Rudolf Ladenstein

Publications
CV
Public outreach and news

Articles

Journal article: ISCIENCE. 2021;24(9):102951
Structures of heat shock factor trimers bound to DNA
Feng N; Feng H; Wang S; Punekar AS; Ladenstein R; Wang D-C; Zhang Q; Ding J; Liu W
Journal article: PROTEIN & CELL. 2016;7(12):916-920
MD simulation of high-resolution X-ray structures reveals post-translational modification dependent conformational changes in HSF-DNA interaction
Feng H; Wang S; Guo L; Punekar AS; Ladenstein R; Wang D-C; Liu W
Journal article: FEBS JOURNAL. 2013;280(11):2537-2563
The lumazine synthase/riboflavin synthase complex: shapes and functions of a highly variable enzyme system
Ladenstein R; Fischer M; Bacher A
Article: FEBS JOURNAL. 2012;279(16):2940-2956
An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity
Wuxiuer Y; Morgunova E; Cols N; Popov A; Karshikoff A; Sylte I; Gonzalez-Duarte R; Ladenstein R; Winberg J-O
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2010;18(10):3518-3534
Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase
Talukdar A; Morgunova E; Duan J; Meining W; Foloppe N; Nilsson L; Bacher A; Illarionov B; Fischer M; Ladenstein R; Cushman M
Journal article: EXTREMOPHILES. 2010;14(2):213-223
Thermodynamic and kinetic stability of a large multi-domain enzyme from the hyperthermophile Aeropyrum pernix
Karlstrom M; Chiaraluce R; Giangiacomo L; Steen IH; Birkeland N-K; Ladenstein R; Consalvi V
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2009;65(Pt 10):1081-1088
Structural insights into the adaptation of proliferating cell nuclear antigen (PCNA) from Haloferax volcanii to a high-salt environment
Morgunova E; Gray FC; MacNeill SA; Ladenstein R
Article: EMBO JOURNAL. 2009;28(16):2479-2489
Structure and function of a novel endonuclease acting on branched DNA substrates
Ren B; Kuehn J; Meslet-Cladiere L; Briffotaux J; Norais C; Lavigne R; Flament D; Ladenstein R; Myllykallio H
Article: NUCLEIC ACIDS RESEARCH. 2008;36(10):3235-3243
Structural analysis of the Sulfolobus solfataricus MCM protein N-terminal domain
Liu W; Pucci B; Rossi M; Pisani FM; Ladenstein R
Article: JOURNAL OF ORGANIC CHEMISTRY. 2008;73(7):2715-2724
N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase:: Design, synthesis, biochemical evaluation, crystallography, and mechanistic implications
Zhang Y; Illarionov B; Morgunova E; Jin G; Bacher A; Fischer M; Ladenstein R; Cushman M
Article: JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2007;12(8):1163-1171
Ultrahigh-resolution study on Pyrococcus abyssi rubredoxin:: II.: Introduction of an O-H•••Sγ-Fe hydrogen bond increased the reduction potential by 65 mV
Boenisch H; Schmidt CL; Bianco P; Ladenstein R
Article: BIOCHEMISTRY. 2007;46(29):8537-8549
Dynamic arrangement of ion pairs and individual contributions to the thermal stability of the cofactor-binding domain of glutamate dehydrogenase from Thermotoga maritima
Danciulescu C; Ladenstein R; Nilsson L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(23):17231-17241
Lumazine synthase from Candida albicans as an anti-fungal target enzyme -: Structural and biochemical basis for drug design
Morgunova E; Saller S; Haase I; Cushman M; Bacher A; Fischer M; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2007;369(2):474-488
Crystal structure of the archaeal heat shock regulator from Pyrococcus furiosus:: A molecular chimera representing eukaryal and bacterial features
Liu W; Vierke G; Wenke A-K; Thomm M; Ladenstein R
Article: EXTREMOPHILES. 2007;11(3):481-493
