Structural studies of fertilisation and zona pellucida module proteins – Luca Jovine's research group

Publications

Selected publications

• Article: CELL. 2024;187(6):1440-1459.e24

  ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat

  Nishio S; Emori C; Wiseman B; Fahrenkamp D; Dioguardi E; Zamora-Caballero S; Bokhove M; Han L; Stsiapanava A; Algarra B; Lu Y; Kodani M; Bainbridge RE; Komondor KM; Carlson AE; Landreh M; Sanctis DD; Yasumasu S; Ikawa M; Jovine L
• Article: NATURE COMMUNICATIONS. 2022;13(1):3880

  Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins

  Moi D; Nishio S; Li X; Valansi C; Langleib M; Brukman NG; Flyak K; Dessimoz C; de Sanctis D; Tunyasuvunakool K; Jumper J; Grana M; Romero H; Aguilar PS; Jovine L; Podbilewicz B
• Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2022;29(3):190-193

  Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH

  Stsiapanava A; Xu C; Nishio S; Han L; Yamakawa N; Carroni M; Tunyasuvunakool K; Jumper J; de Sanctis D; Wu B; Jovine L
• Article: EMBO JOURNAL. 2020;39(24):e106807

  Cryo-EM structure of native human uromodulin, a zona pellucida module polymer

  Stsiapanava A; Xu C; Brunati M; Zamora-Caballero S; Schaeffer C; Bokhove M; Han L; Hebert H; Carroni M; Yasumasu S; Rampoldi L; Wu B; Jovine L
• Article: NATURE COMMUNICATIONS. 2019;10(1):3086

  Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility

  Nishimura K; Dioguardi E; Nishio S; Villa A; Han L; Matsuda T; Jovine L
• Review: CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY. 2018;130:413-442

  Structure of Zona Pellucida Module Proteins

  Bokhove M; Jovine L
• Article: CELL. 2017;169(7):1315-1326.e17

  Structural Basis of Egg Coat-Sperm Recognition at Fertilization

  Raj I; Al Hosseini HS; Dioguardi E; Nishimura K; Han L; Villa A; de Sanctis D; Jovine L
• Article: CELL REPORTS. 2017;19(9):1917-1928

  Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1

  Saito T; Bokhove M; Croci R; Zamora-Caballero S; Han L; Letarte M; de Sanctis D; Jovine L
• Letter: CURRENT BIOLOGY. 2016;26(14):R661-R662

  The structure of sperm Izumo1 reveals unexpected similarities with Plasmodium invasion proteins

  Nishimura K; Han L; Bianchi E; Wright GJ; de Sanctis D; Jovine L
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(6):1552-1557

  A structured interdomain linker directs self-polymerization of human uromodulin

  Bokhove M; Nishimura K; Brunati M; Han L; de Sanctis D; Rampoldi L; Jovine L
• Letter: CURRENT BIOLOGY. 2016;26(3):R100-R101

  Divergent evolution of vitamin B₉ binding underlies Juno-mediated adhesion of mammalian gametes

  Han L; Nishimura K; Al Hosseini HS; Bianchi E; Wright GJ; Jovine L
• Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2013;69(Pt 12):2563-2579

  Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation

  Cherry AL; Finta C; Karlstrom M; Jin Q; Schwend T; Astorga-Wells J; Zubarev RA; Del Campo M; Criswell AR; de Sanctis D; Jovine L; Toftgard R
• Article: CELL. 2010;143(3):404-415

  Insights into Egg Coat Assembly and Egg-Sperm Interaction from the X-Ray Structure of Full-Length ZP3

  Han L; Monne M; Okumura H; Schwend T; Cherry AL; Flot D; Matsuda T; Jovine L
• Article: NATURE. 2008;456(7222):653-657

  Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats

  Monne M; Han L; Schwend T; Burendahl S; Jovine L

All publications from group members

• Article: BLOOD. 2024;143(22):2314-2331

  Mutations causing premature termination codons discriminate and generate cellular and clinical variability in HHT

  Bernabeu-Herrero ME; Patel D; Bielowka A; Zhu J; Jain K; Mackay IS; Guerrero PC; Emanuelli G; Jovine L; Noseda M; Marciniak SJ; Aldred MA; Shovlin CL
• Article: HUMAN MUTATION. 2024;2024:1-13

  Specifications of the ACMG/AMP Variant Curation Guidelines for Hereditary Hemorrhagic Telangiectasia Genes-ENG and ACVRL1

  DeMille D; McDonald J; Bernabeu C; Racher H; Olivieri C; Cantarini C; Sbalchiero A; Thompson BA; Jovine L; Shovlin CL; Dupuis-Girod S; Lesca G; Tusseau M; Ganguly A; Kasthuri RS; Jessen J; Massink MPG; Ichikawa S; Bayrak-Toydemir P
• Journal article: ELIFE. 2024;13:RP93131

  Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse.

  Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
• Journal article: ELIFE. 2024;13

  Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

  Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
• Preprint: ELIFE SCIENCES PUBLICATIONS, LTD. 2024

  Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

  Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
• Journal article: JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE. 2024;8(s1):129

  431 Defective uromodulin polymerization and peptide excretion in a natural canine model of kidney stones

  Furrow E; Rampoldi L; Jovine L; Wesson JA; Treeful AE; Jayachandran M; Lieske JC; Romero MF; Lulich JP
• Article: CELL. 2024;187(6):1440-1459.e24

  ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat

  Nishio S; Emori C; Wiseman B; Fahrenkamp D; Dioguardi E; Zamora-Caballero S; Bokhove M; Han L; Stsiapanava A; Algarra B; Lu Y; Kodani M; Bainbridge RE; Komondor KM; Carlson AE; Landreh M; Sanctis DD; Yasumasu S; Ikawa M; Jovine L
• Dataset: PDB. 2024

  Crystal structure of the complete N-terminal region of human ZP2 (hZP2-N1N2N3)

  Jovine L
• Dataset: PDB. 2024

  Crystal structure of the ZP-N1 and ZP-N2 domains of human ZP2 (hZP2-N1N2)

  Jovine L
• Dataset: PDB. 2024

  Crystal structure of tetrameric collagenase-cleaved Xenopus ZP2-N2N3 (cleaved xZP2-N2N3)

  Jovine L
• Dataset: PDB. 2024

  Crystal structure of the ZP-N2 and ZP-N3 domains of mouse ZP2 (mZP2-N2N3)

  Jovine L
• Dataset: PDB. 2024

  Molecular basis of ZP3/ZP1 heteropolymerization: crystal structure of a native vertebrate egg coat filament fragment

  Jovine L
• Dataset: PDB. 2024

  Molecular basis of ZP3/ZP1 heteropolymerization: crystal structure of a native vertebrate egg coat filament

  Jovine L
• Dataset: EMDB. 2024

  Cryo-EM of tetrameric collagenase-cleaved Xenopus ZP2-N2N3 (cleaved xZP2-N2N3) (C1)

  Jovine L
• Dataset: EMDB. 2024

  Cryo-EM of tetrameric collagenase-cleaved Xenopus ZP2-N2N3 (cleaved xZP2-N2N3) (C2)

  Jovine L
• Preprint: ELIFE SCIENCES PUBLICATIONS, LTD. 2024

  Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

  Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
• Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2024;32:742

  ClinGen HHT Variant Curation Expert Panel's modified variant interpretation and classification guidelines

  Demille D; Sbalchiero A; Cantarini C; Thompson B; McDonald J; Bernabeu C; Dupuis-Girod S; Ganguly A; Giraud S; Ichikawa S; Jessen J; Jovine L; Kasthuri R; Olivieri C; van Amstel JKP; Racher H; Shovlin C; Bayrak-Toydemir P
• Preprint: ELIFE. 2024

  Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

  Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
• Journal article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2023;34(11S):568

  A Canine Model Implicates Uromodulin Peptides in Calcium Oxalate Urinary Stone Risk

  Furrow E; Rampoldi L; Jovine L; Wesson J; Jayachandran M; Lieske JC; Romero MF; Lulich JP
• Preprint: BIORXIV. 2023

  Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

  Elofsson A; Han L; Bianchi E; Wright G; Jovine L
• Preprint: BIORXIV. 2023

  Architecture of the vertebrate egg coat and structural basis of the ZP2 block to polyspermy

  Nishio S; Emori C; Wiseman B; Fahrenkamp D; Dioguardi E; Zamora-Caballero S; Bokhove M; Han L; Stsiapanava A; Lu Y; Kodani M; Bainbridge R; Komondor K; Carlson A; Landreh M; de Sanctis D; Yasumasu S; Ikawa M; Jovine L
• Article: NATURE COMMUNICATIONS. 2023;14(1):3506

  Divergent molecular signatures in fish Bouncer proteins define cross-fertilization boundaries

  Gert KRB; Panser K; Surm J; Steinmetz BS; Schleiffer A; Jovine L; Moran Y; Kondrashov F; Pauli A
• Conference publication: ANGIOGENESIS. 2023;26(1):S18

  ClinGen HHT Variant Curation Expert Panel's Modified Variant Interpretation and Classification Guidelines

  DeMille D; McDonald J; Bernabeu C; Dupuis-Girod S; Ganguly A; Giraud S; Ichikawa S; Jessen J; Jovine L; Kasthuri RS; Olivieri C; van Amstel PHK; Racher H; Shovlin CL; Bayrak-Toydemir P
• Preprint: ELSEVIER BV. 2023

  Architecture of the Vertebrate Egg Coat and Structural Basis of the ZP2 Block to Polyspermy

  Nishio S; Emori C; Wiseman B; Fahrenkamp D; Dioguardi E; Zamora-Caballero S; Bokhove M; Han L; Stsiapanava A; Lu Y; Kodani M; Bainbridge RE; Komondor KM; Carlson AE; Landreh M; Daniele DS; Yasumasu S; Ikawa M; Jovine L
• Dataset: PDB. 2022

  Crystal structure of the trimeric ectodomain of archaeal Fusexin1 (Fsx1)

  Jovine L; Nishio S; Tunyasuvunakool K; Jumper J; De Sanctis D
• Article: NATURE COMMUNICATIONS. 2022;13(1):3880

  Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins

  Moi D; Nishio S; Li X; Valansi C; Langleib M; Brukman NG; Flyak K; Dessimoz C; de Sanctis D; Tunyasuvunakool K; Jumper J; Grana M; Romero H; Aguilar PS; Jovine L; Podbilewicz B
• Article: PROTEIN SCIENCE. 2022;31(6):e4333

  Complementing machine learning-based structure predictions with native mass spectrometry

  Allison TM; Degiacomi MT; Marklund EG; Jovine L; Elofsson A; Benesch JLP; Landreh M
• Preprint: BIORXIV. 2022

  Complementing machine learning-based structure predictions with native mass spectrometry

  Allison TM; Degiacomi MT; Marklund EG; Jovine L; Elofsson A; Benesch JLP; Landreh M
• Dataset: 2022

  Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form III)

  Jovine L
• Dataset: PDB. 2022

  Full-length cryo-EM structure of the native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament

  Jovine L; Xu C; Stsiapanava A; Carroni M; Tunyasuvunakool K; Jumper J
• Dataset: PDB. 2022

  Cryo-EM of the complex between human uromodulin (UMOD)/Tamm-Horsfall protein (THP) and the FimH lectin domain from uropathogenic E. coli

  Jovine L
• Dataset: PDB. 2022

  Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form I)

  Jovine L
• Dataset: PDB. 2022

  Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form II)

  Jovine L
• Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2022;29(3):190-193

  Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH

  Stsiapanava A; Xu C; Nishio S; Han L; Yamakawa N; Carroni M; Tunyasuvunakool K; Jumper J; de Sanctis D; Wu B; Jovine L
• Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:872740

  A Non-Synonymous Point Mutation in a WD-40 Domain Repeat of EML5 Leads to Decreased Bovine Sperm Quality and Fertility

  Nogueira E; Tirpak F; Hamilton LE; Zigo M; Kerns K; Sutovsky M; Kim J; Volkmann D; Jovine L; Taylor JF; Schnabel RD; Sutovsky P
• Preprint: BIORXIV. 2021

  Discovery of archaeal Fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins

  Moi D; Nishio S; Li X; Valansi C; Langleib M; Brukman NG; Flyak K; Dessimoz C; de Sanctis D; Tunyasuvunakool K; Jumper J; Graña M; Romero H; Aguilar PS; Jovine L; Podbilewicz B
• Article: MOLECULAR REPRODUCTION AND DEVELOPMENT. 2021;88(10):686-693

  Using machine learning to study protein-protein interactions: From the uromodulin polymer to egg zona pellucida filaments

  Jovine L
• Book chapter: XIIITH INTERNATIONAL SYMPOSIUM ON SPERMATOLOGY. 2021;p. 83-84

  First Snapshot of How Sperm Binds the Egg at the Molecular Level

  Jovine L
• Article: EMBO JOURNAL. 2020;39(24):e106807

  Cryo-EM structure of native human uromodulin, a zona pellucida module polymer

  Stsiapanava A; Xu C; Brunati M; Zamora-Caballero S; Schaeffer C; Bokhove M; Han L; Hebert H; Carroni M; Yasumasu S; Rampoldi L; Wu B; Jovine L
• Dataset: PDB. 2020

  Cryo-EM of native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament

  Jovine L; Stsiapanava A; Xu C; Carroni M; Wu B
• Dataset: PDB. 2020

  Cryo-EM of elastase-treated human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament

  Jovine L; Stsiapanava A; Xu C; Carroni M; Wu B
• Article: BLOOD. 2020;136(17):1907-1918

  Mutational and phenotypic characterization of hereditary hemorrhagic telangiectasia

  Shovlin CL; Simeoni I; Downes K; Frazer ZC; Megy K; Bernabeu-Herrero ME; Shurr A; Brimley J; Patel D; Kell L; Stephens J; Turbin IG; Aldred MA; Penkett CJ; Ouwehand WH; Jovine L; Turro E
• Preprint: BIORXIV. 2020

  Cryo-EM Structure of Native Human Uromodulin, a Zona Pellucida Module Polymer

  Stsiapanava A; Xu C; Brunati M; Zamora-Caballero S; Schaeffer C; Han L; Carroni M; Yasumasu S; Rampoldi L; Wu B; Jovine L
• Review: MOLECULAR REPRODUCTION AND DEVELOPMENT. 2020;87(3):326-340

  Mammalian egg coat modifications and the block to polyspermy

  Fahrenkamp E; Algarra B; Jovine L
• Preprint: SSRN ELECTRONIC JOURNAL. 2020

  Cryo-EM Structure of Native Human Uromodulin, a Zona Pellucida Module Polymer

  Stsiapanava A; Xu C; Brunati M; Zamora-Caballero S; Schaeffer C; Han L; Carroni M; Yasumasu S; Rampoldi L; Wu B; Jovine L
• Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2020;8:572735

  Molecular Mechanism Underlying the Action ofZona-pellucidaGlycoproteins on Mouse Sperm

  Balbach M; Hamzeh H; Jikeli JF; Brenker C; Schiffer C; Hansen JN; Neugebauer P; Troetschel C; Jovine L; Han L; Florman HM; Kaupp UB; Struenker T; Wachten D
• Article: SCIENTIFIC REPORTS. 2019;9(1):14607

