ottosson L, Fürst CM, Steen J, Aulin C, Clarke JI, Kipar A, Klevenvall L, Yang H, Palmblad K, Park BK, Tracey KJ, Blom AM, Andersson U, Antoine DJ, Erlandsson Harris H
Hepatology 2016 11;64(5):1699-1710

85. A ribonucleotide reductase inhibitor with deoxyribonucleoside-reversible cytotoxicity.
Crona M, Codó P, Jonna VR, Hofer A, Fernandes AP, Tholander F
Mol Oncol 2016 11;10(9):1375-1386

84. Generation and analyses of human synthetic antibody libraries and their application for protein microarrays.
Säll A, Walle M, Wingren C, Müller S, Nyman T, Vala A, Ohlin M, Borrebaeck CAK, Persson H
Protein Eng Des Sel 2016 10;29(10):427-437

83. Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD.
Quistgaard EM, Weininger U, Ural-Blimke Y, Modig K, Nordlund P, Akke M, Löw C
BMC Biol 2016 Sep;14(1):82

82. NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.
Valerie NC, Hagenkort A, Page BD, Masuyer G, Rehling D, Carter M, Bevc L, Herr P, Homan E, Sheppard NG, Stenmark P, Jemth AS, Helleday T
Cancer Res 2016 09;76(18):5501-11

81. The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation.
Schulte T, Mikaelsson C, Beaussart A, Kikhney A, Deshmukh M, Wolniak S, Pathak A, Ebel C, Löfling J, Fogolari F, Henriques-Normark B, Dufrêne YF, Svergun D, Nygren PÅ, Achour A
Sci Rep 2016 09;6():32371

80. The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity.
Sandalova T, Lee M, Henriques-Normark B, Hesek D, Mobashery S, Mellroth P, Achour A
Mol Microbiol 2016 09;101(6):954-67

79. Mutation-Induced Population Shift in the MexR Conformational Ensemble Disengages DNA Binding: A Novel Mechanism for MarR Family Derepression.
Anandapadamanaban M, Pilstål R, Andresen C, Trewhella J, Moche M, Wallner B, Sunnerhagen M
Structure 2016 08;24(8):1311-1321

78. Kinetic investigation of human 5-lipoxygenase with arachidonic acid.
Mittal M, Kumar RB, Balagunaseelan N, Hamberg M, Jegerschöld C, Rådmark O, Haeggström JZ, Rinaldo-Matthis A
Bioorg Med Chem Lett 2016 08;26(15):3547-51

77. Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.
Brunner K, Maric S, Reshma RS, Almqvist H, Seashore-Ludlow B, Gustavsson AL, Poyraz Ö, Yogeeswari P, Lundbäck T, Vallin M, Sriram D, Schnell R, Schneider G
J Med Chem 2016 07;59(14):6848-59

76. Identification of Inhibitors of Pseudomonas aeruginosa Exotoxin-S ADP-Ribosyltransferase Activity.
Pinto AF, Ebrahimi M, Saleeb M, Forsberg Å, Elofsson M, Schüler H
J Biomol Screen 2016 Jul;21(6):590-5

75. Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication.
Schulte T, Liu L, Panas MD, Thaa B, Dickson N, Götte B, Achour A, McInerney GM
Open Biol 2016 Jul;6(7):

74. Coxsackievirus counters the host innate immune response by blocking type III interferon expression.
Lind K, Svedin E, Domsgen E, Kapell S, Laitinen OH, Moll M, Flodström-Tullberg M
J Gen Virol 2016 06;97(6):1368-1380

73. Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Siitonen V, Selvaraj B, Niiranen L, Lindqvist Y, Schneider G, Metsä-Ketelä M
Proc Natl Acad Sci U S A 2016 May;113(19):5251-6

72. Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis.
Kouznetsova E, Kanno T, Karlberg T, Thorsell AG, Wisniewska M, Kursula P, Sjögren C, Schüler H
Structure 2016 05;24(5):789-796

