Selected Publications from the Lars Engstrand Group

Below are selected publications from the Lars Engstrand research group (Centre for Translational Microbiome Research and National Pandemic Centre):

Gudnadottir, U., Kamau, N., Fornes, R., Nguyen, M. H., Callens, S., Fransson, E., Engstrand, L., Bruyndonckx, R., & Brusselaers, N. (n.d.). Antibiotic or gastric acid inhibitor use during pregnancy and postpartum depression: Population-based cohort study. Acta Obstetricia et Gynecologica Scandinavica, n/a(n/a).

Cheng L, Correia MSP, Higdon SM, Romero Garcia F, Tsiara I, Joffré E, Sjöling Å, Boulund F, Norin EL, Engstrand L, Globisch D, Du J. The protective role of commensal gut microbes and their metabolites against bacterial pathogens. Gut Microbes. 2024 Jan-Dec;16(1):2356275. doi: 10.1080/19490976.2024.2356275. Epub 2024 May 26. PMID: 38797999; PMCID: PMC11135852.

Boven, A., Simin, J., Andersson, F. L., Vlieghe, E., Callens, S., Zeebari, Z., Engstrand, L., & Brusselaers, N. (2024). Clostridioides difficile infection, recurrence and the associated healthcare consumption in Sweden between 2006 and 2019: a population-based cohort study. BMC INFECTIOUS DISEASES, 24(1). 

Mpakaniye, P., Boven, A., Callens, S., Engstrand, L., Vlieghe, E., & Brusselaers, N. (2024). Clostridioides difficile recurrence in individuals with and without cancer: a Swedish population-based cohort study. INFECTION, 52(2), 649–660. 

Mazzone, L., Dooling, S. W., Volpe, E., Uljarevic, M., Waters, J. L., Sabatini, A., Arturi, L., Abate, R., Riccioni, A., Siracusano, M., Pereira, M., Engstrand, L., Cristofori, F., Adduce, D., Francavilla, R., Costa-Mattioli, M., & Hardan, A. Y. (2024). Precision microbial intervention improves social behavior but not autism severity: A pilot double-blind randomized placebo-controlled trial. CELL HOST \& MICROBE, 32(1). 

Ali Kiasat, Stefanie Prast-Nielsen, S. R. L. E. F. A. J. L. I. S.-K. A. L. G., & Gustafsson, U. O. (2024). Plasma bile acids in association with Crohn’s disease. Scandinavian Journal of Gastroenterology, 0(0), 1–9. 

Moreels, N., Boven, A., Gressani, O., Andersson, F. L., Vlieghe, E., Callens, S., Engstrand, L., Simin, J., & Brusselaers, N. (2024). The combined effect of systemic antibiotics and proton pump inhibitors on Clostridioides difficile infection and recurrence. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 

Wu, S., Cheng, L., Pennhag, A. A. L., Seifert, M., Guonadottir, U., Engstrand, L., Mints, M., Andersson, S., & Du, J. (2023). The salivary microbiota is altered in cervical dysplasia patients and influenced by conization. IMETA, 2(3). 

Aguilera, K., Bladh, O., Marking, U., Norin, N. G., Rihani, A., Ujvari, D., Ning, F. C., Klingström, J., Havervall, S., Åberg, M., Blom, K., Alm, J. J., & Thålin, C. (2024). Prevalence of SARS-CoV-2 infections among Swedish healthcare workers on duty in December 2023. The Lancet Regional Health - Europe, 100872. 

Stiernborg, M., Prast-Nielsen, S., Melas, P. A., Skott, M., Millischer, V., Boulund, F., Forsell, Y., & Lavebratt, C. (2024). Differences in the gut microbiome of young adults with schizophrenia spectrum disorder: using machine learning to distinguish cases from controls. Brain, Behavior, and Immunity, 117, 298–309. 