  Crystal structure of ErmE-23S rRNA methyltransferase in macrolide resistance

  Stsiapanava A; Selmer M
• Conference publication: ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES. 2019;75:E13

  FERTILIZATION AT THE ATOMIC LEVEL - MARRYING BASIC SCIENCE AND REPRODUCTIVE MEDICINE

  Jovine L
• Conference publication: ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES. 2019;75:E135

  SELECTIVE INHIBITION OF ASTACIN METALLOPEPTIDASES BY MAMMALIAN FETUIN-B

  Cuppari A; Koerschgen H; Fahrenkamp D; Schmitz C; Jahnen-Dechent W; Stoeker W; Jovine L; Gomis-Ruth FX
• Article: SCIENTIFIC REPORTS. 2019;9(1):11601

  Autosomal Dominant Tubulointerstitial Kidney Disease with Adult Onset due to a Novel Renin Mutation Mapping in the Mature Protein

  Schaeffer C; Izzi C; Vettori A; Pasqualetto E; Cittaro D; Lazarevic D; Caridi G; Gnutti B; Mazza C; Jovine L; Scolari F; Rampoldi L
• Article: NATURE COMMUNICATIONS. 2019;10(1):3086

  Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility

  Nishimura K; Dioguardi E; Nishio S; Villa A; Han L; Matsuda T; Jovine L
• Dataset: PDB. 2019

  Molecular basis of egg coat filament cross-linking: high-resolution structure of the partially deglycosylated ZP1 ZP-N1 domain homodimer

  Jovine L
• Dataset: PDB. 2019

  Molecular basis of egg coat filament cross-linking: Zn-SAD structure of the partially deglycosylated ZP1 ZP-N1 domain homodimer

  Jovine L
• Dataset: PDB. 2019

  Molecular basis of egg coat filament cross-linking: structure of the glycosylated ZP1 ZP-N1 domain homodimer

  Jovine L
• Article: GENE. 2019;696:33-39

  Characterization of a mutation in the zona pellucida module of Endoglin that causes Hereditary Hemorrhagic Telangiectasia

  Ruiz-Llorente L; Chiapparino E; Plumitallo S; Danesino C; Bayrak-Toydemir P; Pagella F; Manfredi G; Bernabeu C; Jovine L; Olivieri C
• Preprint: BIORXIV. 2019

  Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility

  Nishimura K; Dioguardi E; Nishio S; Villa A; Han L; Matsuda T; Jovine L
• Article: IUCRJ. 2019;6(Pt 2):317-330

  Structure of mammalian plasma fetuin-B and its mechanism of selective metallopeptidase inhibition

  Cuppari A; Koerschgen H; Fahrenkamp D; Schmitz C; Guevara T; Karmilin K; Kuske M; Olf M; Dietzel E; Yiallouros I; de Sanctis D; Goulas T; Weiskirchen R; Jahnen-Dechent W; Floehr J; Stoecker W; Jovine L; Gomis-Rueth FX
• Review: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. 2018;35(3):367-391

  Revisiting embryo assisted hatching approaches: a systematic review of the current protocols

  Alteri A; Vigano P; Abu Maizar A; Jovine L; Giacomini E; Rubino P
• Editorial comment: BASIC AND CLINICAL ANDROLOGY. 2018;28:13

  Male reproductive health statement (XIIIth international symposium on Spermatology, may 9th-12th 2018, Stockholm, Sweden

  Levine H; Mohri H; Ekbom A; Ramos L; Parker G; Roldan E; Jovine L; Koelle S; Lindstrand A; Immler S; Mortimer S; Mortimer D; van der Horst G; Ishijima S; Aneck-Hahn N; Baldi E; Menkveld R; Rothmann SA; Giwercman A; Giwercman Y; Holmberg M; Kvist U; Bjorndahl L; Holmberg R; Arver S; Flanagan J; Drevet JR
• Review: CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY. 2018;130:413-442

  Structure of Zona Pellucida Module Proteins

  Bokhove M; Jovine L
• Review: SEMINARS IN IMMUNOLOGY. 2017;33(C):3-15

  Biosynthesis of leukotriene B₄

  Wan M; Tang X; Stsiapanava A; Haeggstrom JZ
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(36):9689-9694

  Capturing LTA₄ hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB₄ synthesis

  Stsiapanava A; Samuelsson B; Haeggstrom JZ
• Article: CELL. 2017;169(7):1315-1326.e17

  Structural Basis of Egg Coat-Sperm Recognition at Fertilization

  Raj I; Al Hosseini HS; Dioguardi E; Nishimura K; Han L; Villa A; de Sanctis D; Jovine L
• Dataset: 2017

  Crystal structure of red abalone egg VERL repeat 2 with linker in complex with sperm lysin at 1.8 A resolution

  Jovine L
• Dataset: PDB. 2017

  Crystal structure of red abalone VERL repeat 1 with linker at 2.0 A resolution

  Jovine L
• Dataset: PDB. 2017

  Crystal structure of red abalone VERL repeat 1 at 1.8 A resolution

  Jovine L
• Dataset: PDB. 2017

  In-house sulfur-SAD structure of orthorhombic red abalone lysin at 1.66 A resolution