71. Engineering a thermostable Halothermothrix orenii β-glucosidase for improved galacto-oligosaccharide synthesis.
Hassan N, Geiger B, Gandini R, Patel BK, Kittl R, Haltrich D, Nguyen TH, Divne C, Tan TC
Appl Microbiol Biotechnol 2016 Apr;100(8):3533-43

70. Novel mode of inhibition by D-tagatose 6-phosphate through a Heyns rearrangement in the active site of transaldolase B variants.
Stellmacher L, Sandalova T, Schneider S, Schneider G, Sprenger GA, Samland AK
Acta Crystallogr D Struct Biol 2016 Apr;72(Pt 4):467-76

69. A saposin-lipoprotein nanoparticle system for membrane proteins.
Frauenfeld J, Löving R, Armache JP, Sonnen AF, Guettou F, Moberg P, Zhu L, Jegerschöld C, Flayhan A, Briggs JA, Garoff H, Löw C, Cheng Y, Nordlund P
Nat Methods 2016 Apr;13(4):345-51

68. CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.
Almqvist H, Axelsson H, Jafari R, Dan C, Mateus A, Haraldsson M, Larsson A, Martinez Molina D, Artursson P, Lundbäck T, Nordlund P
Nat Commun 2016 Mar;7():11040

67. Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
Mills SJ, Silvander C, Cozier G, Trésaugues L, Nordlund P, Potter BV
Biochemistry 2016 Mar;55(9):1384-97

66. The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer.
Hafstrand I, Doorduijn EM, Duru AD, Buratto J, Oliveira CC, Sandalova T, van Hall T, Achour A
J Immunol 2016 Mar;196(5):2327-34

65. The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a--an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity.
Lim SM, Yeung K, Trésaugues L, Ling TH, Nordlund P
FEBS J 2016 Mar;283(6):1107-23

64. Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.
Llona-Minguez S, Höglund A, Jacques SA, Johansson L, Calderón-Montaño JM, Claesson M, Loseva O, Valerie NCK, Lundbäck T, Piedrafita J, Maga G, Crespan E, Meijer L, Morón EB, Baranczewski P, Hagbjörk AL, Svensson R, Wiita E, Almlöf I, Visnes T, Jeppsson F, Sigmundsson K, Jensen AJ, Artursson P, Jemth AS, Stenmark P, Berglund UW, Scobie M, Helleday T
J Med Chem 2016 Feb;59(3):1140-1148

63. Crystal structure of the flavoenzyme PA4991 from Pseudomonas aeruginosa.
Jacewicz A, Schnell R, Lindqvist Y, Schneider G
Acta Crystallogr F Struct Biol Commun 2016 Feb;72(Pt 2):105-11

62. A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E2 synthase.
Brock JS, Hamberg M, Balagunaseelan N, Goodman M, Morgenstern R, Strandback E, Samuelsson B, Rinaldo-Matthis A, Haeggström JZ
Proc Natl Acad Sci U S A 2016 Jan;113(4):972-7

2015 - 18 publications

61. Growth of Chitinophaga pinensis on Plant Cell Wall Glycans and Characterisation of a Glycoside Hydrolase Family 27 β-l-Arabinopyranosidase Implicated in Arabinogalactan Utilisation.
McKee LS, Brumer H
PLoS One 2015 ;10(10):e0139932

60. Processing of protein ADP-ribosylation by Nudix hydrolases.
Palazzo L, Thomas B, Jemth AS, Colby T, Leidecker O, Feijs KL, Zaja R, Loseva O, Puigvert JC, Matic I, Helleday T, Ahel I
Biochem J 2015 Jun;468(2):293-301

59. Exploring water as building bricks in enzyme engineering.
Hendil-Forssell P, Martinelle M, Syrén PO
Chem Commun (Camb) 2015 Dec;51(97):17221-4

58. Structural insights into the DNA-binding specificity of E2F family transcription factors.
Morgunova E, Yin Y, Jolma A, Dave K, Schmierer B, Popov A, Eremina N, Nilsson L, Taipale J
Nat Commun 2015 Dec;6():10050

