Rune Toftgård | Karolinska Institutet

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Article: TRANSGENIC RESEARCH. 2021;30(5):701-707
Severe liver disease resembling PSC in mice with K5-Cre mediated deletion of Kruppel-like factor 5 (Klf5)
Bergstrom A; Gerling M; Van Hul N; Fernandez Moro C; Rozell B; Toftgard R; Sur I
Article: INTERNATIONAL JOURNAL OF CANCER. 2020;146(4):1125-1138
GLI1-induced mammary gland tumours are transplantable and maintain major molecular features
Norum JH; Frings O; Kasper M; Bergholtz H; Thime HZ; Bergstrom A; Andersson A; Kuiper R; Fredlund E; Sorlie T; Toftgard R
Article: DEVELOPMENTAL BIOLOGY. 2017;429(1):132-146
Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model
Hoelzl MA; Heby-Henricson K; Gerling M; Dias JM; Kuiper RV; Trunkle C; Bergstrom A; Ericson J; Toftgard R; Teglund S
Article: NATURE CELL BIOLOGY. 2016;18(12):1346-1356
Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours
Blaas L; Pucci F; Messal HA; Andersson AB; Ruiz EJ; Gerling M; Douagi I; Spencer-Dene B; Musch A; Mitter R; Bhaw L; Stone R; Bornhorst D; Sesay AK; Jonkers J; Stamp G; Malanchi I; Toftgard R; Behrens A
Article: NATURE COMMUNICATIONS. 2016;7:12321
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
Gerling M; Buller NVJA; Kirn LM; Joost S; Frings O; Englert B; Bergstrom A; Kuiper RV; Blaas L; Wielenga MCB; Almer S; Kuhl AA; Fredlund E; van den Brink GR; Toftgard R
Article: EMBO JOURNAL. 2016;35(13):1400-1416
SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development
Raducu M; Fung E; Serres S; Infante P; Barberis A; Fischer R; Bristow C; Thezenas M-L; Finta C; Christianson JC; Buffa FM; Kessler BM; Sibson NR; Di Marcotullio L; Toftgard R; D'Angiolella V
Article: NATURE COMMUNICATIONS. 2016;7:11314
FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice
Bosma M; Gerling M; Pasto J; Georgiadi A; Graham E; Shilkova O; Iwata Y; Almer S; Soderman J; Toftgard R; Wermeling F; Bostrom EA; Bostrom PA
Article: METHODS IN MOLECULAR BIOLOGY. 2016;1453:123-136
Isolation and Fluorescence-Activated Cell Sorting of Mouse Keratinocytes Expressing β-Galactosidase.
Kasper M; Toftgård R; Jaks V
Article: STEM CELL REPORTS. 2015;5(5):843-855
Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis
Fullgrabe A; Joost S; Are A; Jacob T; Sivan U; Haegebarth A; Linnarsson S; Simons BD; Clevers H; Toftgard R; Kasper M
Article: STEM CELLS AND DEVELOPMENT. 2015;24(21):2547-2560
Suppressor of Fused Plays an Important Role in Regulating Mesodermal Differentiation of Murine Embryonic Stem Cells In Vivo
Hoelzl MA; Heby-Henricson K; Bilousova G; Rozell B; Kuiper RV; Kasper M; Toftgard R; Teglund S
Journal article: ZEITSCHRIFT FUR GASTROENTEROLOGIE. 2015;53(08)
Aktivierung des Hedgehog Signalwegs im Kolonstroma hemmt Entstehung und Progression von kolorektalen Tumoren
Gerling M; Kirn L; Büller N; Englert B; Frings O; Fredlund E; Kühl A; Kuiper R; van den Brink G; Toftgård R
Article: DEVELOPMENTAL BIOLOGY. 2015;404(2):35-48
A conditional transgenic mouse line for targeted expression of the stem cell marker LGR5
Norum JH; Bergstrom A; Andersson AB; Kuiper RV; Hoelzl MA; Sorlie T; Toftgard R
Article: MOLECULAR CANCER. 2015;14(1):17
β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma
Zinke J; Schneider FT; Harter PN; Thom S; Ziegler N; Toftgard R; Plate KH; Liebner S
Article: CELL REPORTS. 2014;7(3):747-761
Regulated Splicing of the α6 Integrin Cytoplasmic Domain Determines the Fate of Breast Cancer Stem Cells
Goel HL; Gritsko T; Pursell B; Chang C; Shultz LD; Greiner DL; Norum JH; Toftgard R; Shaw LM; Mercurio AM
Journal article: ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE. 2013;140(12):s637
La signalisation par le TNFR1 dans les kératinocytes déficients pour NF-κB induit une inflammation cutanée psoriasiforme dépendante de l’IL-24 chez la souris
Bonnet MC; Kumari S; Ulvmar MH; Wolk K; Karagianni N; Witte E; Uthoff-Hachenberg C; Renauld J-C; Kollias G; Toftgard R; Sabat R; Pasparakis M; Haase I
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2013;69(Pt 12):2563-2579
Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation
Cherry AL; Finta C; Karlstrom M; Jin Q; Schwend T; Astorga-Wells J; Zubarev RA; Del Campo M; Criswell AR; de Sanctis D; Jovine L; Toftgard R
Article: IMMUNITY. 2013;39(5):899-911
Tumor Necrosis Factor Receptor Signaling in Keratinocytes Triggers Interleukin-24-Dependent Psoriasis-like Skin Inflammation in Mice
Kumari S; Bonnet MC; Ulvmar MH; Wolk K; Karagianni N; Witte E; Uthoff-Hachenberg C; Renauld J-C; Kollias G; Toftgard R; Sabat R; Pasparakis M; Haase I
Article: CELL DEATH AND DIFFERENTIATION. 2013;20(8):1080-1088
Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis
Chari NS; Romano RA; Koster MI; Jaks V; Roop D; Flores ER; Teglund S; Sinha S; Gruber W; Aberger F; Medeiros LJ; Toftgard R; McDonnell TJ
Journal article: PANCREATOLOGY. 2013;13(3):s19
Detection of hypoxic areas in a syngeneic, orthotopic model of pancreatic ductal adenocarcinoma in mouse by in vivo imaging using photoacoustics
Heuchel R; Gerling M; Zhao Y; Jose J; Norberg J; Toftgård R; Löhr M
Journal article: CANCER RESEARCH. 2013;73(8_Supplement):1407
Abstract 1407: A transgenic mouse model for the Hedgehog pathway effector GLI1 induced mammary gland tumors.
Norum JH; Andersson A; Kasper M; Sørlie T; Toftgård R
Article: EMBO MOLECULAR MEDICINE. 2013;5(4):488-508
GLI1 regulates a novel neuropilin-2/61 integrin based autocrine pathway that contributes to breast cancer initiation
Goel HL; Pursell B; Chang C; Shaw LM; Mao J; Simin K; Kumar P; Vander Kooi CW; Shultz LD; Greiner DL; Norum JH; Toftgard R; Kuperwasser C; Mercurio AM
Article: GUT. 2013;62(3):348-357
Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine oesophagus
van Dop WA; Rosekrans SL; Uhmann A; Jaks V; Offerhaus GJA; Weerman MAVDB; Kasper M; Heijmans J; Hardwick JCH; Verspaget HW; Hommes DW; Toftgard R; Hahn H; van den Brink GR
Article: BMC CANCER. 2013;13:95
3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing
Longati P; Jia X; Eimer J; Wagman A; Witt M-R; Rehnmark S; Verbeke C; Toftgard R; Lohr M; Heuchel RL
Article: MOLECULAR CARCINOGENESIS. 2012;51(9):754-760
Loss of Trp53 promotes medulloblastoma development but not skin tumorigenesis in Sufu heterozygous mutant mice
Heby-Henricson K; Bergstrom A; Rozell B; Toftgard R; Teglund S
Journal article: GASTROENTEROLOGY. 2012;142(5):s-331
Sa1809 Hedgehog Signaling Stimulates Precursor Cell Accumulation and Impairs Epithelial Maturation in the Murine Esophagus
Rosekrans S; van Dop WA; Uhmann A; Jaks V; Offerhaus J; van den Bergh Weerman MA; Heijmans J; Hardwick JC; Hommes DW; Toftgârd R; Hahn H; van den Brink GR
Article: AMERICAN JOURNAL OF PATHOLOGY. 2011;179(5):2569-2579
Targeted Expression of GLI1 in the Salivary Glands Results in an Altered Differentiation Program and Hyperplasia
Fiaschi M; Kolterud A; Nilsson M; Toftgard R; Rozell B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(10):4099-4104
Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes
Kasper M; Jaks V; Are A; Bergstrom A; Schwager A; Barker N; Toftgard R
Article: PLOS ONE. 2011;6(6):e20580
Increased Expression of the Dyslexia Candidate Gene DCDC2 Affects Length and Signaling of Primary Cilia in Neurons
Massinen S; Hokkanen M-E; Matsson H; Tammimies K; Tapia-Paez I; Dahlstrom-Heuser V; Kuja-Panula J; Burghoorn J; Jeppsson KE; Swoboda P; Peyrard-Janvid M; Toftgard R; Castren E; Kere J
Article: GENES AND CANCER. 2010;1(9):941-951
Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway.
