Publications list from the head of the zebrafish core facility

A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression.
Zhang J, Ye ZW, Bräutigam L, Chakraborty P, Luo Z, Culpepper J, Aslam M, Zhang L, Johansson K, Haeggström JZ, Xu J, Olsson M, Townsend DM, Mehrotra S, Morgenstern R, Tew KD
J Biol Chem 2023 Aug;299(8):104920

Graphene oxide elicits microbiome-dependent type 2 immune responses via the aryl hydrocarbon receptor.
Peng G, Sinkko HM, Alenius H, Lozano N, Kostarelos K, Bräutigam L, Fadeel B
Nat Nanotechnol 2023 Jan;18(1):42-48

Small molecule-mediated disruption of ribosome biogenesis synergizes with FGFR inhibitors to suppress glioma cell growth.
Zisi A, Kanellis DC, Moussaud S, Karlsson I, Carén H, Bräutigam L, Bartek J, Lindström MS
Neuro Oncol 2023 Jun;25(6):1058-1072

CCT3-LINC00326 axis regulates hepatocarcinogenic lipid metabolism.
Søndergaard JN, Sommerauer C, Atanasoai I, Hinte LC, Geng K, Guiducci G, Bräutigam L, Aouadi M, Stojic L, Barragan I, Kutter C
Gut 2022 Jan;71(10):2081-92

Glutaredoxin 2 promotes SP-1-dependent CSPG4 transcription and migration of wound healing NG2 glia and glioma cells: Enzymatic Taoism.
Wilms C, Lepka K, Häberlein F, Edwards S, Felsberg J, Pudelko L, Lindenberg TT, Poschmann G, Qin N, Volbracht K, Prozorovski T, Meuth SG, Kahlert UD, Remke M, Aktas O, Reifenberger G, Bräutigam L, Odermatt B, Berndt C
Redox Biol 2022 Feb;49():102221

MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells.
Karsten S, Fiskesund R, Zhang XM, Marttila P, Sanjiv K, Pham T, Rasti A, Bräutigam L, Almlöf I, Marcusson-Ståhl M, Sandman C, Platzack B, Harris RA, Kalderén C, Cederbrant K, Helleday T, Warpman Berglund U
Cell Death Differ 2022 Jan;29(1):246-261

Novel loss-of-function variant in DENND5A impedes melanosomal cargo transport and predisposes to familial cutaneous melanoma.
Yang M, Johnsson P, Bräutigam L, Yang XR, Thrane K, Gao J, Tobin NP, Zhou Y, Yu R, Nagy N, Engström PG, Tuominen R, Eriksson H, Lundeberg J, Tucker MA, Goldstein AM, Egyhazi-Brage S, Zhao J, Cao Y, Höiom V
Genet Med 2022 Jan;24(1):157-169

A Systematic Analysis of Metal and Metalloid Concentrations in Eight Zebrafish Recirculating Water Systems.
Langa X, Neuhaus P, Lains D, Stewart TJ, Borel N, Certal AC, Monteiro JF, Aleström P, Diaz E, Piragyte I, Bräutigam L, Vázquez R, Hlushchuk R, Gfeller L, Mestrot A, Bigalke M, Varga ZM, Mercader N
Zebrafish 2021 Aug;18(4):252-264

AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma.
Das I, Gad H, Bräutigam L, Pudelko L, Tuominen R, Höiom V, Almlöf I, Rajagopal V, Hansson J, Helleday T, Egyházi Brage S, Warpman Berglund U
Cell Death Differ 2020 Jul;27(7):2081-2098

Correction: Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.
Pudelko L, Rouhi P, Sanjiv K, Gad H, Kalderén C, Höglund A, Squatrito M, Schuhmacher AJ, Edwards S, Hägerstrand D, Berglund UW, Helleday T, Bräutigam L
Oncotarget 2020 Feb;11(8):827

Development of a chemical probe against NUDT15.
Zhang SM, Desroses M, Hagenkort A, Valerie NCK, Rehling D, Carter M, Wallner O, Koolmeister T, Throup A, Jemth AS, Almlöf I, Loseva O, Lundbäck T, Axelsson H, Regmi S, Sarno A, Krämer A, Pudelko L, Bräutigam L, Rasti A, Göttmann M, Wiita E, Kutzner J, Schaller T, Kalderén C, Cázares-Körner A, Page BDG, Krimpenfort R, Eshtad S, Altun M, Rudd SG, Knapp S, Scobie M, Homan EJ, Berglund UW, Stenmark P, Helleday T
Nat Chem Biol 2020 Oct;16(10):1120-1128

MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
Scaletti ER, Vallin KS, Bräutigam L, Sarno A, Warpman Berglund U, Helleday T, Stenmark P, Jemth AS
J Biol Chem 2020 Apr;295(15):4761-4772

Nitric oxide-dependent biodegradation of graphene oxide reduces inflammation in the gastrointestinal tract.
Peng G, Montenegro MF, Ntola CNM, Vranic S, Kostarelos K, Vogt C, Toprak MS, Duan T, Leifer K, Bräutigam L, Lundberg JO, Fadeel B
Nanoscale 2020 Aug;12(32):16730-16737

Visualization of human T lymphocyte-mediated eradication of cancer cells in vivo.
He X, Yin X, Wu J, Wickström SL, Duo Y, Du Q, Qin S, Yao S, Jing X, Hosaka K, Wu J, Jensen LD, Lundqvist A, Salter AI, Bräutigam L, Tao W, Chen Y, Kiessling R, Cao Y
Proc Natl Acad Sci U S A 2020 Sep;117(37):22910-22919

A Chemical Screen Identifies Compounds Limiting the Toxicity of C9ORF72 Dipeptide Repeats.
Corman A, Jung B, Häggblad M, Bräutigam L, Lafarga V, Lidemalm L, Hühn D, Carreras-Puigvert J, Fernandez-Capetillo O
Cell Chem Biol 2019 Feb;26(2):235-243.e5

The Nordic Zebrafish and Husbandry Meeting 2018.
Filipek-Górniok B, Ledin J, Aleström P, Braeutigam L
Zebrafish 2019 Jun;16(3):329-330

An orthotopic glioblastoma animal model suitable for high-throughput screenings.
Pudelko L, Edwards S, Balan M, Nyqvist D, Al-Saadi J, Dittmer J, Almlöf I, Helleday T, Bräutigam L
Neuro Oncol 2018 Oct;20(11):1475-1484

MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation.
Bräutigam L, Zhang J, Dreij K, Spahiu L, Holmgren A, Abe H, Tew KD, Townsend DM, Kelner MJ, Morgenstern R, Johansson K
Redox Biol 2018 Jul;17():171-179

MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.
Jemth AS, Gustafsson R, Bräutigam L, Henriksson L, Vallin KSA, Sarno A, Almlöf I, Homan E, Rasti A, Warpman Berglund U, Stenmark P, Helleday T
Nucleic Acids Res 2018 Nov;46(20):10888-10904

Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.
Pudelko L, Rouhi P, Sanjiv K, Gad H, Kalderén C, Höglund A, Squatrito M, Schuhmacher AJ, Edwards S, Hägerstrand D, Berglund UW, Helleday T, Bräutigam L
Oncotarget 2017 Oct;8(49):84671-84684

Mutations in Cancer Cause Gain of Cysteine, Histidine, and Tryptophan at the Expense of a Net Loss of Arginine on the Proteome Level.
Tsuber V, Kadamov Y, Brautigam L, Berglund UW, Helleday T
Biomolecules 2017 Jul;7(3):

Oxidants and Redox Signaling: Perspectives in Cancer Therapy, Inflammation, and Plasma Medicine.
Bekeschus S, Bräutigam L, Wende K, Hanschmann EM
Oxid Med Cell Longev 2017 ;2017():4020253

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition.
Bräutigam L, Pudelko L, Jemth AS, Gad H, Narwal M, Gustafsson R, Karsten S, Carreras Puigvert J, Homan E, Berndt C, Berglund UW, Stenmark P, Helleday T
Cancer Res 2016 Apr;76(8):2366-75