57. DNA-dependent formation of transcription factor pairs alters their binding specificity.
Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J
Nature 2015 Nov;527(7578):384-8

56. Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity.
Ahmad S, Thulasingam M, Palombo I, Daley DO, Johnson KA, Morgenstern R, Haeggström JZ, Rinaldo-Matthis A
Biochim Biophys Acta 2015 Oct;1854(10 Pt A):1365-71

55. Acid–Base Catalyst Discriminates between a Fructose 6‐Phosphate Aldolase and a Transaldolase. Stellmacher L, Sandalova T, Leptihn S, Schneider G, Sprenger GA, Samland AK, ChemCatChem 2015, 7, 3140

54. Half-of-the-Sites Reactivity of the Castor Δ9-18:0-Acyl Carrier Protein Desaturase.
Liu Q, Chai J, Moche M, Guy J, Lindqvist Y, Shanklin J
Plant Physiol 2015 Sep;169(1):432-41

53. Structure of the Glycosyltransferase Ktr4p from Saccharomyces cerevisiae.
Possner DD, Claesson M, Guy JE
PLoS One 2015 ;10(8):e0136239

52. Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.
Carter M, Jemth AS, Hagenkort A, Page BD, Gustafsson R, Griese JJ, Gad H, Valerie NC, Desroses M, Boström J, Warpman Berglund U, Helleday T, Stenmark P
Nat Commun 2015 Aug;6():7871

51. Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation.
Tan TC, Kracher D, Gandini R, Sygmund C, Kittl R, Haltrich D, Hällberg BM, Ludwig R, Divne C
Nat Commun 2015 Jul;6():7542

50. Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate.
Trésaugues L, Lundbäck T, Welin M, Flodin S, Nyman T, Silvander C, Gräslund S, Nordlund P
PLoS One 2015 ;10(6):e0131507

49. Structure of the nuclease subunit of human mitochondrial RNase P.
Reinhard L, Sridhara S, Hällberg BM
Nucleic Acids Res 2015 Jun;43(11):5664-72

48. Crystal structures of the kinase domain of the sulfate-activating complex in Mycobacterium tuberculosis.
Poyraz Ö, Brunner K, Lohkamp B, Axelsson H, Hammarström LG, Schnell R, Schneider G
PLoS One 2015 ;10(3):e0121494

47. Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein.
Karlberg T, Klepsch M, Thorsell AG, Andersson CD, Linusson A, Schüler H
J Biol Chem 2015 Mar;290(12):7336-44

46. Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa.
Schmidberger JW, Schnell R, Schneider G
Acta Crystallogr D Biol Crystallogr 2015 Mar;71(Pt 3):721-31

45. High-resolution crystal structure of a polyextreme GH43 glycosidase from Halothermothrix orenii with α-L-arabinofuranosidase activity.
Hassan N, Kori LD, Gandini R, Patel BK, Divne C, Tan TC
Acta Crystallogr F Struct Biol Commun 2015 Mar;71(Pt 3):338-45

44. Biochemical and structural characterization of a thermostable β-glucosidase from Halothermothrix orenii for galacto-oligosaccharide synthesis.
Hassan N, Nguyen TH, Intanon M, Kori LD, Patel BK, Haltrich D, Divne C, Tan TC
Appl Microbiol Biotechnol 2015 Feb;99(4):1731-44

2014 - 21 publications

43. A novel cytosolic NADH:quinone oxidoreductase from Methanothermobacter marburgensis.
Ullmann E, Tan TC, Gundinger T, Herwig C, Divne C, Spadiut O
Biosci Rep 2014 Dec;34(6):e00167

42. Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme.
Dobritzsch D, Wang H, Schneider G, Yu S
Biochem J 2014 Sep;462(3):441-52

