Lars Bräutigam

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Articles

Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2023;299(8):104920

A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression

Zhang J; Ye Z-W; Braeutigam L; Chakraborty P; Luo Z; Culpepper J; Aslam M; Zhang L; Johansson K; Haeggstrom JZ; Xu J; Olsson M; Townsend DM; Mehrotra S; Morgenstern R; Tew KD
Article: NEURO-ONCOLOGY. 2023;25(6):1058-1072

Small molecule-mediated disruption of ribosome biogenesis synergizes with FGFR inhibitors to suppress glioma cell growth

Zisi A; Kanellis DC; Moussaud S; Karlsson I; Caren H; Braeutigam L; Bartek J; Lindstrom MS
Journal article: CANCER RESEARCH. 2023;83(7_Supplement):1569

Abstract 1569: OXC-101 kills cancer by disturbing microtubule polymerization and inhibiting MTH1

Berglund UW; Gad H; Sanjiv K; Jemth A-S; Mortusewics O; Brautigam L; Rantala J; Helleday T
Article: NATURE NANOTECHNOLOGY. 2023;18(1):42-48

Graphene oxide elicits microbiome-dependent type 2 immune responses via the aryl hydrocarbon receptor

Peng G; Sinkko HM; Alenius H; Lozano N; Kostarelos K; Brautigam L; Fadeel B
Article: REDOX BIOLOGY. 2022;49:102221

Glutaredoxin 2 promotes SP-1-dependent CSPG4 transcription and migration of wound healing NG2 glia and glioma cells: Enzymatic Taoism

Wilms C; Lepka K; Haeberlein F; Edwards S; Felsberg J; Pudelko L; Lindenberg TT; Poschmann G; Qin N; Volbracht K; Prozorovski T; Meuth SG; Kahlert UD; Remke M; Aktas O; Reifenberger G; Braeutigam L; Odermatt B; Berndt C
Article: GUT. 2022;71(10):2081-2092

CCT3-LINC00326 axis regulates hepatocarcinogenic lipid metabolism

Sondergaard JN; Sommerauer C; Atanasoai I; Hinte LC; Geng K; Guiducci G; Brautigam L; Aouadi M; Stojic L; Barragan I; Kutter C
Article: GENETICS IN MEDICINE. 2022;24(1):157-169

Novel loss-of-function variant in DENND5A impedes melanosomal cargo transport and predisposes to familial cutaneous melanoma

Yang M; Johnsson P; Brautigam L; Yang XR; Thrane K; Gao J; Tobin NP; Zhou Y; Yu R; Nagy N; Engstrom PG; Tuominen R; Eriksson H; Lundeberg J; Tucker MA; Goldstein AM; Egyhazi-Brage S; Zhao J; Cao Y; Hoiom V
Article: CELL DEATH AND DIFFERENTIATION. 2022;29(1):246-261

MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells

Karsten S; Fiskesund R; Zhang X-M; Marttila P; Sanjiv K; Pham T; Rasti A; Brautigam L; Almlof I; Marcusson-Stahl M; Sandman C; Platzack B; Harris RA; Kalderen C; Cederbrant K; Helleday T; Warpman Berglund U
Article: ZEBRAFISH. 2021;18(4):252-264

A Systematic Analysis of Metal and Metalloid Concentrations in Eight Zebrafish Recirculating Water Systems

Langa X; Neuhaus P; Lains D; Stewart TJ; Borel N; Certal AC; Monteiro JF; Alestrom P; Diaz E; Piragyte I; Brautigam L; Vazquez R; Hlushchuk R; Gfeller L; Mestrot A; Bigalke M; Varga ZM; Mercader N
Article: NATURE CHEMICAL BIOLOGY. 2020;16(10):1120-1128

Development of a chemical probe against NUDT15

Zhang SM; Desroses M; Hagenkort A; Valerie NCK; Rehling D; Carter M; Wallner O; Koolmeister T; Throup A; Jemth A-S; Almlof I; Loseva O; Lundback T; Axelsson H; Regmi S; Sarno A; Kraemer A; Pudelko L; Brautigam L; Rasti A; Gottmann M; Wiita E; Kutzner J; Schaller T; Kalderen C; Cazares-Korner A; Page BDG; Krimpenfort R; Eshtad S; Altun M; Rudd SG; Knapp S; Scobie M; Homan EJ; Berglund UW; Stenmark P; Helleday T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(37):22910-22919

