Rudolf Ladenstein

Publications
CV
Public outreach and news

Articles

Journal article: ISCIENCE. 2021;24(9):102951
Structures of heat shock factor trimers bound to DNA
Feng N; Feng H; Wang S; Punekar AS; Ladenstein R; Wang D-C; Zhang Q; Ding J; Liu W
Journal article: PROTEIN & CELL. 2016;7(12):916-920
MD simulation of high-resolution X-ray structures reveals post-translational modification dependent conformational changes in HSF-DNA interaction
Feng H; Wang S; Guo L; Punekar AS; Ladenstein R; Wang D-C; Liu W
Journal article: FEBS JOURNAL. 2013;280(11):2537-2563
The lumazine synthase/riboflavin synthase complex: shapes and functions of a highly variable enzyme system
Ladenstein R; Fischer M; Bacher A
Article: FEBS JOURNAL. 2012;279(16):2940-2956
An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity
Wuxiuer Y; Morgunova E; Cols N; Popov A; Karshikoff A; Sylte I; Gonzalez-Duarte R; Ladenstein R; Winberg J-O
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2010;18(10):3518-3534
Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase
Talukdar A; Morgunova E; Duan J; Meining W; Foloppe N; Nilsson L; Bacher A; Illarionov B; Fischer M; Ladenstein R; Cushman M
Journal article: EXTREMOPHILES. 2010;14(2):213-223
Thermodynamic and kinetic stability of a large multi-domain enzyme from the hyperthermophile Aeropyrum pernix
Karlstrom M; Chiaraluce R; Giangiacomo L; Steen IH; Birkeland N-K; Ladenstein R; Consalvi V
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2009;65(Pt 10):1081-1088
Structural insights into the adaptation of proliferating cell nuclear antigen (PCNA) from Haloferax volcanii to a high-salt environment
Morgunova E; Gray FC; MacNeill SA; Ladenstein R
Article: EMBO JOURNAL. 2009;28(16):2479-2489
Structure and function of a novel endonuclease acting on branched DNA substrates
Ren B; Kuehn J; Meslet-Cladiere L; Briffotaux J; Norais C; Lavigne R; Flament D; Ladenstein R; Myllykallio H
Article: NUCLEIC ACIDS RESEARCH. 2008;36(10):3235-3243
Structural analysis of the Sulfolobus solfataricus MCM protein N-terminal domain
Liu W; Pucci B; Rossi M; Pisani FM; Ladenstein R
Article: JOURNAL OF ORGANIC CHEMISTRY. 2008;73(7):2715-2724
N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase:: Design, synthesis, biochemical evaluation, crystallography, and mechanistic implications
Zhang Y; Illarionov B; Morgunova E; Jin G; Bacher A; Fischer M; Ladenstein R; Cushman M
Article: JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2007;12(8):1163-1171
Ultrahigh-resolution study on Pyrococcus abyssi rubredoxin:: II.: Introduction of an O-H•••Sγ-Fe hydrogen bond increased the reduction potential by 65 mV
Boenisch H; Schmidt CL; Bianco P; Ladenstein R
Article: BIOCHEMISTRY. 2007;46(29):8537-8549
Dynamic arrangement of ion pairs and individual contributions to the thermal stability of the cofactor-binding domain of glutamate dehydrogenase from Thermotoga maritima
Danciulescu C; Ladenstein R; Nilsson L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(23):17231-17241
Lumazine synthase from Candida albicans as an anti-fungal target enzyme -: Structural and biochemical basis for drug design
Morgunova E; Saller S; Haase I; Cushman M; Bacher A; Fischer M; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2007;369(2):474-488
Crystal structure of the archaeal heat shock regulator from Pyrococcus furiosus:: A molecular chimera representing eukaryal and bacterial features
Liu W; Vierke G; Wenke A-K; Thomm M; Ladenstein R
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2007;63(Pt 5):406-408
Crystallization and preliminary X-ray analysis of a RecB-family nuclease from the archaeon Pyrococcus abyssi
Ren B; Kuhn J; Meslet-Cladiere L; Myllykallio H; Ladenstein R
Article: EXTREMOPHILES. 2007;11(3):481-493
Thermal stability of isocitrate dehydrogenase from Archaeoglobus fulgidus studied by crystal structure analysis and engineering of chimers
Stokke R; Karlstrom M; Yang N; Leiros I; Ladenstein R; Kare Birkeland N; Steen IH
Article: EXTREMOPHILES. 2007;11(1):105-114
The phosphofructokinase-B (MJ0406) from Methanocaldococcus jannaschii represents a nucleoside kinase with a broad substrate specificity
Hansen T; Arnfors L; Ladenstein R; Schoenheit P
Article: FEBS JOURNAL. 2006;273(20):4790-4804
Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis
Morgunova E; Illarionov B; Sambaiah T; Haase I; Bacher A; Cushman M; Fischer M; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;362(4):753-770
Multiple assembly states of lumazine synthase: A model relating catalytic function and molecular assembly
Zhang X; Konarev PV; Petoukhov MV; Svergun DI; Xing L; Cheng RH; Haase I; Fischer M; Bacher A; Ladenstein R; Meining W
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2006;62(Pt 9):1085-1097
Structure of Methanocaldococcus jannaschii nucleoside kinase:: an archaeal member of the ribokinase family
Arnfors L; Hansen T; Schoenheit P; Ladenstein R; Meining W
Show more

