PIF - Applications
Small animal imaging is an emerging field which has an impact on various biomedical research areas such as neurology, oncology, cardiology, immunology, and infection biology. The mission of PIF is to bridge the gap between in vitro biomedical research and in vivo investigations.
From mouse to man – from the laboratory bench to the patient’s bedside
This endeavor is achieved by developing novel imaging strategies and animal models to gain knowledge about in vivo physiological and pathological processes. PIF strives to develop methods and techniques that can be applied in the research areas of RS and KI, with a particular focus on KS-H/KI-Syd, including cancer, regenerative medicine, transplantation, hematology, cardiology, vaccines, nanotechnology and advanced cell, gene and tissue therapies (Advanced Therapy Medicinal Products, ATMP).
Applications, methods and techniques
| Applications | Methods and techniques |
|---|---|
| Ultrasound-guided injection | Ultrasound (US) |
| Tumor progression and evaluation of treatment efficacy | Bioluminescence imaging (BLI); fluorescence imaging (FLI); ultrasound imaging (US); MRI; 18F-FDG PET/MRI |
| Tumor perfusion/vascularity | US with contrast; CT with contrast; MRI with contrast |
| Tumor hypoxia | Oxy-Hemo photoacoustic imaging (PA) |
| Cerebral hypoxia | Oxy-Hemo photoacoustic imaging (PA) |
| Lung cancer progression and metastasis analysis | µ-CT |
| Evaluation of pulmonary fibrosis | CT/MRI |
| Bone and fat tissue analysis | µ-CT |
| Biological distribution of nanoparticles/peptides | Bioluminescence imaging (BLI); fluorescence imaging (FLI) |
| Analysis of cardiac function | Echocardiography and strain analysis |
| Cell tracking (CAR-T, NK cells, stromal cells, stem cells) | Bioluminescence imaging (BLI); fluorescence imaging (FLI); 89Zr PET/MRI; magnetic particle imaging (MPI) |
| Evaluation of liver function | CT with contrast; MRI |
| In vivo measurement of spleen size | US; CT with contrast; MRI |