Visualization of human T lymphocyte-mediated eradication of cancer cells in vivo

He X; Yin X; Wu J; Wickstrom SL; Duo Y; Du Q; Qin S; Yao S; Jing X; Hosaka K; Wu J; Jensen LD; Lundqvist A; Salter AI; Brautigam L; Tao W; Chen Y; Kiessling R; Cao Y
Article: NANOSCALE. 2020;12(32):16730-16737

Nitric oxide-dependent biodegradation of graphene oxide reduces inflammation in the gastrointestinal tract

Peng G; Montenegro MF; Ntola CNM; Vranic S; Kostarelos K; Vogt C; Toprak MS; Duan T; Leifer K; Brautigam L; Lundberg JO; Fadeel B
Article: CELL DEATH AND DIFFERENTIATION. 2020;27(7):2081-2098

AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma

Das I; Gad H; Braeutigam L; Pudelko L; Tuominen R; Hoiom V; Almlof I; Rajagopal V; Hansson J; Helleday T; Brage SE; Berglund UW
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(15):4761-4772

MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool

Scaletti ER; Vallin KS; Brautigam L; Sarno A; Berglund UW; Helleday T; Stenmark P; Jemth A-S
Article: CELL CHEMICAL BIOLOGY. 2019;26(2):235-243.e5

A Chemical Screen Identifies Compounds Limiting the Toxicity of C9ORF72 Dipeptide Repeats

Corman A; Jung B; Haggblad M; Brautigam L; Lafarga V; Lidemalm L; Huhn D; Carreras-Puigvert J; Fernandez-Capetillo O
Article: NUCLEIC ACIDS RESEARCH. 2018;46(20):10888-10904

MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP

Jemth A-S; Gustafsson R; Brautigam L; Henriksson L; Vallin KSA; Sarno A; Almlof I; Homan E; Rasti A; Berglund UW; Stenmark P; Helleday T
Article: NEURO-ONCOLOGY. 2018;20(11):1475-1484

An orthotopic glioblastoma animal model suitable for high-throughput screenings

Pudelko L; Edwards S; Balan M; Nyqvist D; Al-Saadi J; Dittmer J; Almlof I; Helleday T; Brautigam L
Article: REDOX BIOLOGY. 2018;17:171-179

MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation

Brautigam L; Zhang J; Dreij K; Spahiu L; Holmgren A; Abe H; Tew KD; Townsend DM; Kelner MJ; Morgenstern R; Johansson K
Article: ONCOTARGET. 2017;8(49):84671-84684

Glioblastoma and glioblastoma stem cells are dependent on functional MTH1

Pudelko L; Rouhi P; Sanjiv K; Gad H; Kalderen C; Hoglund A; Squatrito M; Schuhmacher AJ; Edwards S; Hagerstrand D; Berglund UW; Helleday T; Brautigam L
Article: BIOMOLECULES. 2017;7(3):E49-49

Mutations in Cancer Cause Gain of Cysteine, Histidine, and Tryptophan at the Expense of a Net Loss of Arginine on the Proteome Level

Tsuber V; Kadamov Y; Brautigam L; Berglund UW; Helleday T
Article: ANNALS OF ONCOLOGY. 2016;27(12):2275-2283

Validation and development of MTH1 inhibitors for treatment of cancer

Berglund UW; Sanjiv K; Gad H; Kalderen C; Koolmeister T; Pham T; Gokturk C; Jafari R; Maddalo G; Seashore-Ludlow B; Chernobrovkin A; Manoilov A; Pateras IS; Rasti A; Jemth A-S; Almlof I; Loseva O; Visnes T; Einarsdottir BO; Gaugaz FZ; Saleh A; Platzack B; Wallner OA; Vallin KSA; Henriksson M; Wakchaure P; Borhade S; Herr P; Kallberg Y; Baranczewski P; Homan EJ; Wiita E; Nagpal V; Meijer T; Schipper N; Rudd SG; Brautigam L; Lindqvist A; Filppula A; Lee T-C; Artursson P; Nilsson JA; Gorgoulis VG; Lehtio J; Zubarev RA; Scobie M; Helleday T
Article: CANCER RESEARCH. 2016;76(8):2366-2375

