Tomas Nyman

Publications
Public outreach and news

Articles

Article: NATURE PROTOCOLS. 2024;19(3):791-830
Nano-CUT&Tag for multimodal chromatin profiling at single-cell resolution
Barcenas-Walls JR; Ansaloni F; Herve B; Strandback E; Nyman T; Castelo-Branco G; Bartosovic M
Article: ANTIVIRAL RESEARCH. 2021;190:105074
Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors
Akaberi D; Bahlstrom A; Chinthakindi PK; Nyman T; Sandstrom A; Jarhult JD; Palanisamy N; Lundkvist A; Lennerstrand J
Article: SCIENTIFIC REPORTS. 2021;11(1):1820
Direct detection of SARS-CoV-2 using non-commercial RT-LAMP reagents on heat-inactivated samples
Alekseenko A; Barrett D; Pareja-Sanchez Y; Howard RJ; Strandback E; Ampah-Korsah H; Rovsnik U; Zuniga-Veliz S; Klenov A; Malloo J; Ye S; Liu X; Reinius B; Elsasser SJ; Nyman T; Sandh G; Yin X; Pelechano V
Article: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY. 2019;30(8):1385-1388
Gas-Phase Collisions with Trimethylamine-N-Oxide Enable Activation-Controlled Protein Ion Charge Reduction
Kaldmae M; Osterlund N; Lianoudaki D; Sahin C; Bergman P; Nyman T; Kronqvist N; Ilag LL; Allison TM; Marklund EG; Landreh M
Article: SLAS DISCOVERY. 2018;23(4):353-362
Identification of Poly(ADP-Ribose) Polymerase Macrodomain Inhibitors Using an AlphaScreen Protocol
Ekblad T; Verheugd P; Lindgren AE; Nyman T; Elofsson M; Schuler H
Article: SCIENTIFIC REPORTS. 2017;7:46370
SnoN Stabilizes the SMAD3/SMAD4 Protein Complex
Wallden K; Nyman T; Hallberg BM
Article: PROTEIN ENGINEERING, DESIGN AND SELECTION. 2016;29(10):427-437
Generation and analyses of human synthetic antibody libraries and their application for protein microarrays
Sall A; Walle M; Wingren C; Muller S; Nyman T; Vala A; Ohlin M; Borrebaeck CAK; Persson H
Article: PLOS ONE. 2015;10(6):e0131507
Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate
Tresaugues L; Lundback T; Welin M; Flodin S; Nyman T; Silvander C; Graslund S; Nordlund P
Article: STRUCTURE. 2014;22(5):744-755
Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases
Tresaugues L; Silvander C; Flodin S; Welin M; Nyman T; Graslund S; Hammarstrom M; Berglund H; Nordlund P
Article: JOURNAL OF MOLECULAR BIOLOGY. 2013;425(22):4323-4333
Substrate Specificity and Oligomerization of Human GMP Synthetase
Welin M; Lehtlo L; Johansson A; Flodin S; Nyman T; Tresaugues L; Hammarstrom M; Graslund S; Nordlund P
Article: JOURNAL OF LIPID RESEARCH. 2013;54(6):1630-1643
Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase
Lim SM; Chen D; Teo H; Roos A; Jansson AE; Nyman T; Tresaugues L; Pervushin K; Nordlund P
Article: THE FEBS JOURNAL. 2010;277(23):4920-4930
Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1
Welin M; Egeblad L; Johansson A; Stenmark P; Wang L; Flodin S; Nyman T; Tresaugues L; Kotenyova T; Johansson I; Eriksson S; Eklund H; Nordlund P
Article: NUCLEIC ACIDS RESEARCH (NAR). 2010;38(20):7308-7319
Structural studies of tri-functional human GART
Welin M; Grossmann JG; Flodin S; Nyman T; Stenmark P; Tresaugues L; Kotenyova T; Johansson I; Nordlund P; Lehtio L
Article: PLOS ONE. 2010;5(9):e12907
The Crystal Structure of the Dachshund Domain of Human SnoN Reveals Flexibility in the Putative Protein Interaction Surface
Nyman T; Tresaugues L; Welin M; Lehtio L; Flodin S; Persson C; Johansson I; Hammarstrom M; Nordlund P
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2009;65(Pt 11):1091-1096
Structures of BIR domains from human NAIP and cIAP2
Herman MD; Moche M; Flodin S; Welin M; Tresaugues L; Johansson I; Nilsson M; Nordlund P; Nyman T