  Jovine L
• Dataset: PDB. 2017

  Orthorhombic crystal structure of red abalone lysin at 0.99 A resolution

  Jovine L
• Dataset: PDB. 2017

  Monoclinic crystal structure of red abalone lysin at 2.11 A resolution

  Jovine L
• Dataset: PDB. 2017

  Crystal structure of red abalone egg VERL repeat 3 in complex with sperm lysin at 1.7 A resolution (crystal form I)

  Jovine L
• Dataset: PDB. 2017

  Crystal structure of red abalone egg VERL repeat 3 in complex with sperm lysin at 1.64 A resolution (crystal form II)

  Jovine L
• Dataset: PDB. 2017

  Crystal structure of red abalone VERL repeat 3 at 2.9 A resolution

  Jovine L
• Dataset: PDB. 2017

  Crystal structure of red abalone VERL repeat 2 with linker at 2.5 A resolution

  Jovine L
• Dataset: PDB. 2017

  Crystal structure of the orphan region of human endoglin/CD105 in complex with BMP9

  Jovine L
• Article: CELL REPORTS. 2017;19(9):1917-1928

  Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1

  Saito T; Bokhove M; Croci R; Zamora-Caballero S; Han L; Letarte M; de Sanctis D; Jovine L
• Article: SCIENTIFIC REPORTS. 2016;6:32556

  The C-terminal region of OVGP1 remodels the zona pellucida and modifies fertility parameters

  Algarra B; Han L; Soriano-Ubeda C; Aviles M; Coy P; Jovine L; Jimenez-Movilla M
• Letter: CURRENT BIOLOGY. 2016;26(14):R661-R662

  The structure of sperm Izumo1 reveals unexpected similarities with Plasmodium invasion proteins

  Nishimura K; Han L; Bianchi E; Wright GJ; de Sanctis D; Jovine L
• Dataset: PDB. 2016

  Crystal structure of Izumo1, the mammalian sperm ligand for egg Juno

  Jovine L
• Article: JOURNAL OF STRUCTURAL BIOLOGY. 2016;194(1):1-7

  Easy mammalian expression and crystallography of maltose-binding protein-fused human proteins

  Bokhove M; Al Hosseini HS; Saito T; Dioguardi E; Gegenschatz-Schmid K; Nishimura K; Raj I; de Sanctis D; Han L; Jovine L
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(6):1552-1557

  A structured interdomain linker directs self-polymerization of human uromodulin

  Bokhove M; Nishimura K; Brunati M; Han L; de Sanctis D; Rampoldi L; Jovine L
• Letter: CURRENT BIOLOGY. 2016;26(3):R100-R101

  Divergent evolution of vitamin B₉ binding underlies Juno-mediated adhesion of mammalian gametes

  Han L; Nishimura K; Al Hosseini HS; Bianchi E; Wright GJ; Jovine L
• Article: ELIFE. 2015;4:e08887

  The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin

  Brunati M; Perucca S; Han L; Cattaneo A; Consolato F; Andolfo A; Schaeffer C; Olinger E; Peng J; Santambrogio S; Perrier R; Li S; Bokhove M; Bachi A; Hummler E; Devuyst O; Wu Q; Jovine L; Rampoldi L
• Journal article: REPRODUCTION ABSTRACTS. 2014

  Deletion of the C-terminal region of OVGP1 affects porcine IVF

  Algarra B; Han L; Aviles M; Coy P; Jovine L; Jimenez-Movilla M
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(11):4227-4232

  Binding of Pro-Gly-Pro at the active site of leukotriene A₄ hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor

  Stsiapanava A; Olsson U; Wan M; Kleinschmidt T; Rutishauser D; Zubarev RA; Samuelsson B; Rinaldo-Matthis A; Haeggstrom JZ
• Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2014;70(Pt 2):209-217

  Crystallographic analysis of 1,2,3-trichloropropane biodegradation by the haloalkane dehalogenase DhaA31

  Lahoda M; Mesters JR; Stsiapanava A; Chaloupkova R; Kuty M; Damborsky J; Smatanova IK
• Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2014;1844(2):439-446

  Product formation controlled by substrate dynamics in leukotriene A4 hydrolase

  Stsiapanava A; Tholander F; Kumar RB; Qureshi AA; Niegowski D; Hasan M; Thunnissen M; Haeggstrom JZ; Rinaldo-Matthis A
• Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2013;69(Pt 12):2563-2579

  Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation

  Cherry AL; Finta C; Karlstrom M; Jin Q; Schwend T; Astorga-Wells J; Zubarev RA; Del Campo M; Criswell AR; de Sanctis D; Jovine L; Toftgard R
• Dataset: PDB. 2013

  Crystal structure of full-length human Suppressor of fused (SUFU)

  Jovine L; Toftgård R
• Dataset: PDB. 2013

  Crystal structure of full-length human Suppressor of fused (SUFU) mutant lacking a regulatory subdomain (crystal form I)