Validation and development of MTH1 inhibitors for treatment of cancer.
Warpman Berglund U, Sanjiv K, Gad H, Kalderén C, Koolmeister T, Pham T, Gokturk C, Jafari R, Maddalo G, Seashore-Ludlow B, Chernobrovkin A, Manoilov A, Pateras IS, Rasti A, Jemth AS, Almlöf I, Loseva O, Visnes T, Einarsdottir BO, Gaugaz FZ, Saleh A, Platzack B, Wallner OA, Vallin KS, Henriksson M, Wakchaure P, Borhade S, Herr P, Kallberg Y, Baranczewski P, Homan EJ, Wiita E, Nagpal V, Meijer T, Schipper N, Rudd SG, Bräutigam L, Lindqvist A, Filppula A, Lee TC, Artursson P, Nilsson JA, Gorgoulis VG, Lehtiö J, Zubarev RA, Scobie M, Helleday T
Ann Oncol 2016 Dec;27(12):2275-2283

VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish.
Jensen LD, Nakamura M, Bräutigam L, Li X, Liu Y, Samani NJ, Cao Y
Proc Natl Acad Sci U S A 2015 Nov;112(44):E5944-53

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Gad H, Koolmeister T, Jemth AS, Eshtad S, Jacques SA, Ström CE, Svensson LM, Schultz N, Lundbäck T, Einarsdottir BO, Saleh A, Göktürk C, Baranczewski P, Svensson R, Berntsson RP, Gustafsson R, Strömberg K, Sanjiv K, Jacques-Cordonnier MC, Desroses M, Gustavsson AL, Olofsson R, Johansson F, Homan EJ, Loseva O, Bräutigam L, Johansson L, Höglund A, Hagenkort A, Pham T, Altun M, Gaugaz FZ, Vikingsson S, Evers B, Henriksson M, Vallin KS, Wallner OA, Hammarström LG, Wiita E, Almlöf I, Kalderén C, Axelsson H, Djureinovic T, Puigvert JC, Häggblad M, Jeppsson F, Martens U, Lundin C, Lundgren B, Granelli I, Jensen AJ, Artursson P, Nilsson JA, Stenmark P, Scobie M, Berglund UW, Helleday T
Nature 2014 Apr;508(7495):215-21

Zebrafish heart development is regulated via glutaredoxin 2 dependent migration and survival of neural crest cells.
Berndt C, Poschmann G, Stühler K, Holmgren A, Bräutigam L
Redox Biol 2014 ;2():673-8

An unusual mode of iron-sulfur-cluster coordination in a teleost glutaredoxin.
Bräutigam L, Johansson C, Kubsch B, McDonough MA, Bill E, Holmgren A, Berndt C
Biochem Biophys Res Commun 2013 Jul;436(3):491-6

Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation.
Haunhorst P, Hanschmann EM, Bräutigam L, Stehling O, Hoffmann B, Mühlenhoff U, Lill R, Berndt C, Lillig CH
Mol Biol Cell 2013 Jun;24(12):1895-903

Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1.
Bräutigam L, Jensen LD, Poschmann G, Nyström S, Bannenberg S, Dreij K, Lepka K, Prozorovski T, Montano SJ, Aktas O, Uhlén P, Stühler K, Cao Y, Holmgren A, Berndt C
Proc Natl Acad Sci U S A 2013 Dec;110(50):20057-62

Opposing effects of circadian clock genes bmal1 and period2 in regulation of VEGF-dependent angiogenesis in developing zebrafish.
Jensen LD, Cao Z, Nakamura M, Yang Y, Bräutigam L, Andersson P, Zhang Y, Wahlberg E, Länne T, Hosaka K, Cao Y
Cell Rep 2012 Aug;2(2):231-41

Vertebrate-specific glutaredoxin is essential for brain development.
Bräutigam L, Schütte LD, Godoy JR, Prozorovski T, Gellert M, Hauptmann G, Holmgren A, Lillig CH, Berndt C
Proc Natl Acad Sci U S A 2011 Dec;108(51):20532-7

Localized expression of urocortin genes in the developing zebrafish brain.
Bräutigam L, Hillmer JM, Söll I, Hauptmann G
J Comp Neurol 2010 Aug;518(15):2978-95

Indicators summary for verified articles and reviews

 P 30 Number of verified publications

Sum JIF 418.27 Sum of Latest Known Journal Impact Factor

C 1101 Total number of citations

Avg C top5 133.6 Average number of citations for the 5 highest cited publications

Avg JIF top5 38.8 Average Journal Impact Factor for the 5 publications with highest JIF

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