Article: PROTEINS: STRUCTURE, FUNCTION AND BIOINFORMATICS. 2009;74(1):212-221
The structure of the PP2A regulatory subunit B56γ: The remaining piece of the PP2A jigsaw puzzle
Magnusdottir A; Stenmark P; Flodin S; Nyman T; Kotenyova T; Graslund S; Ogg D; Nordlund P
Article: PROTEINS: STRUCTURE, FUNCTION AND BIOINFORMATICS. 2008;73(4):1047-1052
The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site
Tresaugues L; Stenmark P; Schuler H; Flodin S; Welin M; Nyman T; Hammarstrom M; Moche M; Graslund S; Nordlund P
Article: FEBS LETTERS. 2008;582(25-26):3590-3594
Completing the family portrait of the anti-apoptotic Bcl-2 proteins: Crystal structure of human Bfl-1 in complex with Bim
Herman MD; Nyman T; Welin M; Lehtio L; Flodin S; Tresaugues L; Kotenyova T; Flores A; Nordlund P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(18):11861-11865
The crystal structure of the human Toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer
Nyman T; Stenmark P; Flodin S; Johansson I; Hammarstroem M; Nordlund P
Article: NATURE METHODS. 2007;4(12):1019-1021
In situ proteolysis for protein crystallization and structure determination
Dong A; Xu X; Edward AM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(24):17828-17836
Crystal structure of human cytosolic 5′-nucleotidase II -: Insights into allosteric regulation and substrate recognition
Wallden K; Stenmark P; Nyman T; Flodin S; Graslund S; Loppnau P; Bianchi V; Nordlund P
Article: JOURNAL OF NEUROCHEMISTRY. 2007;101(4):906-917
The structure of human collapsin response mediator protein 2, a regulator of axonal growth
Stenmark P; Ogg D; Flodin S; Flores A; Kotenyova T; Nyman T; Nordlund P; Kursula P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(32):22434-22438
The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions
Magnusdottir A; Stenmark P; Flodin S; Nyman T; Hammarstrom M; Ehn M; Bakali H MA; Berglund H; Nordlund P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(18):15828-15833
A cross-linked profilin-actin heterodimer interferes with elongation at the fast-growing end of F-actin.
Nyman T; Page R; Schutt CE; Karlsson R; Lindberg U
Article: JOURNAL OF MOLECULAR BIOLOGY. 2002;317(4):577-589
The role of MeH73 in actin polymerization and ATP hydrolysis
Nyman T; Schüler H; Korenbaum E; Schutt CE; Karlsson R; Lindberg U
Article: MOLECULAR MICROBIOLOGY. 2001;39(3):606-619
Actin is ADP-ribosylated by the Salmonella enterica virulence-associated protein SpvB
Tezcan-Merdol D; Nyman T; Lindberg U; Haag F; Koch-Nolte F; Rhen M
Article: EXPERIMENTAL CELL RESEARCH. 2000;256(1):112-121
Effects of cross-linked profilin:beta/gamma-actin on the dynamics of the microfilament system in cultured cells.
Hájková L; Nyman T; Lindberg U; Karlsson R
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Preprint: BIORXIV. 2024
Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries
Akaberi D; Lati MP; Krambrich J; Berger J; Neilsen G; Strandback E; Turunen SP; Wannberg J; Gullberg H; Moche M; Chinthakindi PK; Nyman T; Sarafianos SG; Sandström A; Järhult JD; Sandberg K; Lundkvist Å; Verho O; Lennerstrand J
Preprint: MEDRXIV. 2020
Detection of SARS-CoV-2 using non-commercial RT-LAMP reagents and raw samples
Alekseenko A; Barrett D; Pareja-Sanchez Y; J Howard R; Strandback E; Ampah-Korsah H; Rovšnik U; Zuniga-Veliz S; Klenov A; Malloo J; Ye S; Liu X; Reinius B; Elsässer S; Nyman T; Sandh G; Yin X; Pelechano V

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