Tostar U; Toftgård R; Zaphiropoulos PG; Shimokawa T
Article: MOLECULAR PHARMACOLOGY. 2010;78(3):486-496
Antipsychotic Drugs Regulate Hedgehog Signaling by Modulation of 7-Dehydrocholesterol Reductase Levels
Lauth M; Rohnalter V; Bergstrom A; Kooshesh M; Svenningsson P; Toftgard R
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2010;17(6):718-725
DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS
Lauth M; Bergstrom A; Shimokawa T; Tostar U; Jin Q; Fendrich V; Guerra C; Barbacid M; Toftgard R
Journal article: GASTROENTEROLOGY. 2010;138(5):s-34
186 Constitutive Hedgehog Signaling Impairs Maturation and Migration of Esophageal Epithelial Precursor Cells
van Dop WA; Uhmann A; Jaks V; Offerhaus J; van den Bergh Weerman MA; Heijmans J; Hommes DW; Hardwick JC; Toftgård R; Hahn H; van den Brink GR
Article: SCIENCE. 2010;327(5971):1385-1389
Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin
Snippert HJ; Haegebarth A; Kasper M; Jaks V; van Es JH; Barker N; van de Wetering M; van den Born M; Begthel H; Vries RG; Stange DE; Toftgard R; Clevers H
Article: EXPERIMENTAL DERMATOLOGY. 2009;18(12):1044-1052
MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer
Boyd S; Virolainen S; Parssinen J; Skoog T; van Hogerlinden M; Latonen L; Kyllonen L; Toftgard R; Saarialho-Kere U
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2009;129(11):2584-2593
Timed NF-κB Inhibition in Skin Reveals Dual Independent Effects on Development of HED/EDA and Chronic Inflammation
Ulvmar MH; Sur I; Memet S; Toftgard R
Article: DEVELOPMENTAL BIOLOGY. 2009;330(2):452-460
Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia
Jia J; Kolterud A; Zeng H; Hoover A; Teglund S; Toftgard R; Liu A
Article: CANCER RESEARCH. 2009;69(11):4810-4817
Development of Mammary Tumors by Conditional Expression of GLI1
Fiaschi M; Rozell B; Bergstrom A; Toftgard R
Article: MOLECULAR CARCINOGENESIS. 2009;48(5):408-419
Tumor Suppressor Gene Co-Operativity in Compound Patched1 and Suppressor of Fused Heterozygous Mutant Mice
Svard J; Rozell B; Toftgard R; Teglund S
Article: JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH. 2009;29(1):44-51
Inhibition of NF-κB signaling interferes with phorbol ester-induced growth arrest of keratinocytes in a TNFR1-independent manner
Sur I; Ulvmar M; Jungedal R; Toftgard R
Article: NATURE GENETICS. 2008;40(11):1291-1299
Lgr5 marks cycling, yet long-lived, hair follicle stem cells
Jaks V; Barker N; Kasper M; Van Es JH; Snippert HJ; Clevers H; Toftgard R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(21):14345-14354
Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal
Shimokawa T; Tostar U; Lauth M; Palaniswamy R; Kasper M; Toftgard R; Zaphiropoulos PG
Article: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. 2008;73:351-356
Very long-term self-renewal of small intestine, colon, and hair follicles from cycling Lgr5+ve stem cells.
Barker N; van Es JH; Jaks V; Kasper M; Snippert H; Toftgård R; Clevers H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(49):36090-36101
Targeted expression of GLI1 in the mammary gland disrupts pregnancy-induced maturation and causes lactation failure
Fiaschi M; Rozell B; Bergstrom A; Toftgard R; Kleman MI
Journal article: DRUG DISCOVERY TODAY: THERAPEUTIC STRATEGIES. 2007;4(4):229-235
Strategies for Hedgehog inhibition and its potential role in cancer treatment
Kolterud Å; Toftgård R
Article: CELL CYCLE. 2007;6(20):2458-2463
Non-canonical activation of GLI transcription factors -: Implications for targeted anti-cancer therapy
Lauth M; Toftgard R
Article: ONCOGENE. 2007;26(35):5163-5168
Phorbol esters inhibit the Hedgehog signalling pathway downstream of Suppressor of Fused, but upstream of Gli
Lauth M; Bergstrom A; Toftgard R
Article: ONCOGENE. 2007;26(34):4889-4896
Distinct roles of first exon variants of the tumor-suppressor Patched1 in Hedgehog signaling
Shimokawa T; Svard J; Heby-Henricson K; Teglund S; Toftgard R; Zaphiropoulos PG
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(20):8455-8460
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
Lauth M; Bergstrom A; Shimokawa T; Toftgard R
Article: NATURE GENETICS. 2006;38(10):1204-1209
Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus
Lee K; Jeong J; Kwak I; Yu C-T; Lanske B; Soegiarto DW; Toftgard R; Tsai M-J; Tsai S; Lydon JP; DeMayo FJ
Article: JOURNAL OF CELL SCIENCE. 2006;119(17):3593-3601
Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis
Sur I; Rozell B; Jaks V; Bergstrom A; Toftgard R
Article: BIOCHEMICAL JOURNAL. 2006;394(Pt 1):19-26
Inhibition of GLI1 gene activation by patched1
Rahnama F; Shimokawa T; Lauth M; Finta C; Kogerman P; Teglund S; Toftgård R; Zaphiropoulos PG
Article: DEVELOPMENTAL CELL. 2006;10(2):187-197
Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway
Svärd J; Henricson KH; Persson-Lek M; Rozell B; Lauth M; Bergstrm Å; Ericson J; Toftgård R; Teglund S
Article: JOURNAL OF PATHOLOGY. 2006;208(1):17-25
Deregulation of the hedgehog signalling pathway:: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development
Tostar U; Malm CJ; Meis-Kindblom JM; Kindblom LG; Toftgård R; Undén AB
Journal article: DRUG DISCOVERY TODAY: DISEASE MECHANISMS. 2004;1(2):267-272
Non-melanoma skin cancer: pathogenesis and mechanisms
Lauth M; Unden AB; Toftgård R
Article: BMC GENOMICS. 2004;5(1):49
The FU gene and its possible protein isoforms -: art. no. 49
Osterlund T; Everman DB; Betz RC; Mosca M; Nöthen MM; Schwartz CE; Zaphiropoulos PG; Toftgård R
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2004;123(1):101-108
Characterization of the progressive skin disease and inflammatory cell infiltrate in mice with inhibited NF-κB signaling
van Hogerlinden M; Rozell BL; Toftgård R; Sundberg JP
Article: CANCER RESEARCH. 2004;64(8):2699-2704
Ultraviolet irradiation represses PATCHED gene transcription in human epidermal keratinocytes through an activator protein-1-dependent process
Brellier F; Marionnet C; Chevallier-Lagente O; Toftgard R; Mauviel A; Sarasin A; Magnaldo T
Article: GENE. 2004;330:101-114
Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site
