Alena Stsiapanava

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Article: CELL. 2024;187(6):1440-1459.e24
ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat
Nishio S; Emori C; Wiseman B; Fahrenkamp D; Dioguardi E; Zamora-Caballero S; Bokhove M; Han L; Stsiapanava A; Algarra B; Lu Y; Kodani M; Bainbridge RE; Komondor KM; Carlson AE; Landreh M; Sanctis DD; Yasumasu S; Ikawa M; Jovine L
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2022;29(3):190-193
Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH
Stsiapanava A; Xu C; Nishio S; Han L; Yamakawa N; Carroni M; Tunyasuvunakool K; Jumper J; de Sanctis D; Wu B; Jovine L
Article: EMBO JOURNAL. 2020;39(24):e106807
Cryo-EM structure of native human uromodulin, a zona pellucida module polymer
Stsiapanava A; Xu C; Brunati M; Zamora-Caballero S; Schaeffer C; Bokhove M; Han L; Hebert H; Carroni M; Yasumasu S; Rampoldi L; Wu B; Jovine L
Article: SCIENTIFIC REPORTS. 2019;9(1):14607
Crystal structure of ErmE-23S rRNA methyltransferase in macrolide resistance
Stsiapanava A; Selmer M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(36):9689-9694
Capturing LTA₄ hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB₄ synthesis
Stsiapanava A; Samuelsson B; Haeggstrom JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(11):4227-4232
Binding of Pro-Gly-Pro at the active site of leukotriene A₄ hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor
Stsiapanava A; Olsson U; Wan M; Kleinschmidt T; Rutishauser D; Zubarev RA; Samuelsson B; Rinaldo-Matthis A; Haeggstrom JZ
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2014;70(Pt 2):209-217
Crystallographic analysis of 1,2,3-trichloropropane biodegradation by the haloalkane dehalogenase DhaA31
Lahoda M; Mesters JR; Stsiapanava A; Chaloupkova R; Kuty M; Damborsky J; Smatanova IK
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2014;1844(2):439-446
Product formation controlled by substrate dynamics in leukotriene A4 hydrolase
Stsiapanava A; Tholander F; Kumar RB; Qureshi AA; Niegowski D; Hasan M; Thunnissen M; Haeggstrom JZ; Rinaldo-Matthis A
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2011;67(Pt 3):397-400
Crystallization and crystallographic analysis of the Rhodococcus rhodochrous NCIMB 13064 DhaA mutant DhaA31 and its complex with 1,2,3-trichloropropane
Lahoda M; Chaloupkova R; Stsiapanava A; Damborsky J; Smatanova IK
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2011;67(Pt 2):253-257
Crystallization and preliminary X-ray diffraction analysis of the wild-type haloalkane dehalogenase DhaA and its variant DhaA13 complexed with different ligands
Stsiapanava A; Chaloupkova R; Fortova A; Brynda J; Weiss MS; Damborsky J; Smatanova IK
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2010;66(Pt 9):962-969
Atomic resolution studies of haloalkane dehalogenases DhaA04, DhaA14 and DhaA15 with engineered access tunnels
Stsiapanava A; Dohnalek J; Gavira JA; Kuty M; Koudelakova T; Damborsky J; Smatanova IK
Article: JOURNAL OF MOLECULAR BIOLOGY. 2009;392(5):1339-1356
Pathways and Mechanisms for Product Release in the Engineered Haloalkane Dehalogenases Explored Using Classical and Random Acceleration Molecular Dynamics Simulations
Klvana M; Pavlova M; Koudelakova T; Chaloupkova R; Dvorak P; Prokop Z; Stsiapanava A; Kuty M; Kuta-Smatanova I; Dohnalek J; Kulhanek P; Wade RC; Damborsky J

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Preprint: BIORXIV. 2023
Architecture of the vertebrate egg coat and structural basis of the ZP2 block to polyspermy
Nishio S; Emori C; Wiseman B; Fahrenkamp D; Dioguardi E; Zamora-Caballero S; Bokhove M; Han L; Stsiapanava A; Lu Y; Kodani M; Bainbridge R; Komondor K; Carlson A; Landreh M; de Sanctis D; Yasumasu S; Ikawa M; Jovine L
Dataset: 2022
Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form III)
Jovine L
Preprint: BIORXIV. 2020
Cryo-EM Structure of Native Human Uromodulin, a Zona Pellucida Module Polymer
Stsiapanava A; Xu C; Brunati M; Zamora-Caballero S; Schaeffer C; Han L; Carroni M; Yasumasu S; Rampoldi L; Wu B; Jovine L
Preprint: SSRN ELECTRONIC JOURNAL. 2020
Cryo-EM Structure of Native Human Uromodulin, a Zona Pellucida Module Polymer
Stsiapanava A; Xu C; Brunati M; Zamora-Caballero S; Schaeffer C; Han L; Carroni M; Yasumasu S; Rampoldi L; Wu B; Jovine L
Review: SEMINARS IN IMMUNOLOGY. 2017;33(C):3-15
Biosynthesis of leukotriene B₄
Wan M; Tang X; Stsiapanava A; Haeggstrom JZ
Published conference paper: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2008;64(Pt 2):137-140
Crystals of DhaA mutants from Rhodococcus rhodochrous NCIMB 13064 diffracted to ultrahigh resolution:: crystallization and preliminary diffraction analysis
Stsiapanava A; Koudelakova T; Lapkouski M; Pavlova M; Damborsky J; Smatanova IK

Employments

Researcher, Department of Medicine, Huddinge, Karolinska Institutet, 2024-
Postdoctoral Researcher, Department of Cell and Molecular Biology, Uppsala University, 2017-2019

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