Thermal stability of isocitrate dehydrogenase from Archaeoglobus fulgidus studied by crystal structure analysis and engineering of chimers
Stokke R; Karlstrom M; Yang N; Leiros I; Ladenstein R; Kare Birkeland N; Steen IH
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2007;63(Pt 5):406-408
Crystallization and preliminary X-ray analysis of a RecB-family nuclease from the archaeon Pyrococcus abyssi
Ren B; Kuhn J; Meslet-Cladiere L; Myllykallio H; Ladenstein R
Article: EXTREMOPHILES. 2007;11(1):105-114
The phosphofructokinase-B (MJ0406) from Methanocaldococcus jannaschii represents a nucleoside kinase with a broad substrate specificity
Hansen T; Arnfors L; Ladenstein R; Schoenheit P
Article: FEBS JOURNAL. 2006;273(20):4790-4804
Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis
Morgunova E; Illarionov B; Sambaiah T; Haase I; Bacher A; Cushman M; Fischer M; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;362(4):753-770
Multiple assembly states of lumazine synthase: A model relating catalytic function and molecular assembly
Zhang X; Konarev PV; Petoukhov MV; Svergun DI; Xing L; Cheng RH; Haase I; Fischer M; Bacher A; Ladenstein R; Meining W
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2006;62(Pt 9):1085-1097
Structure of Methanocaldococcus jannaschii nucleoside kinase:: an archaeal member of the ribokinase family
Arnfors L; Hansen T; Schoenheit P; Ladenstein R; Meining W
Journal article: MICROSCOPY AND MICROANALYSIS. 2006;12(S02):382-383
The Icosahedral 180 Subunit Capsid of the Aquifex aeolicus Luzmazine Synthase IDEA Mutant Does Not Follow the Quasi-equivalence
Xing L; Nilsson J; Zhang X; Fischer M; Bacher A; Meining W; Ladenstein R; Cheng H
Article: FEBS JOURNAL. 2006;273(13):2851-2868
The crystal structure of a hyperthermostable subfamily II isocitrate dehydrogenase from Thermotoga maritima
Karlstrom M; Steen IH; Madern D; Fedoy A-E; Birkeland N-K; Ladenstein R
Article: JOURNAL OF ORGANIC CHEMISTRY. 2005;70(20):8162-8170
Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7-dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase
Cushman M; Jin GY; Illarionov B; Fischer M; Ladenstein R; Bacher A
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2005;61(Pt 7):990-1004
Ultrahigh-resolution study on Pyrococcus abyssi rubredoxin.: I.: 0.69 Å X-ray structure of mutant W4L/R5S
Bönisch H; Schmidt CL; Bianco P; Ladenstein R
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2005;61(Pt 6):591-594
Expression, purification, crystallization and preliminary X-ray analysis of a nucleoside kinase from the hyperthermophile Methanocaldococcus jannaschii
Arnfors L; Hansen T; Meining W; Schönheit P; Ladenstein R
Article: BIOCHEMISTRY. 2005;44(8):2746-2758
Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: Binding mode of a new class of purinetrione inhibitors
Morgunova E; Meining W; Illarionov B; Haase I; Jin GY; Bacher A; Cushman M; Fischer M; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2005;345(3):579-598
Drosophila alcohol dehydrogenase: Acetate-enzyme interactions and novel insights into the effects of electrostatics on catalysis
Benach J; Winberg JO; Svendsen JS; Atrian S; Gonzàlez-Duarte R; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2005;345(3):559-577
Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability
Karlström M; Stokke R; Steen IH; Birkeland NK; Ladenstein R
Article: FEBS JOURNAL. 2004;271(16):3437-3448
Functional properties of the protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus - A member of a novel protein family related to protein disulfide-isomerase