Ågren M; Kogerman P; Kleman MI; Wessling M; Toftgård R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(14):4972-4977
Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-κB inhibition
Lind MH; Rozell B; Wallin RPA; van Hogerlinden M; Ljunggren HG; Toftgård R; Sur I
Article: ARCHIVES OF DERMATOLOGICAL RESEARCH. 2004;295(11):482-489
Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element
Maijgren S; Sur I; Nilsson M; Toftgård R
Article: BIOCHEMICAL JOURNAL. 2004;378(Pt 2):325-334
Distinct roles of PTCH2 splice variants in Hedgehog signalling
Rahnama F; Toftgård R; Zaphiropoulos PG
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(7):5621-5629
Role for ELOVL3 and fatty acid chain length in development of hair and skin function
Westerberg R; Tvrdik P; Undén AB; Månsson JE; Norlén L; Jakobsson A; Holleran WH; Elias PM; Asadi A; Flodby P; Toftgård R; Capecchi MR; Jacobsson A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(2):1197-1205
Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1
Bigelow RLH; Chari NS; Undén AB; Spurgers KB; Lee SJ; Roop DR; Toftgård R; McDonnell TJ
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2003;198(12):1959-1964
The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor κB activation by tumor necrosis factor
Regamey A; Hohl D; Liu JW; Roger T; Kogerman P; Toftgård R; Huber M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(7):5116-5122
Characterization of the physical interaction of Gli proteins with SUFU proteins
Dunaeva M; Michelson P; Kogerman P; Toftgard R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(38):35156-35161
Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1
Mao JH; Maye P; Kogerman P; Tejedor FJ; Toftgard R; Xie W; Wu GQ; Wu DQ
Article: ONCOGENE. 2002;21(39):6007-6016
Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein
Kogerman P; Krause D; Rahnama F; Kogerman L; Undén AB; Zaphiropoulos PG; Toftgård R
Article: ONCOGENE. 2002;21(32):4969-4977
Inhibition of Rel/Nuclear Factor-κB signaling in skin results in defective DNA damage-induced cell cycle arrest and Ha-ras- and p53-independent tumor development
van Hogerlinden M; Auer G; Toftgård R
Article: EUROPEAN JOURNAL OF CELL BIOLOGY. 2002;81(6):323-334
Human Kruppel-like factor5/KLF5:: Synergy with NF-κB/Rel factors and expression in human skin and hair follicles
Sur I; Undén AB; Toftgård R
Article: ONCOGENE. 2001;20(53):7770-7778
PATCHED and p53 gene alterations in sporadic and hereditary basal cell cancer
Ling G; Ahmadian A; Persson Å; Undén AB; Afink G; Williams C; Uhlén M; Toftgård R; Lundeberg J; Pontén F
Article: FEBS LETTERS. 2001;505(1):13-17
Genomic organization and embryonic expression of Suppressor of Fused, a candidate gene for the split-hand/split-foot malformation type 3
Grimm T; Teglund S; Tackels D; Sangiorgi E; Gurrieri F; Schwartz C; Toftgård R
Article: BRITISH JOURNAL OF DERMATOLOGY. 2000;143(4):709-719
Retinoids induce apoptosis in cultured keratinocytes
Islam TC; Skarin T; Sumitran S; Toftgård R
Article: MOLECULAR CELL BIOLOGY RESEARCH COMMUNICATIONS. 2000;3(6):367-373
Repression of transcription by HoxC11 upon phorbol ester stimulation.
Sur IP; Toftgård R
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2000;16(5):943-949
Patched 2, located in 1p32-34, is not mutated in high stage neuroblastoma tumors
Jögi A; Abel F; Sjöberg RM; Toftgård R; Zaphiropoulos PG; Påhlman S; Martinsson T; Axelson H
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(7):3438-3443
Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
Nilsson M; Undèn AB; Krause D; Malmqwist U; Raza K; Zaphiropoulos PG; Toftgård R
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 1999;122(2):89-106
Protection against 12-O-tetradecanoylphorbol-13-acetate induced skin-hyperplasia and tumor promotion, in a two-stage carcinogenesis mouse model, by the 2,3-dimethyl-6 (2-dimethylaminoethyl)-6H-indolo-[2,3-b]quinoxaline analogue of ellipticine
Skarin T; Rozell BL; Bergman J; Toftgård R; Möller L
Article: NATURE CELL BIOLOGY. 1999;1(5):312-319
Mammalian Suppressor-of-Fused modulates nuclear-cytoplasmic shuttling of GLI-1
Kogerman P; Grimm T; Kogerman L; Krause D; Undén AB; Sandstedt B; Toftgård R; Zaphiropoulos PG
Article: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 1999;21(2):177-184
Cis-acting sequences from the rat cytochrome P4502B1 gene confer pulmonary and phenobarbital-inducible expression in transgenic mice
Skarin T; Becher R; Bucht A; Duvefelt K; Bohm S; Ranneberg-Nilsen T; Lilleaas EM; Schwarze PE; Toftgård R
Article: CANCER RESEARCH. 1999;59(14):3299-3303
Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-κB signaling
van Hogerlinden M; Rozell BL; Ährlund-Richter L; Toftgård R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(19):13511-13518
Repression of dioxin signal transduction in fibroblasts -: Identification of a putative repressor associated with Arnt
Gradin K; Toftgård R; Poellinger L; Berghard A
Article: EUROPEAN JOURNAL OF CANCER. 1999;35(5):711-713
The patched/hedgehog/smoothened signalling pathway in human breast cancer:: No evidence for H133YSHH, PTCH and SMO mutations
Vorechovsky I; Benediktsson KP; Toftgård R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(6):2880-2884
GLI3 mutations in human disorders mimic Drosophila Cubitus interruptus protein functions and localization
Shin SH; Kogerman P; Lindström E; Toftgárd R; Biesecker LG
Article: CANCER RESEARCH. 1999;59(4):787-792
PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas
Zaphiropoulos PG; Undén AB; Rahnama F; Hollingsworth RE; Toftgård R
Article: CLINICAL GENETICS. 1998;54(3):239-241
Dinucleotide repeat polymorphism within the tumor suppressor gene PTCH at 9q22
Louhelainen J; Lindstrom E; Hemminki K; Toftgard R
Article: BRITISH JOURNAL OF DERMATOLOGY. 1998;139(2):271-275
Treatment of venous leg ulcers with cryopreserved cultured allogeneic keratinocytes:: a prospective open controlled study
Lindgren C; Marcusson JA; Toftgård R
Journal article: JOURNAL OF DERMATOLOGICAL SCIENCE. 1998;16:s153
Strong expression of the human patched and sonic hedgehog genes is a characteristic feature of the inductive phase of human hair follicle development
