Research at OnkPat
OnkPat consists of more than 30 research groups
A novel mechanism of immune escape
Shi Yong Neo and Andreas Lundqvist with colleagues at Karolinska Institutet have identified a novel mechanism how tumor cells can hijack the immune system to inhibit anti-tumor immune responses in breast cancer and sarcoma. The results have been published in The Journal of Clinical Investigation.
New principle for activation of cancer genes discovered
New principle for activation of cancer genes discovered
Researchers has long known that some genes can cause cancer when overactive, but exactly what happens inside the cell nucleus when the cancer grows has so far remained enigmatic. Now, Anita Göndör at OnkPat together with colleagues have found a new mechanism that renders one canonical driver of cancer overactive. The findings, published in Nature Genetics, create conditions for brand new strategies to fight cancer.
Fertility-sparing surgery is as good as radical surgery for early ovarian cancer
Young women with early stage ovarian cancer can undergo fertility-preserving surgery without affecting the safety of their cancer treatment, Gry Johansen and Kenny Rodriguez-Wallberg from OnkPat report in a national study published in the journal Gynecologic Oncology.
Smaller operational margins just as safe in high-risk melanoma
Hanna Eriksson and Deborah Utjés from OnkPat have in a multicenter study shown that it is enough with two centimeter margin at surgery for malignant melanoma instead of up to four centimeters which has been used. In the study, published in The Lancet, the researchers has followed over 900 patients for an average span of 19 years.