41. Structural basis for regulation of the human acetyl-CoA thioesterase 12 and interactions with the steroidogenic acute regulatory protein-related lipid transfer (START) domain.
Swarbrick CM, Roman N, Cowieson N, Patterson EI, Nanson J, Siponen MI, Berglund H, Lehtiö L, Forwood JK
J Biol Chem 2014 Aug;289(35):24263-74

40. Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.
Guettou F, Quistgaard EM, Raba M, Moberg P, Löw C, Nordlund P
Nat Struct Mol Biol 2014 Aug;21(8):728-31

39. Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family.
Pinto AF, Schüler H
Curr Top Microbiol Immunol 2015 ;384():153-66

38. Structural and biochemical characterization of human PR70 in isolation and in complex with the scaffolding subunit of protein phosphatase 2A.
Dovega R, Tsutakawa S, Quistgaard EM, Anandapadamanaban M, Löw C, Nordlund P
PLoS One 2014 ;9(7):e101846

37. Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.
Löw C, Quistgaard EM, Kovermann M, Anandapadamanaban M, Balbach J, Nordlund P
Biol Chem 2014 Jul;395(7-8):881-9

36. Crystal structure of human CRMP-4: correction of intensities for lattice-translocation disorder.
Ponnusamy R, Lebedev AA, Pahlow S, Lohkamp B
Acta Crystallogr D Biol Crystallogr 2014 Jun;70(Pt 6):1680-94

35. Structure and inhibition of mouse leukotriene C4 synthase.
Niegowski D, Kleinschmidt T, Ahmad S, Qureshi AA, Mårback M, Rinaldo-Matthis A, Haeggström JZ
PLoS One 2014 ;9(5):e96763

34. Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.
Trésaugues L, Silvander C, Flodin S, Welin M, Nyman T, Gräslund S, Hammarström M, Berglund H, Nordlund P
Structure 2014 May;22(5):744-55

33. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Gad H, Koolmeister T, Jemth AS, Eshtad S, Jacques SA, Ström CE, Svensson LM, Schultz N, Lundbäck T, Einarsdottir BO, Saleh A, Göktürk C, Baranczewski P, Svensson R, Berntsson RP, Gustafsson R, Strömberg K, Sanjiv K, Jacques-Cordonnier MC, Desroses M, Gustavsson AL, Olofsson R, Johansson F, Homan EJ, Loseva O, Bräutigam L, Johansson L, Höglund A, Hagenkort A, Pham T, Altun M, Gaugaz FZ, Vikingsson S, Evers B, Henriksson M, Vallin KS, Wallner OA, Hammarström LG, Wiita E, Almlöf I, Kalderén C, Axelsson H, Djureinovic T, Puigvert JC, Häggblad M, Jeppsson F, Martens U, Lundin C, Lundgren B, Granelli I, Jensen AJ, Artursson P, Nilsson JA, Stenmark P, Scobie M, Berglund UW, Helleday T
Nature 2014 Apr;508(7495):215-21

32. Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors.
Liscio P, Carotti A, Asciutti S, Karlberg T, Bellocchi D, Llacuna L, Macchiarulo A, Aaronson SA, Schüler H, Pellicciari R, Camaioni E
J Med Chem 2014 Mar;57(6):2807-12

31. Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.
Stsiapanava A, Olsson U, Wan M, Kleinschmidt T, Rutishauser D, Zubarev RA, Samuelsson B, Rinaldo-Matthis A, Haeggström JZ
Proc Natl Acad Sci U S A 2014 Mar;111(11):4227-32

30. Epitope-specific antibody response is controlled by immunoglobulin V(H) polymorphisms.
Raposo B, Dobritzsch D, Ge C, Ekman D, Xu B, Lindh I, Förster M, Uysal H, Nandakumar KS, Schneider G, Holmdahl R
J Exp Med 2014 Mar;211(3):405-11

29. ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics.
Marteyn BS, Karimova G, Fenton AK, Gazi AD, West N, Touqui L, Prevost MC, Betton JM, Poyraz O, Ladant D, Gerdes K, Sansonetti PJ, Tang CM
mBio 2014 Mar;5(2):e00022-14

28. Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism.
Niegowski D, Kleinschmidt T, Olsson U, Ahmad S, Rinaldo-Matthis A, Haeggström JZ
J Biol Chem 2014 Feb;289(8):5199-207

27. Structural and functional insights into peptidoglycan access for the lytic amidase LytA of Streptococcus pneumoniae.
Mellroth P, Sandalova T, Kikhney A, Vilaplana F, Hesek D, Lee M, Mobashery S, Normark S, Svergun D, Henriques-Normark B, Achour A
mBio 2014 Feb;5(1):e01120-13

26. Product formation controlled by substrate dynamics in leukotriene A4 hydrolase.
Stsiapanava A, Tholander F, Kumar RB, Qureshi AA, Niegowski D, Hasan M, Thunnissen M, Haeggström JZ, Rinaldo-Matthis A
Biochim Biophys Acta 2014 Feb;1844(2):439-46

25. Structural basis for binding of fluorinated glucose and galactose to Trametes multicolor pyranose 2-oxidase variants with improved galactose conversion.
Tan TC, Spadiut O, Gandini R, Haltrich D, Divne C
PLoS One 2014 ;9(1):e86736

24. The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold.
Schulte T, Löfling J, Mikaelsson C, Kikhney A, Hentrich K, Diamante A, Ebel C, Normark S, Svergun D, Henriques-Normark B, Achour A
Open Biol 2014 Jan;4():130090

23. RipD (Rv1566c) from Mycobacterium tuberculosis: adaptation of an NlpC/p60 domain to a non-catalytic peptidoglycan-binding function.
Böth D, Steiner EM, Izumi A, Schneider G, Schnell R
Biochem J 2014 Jan;457(1):33-41

2013 - 14 publications

22. Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3.
Lindgren AE, Karlberg T, Ekblad T, Spjut S, Thorsell AG, Andersson CD, Nhan TT, Hellsten V, Weigelt J, Linusson A, Schüler H, Elofsson M
J Med Chem 2013 Dec;56(23):9556-68

21. Discovery of an allosteric inhibitor binding site in 3-Oxo-acyl-ACP reductase from Pseudomonas aeruginosa.
Cukier CD, Hope AG, Elamin AA, Moynie L, Schnell R, Schach S, Kneuper H, Singh M, Naismith JH, Lindqvist Y, Gray DW, Schneider G
ACS Chem Biol 2013 Nov;8(11):2518-27

20. Substrate specificity and oligomerization of human GMP synthetase.
Welin M, Lehtiö L, Johansson A, Flodin S, Nyman T, Trésaugues L, Hammarström M, Gräslund S, Nordlund P
J Mol Biol 2013 Nov;425(22):4323-33

19. Metal-mediated crystallization of the xylose transporter XylE from Escherichia coli in three different crystal forms.
Quistgaard EM, Löw C, Moberg P, Nordlund P
J Struct Biol 2013 Nov;184(2):375-8

18. Nanobody mediated crystallization of an archeal mechanosensitive channel.
Löw C, Yau YH, Pardon E, Jegerschöld C, Wåhlin L, Quistgaard EM, Moberg P, Geifman-Shochat S, Steyaert J, Nordlund P
PLoS One 2013 ;8(10):e77984

17. Structural insights into substrate recognition in proton-dependent oligopeptide transporters.
Guettou F, Quistgaard EM, Trésaugues L, Moberg P, Jegerschöld C, Zhu L, Jong AJ, Nordlund P, Löw C
EMBO Rep 2013 Sep;14(9):804-10

16. PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.
Lindgren AE, Karlberg T, Thorsell AG, Hesse M, Spjut S, Ekblad T, Andersson CD, Pinto AF, Weigelt J, Hottiger MO, Linusson A, Elofsson M, Schüler H
ACS Chem Biol 2013 Aug;8(8):1698-703