Undén AB; Sandstedt B; Toftgård R; Ståhle-Bäckdahl M
Article: MOLECULAR CARCINOGENESIS. 1998;21(2):87-92
Mutation analysis of the human homologue of Drosophila patched and the xeroderma pigmentosum complementation group A genes in squamous cell carcinomas of the skin
Eklund LK; Lindström E; Undén AB; Lundh-Rozell B; Ståhle-Bäckdahl M; Zaphiropoulos PG; Toftgård R; Söderkvist P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(2):565-569
UVB-induced association of tumor necrosis factor (TNF) receptor 1 TNF receptor-associated factor-2 mediates activation of Rel proteins
Tobin D; van Hogerlinden M; Toftgård R
Article: CANCER RESEARCH. 1997;57(21):4731-4735
Patched (ptch)-associated preferential expression of smoothened (smoh) in human basal cell carcinoma of the skin
Kallassy M; Toftgard R; Ueda M; Nakazawa K; Vorechovsky I; Yamasaki H; Nakazawa H
Article: CANCER RESEARCH. 1997;57(21):4677-4681
Trichoepitheliomas contain somatic mutations in the overexpressed PTCH gene: Support for a gatekeeper mechanism in skin tumorigenesis
Vorechovsky I; Unden AB; Sandstedt B; Toftgard R; StahleBackdahl M
Article: MOLECULAR CANCER RESEARCH. 1997;8(8):913-920
Characterization of a nuclear factor that binds juxtapose with ATF3/Jun on a composite response element specifically mediating induced transcription in response to an epidermal growth factor Ras/Raf signaling pathway
Nilsson M; Ford J; Bohm S; Toftgard R
Article: ONCOGENE. 1997;15(3):361-366
Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours
Vorechovsky I; Tingby O; Hartman M; Stromberg B; Nister M; Collins VP; Toftgard R
Article: CANCER RESEARCH. 1997;57(12):2336-2340
Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma
Unden AB; Zaphiropoulos PG; Bruce K; Toftgard R; StahleBackdahl M
Article: CYTOGENETIC AND GENOME RESEARCH. 1997;76(3-4):208-213
Pulsed-field gel electrophoresis and FISH mapping of chromosome 9q22: Placement of a novel zinc finger gene within the NBCCS and ESS1 region
Levanat S; Chidambaram A; Wicking C; BrayWard P; Pressman C; Toftgard R; Gailani MR; Myers JC; Wainwright B; Dean M; Bale AE
Article: ACTA DERMATO-VENEREOLOGICA. 1997;77(1):4-9
Fine mapping of the locus for nevoid basal cell carcinoma syndrome on chromosome 9q
Unden AB; StahleBackdahl M; Holmberg E; Larsson C; Toftgard R
Article: DNA AND CELL BIOLOGY. 1996;15(12):1049-1056
cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region
Zaphiropoulos PG; Toftgard R
Article: CANCER RESEARCH. 1996;56(20):4562-4565
Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: Different in vivo mechanisms of PTCH inactivation
Unden AB; Holmberg E; LundhRozell B; StahleBackdahl M; Zaphiropoulos PG; Toftgard R; Vorechovsky I
Article: MOLECULAR AND CELLULAR BIOLOGY. 1996;16(10):5221-5231
Functional interference between hypoxia and dioxin signal transduction pathways: Competition for recruitment of the Arnt transcription factor
Gradin K; McGuire J; Wenger RH; Kvietikova I; Whitelaw ML; Toftgard R; Tora L; Gassmann M; Poellinger L
Article: BRITISH JOURNAL OF CANCER. 1996;74(2):246-250
Differential allele loss on chromosome 9q22.3 in human non-melanoma skin cancer
Holmberg E; Rozell BL; Toftgard R
Article: CELL. 1996;85(6):841-851
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
Hahn H; Wicking C; Zaphiropoulos PG; Gailani MR; Shanley S; Chidambaram A; Vorechovsky I; Holmberg E; Unden AB; Gillies S; Negus K; Smyth I; Pressman C; Leffell DJ; Gerrard B; Goldstein AM; Dean M; Toftgard R; ChenevixTrench G; Wainwright B; Bale AE
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(21):12125-12128
A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities
Hahn H; Christiansen J; Wicking C; Zaphiropoulos PG; Chidambaram A; Gerrard B; Vorechovsky I; Bale AE; Toftgard R; Dean M; Wainwright B
Article: ONCOGENE. 1996;12(4):785-793
Ras-independent activation of Rel-family transcription factors by UVB and TPA in cultured keratinocytes
Tobin D; Nilsson M; Toftgard R
Article: IN VITRO CELLULAR AND DEVELOPMENTAL BIOLOGY - ANIMAL. 1995;31(10):790-795
ROLE OF PROTEIN-KINASE-C IN GROWTH-STIMULATION OF PRIMARY MOUSE COLONIC EPITHELIAL-CELLS
BRANTING C; TOFTGARD R; HALLSTROM IP; RAFTER J
Article: MOLECULAR PHARMACOLOGY. 1995;48(4):610-615
DIFFERENTIAL-EFFECTS OF A TOPOISOMERASE-I INHIBITOR ON DIOXIN INDUCIBILITY AND HIGH-LEVEL EXPRESSION OF THE CYTOCHROME P450IA1 GENE
GRADIN K; TOFTGARD R; BERGHARD A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(20):12210-12218
ACTIVATED HA-RAS BUT NOT TPA INDUCES TRANSCRIPTION THROUGH BINDING-SITES FOR ACTIVATING TRANSCRIPTION FACTOR 3/JUN AND A NOVEL NUCLEAR FACTOR
NILSSON M; TOFTGARD R; BOHM S
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1994;269(38):23800-23807
A TYROSINE KINASE-DEPENDENT PATHWAY REGULATES LIGAND-DEPENDENT ACTIVATION OF THE DIOXIN RECEPTOR IN HUMAN KERATINOCYTES
GRADIN K; WHITELAW ML; TOFTGARD R; POELLINGER L; BERGHARD A
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1994;203(1):545-552
NUCLEAR ORPHAN RECEPTOR-BINDING RETINOIC ACID RESPONSE ELEMENTS IN KERATINOCYTES
ISLAM TC; TOFTGARD R
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1994;201(3):1495-1501
GENETIC INSTABILITY OF MICROSATELLITE MARKERS IN REGION-Q22.3-Q31 OF CHROMOSOME-9 IN SKIN SQUAMOUS-CELL CARCINOMAS
ZAPHIROPOULOS PG; SODERKVIST P; HEDBLAD MA; TOFTGARD R
Journal article: CARCINOGENESIS. 1993;14(8):1723-1725
LACK OF INITIATING CAPACITY OF THE GENOTOXIC AIR POLLUTANT 2-NITROFLUORENE IN THE MOUSE SKIN 2-STAGE CARCINOGENESIS SYSTEM
MOLLER L; ZEISIG M; TOFTGARD R
Journal article: TOXICOLOGY. 1992;75(3):199-208
A SUBPOPULATION OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED PAPILLOMAS IS NOT INHIBITED BY RETINOIC ACID
ISLAM TC; TOFTGARD R
Journal article: CARCINOGENESIS. 1992;13(4):651-655
THE STABILITY OF DIOXIN-RECEPTOR LIGANDS INFLUENCES CYTOCHROME-P450IA1 EXPRESSION IN HUMAN KERATINOCYTES
BERGHARD A; GRADIN K; TOFTGARD R
Journal article: ACTA DERMATO-VENEREOLOGICA. 1992;72(1):61-64
Allogeneic cultured keratinocytes in the treatment of leg ulcers. A pilot study.