All other publications

Preprint: SSRN ELECTRONIC JOURNAL. 2021
Structures of Heat Shock Factor Trimers Bound to DNA Reveal the Panoramic Architecture of the HSF-Regulated Transcriptional Machinery
Feng N; Feng H; Wang S; Punekar AS; Ladenstein R; Wang D-C; Zhang Q; Ding J; Liu W
Review: BIOTECHNOLOGY REPORTS. 2020;27:e00494
Second career of a biosynthetic enzyme: Lumazine synthase as a virus-like nanoparticle in vaccine development.
Ladenstein R; Morgunova E
Review: FEBS JOURNAL. 2015;282(20):3899-3917
Rigidity versus flexibility: the dilemma of understanding protein thermal stability
Karshikoff A; Nilsson L; Ladenstein R
Conference publication: FEBS JOURNAL. 2010;277:265
Kinetic characterization of the Drosophila lebanonensis ADH T114V mutant
Wuxiuer Y; Cols N; Gonzalez-Duarte R; Ladenstein R; Sylte I; Winberg J-O
Review: BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT. 2009;23(2):1153-1161
METAMORPHOSIS OF AN ENZYME
Ladenstein R; Meining W; Zhang X; Fischer M; Bacher A
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2008;65(24):3918-3935
Structure-function relationships in short-chain alcohol dehydrogenases
Ladenstein R; Winberg J-O; Benach J
Letter: JOURNAL OF APPLIED CRYSTALLOGRAPHY. 2008;41:659
Of crystals, structure factors and diffraction images
Jovine L; Morgunova E; Ladenstein R
Published conference paper: BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT. 2008;22(1):612-619
Heat capacity, configurational entropy, and the role of ionic interactions in protein thermostability
Ladenstein R
Review: EXTREMOPHILES. 2008;12(1):29-38
Reconsideration of an early dogma, saying "there is no evidence for disulfide bonds in proteins from archaea"
Ladenstein R; Ren B
Review: FEBS JOURNAL. 2006;273(18):4170-4185
Protein disulfides and protein disulfide oxidoreductases in hyperthermophiles
Ladenstein R; Ren B
Conference publication: ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2002;58:C107
ON THE ENZYMATIC MECHANISM OF LUMAZINE SYNTHASE
Meining W; Zhang X; Fischer M; Bacher A; Ladenstein R
Review: TRENDS IN BIOCHEMICAL SCIENCES. 2001;26(9):550-556
Ion pairs and the thermotolerance of proteins from hyperthermophiles: a 'traffic rule' for hot roads
Karshikoff A; Ladenstein R
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;130(1-3):405-415
Genesis of Drosophila ADH:: the shaping of the enzymatic activity from a SDR ancestor
Benach J; Atrian S; Ladenstein R; Gonzàlez-Duarte R
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2001;334:74-88
Protein disulfide oxidoreductase from Pyrococcus furiosus:: Structural properties
Ren B; Ladenstein R
Conference publication: ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 1999;55:289
THE REACTION AND INHIBITION MECHANISM OF DROSOPHILA ADH BY X-RAY CRYSTALLOGRAPHY. NAD-KETONE ADDUCT AT 1.4Å.
Benach J; Ladenstein R; Atrian S; Gonzalez-Duarte R
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 1996;24(1):89-94
Biosynthesis of riboflavin: Structure and mechanism of lumazine synthase
Bacher A; Fischer M; Kis K; Kugelbrey K; Mortl S; Scheuring J; Weinkauf S; Eberhardt S; SchmidtBase K; Huber R; Ritsert K; Cushman M; Ladenstein R
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 1996;24(1):34S
Structural investigation on recombinant riboflavin synthase from E-coli
Tibbelin G; Eberhardt S; Richter G; Bacher A; Ladenstein R
Other: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 1995;51(Pt 5):824-826
CRYSTALLIZATION AND PRELIMINARY-X-RAY DIFFRACTION ANALYSIS OF GLUTATHIONE-PEROXIDASE FROM HUMAN PLASMA
REN B; HUANG WH; AKESSON B; LADENSTEIN R
Other: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 1995;51(Pt 3):395-398
PRELIMINARY CRYSTALLOGRAPHIC ANALYSIS OF AN EXTREMELY THERMOSTABLE GLUTAMATE-DEHYDROGENASE FROM THE ARCHAEON PYROCOCCUS-WOESEI
KNAPP S; KARSHIKOFF A; WALDKOTER K; RUDIGER A; ANTRANIKIAN G; LADENSTEIN R
Other: JOURNAL OF MOLECULAR BIOLOGY. 1995;247(5):840-846
DNA-BINDING SURFACE OF THE SSO7D PROTEIN FROM SULFOLOBUS-SOLFATARICUS
BAUMANN H; KNAPP S; KARSHIKOFF A; LADENSTEIN R; HARD T
Show more

Employments

Professor Emeritus, Department of Medicine, Huddinge, Karolinska Institutet, 2025-2027
Professor, Department of Biosciences and Nutrition, Karolinska Institutet, 1994-2010

Articles

All other publications

Employments

News from KI

Events from KI