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition

Brautigam L; Pudelko L; Jemth A-S; Gad H; Narwal M; Gustafsson R; Karsten S; Puigvert JC; Homan E; Berndt C; Berglund UW; Stenmark P; Helleday T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(44):E5944-E5953

VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish

Jensen LD; Nakamura M; Brautigam L; Li X; Liu Y; Samani NJ; Cao Y
Article: NATURE. 2014;508(7495):215-221

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Gad H; Koolmeister T; Jemth A-S; Eshtad S; Jacques SA; Strom CE; Svensson LM; Schultz N; Lundback T; Einarsdottir BO; Saleh A; Gokturk C; Baranczewski P; Svensson R; Berntsson RP-A; Gustafsson R; Stromberg K; Sanjiv K; Jacques-Cordonnier M-C; Desroses M; Gustavsson A-L; Olofsson R; Johansson F; Homan EJ; Loseva O; Brautigam L; Johansson L; Hoglund A; Hagenkort A; Pham T; Altun M; Gaugaz FZ; Vikingsson S; Evers B; Henriksson M; Vallin KSA; Wallner OA; Hammarstrom LGJ; Wiita E; Almlof I; Kalderen C; Axelsson H; Djureinovic T; Puigvert JC; Haggblad M; Jeppsson F; Martens U; Lundin C; Lundgren B; Granelli I; Jensen AJ; Artursson P; Nilsson JA; Stenmark P; Scobie M; Berglund UW; Helleday T
Article: REDOX BIOLOGY. 2014;2:673-678

Zebrafish heart development is regulated via glutaredoxin 2 dependent migration and survival of neural crest cells

Berndt C; Poschmann G; Stuehler K; Holmgren A; Brautigam L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(50):20057-20062

Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1

Brautigam L; Jensen LDE; Poschmann G; Nystrom S; Bannenberg S; Dreij K; Lepka K; Prozorovski T; Montano SJ; Aktas O; Uhlen P; Stuehler K; Cao Y; Holmgren A; Berndt C
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2013;436(3):491-496

An unusual mode of iron-sulfur-cluster coordination in a teleost glutaredoxin

Brautigam L; Johansson C; Kubsch B; McDonough MA; Bill E; Holmgren A; Berndt C
Article: MOLECULAR BIOLOGY OF THE CELL. 2013;24(12):1895-1903

Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation

Haunhorst P; Hanschmann E-M; Braeutigam L; Stehling O; Hoffmann B; Muehlenhoff U; Lill R; Berndt C; Lillig CH
Article: CELL REPORTS. 2012;2(2):231-241

Opposing Effects of Circadian Clock Genes Bmal1 and Period2 in Regulation of VEGF-Dependent Angiogenesis in Developing Zebrafish

Jensen LD; Cao Z; Nakamura M; Yang Y; Brautigam L; Andersson P; Zhang Y; Wahlberg E; Lanne T; Hosaka K; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(51):20532-20537

Vertebrate-specific glutaredoxin is essential for brain development

Brautigam L; Schuette LD; Godoy JR; Prozorovski T; Gellert M; Hauptmann G; Holmgren A; Lillig CH; Berndt C
Article: JOURNAL OF COMPARATIVE NEUROLOGY. 2010;518(15):2978-2995

Localized Expression of Urocortin Genes in the Developing Zebrafish Brain

Brautigam L; Hillmer JM; Soll I; Hauptmann G
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Preprint: BIORXIV. 2023

Biodistribution of DNA-origami nanostructures in live zebrafish embryos with single-cell resolution

Kolonelou C; Bräutigam L; Edwards S; Engström E; Dias J; Spratt J; Karampelias C; Wennmalm S; Brismar H; Andersson O; Teixeira A
Preprint: BIORXIV. 2023