Marcusson JA; Lindgren C; Berghard A; Toftgård R
Journal article: ACTA DERMATO-VENEREOLOGICA. 1992;72(1):61-64
ALLOGENEIC CULTURED KERATINOCYTES IN THE TREATMENT OF LEG ULCERS - A PILOT-STUDY
MARCUSSON JA; LINDGREN C; BERGHARD A; TOFTGARD R
Journal article: IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY : JOURNAL OF THE TISSUE CULTURE ASSOCIATION. 1991;27(12):927-932
PROLIFERATIVE POTENTIAL AND EXPRESSION OF CELL TYPE SPECIFIC FUNCTIONS IN PRIMARY MOUSE COLONIC EPITHELIAL-CELLS
BRANTING C; ALLINGER UG; TOFTGARD R; RAFTER J
Journal article: CARCINOGENESIS. 1991;12(11):2007-2015
USE OF ARTIFICIAL-INTELLIGENCE IN STRUCTURE AFFINITY CORRELATIONS OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) RECEPTOR LIGANDS
RANNUG U; SJOGREN M; RANNUG A; GILLNER M; TOFTGARD R; GUSTAFSSON JA; ROSENKRANZ H; KLOPMAN G
Journal article: IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY : JOURNAL OF THE TISSUE CULTURE ASSOCIATION. 1991;27(7):562-568
GROWTH-REGULATION OF SERUM-FREE CULTURES OF EPITHELIAL-CELLS FROM NORMAL HUMAN BUCCAL MUCOSA
SUNDQVIST K; LIU Y; ARVIDSON K; ORMSTAD K; NILSSON L; TOFTGARD R; GRAFSTROM RC
Journal article: ACTA CHIRURGICA SCANDINAVICA. 1991;:57-70
AIR-POLLUTANTS - A POSSIBLE FACTOR IN GASTROINTESTINAL CANCER
MOLLER L; TORNQUIST S; TOFTGARD R; RAFTER J; MIDTVEDT T; GUSTAFSSON JA
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1990;265(34):21086-21090
SERUM AND EXTRACELLULAR CALCIUM MODULATE INDUCTION OF CYTOCHROME-P-450IA1 IN HUMAN KERATINOCYTES
BERGHARD A; GRADIN K; TOFTGARD R
Journal article: CARCINOGENESIS. 1990;11(8):1249-1254
2-NITROFLUORENE METABOLISM IN THE RAT LUNG - PHARMACOKINETIC AND METABOLIC EFFECTS OF BETA-NAPHTHOFLAVONE TREATMENT
TORNQUIST S; MOLLER L; GABRIELSSON J; GUSTAFSSON JA; TOFTGARD R
Journal article: CANCER RESEARCH. 1990;50(5):1626-1633
ISOLATION AND CHARACTERIZATION OF COMPLEMENTARY-DNA CLONES CORRESPONDING TO GENES INDUCED IN MOUSE EPIDERMIS INVIVO BY TUMOR PROMOTERS
BOHM S; BERGHARD A; PERESWETOFFMORATH C; TOFTGARD R
Journal article: MOLECULAR INFORMATICS. 1989;8(2):83-89
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) ANALYSIS USING THE PARTIAL LEAST-SQUARES (PLS) METHOD - THE BINDING OF POLYCYCLIC AROMATIC-HYDROCARBONS (PAH) TO THE RAT-LIVER 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) RECEPTOR
JOHNELS D; GILLNER M; NORDEN B; TOFTGARD R; GUSTAFSSON JA
Journal article: CARCINOGENESIS. 1988;9(12):2209-2214
AGE-DEPENDENT EXPRESSION OF CYTOCHROME-P-450B AND METABOLISM OF THE POTENT CARCINOGEN 2-NITROFLUORENE IN THE RAT LUNG
TORNQUIST S; SUNDIN M; MOLLER L; GUSTAFSSON JA; TOFTGARD R
Journal article: DRUG METABOLISM AND DISPOSITION. 1988;16(6):842-847
BIOAVAILABILITY OF BENZO(A)PYRENE DEPOSITED IN THE LUNG - CORRELATION WITH DISSOLUTION FROM URBAN AIR PARTICULATES AND COVALENTLY BOUND DNA ADDUCTS
TORNQUIST S; NICKLASSON M; SODERKVIST P; NYBOM L; TOFTGARD R
Journal article: CANCER RESEARCH. 1988;48(11):3045-3049
DIFFERENTIAL EXPRESSION OF THE CYTOCHROME P-450C AND P-450D GENES IN THE RAT VENTRAL PROSTATE AND LIVER
SODERKVIST P; POELLINGER L; TOFTGARD R; GUSTAFSSON JA
Journal article: CARCINOGENESIS. 1988;9(1):111-115
TCDD RECEPTOR LIGANDS PRESENT IN EXTRACTS OF URBAN AIR PARTICULATE MATTER INDUCE ARYL-HYDROCARBON HYDROXYLASE-ACTIVITY AND CYTOCHROME-P-450C GENE-EXPRESSION IN RAT HEPATOMA-CELLS
FRANZEN B; HAAPARANTA T; GUSTAFSSON JA; TOFTGARD R
Journal article: TOXICOLOGY. 1987;47(3):235-245
A COMPARISON OF THE BINDING AND DISTRIBUTION OF BENZO(A)PYRENE IN HUMAN AND RAT SERUM
AARSTAD K; TOFTGARD R; NILSEN OG
Journal article: CARCINOGENESIS. 1987;8(12):1847-1852
METABOLISM OF THE CARCINOGENIC AIR POLLUTANT 2-NITROFLUORENE IN THE ISOLATED PERFUSED RAT LUNG AND LIVER
MOLLER L; TORNQUIST S; BEIJE B; RAFTER J; TOFTGARD R; GUSTAFSSON JA
Journal article: BIOCHEMICAL PHARMACOLOGY. 1986;35(21):3733-3738
RAT LUNG AND LIVER MICROSOMAL CYTOCHROME-P-450 ISOZYMES INVOLVED IN THE HYDROXYLATION OF NORMAL-HEXANE
TOFTGARD R; HAAPARANTA T; ENG L; HALPERT J
Journal article: TOXICOLOGY. 1986;41(2):131-144
POLYCHLORINATED TERPHENYLS - ALTERATIONS IN LIVER MORPHOLOGY AND INDUCTION OF CYTOCHROME-P-450
TOFTGARD R; NILSEN OG; CARLSTEDTDUKE J; GLAUMANN H
Journal article: TOXICOLOGY. 1986;39(3):225-231
RAT LUNG AND LIVER CYTOCHROME-P-450 ISOZYMES INVOLVED IN THE HYDROXYLATION OF META-XYLENE
TOFTGARD R; HAAPARANTA T; HALPERT J
Journal article: CANCER RESEARCH. 1985;45(11 Pt 2):5845-5850
Keratin gene expression in mouse skin tumors and in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate.
Toftgard R; Yuspa SH; Roop DR
Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 1985;54(2):185-198
INVESTIGATION OF ABSORPTION, METABOLISM KINETICS AND DNA-BINDING OF INTRATRACHEALLY ADMINISTERED BENZO[A]-PYRENE IN THE ISOLATED, PERFUSED RAT LUNG - A COMPARATIVE-STUDY BETWEEN MICROCRYSTALLINE AND PARTICULATE ADSORBED BENZO[A]PYRENE
TORNQUIST S; WIKLUND L; TOFTGARD R
Journal article: CARCINOGENESIS. 1985;6(4):655-657
Proto-oncogene expression during two-stage carcinogenesis in mouse skin.
Toftgard R; Roop DR; Yuspa SH
Journal article: ENVIRONMENT INTERNATIONAL. 1985;11(2-4):347-354
PHARMACOKINETIC INVESTIGATION OF THE FATE OF PARTICLE ADSORBED POLYCYCLIC AROMATIC-HYDROCARBONS IN THE ISOLATED, PERFUSED AND VENTILATED RAT LUNG .1. DNA-BINDING, DOSE-DEPENDENT METABOLISM, AND BIOAVAILABILITY, USING BENZO(A)PYRENE AS THE MODEL-COMPOUND
TORNQUIST S; TOFTGARD R; WICKLUND L
Journal article: ENVIRONMENT INTERNATIONAL. 1985;11(2-4):369-374
CHARACTERIZATION OF TCDD-RECEPTOR LIGANDS PRESENT IN EXTRACTS OF URBAN PARTICULATE MATTER
TOFTGARD R; FRANZEN B; GUSTAFSSON JA; LOFROTH G
Journal article: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1985;455:426-435
The use of cDNA clones and monospecific antibodies as probes to monitor keratin gene expression.