  Jovine L; Toftgård R
• Dataset: PDB. 2013

  Crystal structure of a human Suppressor of fused (SUFU)-GLI3p complex

  Jovine L; Toftgård R
• Dataset: PDB. 2013

  Crystal structure of full-length human Suppressor of fused (SUFU) mutant lacking a regulatory subdomain (crystal form II)

  Jovine L; Toftgård R
• Dataset: PDB. 2013

  Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex

  Jovine L; Toftgård R
• Article: MOLECULAR BIOLOGY AND EVOLUTION (MBE). 2012;29(9):2147-2155

  Evolution of the Voltage Sensor Domain of the Voltage-Sensitive Phosphoinositide Phosphatase VSP/TPTE Suggests a Role as a Proton Channel in Eutherian Mammals

  Sutton KA; Jungnickel MK; Jovine L; Florman HM
• Conference publication: THE FEBS JOURNAL. 2012;279:26

  Hedgehog signalling and cancer initiation

  Toftgard R; Finta C; Cherry A; Fullgrabe A; Kasper M; Jovine L
• Review: BIOLOGY OF REPRODUCTION. 2011;85(4):661-669

  A Structural View of Egg Coat Architecture and Function in Fertilization

  Monne M; Jovine L
• Article: MOLECULAR BIOLOGY AND EVOLUTION (MBE). 2011;28(7):1963-1966

  The Molecular Basis of Sex: Linking Yeast to Human

  Swanson WJ; Aagaard JE; Vacquier VD; Monne M; Al Hosseini HS; Jovine L
• Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2011;67(Pt 3):397-400

  Crystallization and crystallographic analysis of the Rhodococcus rhodochrous NCIMB 13064 DhaA mutant DhaA31 and its complex with 1,2,3-trichloropropane

  Lahoda M; Chaloupkova R; Stsiapanava A; Damborsky J; Smatanova IK
• Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2011;67(Pt 2):253-257

  Crystallization and preliminary X-ray diffraction analysis of the wild-type haloalkane dehalogenase DhaA and its variant DhaA13 complexed with different ligands

  Stsiapanava A; Chaloupkova R; Fortova A; Brynda J; Weiss MS; Damborsky J; Smatanova IK
• Editorial comment: MOLECULAR REPRODUCTION AND DEVELOPMENT. 2011;78(1):1

  X-ray of fertilization

  Jovine L
• Article: CELL. 2010;143(3):404-415

  Insights into Egg Coat Assembly and Egg-Sperm Interaction from the X-Ray Structure of Full-Length ZP3

  Han L; Monne M; Okumura H; Schwend T; Cherry AL; Flot D; Matsuda T; Jovine L
• Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2010;66(Pt 9):962-969

  Atomic resolution studies of haloalkane dehalogenases DhaA04, DhaA14 and DhaA15 with engineered access tunnels

  Stsiapanava A; Dohnalek J; Gavira JA; Kuty M; Koudelakova T; Damborsky J; Smatanova IK
• Article: JOURNAL OF MOLECULAR BIOLOGY. 2009;392(5):1339-1356

  Pathways and Mechanisms for Product Release in the Engineered Haloalkane Dehalogenases Explored Using Classical and Random Acceleration Molecular Dynamics Simulations

  Klvana M; Pavlova M; Koudelakova T; Chaloupkova R; Dvorak P; Prokop Z; Stsiapanava A; Kuty M; Kuta-Smatanova I; Dohnalek J; Kulhanek P; Wade RC; Damborsky J
• Article: NATURE. 2008;456(7222):653-657

  Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats

  Monne M; Han L; Schwend T; Burendahl S; Jovine L
• Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2008;370(3):410-413

  Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage

  Santambrogio S; Cattaneo A; Bernascone I; Schwend T; Jovine L; Bachi A; Rampoldi L
• Letter: JOURNAL OF APPLIED CRYSTALLOGRAPHY. 2008;41:659

  Of crystals, structure factors and diffraction images

  Jovine L; Morgunova E; Ladenstein R
• Published conference paper: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2008;64(Pt 2):137-140

  Crystals of DhaA mutants from Rhodococcus rhodochrous NCIMB 13064 diffracted to ultrahigh resolution:: crystallization and preliminary diffraction analysis

  Stsiapanava A; Koudelakova T; Lapkouski M; Pavlova M; Damborsky J; Smatanova IK
• Journal article: SOCIETY OF REPRODUCTION AND FERTILITY SUPPLEMENT. 2007;63:187-201

  Features that affect secretion and assembly of zona pellucida glycoproteins during mammalian oogenesis.

  Jovine L; Qi H; Williams Z; Litscher ES; Wassarman PM
• Review: SEMINARS IN REPRODUCTIVE MEDICINE. 2006;24(4):204-216

  Tracking down the ZP domain:: From the mammalian zona pellucida to the molluscan vitelline envelope

  Monne M; Han L; Jovine L
• Article: BMC BIOCHEMISTRY. 2006;7:11

  The PLAC1-homology region of the ZP domain is sufficient for protein polymerisation.