Fransson, E., Hamsten, M., Jonsson, M., West, C., Jenmalm, M., & Engstrand, L. (2023). Restoration of microbiota in newborns (ROMANS) -a randomized placebo-controlled multicenter allergy prevention study. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 102(1), 90. 

Kimmel, M., Tong, B., Devall, A. E., Bjorvang, R., Schuppe-Koistinen, I. I., Engstrand, L., Hugerth, L., Fransson, E., & Skalidou, A. (2023). Components of Mental Distress During Pregnancy in Relation to the Microbiome: Data From US and Swedish Cohorts. NEUROPSYCHOPHARMACOLOGY, 48(1), 341–342.

Liu, Q., Wang, X., Engstrand, L., Sadr-Azodi, O., Fall, K., & Brusselaers, N. (2023). Maintenance proton pump inhibitor usage and risk of colorectal cancer: A population-based Swedish cohort study. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 32(1), 77–78.

Boven, A., Vlieghe, E., Engstrand, L., Andersson, F. L., Callens, S., Simin, J., & Brusselaers, N. (2023). Clostridioides difficile infection-associated cause-specific and all-cause mortality: a population-based cohort study. CLINICAL MICROBIOLOGY AND INFECTION, 29(11), 1424–1430. 

Hwang, I.-C., Vasquez, R., Song, J. H., Engstrand, L., Valeriano, V. D., & Kang, D.-K. (2023). Alterations in the gut microbiome and its metabolites are associated with the immune response to mucosal immunization with Lactiplantibacillus plantarum-displaying recombinant SARS-CoV-2 spike epitopes in mice. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 13. 

Thorpe, H. A., Tourrette, E., Yahara, K., Vale, F. F., Liu, S., Oleastro, M., Alarcon, T., Perets, T.-T., Latifi-Navid, S., Yamaoka, Y., Martinez-Gonzalez, B., Karayiannis, I., Karamitros, T., Sgouras, D. N., Elamin, W., Pascoe, B., Sheppard, S. K., Ronkainen, J., Aro, P., … Falush, D. (2023). Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations (vol 13, 6842, 2022). NATURE COMMUNICATIONS, 14(1).

Grahnemo, L., Nethander, M., Coward, E., Gabrielsen, M. E., Sree, S., Billod, J.-M., Sjogren, K., Engstrand, L., Dekkers, K. F., Fall, T., Langhammer, A., Hveem, K., & Ohlsson, C. (2023). Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study. NATURE COMMUNICATIONS, 14(1).

Ebrahimi, F., Simon, T. G., Hagstrom, H., Sun, J., Bergman, D., Forss, A., Roelstraete, B., Engstrand, L., & Ludvigsson, J. F. (2023). Antibiotic use and development of nonalcoholic fatty liver disease: A population-based case-control study. LIVER INTERNATIONAL.

Kiasat, A., Rautiainen, S., Prast-Nielsen, S., Engstrand, L., Schuppe-Koistinen, I., Gustafsson, U. O. O., & Granstrom, A. L. (2023). Evaluation of plasma Short chain fatty acid levels as markers for Inflammatory bowel disease. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY.

Cheng, L., Liu, T., Liu, Q., Lian, L., Tang, G., Mille, L. S., Garcia, F. R., Engstrand, L., Zhang, Y. S., & Du, J. (2023). A 3D Bioprinted Gut Anaerobic Model for Studying Bacteria-Host Interactions. RESEARCH, 6.

Huch, S., Nersisyan, L., Ropat, M., Barrett, D., Wu, M., Wang, J., Valeriano, V. D., Vardazaryan, N., Huerta-Cepas, J., Wei, W., Du, J., Steinmetz, L. M., Engstrand, L., & Pelechano, V. (2023). Atlas of mRNA translation and decay for bacteria. NATURE MICROBIOLOGY.

