Research at OnkPat

In an article in Journal of Translational Medicine the workflow of the Swedish Childhood Tumor Biobank (BTB) from sample collection and processing to the generation of genomic data and services offered is described. The BTB is a biobank for samples from children with CNS tumors and other solid tumors.

The results from the first 117 children who received whole-genome sequencing via the national project GMS Children's Cancer show that in 90 percent of the cases, genetic changes of clinical importance were found. The extensive work has been carried out by more than 30 researchers and clinics from all over the country. The result is now published in JCO Precision Oncology. The Swedish Childhood Tumor Biobank (BTB) has played an important role in the implementation of the study.

Kasper Karlsson and colleagues at Stanford University published a new study in Nature. They show that important aspects of early tumor evolution can be recapitulated by experimental evolution in vitro using gastric organoids.