  Jovine L; Janssen WG; Litscher ES; Wassarman PM
• Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2006;207(1):30-39

  Polypeptide encoded by mouse ZP3 exon-7 is necessary and sufficient for binding of mouse sperm in vitro

  Williams Z; Litscher ES; Jovine L; Wassarman PM
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(45):37585-37598

  Mass spectrometric evidence that proteolytic processing of rainbow trout egg vitelline envelope proteins takes place on the egg

  Darie CC; Biniossek ML; Gawinowicz MA; Milgrom Y; Thumfart JO; Jovine L; Litscher ES; Wassarman PM
• Review: ANNUAL REVIEW OF BIOCHEMISTRY. 2005;74:83-114

  Zona pellucida domain proteins

  Jovine L; Darie CC; Litscher ES; Wassarman PM
• Dataset: PDB. 2005

  CRYSTAL STRUCTURE OF THE CONSERVED DOMAIN IV OF E. COLI 4.5S RNA

  Nagai K
• Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2005;234(1-2):95-103

  Recent aspects of mammalian fertilization research

  Wassarman PM; Jovine L; Qi HY; Williams Z; Darie C; Litscher ES
• Published conference paper: EUROPEAN JOURNAL OF OBSTETRICS AND GYNECOLOGY AND REPRODUCTIVE BIOLOGY. 2004;115:S57-S60

  Egg-sperm interactions at fertilization in mammals

  Wassarman PA; Jovine L; Litscher ES; Qi HY; Williams Z
• Article: BIOCHEMISTRY. 2004;43(23):7459-7478

  Structural characterization of fish egg vitelline envelope proteins by mass spectrometry

  Darie CC; Biniossek ML; Jovine L; Litscher ES; Wassarman PM
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(16):5922-5927

  A duplicated motif controls assembly of zona pellucida domain proteins

  Jovine L; Qi HY; Williams Z; Litscher ES; Wassarman PM
• Article: CYTOGENETIC AND GENOME RESEARCH. 2004;105(2-4):228-234

  Mouse zona pellucida genes and glycoproteins

  Wassarman PM; Jovine L; Litscher ES
• Review: EMBO JOURNAL. 2003;22(14):3479-3485

  Structure, function and evolution of the signal recognition particle

  Nagai K; Oubridge C; Kuglstatter A; Menichelli E; Isel C; Jovine L
• Journal article: TRENDS IN BIOTECHNOLOGY. 2002;20(12):491-492

  Macromolecular mimicry in protein synthesis: beware of imitations

  Jovine L
• Article: BMC CELL BIOLOGY. 2002;3:28

  Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear

  Jovine L; Park J; Wassarman PM
• Dataset: PDB. 2002

  CRYSTAL STRUCTURE OF SRP19 IN COMPLEX WITH THE S DOMAIN OF SIGNAL RECOGNITION PARTICLE RNA

  Nagai K
• Article: MOLECULAR CELL. 2002;9(6):1251-1261

  Crystal structure of SRP19 in complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle

  Oubridge C; Kuglstatter A; Jovine L; Nagai K
• Article: NATURE CELL BIOLOGY. 2002;4(6):457-461

  The ZP domain is a conserved module for polymerization of extracellular proteins

  Jovine L; Qi HY; Williams Z; Litscher E; Wassarman PM
• Journal article: TRENDS IN BIOTECHNOLOGY. 2002;20(5):190

  Molecular beacons meet DNA–protein interactions: bye bye bandshift?

  Jovine L
• Book chapter: GENE EXPRESSION AT THE BEGINNING OF ANIMAL DEVELOPMENT: ADVANCES IN DEVELOPMENTAL BIOLOGY. 2002;p. 31-54

  Egg zona pellucida, egg vitelline envelope, and related extracellular glycoproteins

  Jovine L; Litscher ES; Wassarman PM
• Editorial comment: TRENDS IN BIOTECHNOLOGY. 2001;19(12):487-488

  New molecular beacons for targeting double-stranded DNA under native conditions

  Jovine L
• Journal article: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2001;12(7):286

  Heavier weight on tubby

  Jovine L
• Journal article: TRENDS IN BIOTECHNOLOGY. 2001;19(8):284

  Heavier weight on tubby

  Jovine L
• Review: NATURE CELL BIOLOGY. 2001;3(2):E59-E64

  A profile of fertilization in mammals

  Wassarman PM; Jovine L; Litscher ES
• Corrigendum: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2000;56(# (Pt 11)):1512

  Crystallization and preliminary X-ray analysis of the conserved domain IV of Escherichia coli 4.5S RNA (vol D56, pg 1033, 2000)

  Jovine L; Hainzl T; Oubridge C; Nagai K
• Corrigendum: JOURNAL OF MOLECULAR BIOLOGY. 2000;303(1):113

  The crystal structure of yeast phenylalanine tRNA at 2.0 Å resolution:: Cleavage by Mg²⁺ in 15-year old crystals (vol 301, pg 401, 2000)

  Jovine L; Djordjevic S; Rhodes D
• Article: JOURNAL OF MOLECULAR BIOLOGY. 2000;301(2):401-414

  The crystal structure of yeast phenylalanine tRNA at 2.0 Å resolution:: Cleavage by Mg²⁺ in 15-year old crystals

  Jovine L; Djordjevic S; Rhodes D
• Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2000;56(Pt 8):1033-1037