Hwang, I.-C., Valeriano, V. D., Song, J. H., Pereira, M., Oh, J. K., Han, K., Engstrand, L., & Kang, D.-K. (2023). Mucosal immunization with lactiplantibacillus plantarum-displaying recombinant SARS-CoV-2 epitopes on the surface induces humoral and mucosal immune responses in mice. MICROBIAL CELL FACTORIES, 22(1).

Lin, W., Garcia, F. R., Norin, E. L., Kart, D., Engstrand, L., Du, J., & Globisch, D. (2023). Sensitive quantification of short-chain fatty acids combined with global metabolomics in microbiome cultures. CHEMICAL COMMUNICATIONS, 59(39), 5843–5846.

Alexandersson, B. T., Hugerth, L. W., Hedin, C., Forsberg, A., Talley, N. J., Agreus, L., Jarbrink-Sehgal, E., Engstrand, L., Andreasson, A., & Schmidt, P. T. (n.d.). Diverticulosis is not associated with altered gut microbiota nor is it predictive of future diverticulitis: a population-based colonoscopy study. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY.

Debelius, J. W., Engstrand, L., Matussek, A., Brusselaers, N., Morton, J. T., Stenmarker, M., & Olsen, R. S. (n.d.). The Local Tumor Microbiome Is Associated with Survival in Late-Stage Colorectal Cancer Patients. MICROBIOLOGY SPECTRUM.

Kallner, A., Debelius, J., Schuppe-Koistinen, I., Pereira, M., & Engstrand, L. (2023). Effects of Consuming Fermented Fish (Surstromming) on the Fecal Microflora in Healthy Individuals. JOURNAL OF MEDICINAL FOOD, 26(3), 185–192.

Gudnadottir, U., Du, J., Hugerth, L. W., Engstrand, L., Schuppe-Koistinen, I., Wiberg Itzel, E., Fransson, E., & Brusselaers, N. (2023). Pre-pregnancy complications - associated factors and wellbeing in early pregnancy: a Swedish cohort study. BMC Pregnancy and Childbirth, 23(1), 153.

Sorini, C., Tripathi, K. P., Wu, S., Higdon, S. M., Wang, J., Cheng, L., Banerjee, S., Reinhardt, A., Kreslavsky, T., Thorell, A., Engstrand, L., Du, J., & Villablanca, E. J. (2023). Metagenomic and single-cell RNA-Seq survey of the Helicobacter pylori-infected stomach in asymptomatic individuals. JCI INSIGHT, 8(4).

Norenhag, J., Edfeldt, G., Du, J., Stalberg, K., Garcia, F., Hugerth, L. W., Engstrand, L., Koistinen, I. S., Fransson, E., & Olovsson, M. (2022). THE VAGINAL MICROBIOTA COMPOSITION IS ASSOCIATED WITH SEVERITY OF CERVICAL DYSPLASIA. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 32(2), A31.

Hases, L., Stepanauskaite, L., Birgersson, M., Brusselaers, N., Schuppe-Koistinen, I., Archer, A., Engstrand, L., & Williams, C. (2023). High-fat diet and estrogen modulate the gut microbiota in a sex-dependent manner in mice. COMMUNICATIONS BIOLOGY, 6(1).

Hiippala, K., Khan, I., Ronkainen, A., Boulund Fredrik and Vaha-Makila, H., Suutarinen, M., Seifert, M., Engstrand, L., & Satokari, R. (2022). Novel strain of Pseudoruminococcus massiliensis possesses traits important in gut adaptation and host-microbe interactions. GUT MICROBES, 14(1).

Fornes, R., Simin, J., Nguyen, M. H., Cruz Gonzalo and Crisosto, N., van der Schaaf, M., & Engstrand Lars and Brusselaers, N. (2022). Pregnancy, perinatal and childhood outcomes in women with and without polycystic ovary syndrome and metformin during pregnancy: a nationwide population-based study. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 20(1).