Pedone E; Ren B; Ladenstein R; Rossi M; Bartolucci S
Article: BIOCHEMICAL JOURNAL. 2004;381(Pt 2):489-494
Human hereditary glutathione synthetase deficiency:: kinetic properties of mutant enzymes
Njålsson R; Carlsson K; Bhansali V; Luo JL; Nilsson L; Ladenstein R; Anderson M; Larsson A; Norgren S
Article: JOURNAL OF MOLECULAR BIOLOGY. 2004;335(1):343-356
The 2.9 Å resolution crystal structure of malate dehydrogenase from Archaeoglobus fulgidus:: Mechanisms of oligomerisation and thermal stabilisation
Irimia A; Vellieux FMD; Madern D; Zaccaï G; Karshikoff A; Tibbelin G; Ladenstein R; Lien T; Birkeland NK
Article: JOURNAL OF MOLECULAR BIOLOGY. 2003;331(5):1053-1063
The structure of the N-terminal domain of riboflavin synthase in complex with riboflavin at 2.6 A resolution
Meining W; Eberhardt S; Bacher A; Ladenstein R
Article: CHEMBIOCHEM. 2003;4(8):734-741
Protein stabilisation by compatible solutes: Effect of mannosylglycerate on unfolding thermodynamics and activity of ribonuclease A
Faria TQ; Knapp S; Ladenstein R; Maçanita AL; Santos H
Article: JOURNAL OF MOLECULAR BIOLOGY. 2003;329(3):467-477
The multi-layered structure of Dps with a novel di-nuclear ferroxidase center
Ren B; Tibbelin G; Kajino T; Asami O; Ladenstein R
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2003;51(2):289-298
The catalytic mechanism of Drosophila alcohol dehydrogenase:: Evidence for a proton relay modulated by the coupled ionization of the active site lysine/tyrosine pair and a NAD⁺ ribose OH switch
Koumanov A; Benach J; Atrian S; Gonzàlez-Duarte R; Karshikoff A; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2003;328(1):167-182
A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus
Zhang XF; Meining W; Cushman M; Haase I; Fischer M; Bacher A; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2003;326(3):783-793
Enzyme catalysis via control of activation entropy:: Site-directed mutagenesis of 6,7-dimethyl-8-ribityl-lumazine synthase
Fischer M; Haase I; Kis K; Meining W; Ladenstein R; Cushman M; Schramek N; Huber R; Bacher A
Article: BIOCHEMISTRY. 2002;41(52):15524-15535
Structural and thermodynamic studies on a salt-bridge triad in the NADP-binding domain of glutamate dehydrogenase from Thermotoga maritima: Cooperativity and electrostatic contribution to stability
Lebbink JHG; Consalvi V; Chiaraluce R; Berndt KD; Ladenstein R
Article: BIOCHEMISTRY. 2002;41(50):14659-14668
Structure of bacterial 3β/17β-hydroxysteroid dehydrogenase at 1.2 Å resolution: A model for multiple steroid recognition
Benach J; Filling C; Oppermann UCT; Roversi P; Bricogne G; Berndt KD; Jörnvall H; Ladenstein R
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2002;58(Pt 12):2162-2164
Crystallization and preliminary X-ray structure analysis of isocitrate dehydrogenase from two hyperthermophiles, Aeropyrum pernix and Thermotoga maritima
Karlström M; Steen IH; Tibbelin G; Lien T; Birkeland NK; Ladenstein R
Article: FEBS LETTERS. 2002;530(1-3):79-84
Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain protein with oxidizing activity
Jiménez A; Johansson C; Ljung J; Sagemark J; Berndt KD; Ren B; Tibbelin G; Ladenstein R; Kieselbach T; Holmgren A; Gustafsson J; Miranda-Vizuete A
Article: JOURNAL OF MOLECULAR BIOLOGY. 2002;321(2):341-353
Formation of metal nanoclusters on specific surface sites of protein molecules
Braun N; Meining W; Hars U; Fischer M; Ladenstein R; Huber R; Bacher A; Weinkauf S; Bachmann L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(28):25677-25684