The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ

Li X; Hernandez I; Häggblad M; Lidemalm L; Brautigam L; Lucas JJ; Carreras-Puigvert J; Hühn D; Fernandez-Capetillo O
Conference publication: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2022;93:A88

HIGH THROUGHPUT SCREENING REVEAL DRUGS TO RESCUE POLYQ INDUCED TOXICITY IN HUNTINGTON'S DISEASE CELL AND ANIMAL MODELS

Li X; Haggblad M; Brautigam L; Carreras-Puigvert J; Huhn D; Fernandez-Capetillo O
Book chapter: LABORATORY FISH IN BIOMEDICAL RESEARCH. 2022;p. 3-21

Chapter 1 Biology and research applications

Lars B; Beata F-G
Corrigendum: ONCOTARGET. 2020;11(8):827

Correction: Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.

Pudelko L; Rouhi P; Sanjiv K; Gad H; Kalderén C; Höglund A; Squatrito M; Schuhmacher AJ; Edwards S; Hägerstrand D; Berglund UW; Helleday T; Bräutigam L
Meeting abstract: ANNALS OF ONCOLOGY. 2019;30:vii8

Therapeutic implications of MTH1 inhibitor TH1579 in cutaneous malignant melanoma

Das I; Gad H; Brautigam L; Pudelko L; Tuominen R; Hoiom V; Almlof I; Hansson J; Helleday T; Brage SE; Berglund UW
Editorial comment: ZEBRAFISH. 2019;16(3):329-330

The Nordic Zebrafish and Husbandry Meeting 2018.

Filipek-Górniok B; Ledin J; Aleström P; Braeutigam L
Conference publication: GLIA. 2019;67:E125

Redox regulated migration of glia cells

Wilms C; Lepka K; Pudelko L; Brautigam L; Haberlein F; Odermatt B; Aktas O; Berndt C
Book chapter: GLUTATHIONE. 2018;p. 215-226

The Role of Glutathione in Biosynthetic Pathways and Regulation of the Eicosanoid Metabolism

Morgenstern R; Haeggström JZ; Jakobsson P-J; Flohé L
Meeting abstract: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2018;138(5):S200

Effects of MTH1 inhibitor TH1579 on cutaneous melanoma

Das I; Gad H; Pudelko L; Brautigam L; Tuominen R; Helleday T; Hansson J; Brage S; Berglund U
Corrigendum: NATURE. 2017;544(7651):508

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool (vol 508, pg 215, 2014)

Gad H; Koolmeister T; Jemth A-S; Eshtad S; Jacques SA; Strom CE; Svensson LM; Schultz N; Lundback T; Einarsdottir BO; Saleh A; Gokturk C; Baranczewski P; Svensson R; Berntsson RP-A; Gustafsson R; Stromberg K; Sanjiv K; Jacques-Cordonnier M-C; Desroses M; Gustavsson A-L; Olofsson R; Johansson F; Homan EJ; Loseva O; Brautigam L; Johansson L; Hoglund A; Hagenkort A; Pham T; Altun M; Gaugaz FZ; Vikingsson S; Evers B; Henriksson M; Vallin KSA; Wallner OA; Hammarstrom LGJ; Wiita E; Almlof I; Kalderen C; Axelsson H; Djureinovic T; Puigvert JC; Haggblad M; Jeppsson F; Martens U; Lundin C; Lundgren B; Granelli I; Jensen AJ; Artursson P; Nilsson JA; Stenmark P; Scobie M; Berglund UW; Helleday T
Editorial comment: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2017;2017:4020253

Oxidants and Redox Signaling: Perspectives in Cancer Therapy, Inflammation, and Plasma Medicine

Bekeschus S; Brautigam L; Wende K; Hanschmann E-M
Thesis / dissertation: 2012

Urocortins in the zebrafish brain and redox regulation of embryonic development through glutaredoxins

Bräutigam, Lars

Employments

Affiliated to Research, Department of Laboratory Medicine, Karolinska Institutet, 2023-2026

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Biosciences and Nutrition, Karolinska Institutet, 2012

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