Roop DR; Cheng CK; Toftgard R; Stanley JR; Steinert PM; Yuspa SH
Journal article: CARCINOGENESIS. 1984;5(7):925-930
SHORT-TERM BIOASSAYS OF NITRO-DERIVATIVES OF BENZO[A]PYRENE AND PERYLENE
LOFROTH G; TOFTGARD R; NILSSON L; AGURELL E; GUSTAFSSON JA
Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 1983;46(3):335-346
COMPOUNDS IN URBAN AIR COMPETE WITH 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN FOR BINDING TO THE RECEPTOR PROTEIN
TOFTGARD R; LOFROTH G; CARLSTEDTDUKE J; KURL R; GUSTAFSSON JA
Journal article: TOXICOLOGY. 1983;28(1-2):117-131
EFFECTS OF XYLENE EXPOSURE ON THE METABOLISM OF ANTIPYRINE INVITRO AND INVIVO IN THE RAT
TOFTGARD R
Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 1983;46(2):151-163
METABOLIC-ACTIVATION OF PROMUTAGENS, DETECTABLE IN AMES SALMONELLA ASSAY, BY 5000 X G SUPERNATANT OF RAT VENTRAL PROSTATE
SODERKVIST P; BUSK L; TOFTGARD R; GUSTAFSSON JA
Journal article: TOXICOLOGY. 1983;27(2):119-137
INDUCTION OF CYTOCHROME-P-450 IN THE RAT-LIVER AFTER EXPOSURE TO XYLENES, DOSE-RESPONSE RELATIONSHIP AND DEPENDENCE ON ENDOCRINE FACTORS
TOFTGARD R; NILSEN OG; GLAUMANN H; GUSTAFSSON JA
Journal article: BIOCHEMICAL PHARMACOLOGY. 1983;32(10):1547-1552
BIOTRANSFORMATION OF BENZO[A]PYRENE AND 7-ETHOXYRESORUFIN AND HEME-STAINING PROTEINS IN MICROSOMES FROM HUMAN-FETAL LIVER AND PLACENTA
BLANCK A; RANE A; TOFTGARD R; GUSTAFSSON JA
Journal article: MOLECULAR PHARMACOLOGY. 1983;23(1):265-271
XYLENE INDUCES A CYTOCHROME-P-450 ISOZYME IN RAT-LIVER SIMILAR TO THE MAJOR ISOZYME INDUCED BY PHENOBARBITAL
TOFTGARD R; HALPERT J; GUSTAFSSON JA
Journal article: NEUROTOXICOLOGY. 1983;4(4):43-56
INCREASED AMINE TURNOVER IN SEVERAL HYPOTHALAMIC NORADRENALINE NERVE-TERMINAL SYSTEMS AND CHANGES IN PROLACTIN SECRETION IN THE MALE-RAT BY EXPOSURE TO VARIOUS CONCENTRATIONS OF TOLUENE
ANDERSSON K; NILSEN OG; TOFTGARD R; ENEROTH P; GUSTAFSSON JA; BATTISTINI N; AGNATI LF
Journal article: ACTA PHARMACOLOGICA ET TOXICOLOGICA. 1982;51(2):108-114
DOSE DEPENDENT INDUCTION OF RAT-LIVER MICROSOMAL CYTOCHROME-P-450 AND MICROSOMAL ENZYMATIC-ACTIVITIES AFTER INHALATION OF TOLUENE AND DICHLOROMETHANE
TOFTGARD R; NILSEN OG; GUSTAFSSON JA
Journal article: TOXICOLOGY LETTERS. 1982;12(2-3):115-123
TOLUENE AND TELENCEPHALIC DOPAMINE - SELECTIVE REDUCTION OF AMINE TURNOVER IN DISCRETE DA NERVE-TERMINAL SYSTEMS OF THE ANTERIOR CAUDATE-NUCLEUS BY LOW CONCENTRATIONS OF TOLUENE
FUXE K; ANDERSSON K; NILSEN OG; TOFTGARD R; ENEROTH P; GUSTAFSSON JA
Journal article: ARCHIVES OF TOXICOLOGY. 1982;50(1):1-10
PHTHALATE-ESTERS .1. EFFECTS ON CYTOCHROME-P-450 MEDIATED METABOLISM IN RAT-LIVER AND LUNG, SERUM ENZYMATIC-ACTIVITIES AND SERUM-PROTEIN LEVELS
WALSETH F; TOFTGARD R; NILSEN OG
Journal article: TOXICOLOGY LETTERS. 1982;10(1):61-69
INDUCTION OF CYTOCHROME-P-450 RELATED METABOLIC-ACTIVITIES IN THE RAT VENTRAL PROSTATE
SODERKVIST P; TOFTGARD R; GUSTAFSSON JA
Journal article: TOXICOLOGY. 1982;23(2-3):197-212
EFFECTS OF XYLENE AND XYLENE ISOMERS ON CYTOCHROME-P-450 AND INVITRO ENZYMATIC-ACTIVITIES IN RAT-LIVER, KIDNEY AND LUNG
TOFTGARD R; NILSEN OG
Journal article: ARCHIVES OF TOXICOLOGY. 1981;49(1):1-13
EFFECTS OF CHLORINATED PARAFFINS ON RAT-LIVER MICROSOMAL ACTIVITIES AND MORPHOLOGY - IMPORTANCE OF THE LENGTH AND THE DEGREE OF CHLORINATION OF THE CARBON CHAIN
NILSEN OG; TOFTGARD R; GLAUMANN H
Journal article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 1981;60(3):535-548
PRODUCTION OF DISCRETE CHANGES IN DOPAMINE AND NORADRENALINE LEVELS AND TURNOVER IN VARIOUS PARTS OF THE RAT-BRAIN FOLLOWING EXPOSURE TO XYLENE, ORTHO-XYLENE, META-XYLENE, AND PARA-XYLENE, AND ETHYLBENZENE
ANDERSSON K; FUXE K; NILSEN OG; TOFTGARD R; ENEROTH P; GUSTAFSSON JA
Journal article: ACTA PHARMACOLOGICA ET TOXICOLOGICA. 1981;48(5):369-376
REGIO-SELECTIVITY OF PURIFIED FORMS OF RABBIT LIVER MICROSOMAL CYTOCHROME-P-450 IN THE METABOLISM OF BENZO(A)PYRENE, NORMAL-HEXANE AND 7-ETHOXYRESORUFIN
NILSEN OG; TOFTGARD R; ENG L; GUSTAFSSON JA
Journal article: ARCHIVES OF TOXICOLOGY. 1981;47(1):1-11
EFFECTS OF POLYCHLORINATED TERPHENYLS AND PARAFFINS ON RAT-LIVER MICROSOMAL CYTOCHROME-P-450 AND INVITRO METABOLIC-ACTIVITIES
NILSEN OG; TOFTGARD R
Journal article: SCANDINAVIAN JOURNAL OF WORK, ENVIRONMENT & HEALTH. 1981;7(1):31-37
CHANGES IN RAT-LIVER MICROSOMAL CYTOCHROME-P-450 AND ENZYMATIC-ACTIVITIES AFTER THE INHALATION OF N-HEXANE, XYLENE, METHYL ETHYL KETONE AND METHYLCHLOROFORM FOR 4 WEEKS
TOFTGARD R; NILSEN OG; GUSTAFSSON JA
Journal article: PROGRESS IN CLINICAL AND BIOLOGICAL RESEARCH. 1981;75B:191-205
Induction of cytochrome P-450 and metabolic activation of mutagens in the rat ventral prostate.
Gustafsson JA; Söderkvist P; Haaparanta T; Busk L; Pousette A; Glaumann H; Toftgård R; Högberg B
Journal article: TOXICOLOGY LETTERS. 1980;6(6):399-404
EFFECTS OF ACRYLONITRILE ON RAT-LIVER CYTOCHROME-P-450, BENZO(A)PYRENE METABOLISM AND SERUM HORMONE LEVELS
NILSEN OG; TOFTGARD R; ENEROTH P
Journal article: TOXICOLOGY LETTERS. 1980;5(6):393-398
TOLUENE-INDUCED ACTIVATION OF CERTAIN HYPOTHALAMIC AND MEDIAN-EMINENCE CATECHOLAMINE NERVE-TERMINAL SYSTEMS OF THE MALE-RAT AND ITS EFFECTS ON ANTERIOR-PITUITARY HORMONE-SECRETION
ANDERSSON K; FUXE K; TOFTGARD R; NILSEN OG; ENEROTH P; GUSTAFSSON JA
Journal article: ACTA PHARMACOLOGICA ET TOXICOLOGICA. 1980;46(5):353-361
CORRELATION BETWEEN CHANGES IN ENZYMATIC-ACTIVITIES AND INDUCTION OF DIFFERENT FORMS OF RAT-LIVER MICROSOMAL CYTOCHROME-P-450 AFTER PHENOBARBITAL, 3-METHYLCHOLANTHRENE AND 16-ALPHA-CYANOPREGNENOLONE TREATMENT
TOFTGARD R; NILSEN OG; INGELMANSUNDBERG M; GUSTAFSSON JA
Journal article: SCANDINAVIAN JOURNAL OF WORK, ENVIRONMENT & HEALTH. 1980;6(1):1-18
BIOTRANSFORMATION OF ORGANIC-SOLVENTS - A REVIEW
TOFTGARD R; GUSTAFSSON JA
Journal article: DEV TOXICOL ENVIRON SCI. 1980;8:525-528
Changes in rat liver morphology and metabolic activities after exposure to chlorinated paraffins.