Critical residues for structure and catalysis in short-chain dehydrogenases/reductases
Filling C; Berndt KD; Benach J; Knapp S; Prozorovski T; Nordling E; Ladenstein R; Jörnvall H; Oppermann U
Article: JOURNAL OF MOLECULAR BIOLOGY. 2002;319(3):791-805
The structure of the soluble domain of an archaeal Rieske iron-sulfur protein at 1.1 Å resolution
Bönisch H; Schmidt CL; Schäfer G; Ladenstein R
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2001;289(3):712-717
Structural role of conserved Asn179 in the short-chain dehydrogenase/reductase scaffold
Filling C; Nordling E; Benach J; Berndt KD; Ladenstein R; Jörnvall H; Oppermann U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(47):43924-43931
Comparison of isocitrate dehydrogenase from three hyperthermophiles reveals differences in thermostability, cofactor specificity, oligomeric state, and phylogenetic affiliation
Steen IH; Madern D; Karlström M; Lien T; Ladenstein R; Birkeland NK
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(40):37215-37222
DNA topoisomerase VI generates ATP-dependent double-strand breaks with two-nucleotide overhangs
Buhler C; Lebbink JHG; Bocs C; Ladenstein R; Forterre P
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2001;57(Pt 9):1296-1299
Crystallization and preliminary crystallographic analysis of the recombinant N-terminal domain of riboflavin synthase
Meining W; Eberhardt S; Bacher A; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2001;306(5):1099-1114
X-ray structure analysis and crystallographic refinement of lumazine synthase from the hyperthermophile Aquifex aeolicus at 1.6 Å resolution: Determinants of thermostability revealed from structural comparisons
Zhang XF; Meining W; Fischer M; Bacher A; Ladenstein R
Article: INTERNATIONAL DAIRY JOURNAL. 2001;11(1-2):71-81
The effect of storage and heat treatment on glutathione peroxidase in bovine milk and whey
Lindmark-Månsson H; Chen J; Paulsson M; Aldén G; Ren B; Ladenstein R; Åkesson B
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2000;56(Pt 11):1470-1472
Crystallization and preliminary X-ray crystallographic studies of the thermoactive pullulanase type I, hydrolyzing α-1,6 glycosidic linkages, from Fervidobacterium pennivorans Ven5
Lebbink JHG; Bertoldo C; Tibbelin G; Andersen JT; Duffner F; Antranikian G; Ladenstein R
Article: PROTEIN ENGINEERING DESIGN & SELECTION. 2000;13(7):501-507
Thermal unfolding and conformational stability of the recombinant domain II of glutamate dehydrogenase from the hyperthermophile Thermotoga maritima
Consalvi V; Chiaraluce R; Giangiacomo L; Scandurra R; Christova P; Karshikoff A; Knapp S; Ladenstein R
Article: FEBS JOURNAL. 2000;267(12):3613-3622
Structure-function relationships in Drosophila melanogaster alcohol dehydrogenase allozymes ADH^S, ADH^F and ADH^UF, and distantly related forms
Benach J; Atrian S; Fibla J; Gonzàlez-Duarte R; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2000;299(1):181-197
The atomic structure of pentameric lumazine synthase from Saccharomyces cerevisiae at 1.85 Å resolution reveals the binding mode of a phosphonate intermediate analogue
Meining W; Mörtl S; Fischer M; Cushman M; Bacher A; Ladenstein R
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2000;56(Pt 5):643-644
Crystallization and preliminary crystallographic analysis of Rieske iron-sulfur protein II (soxF) from Sulfolobus acidocaldarius
Bönisch H; Schmidt CL; Schäfer G; Ladenstein R
Article: EXTREMOPHILES. 1999;3(3):191-198
Extrinsic protein stabilization by the naturally occurring osmolytes β-hydroxyectoine and betaine