  Crystallization and preliminary X-ray analysis of the conserved domain IV of Escherichia coli 4.5S RNA

  Jovine L; Hainz T; Oubridge C; Nagai K
• Article: JOURNAL OF APPLIED CRYSTALLOGRAPHY. 2000;33(2):988-989

  A simple technique to control macromolecular crystal nucleation efficiently using a standard vapour-diffusion setup

  Jovine L
• Article: STRUCTURE. 2000;8(5):527-540

  Crystal structure of the Ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA

  Jovine L; Hainzl T; Oubridge C; Scott WG; Li J; Sixma TK; Wonacott A; Skarzynski T; Nagai K
• Dataset: 2000

  CRYSTAL STRUCTURE OF YEAST PHENYLALANINE TRANSFER RNA AT 2.0 A RESOLUTION

  Jovine L; Djordjevic S; Rhodes D
• Article: FEBS LETTERS. 2000;468(1):59-64

  The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the Down critical region

  Acquati F; Accarino M; Nucci C; Fumagalli P; Jovine L; Ottolenghi S; Taramelli R
• Conference publication: ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES. 1996;52:C163

  U1A SPLICEOSOMAL PROTEIN BINDS TO TWO DIFFERENT RNA TARGETS USING THE SAME STRATEGY

  Nagai K; Oubridge O; Price S; Jovine L; Avis J; Evans PR
• Article: STRUCTURE. 1996;4(5):621-631

  Two structurally different RNA molecules are bound by the spliceosomal protein U1A using the same recognition strategy

  Jovine L; Oubridge C; Avis JM; Nagai K
• Journal article: GENETICS. 1993;133(2):183-191

  CONDITIONAL MUTATIONS IN THE YEAST DNA PRIMASE GENES AFFECT DIFFERENT ASPECTS OF DNA METABOLISM AND INTERACTIONS IN THE DNA-POLYMERASE ALPHA-PRIMASE COMPLEX

  LONGHESE MP; JOVINE L; PLEVANI P; LUCCHINI G
• Dataset:

  Crystal structure of the orphan region of human endoglin/CD105

  Saito T; Bokhove M; de Sanctis D; Jovine L
• Dataset:

  Crystal structure of mouse fetuin-B

  Fahrenkamp D; Dietzel E; de Sanctis D; Jovine L
• Dataset:

  Crystal structure of full-length sperm receptor ZP3 at 2.6 A resolution

  Monne M; Jovine L
• Dataset:

  Crystal structure of full-length sperm receptor ZP3 at 2.0 A resolution

  Monne M; Jovine L
• Dataset:

  ZP-N domain of mammalian sperm receptor ZP3 (crystal form III)

  Monne M; Jovine L
• Dataset:

  ZP-N domain of mammalian sperm receptor ZP3 (crystal form I)

  Jovine L; Monne M
• Dataset:

  HUMAN U1A/U1A PRE-MRNA 3'UTR COMPLEX (THEORETICAL MODEL)

  Jovine L; Oubridge C; Avis JM; Nagai K
• Dataset:

  Crystal structure of the polymerization region of human uromodulin/Tamm-Horsfall protein

  Bokhove M; De Sanctis D; Jovine L
• Dataset:

  Crystal structure of human BMP9 at 1.87 A resolution

  Saito T; Bokhove M; Jovine L
• Dataset:

  Crystal structure of the zona pellucida module of human endoglin/CD105

  Bokhove M; Saito T; Jovine L
• Dataset:

  Crystal structure of the ZP-N1 domain of mouse sperm receptor ZP2 at 0.95 A resolution

  Dioguardi E; Han L; Nishimura K; De Sanctis D; Jovine L
• Dataset:

  Crystal structure of Juno, the mammalian egg receptor for sperm Izumo1

  Nishimura K; Han L; Jovine L
• Dataset:

  Crystal structure of the ZP-C domain of mouse ZP2

  Nishimura K; Jovine L
• Dataset:

  ZP-N domain of mammalian sperm receptor ZP3 (crystal form II)

  Jovine L; Monne M
• Dataset:

  ZP-N domain of mammalian sperm receptor ZP3 (crystal form II, processed in P21221)

  Jovine L; Monne M
• Preprint:

  Architecture of the Vertebrate Egg Coat and Structural Basis of the ZP2 Block to Polyspermy

  Nishio S; Emori C; Wiseman B; Fahrenkamp D; Dioguardi E; Zamora-Caballero S; Bokhove M; Han L; Stsiapanava A; Lu Y; Kodani M; Bainbridge RE; Komondor KM; Carlson AE; Landreh M; Daniele DS; Yasumasu S; Ikawa M; Jovine L
• Show more

Staff and contact

Group leader

• 

  Luca Jovine

  Professor

  E-mail luca.jovine@ki.se

All members of the group

• 

  Luca Jovine

  Professor

  E-mail luca.jovine@ki.se
• 

  Alena Stsiapanava

  Researcher

  E-mail alena.stsiapanava@ki.se
• Laia Torres Masdéu

  E-mail laia.torres.masdeu@ki.se
• 

  Han Wang

  Postdoctoral Researcher

  E-mail han.wang@ki.se

Other people connected to the group

• Stsiapanava, Alena