Nilsen OG; Toftgård R; Glaumann H
Journal article: ACTA PHARMACOLOGICA ET TOXICOLOGICA. 1978;43(4):299-305
QUALITATIVE ALTERATIONS OF CYTOCHROME-P-450 IN MOUSE-LIVER MICROSOMES AFTER ADMINISTRATION OF ACRYLAMIDE AND METHYLMETHACRYLATE
NILSEN OG; TOFTGARD R; INGELMANSUNDBERG M; GUSTAFSSON JA
Journal article: ANALYTICA CHIMICA ACTA. 1978;99(2):383-385
Fluorimetric determination of lactate with immobilized lactate dehydrogenase
Toftgård R; Anfält T; Granéli A
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All other publications

Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2021;289(5):601-603
The origin of cancer Introduction
Toftgard R
Corrigendum: NATURE COMMUNICATIONS. 2016;7:12936
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth (vol 7, 12321, 2016)
Gerling M; Buller NVJA; Kirn LM; Joost S; Frings O; Englert B; Bergstrom A; Kuiper RV; Blaas L; Wielenga MCB; Almer S; Kuhl AA; Fredlund E; van den Brink GR; Toftgard R
Other: CELL DEATH AND DIFFERENTIATION. 2015;22(6):887
Alberto Gulino MD, PhD (1952-2014) Obituary
Toftgard R; Ruiz i Altaba A
Editorial comment: DEVELOPMENTAL CELL. 2014;31(1):1-2
Think Inside the BOCs: A Mechanism Underlying Medulloblastoma Progression
Lauth M; Toftgard R
Dataset: PDB. 2013
Crystal structure of full-length human Suppressor of fused (SUFU)
Jovine L; Toftgård R
Dataset: PDB. 2013
Crystal structure of full-length human Suppressor of fused (SUFU) mutant lacking a regulatory subdomain (crystal form I)
Jovine L; Toftgård R
Dataset: PDB. 2013
Crystal structure of a human Suppressor of fused (SUFU)-GLI3p complex
Jovine L; Toftgård R
Dataset: PDB. 2013
Crystal structure of full-length human Suppressor of fused (SUFU) mutant lacking a regulatory subdomain (crystal form II)
Jovine L; Toftgård R
Dataset: PDB. 2013
Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex
Jovine L; Toftgård R
Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2013;274(2):102-104
Breast cancer biology and the future of tailored therapies
Bergh J; Hall P; Ostman A; Toftgard R
Letter: ACTA ONCOLOGICA. 2013;52(4):862-U221
Early and persisting response to vismodegib in a patient with bone metastasizing medulloblastoma
Asklund T; Henriksson R; Axelsson J; Bergstrom A; Kasper M; Ogren M; Toftgard R; Riklund KA
Meeting abstract: CANCER RESEARCH. 2013;73:b28
Signaling by PDGF-CC in the maintenance of a protumorigenic breast cancer microenvironment
Roswell P; Haller K; Petersson A; Anderberg C; Li H; Norum J-H; Toftgard R; Eriksson U; Pietras K
Editorial comment: CANCER CELL. 2013;23(1):3-5
Smoothing Out Drug Resistance
Kasper M; Toftgard R
Corrigendum: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(14):5548
Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes (vol 108, pg 4099, 2011)
Kasper M; Jaks V; Are A; Bergstrom A; Schwager A; Svard J; Teglund S; Barker N; Toftgard R
Review: JOURNAL OF CLINICAL INVESTIGATION. 2012;122(2):455-463
Basal cell carcinoma - molecular biology and potential new therapies
Kasper M; Jaks V; Hohl D; Toftgard R
Conference publication: THE FEBS JOURNAL. 2012;279:26
Hedgehog signalling and cancer initiation
Toftgard R; Finta C; Cherry A; Fullgrabe A; Kasper M; Jovine L
Conference publication: EUROPEAN JOURNAL OF CANCER. 2011;47:S99-S100
Mammary Gland Tumour Formation in Conditional Transgenic Mice Expressing GLI1
Norum JH; Kasper M; Jaks V; Toftgard R
Editorial comment: NATURE MEDICINE. 2011;17(6):669
Rune Toftgard
Toftgard R
Review: ADVANCES IN CANCER RESEARCH. 2011;110:1-17
Hedgehog Signaling and Pancreatic Tumor Development
Lauth M; Toftgard R
Conference publication: EJC SUPPLEMENTS. 2010;8(5):87
Hedgehog signalling in skin and pancreatic cancer
Toftgard R
Meeting abstract: EJC SUPPLEMENTS. 2010;8(5):219
Long-term GLI1 expression induces mammary gland tumour formation in nulliparous transgenic mice
Norum JH; Kasper M; Jaks V; Toftgard R
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1422-1428
The hair follicle-a stem cell zoo
Jaks V; Kasper M; Toftgard R
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2010;1805(2):181-208
Hedgehog beyond medulloblastoma and basal cell carcinoma
Teglund S; Toftgard R
Editorial comment: NATURE MEDICINE. 2009;15(9):994-996
Two sides to cilia in cancer
Toftgard R
Review: CARCINOGENESIS. 2009;30(6):903-911
Hedgehog signalling in breast cancer
Kasper M; Jaks V; Fiaschi M; Toftgard R
Conference publication: CANCER RESEARCH. 2009;69
Reciprocal interactions between the p63/Hedgehog pathways regulate bcl-2 expression in keratinocytes
Chari N; Koster M; Roop D; DiGiovanni J; Waters L; Teglund S; Toftgard R; McDonnell T
Conference publication: ACS NATIONAL MEETING BOOK OF ABSTRACTS. 2009;237
GLI transcription factors as pharmacological targets
Toftgard R; Lauth M
Editorial comment: NATURE GENETICS. 2008;40(9):1040-1041
Hedgehog in Wnterland
Roop D; Toftgard R
Other: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2008;128(8):1875-1877
Meeting report of the conference on UV-Radiation-Induced Disease--Roles of UVA and UVB.
Emeny J; Hansson J; Toftgård R; Segerbäck D
Review: INTERNATIONAL REVIEWS OF IMMUNOLOGY. 2008;27(4):205-223
The two-faced NF-κB in the skin
Sur I; Ulvmar M; Toftgard R
Editorial comment: JOURNAL OF HEPATOLOGY. 2007;47(6):860-867
Tumour suppressors in liver carcinogenesis
Dufour J-F; Huber O; Kozma SC; Lu X; Toftgard R
Review: CURRENT OPINION IN INVESTIGATIONAL DRUGS. 2007;8(6):457-461
The Hedgehog pathway as a drug target in cancer therapy
Lauth M; Toftgard R
Review: HUMAN MUTATION. 2006;27(3):215-219
PTCH mutations:: Distribution and analyses
Lindström E; Shimokawa T; Toftgård R; Zaphiropoulos PG
Corrigendum: DEVELOPMENTAL CELL. 2006;10(3):409
Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian hedgehog signaling pathway (vol 10, pg 187, 2006)
Svärd J; Heby-Henricson K; Persson-Lek M; Rozell B; Lauth M; Bergström A; Ericson J; Toftgård R; Teglund S
Published conference paper: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(Suppl 1):11873-11880
Indian hedgehog and β-catenin signaling:: Role in the sebaceous lineage of normal and neoplastic mammalian epidermis
Niemann C; Unden AB; Lyle S; Zouboulis CC; Toftgård R; Watt FM
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2002;119(3):752
Characterisation of the cylindroma tumour suppressor gene
Regamey A; Liu JW; Toftgard R; Unden AB; Itin P; Hohl D; Huber M
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2001;117(3):775
The Elovl3 gene is required for normal development of hair follicles and skin barrier function
Westerberg R; Tvrdik P; Undén B; Månsson JE; Norén L; Asadi A; Toftgård R; Capecchi MR; Jacobsson A
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2000;57(12):1720-1731
Hedgehog signalling in cancer
Toftgård R
Conference publication: AMERICAN JOURNAL OF HUMAN GENETICS. 1999;65(4):A10
The spectrum of germline PATCHED mutations in UK families with naevoid basal cell carcinoma syndrome (Gorlin syndrome).