Knapp S; Ladenstein R; Galinski EA
Article: JOURNAL OF MOLECULAR BIOLOGY. 1999;289(2):357-369
Engineering activity and stability of Thermotoga maritima glutamate dehydrogenase.: II:: Construction of a 16-residue ion-pair network at the subunit interface
Lebbink JHG; Knapp S; van der Oost J; Rice D; Ladenstein R; de Vos WM
Article: JOURNAL OF MOLECULAR BIOLOGY. 1999;289(2):335-355
The catalytic reaction and inhibition mechanism of Drosophila alcohol dehydrogenase:: Observation of an enzyme-bound NAD-ketone adduct at 1.4 Å resolution by X-ray crystallography
Benach J; Atrian S; González-Duarte R; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 1999;285(2):689-702
Refined crystal structure of a superoxide dismutase from the hyperthermophilic archaeon Sulfolobus acidocaldarius at 2.2 Å resolution
Knapp S; Kardinahl S; Hellgren N; Tibbelin G; Schäfer G; Ladenstein R
Article: PROTEIN ENGINEERING DESIGN & SELECTION. 1998;11(10):867-872
Proteins from thermophilic and mesophilic organisms essentially do not differ in packing
Karshikoff A; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 1998;282(2):383-399
The refined crystal structure of Drosophila lebanonensis alcohol dehydrogenase at 1.9 Å resolution
Benach J; Atrian S; Gonzàlez-Duarte R; Ladenstein R
Article: JOURNAL OF STRUCTURAL BIOLOGY. 1998;123(1):30-36
Two-dimensional crystallization of the chaperonin TF55 from the hyperthermophilic archaeon Sulfolobus solfataricus
Ellis MJ; Knapp S; Koeck PJB; Fakoor-Biniaz Z; Ladenstein R; Hebert H
Article: FEBS LETTERS. 1998;432(3):141-144
Isolation and structure of repressor-like proteins from the archaeon Sulfolobus solfataricus -: Co-purification of RNase A with Sso7c
Oppermann UCT; Knapp S; Bonetto V; Ladenstein R; Jörnvall H
Article: JOURNAL OF MOLECULAR BIOLOGY. 1998;280(2):287-296
Engineering activity and stability of Thermotoga maritima glutamate dehydrogenase.: I.: Introduction of a six-residue ion-pair network in the hinge region
Lebbink JHG; Knapp S; van der Oost J; Rice D; Ladenstein R; de Vos WM
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 1998;5(7):602-611
A protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus contains two thioredoxin fold units
Ren B; Tibbelin G; de Pascale D; Rossi M; Bartolucci S; Ladenstein R
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 1998;5(7):579-584
Architecture of nonspecific protein-DNA interactions in the Sso7d-DNA complex
Agback P; Baumann H; Knapp S; Ladenstein R; Härd T
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 1998;31(3):309-319
Thermal unfolding of small proteins with SH3 domain folding pattern
Knapp S; Mattson PT; Christova P; Berndt KD; Karshikoff A; Vihinen M; Smith CIE; Ladenstein R
Article: NUCLEIC ACIDS RESEARCH. 1998;26(10):2322-2328
In vitro DNA binding of the archaeal protein Sso7d induces negative supercoiling at temperatures typical for thermophilic growth
López-García P; Knapp S; Ladenstein R; Forterre P
Article: JOURNAL OF MOLECULAR BIOLOGY. 1998;276(4):775-786
Thermodynamic characterization of non-sequence-specific DNA-binding by the Sso7d protein from Sulfolobus solfataricus
Lundbäck T; Hansson H; Knapp S; Ladenstein R; Härd T
Article: JOURNAL OF STRUCTURAL BIOLOGY. 1998;121(1):53-60
Evidence for local 32 symmetry in homotrimeric riboflavin synthase of Escherichia coli
Meining W; Tibbelin G; Ladenstein R; Eberhardt S; Fischer M; Bacher A
Journal article: APTAMERS IN BIOTECHNOLOGY. 1998;61:37-85
Proteins from hyperthermophiles: stability and enzymatic catalysis close to the boiling point of water.
