Research at OnkPat

Linda Lindström at the Department of Oncology-Pathology has together with colleagues done a 20-year follow-up of premenopausal women with breast cancer to investigate the long-term benefit of hormone-lowering treatment. The study, published in the Journal of Clinical Oncology, indicates that the treatment provides protection even after a longer period of time and that different patients seem to benefit from different hormonal treatments.

Arne Östman and group members, with partners at Uppsala University and FIMM/Helsinki University, have published in Journal of the National Cancer Institute their discovery of novel prognosis-associated fibroblast subsets in non-small cell lung cancer (NSCLC).

The study analyzed more than 600 cases of NSCLC, using novel methods for multiplex staining and digital image analyses. Two different fibroblast types were identified, associated with good and bad prognosis, respectively. These subsets also showed different associations with driver mutations and immune features suggesting new mechanisms for the interplay between malignant cells, fibroblasts and immune cells.  Upcoming studies will analyze these mechanisms and the ability of the fibroblast subsets to act as treatment-predictive biomarkers.

The 2021 Dan Grandér Prize for best thesis at Karolinska Institutet within the field of cancer research is awarded to Xiaofei Ye for translating sequencing data into an understanding of disease mechanisms that potentially may lead to better diagnosis and treatment of lymphoma.

Xiaofei Ye will present his research at “Frontiers in Cancer Research and Therapy” conference at BioClinicum on 30 September 2022.