Rooker SJ; Hardy C; Fullwood P; Toftgard R; Kogerman P; Farndon PA; Richards FM
Conference publication: JOURNAL OF MEDICAL GENETICS. 1999;36:S98
Mutation analysis of the patched promoter region and alternative 5'exons in naevoid basal cell carcinoma syndrome (Gorlin syndrome)
Rooker S; Hardy C; Fullwood P; Toftgard R; Kogerman P; Farndon P; Richards FM
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1998;110(4):624
Strong expression of the human patched and sonic hedgehog genes is a characteristic feature of the inductive phase of human hair follicle development
Undén AB; Sandstedt B; Toftgård R; Ståhle-Bäckdahl M
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1997;108(4):352
The gene for Gorlin's syndrome, human patched, is consistently overexpressed in both hereditary and sporadic basal cell carcinomas
Unden AB; Bruce K; Zaphiropoulos PG; Toftgard R; StahleBackdahl M
Letter: NATURE GENETICS. 1996;14(1):78-81
The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas
Gailani MR; StahleBackdahl M; Leffell DJ; Glynn M; Zaphiropoulos PG; Pressman C; Unden AB; Dean M; Brash DE; Bale AE; Toftgard R
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1996;107(3):206
Evidence for genetic heterogeneity in basal cell carcinoma syndrome and further narrowing of the locus on chromosome 9 q
Unden AB; StahleBackdahl M; Holmberg E; Larsson C; Toftgard R
Conference publication: CYTOGENETIC AND GENOME RESEARCH. 1993;64(2):120
THE ROLE OF TUMOR PROMOTION AND GENE-REGULATION IN CARCINOGENESIS
TOFTGARD R
Book chapter: NITROARENES: ENVIRONMENTAL SCIENCE RESEARCH. 1990;p. 39-59
In Vivo Metabolism and Genotoxic Effects of the Air Pollutant and Marker for Nitro-Pah’s, 2-Nitrofluorene
Möller L; Rafter J; Törnquist S; Eriksson L; Beije B; Toftgård R; Midvedt T; Corrie M; Gustafsson J-Å
Conference publication: EUROPEAN JOURNAL OF CANCER AND CLINICAL ONCOLOGY. 1987;23(11):1736-1737
EARLY CHANGES IN GENE-EXPRESSION INDUCED BY TUMOR PROMOTERS IN MOUSE SKIN KERATINOCYTES
BOHM S; PERESWETOFFMORATH C; BERGHARD A; HYVONEN K; TOFTGARD R
Conference publication: JOURNAL OF CELLULAR BIOCHEMISTRY. 1987;:44
REGULATION OF ORNITHINE DECARBOXYLASE MESSENGER-RNA LEVELS BY TUMOR PROMOTERS IN MOUSE KERATINOCYTES
TOFTGARD R; MORATH C; HYVONEN K
Book chapter: INDIVIDUAL SUSCEPTIBILITY TO GENOTOXIC AGENTS IN THE HUMAN POPULATION: ENVIRONMENTAL SCIENCE RESEARCH. 1984;p. 89-108
On the Possible Significance of TCDD Receptor Based Assays in Attempts to Estimate Environmental Health Hazards
Gustafsson JÅ; Carlstedt-Duke J; Gillner M; Hansson L-A; Högberg B; Lund J; Löfroth G; Poellinger L; Toftgård R
Conference publication: MUTATION RESEARCH - ENVIRONMENTAL MUTAGENESIS AND RELATED SUBJECTS INCLUDING METHODOLOGY. 1982;97(3):208
NITROARENES - MUTAGENICITY IN THE AMES SALMONELLA MICROSOME ASSAY AND AFFINITY TO THE TCDD-RECEPTOR PROTEIN
NILSSON L; LOFROTH G; TOFTGARD R; GREIBROKK T
Book chapter: CHLORINATED DIOXINS & RELATED COMPOUNDS. 1982;p. 355-365
THE DETECTION AND FUNCTION OF THE CYTOSOLIC RECEPTOR FOR 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN (TCDD) AND RELATED COCARCINOGENS
Carlstedt-Duker J; Kurl R; Poellinger L; Gillner M; Hansson L-A; Toftgård R; Höberg B; Gustafsson J-Å
Conference publication: PROSTATE. 1982;3(3):319-320
METABOLIC-ACTIVATION OF PROMUTAGENIC SUBSTANCES TO ACTIVE MUTAGENS IN THE RAT VENTRAL PROSTATE
SODERKVIST P; BUSK L; TOFTGARD R; GUSTAFSSON JA
Conference publication: ACTA PHARMACOLOGICA ET TOXICOLOGICA. 1981;49:29
THE EFFECTS OF SUB-ACUTE EXPOSURE TO VARIOUS CONCENTRATIONS OF TOLUENE, XYLENE AND OTHER TYPES OF ORGANIC-SOLVENTS ON DOPAMINE AND NORADRENALINE NERVE-TERMINAL SYSTEMS IN THE RAT-BRAIN AND ON THE SECRETION OF HORMONES FROM THE ANTERIOR-PITUITARY GLAND
ANDERSSON K; FUXE K; TOFTGARD R; ENROTH P; GUSTAFSSON JA
Conference publication: ACTA PHARMACOLOGICA ET TOXICOLOGICA. 1981;49:47
METABOLIC-ACTIVATION OF MUTAGENS AND ENZYMATIC-ACTIVITIES IN THE RAT VENTRAL PROSTATE
SODERKVIST P; BUSK L; TOFTGARD R; GUSTAFSSON JA
Book chapter: INDUSTRIAL AND ENVIRONMENTAL XENOBIOTICS: PROCEEDINGS IN LIFE SCIENCES. 1981;p. 307-317
Induction of Cytochrome P-450 in Rat Liver After Inhalation of Aromatic Organic Solvents
Toftgård R; Nilsen OG
Book chapter: MICROSOMES, DRUG OXIDATIONS AND CHEMICAL CARCINOGENESIS. 1980;p. 1235-1238
THE INFLUENCE OF ORGANIC SOLVENTS ON CYTOCHROME P-450-MEDIATED METABOLISM OF BIPHENYL AND BENZO(A)PYRENE
Nilsen OG; Toftgård R
Conference publication: TOXICOLOGY LETTERS. 1980;:106
CHANGES IN RAT-LIVER MORPHOLOGY AND METABOLIC-ACTIVITIES AFTER EXPOSURE TO CHLORINATED PARAFFINS
NILSEN OG; TOFTGARD R; GLAUMANN H
Book chapter: ABSTRACTS. 1978;p. 139
339 INDUCTION OF DIFFERENT FORMS OF CYTOCHROME P-450 BY INDUSTRIAL CHEMICALS
Toftgård R; Nilsen OG
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Grants

Hedgehog signaling in cancer development and as a target for the development of new cancer drugs.
Swedish Cancer Society
1 January 2016
Hedgehog signaling in cancer development and as a target for the development of new cancer drugs.
Swedish Cancer Society
1 January 2015
Hedgehog signaling in cancer development and as a target for the development of new cancer drugs.
Swedish Cancer Society
1 January 2014
Molecular and biochemical analysis of Hedgehog signaling and characterization of epithelial skin stem cells.
Swedish Research Council
1 January 2013 - 31 December 2016
Characterization of epithelial stem cells marked by Lgr5 or Lgr6 expression and the role of Hedgehog signaling.
Swedish Research Council
1 January 2010 - 31 December 2012

Employments

Professor Emeritus/Emerita, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2025
Professor, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2024

Degrees and Education

Docent, Karolinska Institutet, 1985

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