Ladenstein R; Antranikian G
Article: FEBS LETTERS. 1997;413(2):191-193
Drosophila alcohol dehydrogenase: evaluation of Ser(139) site-directed mutants
Cols N; Atrian S; Benach J; Ladenstein R; GonzalezDuarte R
Article: JOURNAL OF STRUCTURAL BIOLOGY. 1997;119(1):1-5
Crystallization and preliminary X-ray structure analysis of a hyperthermostable thioltransferase from the archaeon Pyrococcus furiosus
Ren B; Tibbelin G; dePascale D; Rossi M; Bartolucci S; Ladenstein R
Article: PROTEIN SCIENCE. 1997;6(6):1190-1196
Optimization of the electrostatic interactions between ionized groups and peptide dipoles in proteins
Spassov VZ; Ladenstein R; Karshikoff AD
Article: JOURNAL OF MOLECULAR BIOLOGY. 1997;268(5):869-885
The crystal structure of seleno-glutathione peroxidase from human plasma at 2.9 angstrom resolution
Ren B; Huang WH; Akesson B; Ladenstein R
Article: JOURNAL OF MOLECULAR BIOLOGY. 1997;267(4):916-932
Crystal structure of glutamate dehydrogenase from the hyperthermophilic eubacterium Thermotoga maritima at 3.0 angstrom resolution
Knapp S; deVos WM; Rice D; Ladenstein R
Article: BIOCHEMISTRY. 1997;36(1):34-40
Active site directed mutagenesis of 3 beta/17 beta-hydroxysteroid dehydrogenase establishes differential effects on short-chain dehydrogenase/reductase reactions
Oppermann UCT; Filling C; Berndt KD; Persson B; Benach J; Ladenstein R; Jornvall H
Article: JOURNAL OF MOLECULAR BIOLOGY. 1996;264(5):1132-1144
Thermal unfolding of the DNA-binding protein Sso7d from the hyperthermophile Sulfolobus solfataricus
Knapp S; Karshikoff A; Berndt KD; Christova P; Atanasov B; Ladenstein R
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 1996;52(Pt 3):447-452
Locating a local symmetry axis from patterson map cross vectors: Application to crystal data from GroEL, GTP cyclohydrolase I and the proteosome
Stubbs MT; Nar H; Lowe J; Huber R; Ladenstein R; Spangfort MD; Svensson LA
Article: FEBS JOURNAL. 1996;236(1):144-148
Crystallization and crystal packing of recombinant 3 (or 17) beta-hydroxysteroid dehydrogenase from Comamonas testosteroni ATTC 11996
Benach J; Knapp S; Oppermann UCT; Hagglund O; Jornvall H; Ladenstein R
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 1995;117(51):12883-12884
Flexibility of an arginine side chain at a DNA-protein interface
Berglund H; Baumann H; Knapp S; Ladenstein R; Hard T
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 1995;23(4):595-597