15. Structural and biophysical characterization of the cytoplasmic domains of human BAP29 and BAP31.
Quistgaard EM, Löw C, Moberg P, Guettou F, Maddi K, Nordlund P
PLoS One 2013 ;8(8):e71111

14. High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation.
Anandapadamanaban M, Andresen C, Helander S, Ohyama Y, Siponen MI, Lundström P, Kokubo T, Ikura M, Moche M, Sunnerhagen M
Nat Struct Mol Biol 2013 Aug;20(8):1008-14

13. Enzymatic production of 'monoclonal stoichiometric' single-stranded DNA oligonucleotides.
Ducani C, Kaul C, Moche M, Shih WM, Högberg B
Nat Methods 2013 Jul;10(7):647-52

12. The crystal structure of the lumenal domain of Erv41p, a protein involved in transport between the endoplasmic reticulum and Golgi apparatus.
Biterova EI, Svärd M, Possner DD, Guy JE
J Mol Biol 2013 Jun;425(12):2208-18

11. Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct Substrates.
Chen MW, Lohkamp B, Schnell R, Lescar J, Schneider G
PLoS One 2013 ;8(6):e66936

10. Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters.
Quistgaard EM, Löw C, Moberg P, Trésaugues L, Nordlund P
Nat Struct Mol Biol 2013 Jun;20(6):766-8

9. Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase.
Lim SM, Chen D, Teo H, Roos A, Jansson AE, Nyman T, Trésaugues L, Pervushin K, Nordlund P
J Lipid Res 2013 Jun;54(6):1630-43

8. Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains.
Forst AH, Karlberg T, Herzog N, Thorsell AG, Gross A, Feijs KL, Verheugd P, Kursula P, Nijmeijer B, Kremmer E, Kleine H, Ladurner AG, Schüler H, Lüscher B
Structure 2013 Mar;21(3):462-75

7. Structure of LdtMt2, an L,D-transpeptidase from Mycobacterium tuberculosis.
Böth D, Steiner EM, Stadler D, Lindqvist Y, Schnell R, Schneider G
Acta Crystallogr D Biol Crystallogr 2013 Mar;69(Pt 3):432-41

2012 - 6 publications

6. Unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics.
Allerbring EB, Duru AD, Uchtenhagen H, Madhurantakam C, Tomek MB, Grimm S, Mazumdar PA, Friemann R, Uhlin M, Sandalova T, Nygren PÅ, Achour A
Eur J Immunol 2012 Nov;42(11):2990-3000

5. High-resolution insights into binding of unfolded polypeptides by the PPIase chaperone SlpA.
Quistgaard EM, Nordlund P, Löw C
FASEB J 2012 Oct;26(10):4003-13

4. Discovery of ligands for ADP-ribosyltransferases via docking-based virtual screening.
Andersson CD, Karlberg T, Ekblad T, Lindgren AE, Thorsell AG, Spjut S, Uciechowska U, Niemiec MS, Wittung-Stafshede P, Weigelt J, Elofsson M, Schüler H, Linusson A
J Med Chem 2012 Sep;55(17):7706-18

3. Inflammation-associated nitrotyrosination affects TCR recognition through reduced stability and alteration of the molecular surface of the MHC complex.
Madhurantakam C, Duru AD, Sandalova T, Webb JR, Achour A
PLoS One 2012 ;7(3):e32805

2. Tetrahydrodipicolinate N-succinyltransferase and dihydrodipicolinate synthase from Pseudomonas aeruginosa: structure analysis and gene deletion.
Schnell R, Oehlmann W, Sandalova T, Braun Y, Huck C, Maringer M, Singh M, Schneider G
PLoS One 2012 ;7(2):e31133

1. High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C.
Willander H, Askarieh G, Landreh M, Westermark P, Nordling K, Keränen H, Hermansson E, Hamvas A, Nogee LM, Bergman T, Saenz A, Casals C, Åqvistg J, Jörnvall H, Berglund H, Presto J, Knight SD, Johansson J
Proc Natl Acad Sci U S A 2012 Feb;109(7):2325-9