Crystallization and preliminary crystallographic analysis of an amylopullulanase from the hyperthermophilic archaeon Pyrococcus woesei
Knapp S; Rudiger A; Antranikian G; Jorgensen PL; Ladenstein R
Article: PROTEIN SCIENCE. 1995;4(8):1516-1527
THE OPTIMIZATION OF PROTEIN-SOLVENT INTERACTIONS - THERMOSTABILITY AND THE ROLE OF HYDROPHOBIC AND ELECTROSTATIC INTERACTIONS
SPASSOV VZ; KARSHIKOFF AD; LADENSTEIN R
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 1995;51(Pt 1):69-72
WELL-ORDERED CRYSTALS OF A SHORT-CHAIN ALCOHOL-DEHYDROGENASE FROM DROSOPHILA-LEBANONENSIS - RE-EVALAUTION OF THE CRYSTALLOGRAPHIC DATA AND ROTATION FUNCTION-ANALYSIS
LADENSTEIN R; TIBBELIN G; KARSHIKOFF A; ATRIAN S; GONZALEZDUARTE R
Journal article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 1994;1(11):808-819
SOLUTION STRUCTURE AND DNA-BINDING PROPERTIES OF A THERMOSTABLE PROTEIN FROM THE ARCHAEON SULFOLOBUS-SOLFATARICUS
BAUMANN H; KNAPP S; LUNDBACK T; LADENSTEIN R; HARD T
Journal article: JOURNAL OF MOLECULAR BIOLOGY. 1994;242(4):397-407
THE MOLECULAR CHAPERONIN TF55 FROM THE THERMOPHILIC ARCHAEON SULFOLOBUS-SOLFATARICUS - A BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION
KNAPP S; SCHMIDTKREY I; HEBERT H; BERGMAN T; JORNVALL H; LADENSTEIN R
Journal article: PROTEIN SCIENCE. 1994;3(9):1556-1569
OPTIMIZATION OF THE ELECTROSTATIC INTERACTIONS IN PROTEINS OF DIFFERENT FUNCTIONAL AND FOLDING TYPE
SPASSOV VZ; KARSHIKOFF AD; LADENSTEIN R
Journal article: FEBS JOURNAL. 1994;223(3):1007-1017
THE LUMAZINE SYNTHASE RIBOFLAVIN SYNTHASE COMPLEX OF BACILLUS-SUBTILIS - X-RAY STRUCTURE-ANALYSIS OF HOLLOW RECONSTITUTED BETA-SUBUNIT CAPSIDS
LADENSTEIN R; RITSERT K; HUBER R; RICHTER G; BACHER A
Journal article: JOURNAL OF MOLECULAR BIOLOGY. 1994;240(4):372-384
ELECTROSTATIC PROPERTIES OF 2 PORIN CHANNELS FROM ESCHERICHIA-COLI
KARSHIKOFF A; SPASSOV V; COWAN SW; LADENSTEIN R; SCHIRMER T
Journal article: FEBS JOURNAL. 1993;215(3):663-670
ELECTROSTATIC EVIDENCE FOR THE ACTIVATION OF THE GLUTATHIONE THIOL BY TYR7 IN PI-CLASS GLUTATHIONE TRANSFERASES
KARSHIKOFF A; REINEMER P; HUBER R; LADENSTEIN R
Show more

All other publications

Preprint: SSRN ELECTRONIC JOURNAL. 2021
Structures of Heat Shock Factor Trimers Bound to DNA Reveal the Panoramic Architecture of the HSF-Regulated Transcriptional Machinery
Feng N; Feng H; Wang S; Punekar AS; Ladenstein R; Wang D-C; Zhang Q; Ding J; Liu W
Review: BIOTECHNOLOGY REPORTS. 2020;27:e00494
Second career of a biosynthetic enzyme: Lumazine synthase as a virus-like nanoparticle in vaccine development.
Ladenstein R; Morgunova E
Review: FEBS JOURNAL. 2015;282(20):3899-3917
Rigidity versus flexibility: the dilemma of understanding protein thermal stability
Karshikoff A; Nilsson L; Ladenstein R
Conference publication: FEBS JOURNAL. 2010;277:265
Kinetic characterization of the Drosophila lebanonensis ADH T114V mutant
Wuxiuer Y; Cols N; Gonzalez-Duarte R; Ladenstein R; Sylte I; Winberg J-O
Review: BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT. 2009;23(2):1153-1161
METAMORPHOSIS OF AN ENZYME
Ladenstein R; Meining W; Zhang X; Fischer M; Bacher A
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2008;65(24):3918-3935
Structure-function relationships in short-chain alcohol dehydrogenases
Ladenstein R; Winberg J-O; Benach J
Letter: JOURNAL OF APPLIED CRYSTALLOGRAPHY. 2008;41:659
Of crystals, structure factors and diffraction images
Jovine L; Morgunova E; Ladenstein R
Published conference paper: BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT. 2008;22(1):612-619
Heat capacity, configurational entropy, and the role of ionic interactions in protein thermostability
Ladenstein R
Review: EXTREMOPHILES. 2008;12(1):29-38
Reconsideration of an early dogma, saying "there is no evidence for disulfide bonds in proteins from archaea"
Ladenstein R; Ren B
Review: FEBS JOURNAL. 2006;273(18):4170-4185
Protein disulfides and protein disulfide oxidoreductases in hyperthermophiles
Ladenstein R; Ren B
Conference publication: ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2002;58:C107
ON THE ENZYMATIC MECHANISM OF LUMAZINE SYNTHASE
Meining W; Zhang X; Fischer M; Bacher A; Ladenstein R
Review: TRENDS IN BIOCHEMICAL SCIENCES. 2001;26(9):550-556
Ion pairs and the thermotolerance of proteins from hyperthermophiles: a 'traffic rule' for hot roads
Karshikoff A; Ladenstein R
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;130(1-3):405-415
Genesis of Drosophila ADH:: the shaping of the enzymatic activity from a SDR ancestor
Benach J; Atrian S; Ladenstein R; Gonzàlez-Duarte R
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2001;334:74-88
Protein disulfide oxidoreductase from Pyrococcus furiosus:: Structural properties
Ren B; Ladenstein R
Conference publication: ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 1999;55:289
THE REACTION AND INHIBITION MECHANISM OF DROSOPHILA ADH BY X-RAY CRYSTALLOGRAPHY. NAD-KETONE ADDUCT AT 1.4Å.
Benach J; Ladenstein R; Atrian S; Gonzalez-Duarte R
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 1996;24(1):34S
Structural investigation on recombinant riboflavin synthase from E-coli
Tibbelin G; Eberhardt S; Richter G; Bacher A; Ladenstein R
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 1996;24(1):89-94
Biosynthesis of riboflavin: Structure and mechanism of lumazine synthase
Bacher A; Fischer M; Kis K; Kugelbrey K; Mortl S; Scheuring J; Weinkauf S; Eberhardt S; SchmidtBase K; Huber R; Ritsert K; Cushman M; Ladenstein R
Other: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 1995;51(Pt 5):824-826
CRYSTALLIZATION AND PRELIMINARY-X-RAY DIFFRACTION ANALYSIS OF GLUTATHIONE-PEROXIDASE FROM HUMAN PLASMA
REN B; HUANG WH; AKESSON B; LADENSTEIN R
Other: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 1995;51(Pt 3):395-398
PRELIMINARY CRYSTALLOGRAPHIC ANALYSIS OF AN EXTREMELY THERMOSTABLE GLUTAMATE-DEHYDROGENASE FROM THE ARCHAEON PYROCOCCUS-WOESEI
KNAPP S; KARSHIKOFF A; WALDKOTER K; RUDIGER A; ANTRANIKIAN G; LADENSTEIN R
Other: JOURNAL OF MOLECULAR BIOLOGY. 1995;247(5):840-846
DNA-BINDING SURFACE OF THE SSO7D PROTEIN FROM SULFOLOBUS-SOLFATARICUS
BAUMANN H; KNAPP S; KARSHIKOFF A; LADENSTEIN R; HARD T
Book chapter: BIOORGANIC CHEMISTRY FRONTIERS: BIOORGANIC CHEMISTRY FRONTIERS. 1993;p. 147-192
Biosynthesis of Flavins
Bacher A; Eisenreich W; Kis K; Ladenstein R; Richter G; Scheuring J; Weinkauf S
Show more

Employments

Professor Emeritus/Emerita, Department of Medicine, Huddinge, Karolinska Institutet, 2025-2026
Professor, Department of Biosciences and Nutrition, Karolinska Institutet, 1994-2010

Articles

All other publications

Employments

News from KI

Events from KI