Nguyen, M. H., Fornes, R., Kamau, N., Danielsson, H., Callens, S., Fransson, E., Engstrand, L., Bruyndonckx, R., & Brusselaers, N. (2022). Antibiotic use during pregnancy and the risk of preterm birth: a population-based Swedish cohort study. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 77(5), 1461–1467.

Krog, M. C., Madsen, M. E., Bliddal, S., Bashir, Z., Vexo, L. E., Hartwell, D., Hugerth, L. W., Fransson, E., Hamsten, M., Boulund, F., Wannerberger, K., Engstrand, L., Schuppe-Koistinen, I., & Nielsen, H. S. (2022). The microbiome in reproductive health: protocol for a systems biology approach using a prospective, observational study design. HUMAN REPRODUCTION OPEN, 2022(2).

Marabita, F., James, T., Karhu, A., Virtanen Heidi and Kettunen, K., Stenlund, H., Boulund, F., Hellstrom, C., Neiman, M., Mills, R., Perheentupa, T., Laivuori, H., Helkkula, P., Byrne, M., Jokinen, I., Honko, H., Kallonen, A., Ermes Miikka and Simila, H., Lindholm, M., Widen, E., … Kallioniemi, O. (2022). Article Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health. CELL SYSTEMS, 13(3), 241+.

Forsberg, A., Westerberg, M., Metcalfe, C., Steele, R., Blom, J., Engstrand, L., Fritzell, K., Hellstrom, M., Levin, L.-A., Lowbeer, C., Pischel, A., Stromberg, U., Tornberg, S., Wengstrom, Y., Ekbom, A., Holmberg, L., Hultcrantz, R., & Investigators, S. (2022). Once-only colonoscopy or two rounds of faecal immunochemical testing 2 years apart for colorectal cancer screening (SCREESCO): preliminary report of a randomised controlled trial. LANCET GASTROENTEROLOGY & HEPATOLOGY, 7(6), 513–521.

Krog, M. C., Hugerth, L. W., Fransson, E., Bashir, Z., Andersen, A. N., Edfeldt, G., Engstrand, L., Schuppe-Koistinen, I., & Nielsen, H. S. (2022). The healthy female microbiome across body sites: effect of hormonal contraceptives and the menstrual cycle. HUMAN REPRODUCTION, 37(7), 1525–1543.

Olsson, L. M., Boulund, F., Nilsson, S., Khan, M. T., Gummesson, A., Fagerberg, L., Engstrand, L., Perkins, R., Uhlen, M., Bergstrom, G., Tremaroli, V., & Backhed, F. (2022). Dynamics of the normal gut microbiota: A longitudinal one-year population study in Sweden. CELL HOST & MICROBE, 30(5), 726+.

Berntson, L., Oman, A., Engstrand, L., & Dicksved, J. (2022). A Pilot Study Investigating Faecal Microbiota After Two Dietary Interventions in Children with Juvenile Idiopathic Arthritis. CURRENT MICROBIOLOGY, 79(7).

Grahnemo, L., Nethander, M., Coward, E., Gabrielsen, M. E., Sree, S., Billod, J.-M., Engstrand, L., Abrahamsson, S., Langhammer, A., & Hveem Kristian and Ohlsson, C. (2022). Cross-sectional associations between the gut microbe Ruminococcus gnavus and features of the metabolic syndrome. LANCET DIABETES & ENDOCRINOLOGY, 10(7), 481–483.

Fransson, E., Gudnadottir, U., Hugerth, L. W., Itzel, E. W., Hamsten, M., Boulund, F., Pennhag, A., Du, J., Schuppe-Koistinen, I., & Brusselaers Nele and Engstrand, L. (2022). Cohort profile: the Swedish Maternal Microbiome project (SweMaMi) - assessing the dynamic associations between the microbiome and maternal and neonatal adverse events. BMJ OPEN, 12(10).

Thorpe, H. A., Tourrette, E., Yahara, K., Vale, F. F., Liu, S., Oleastro, M., Alarcon, T., Perets, T.-T., Latifi-Navid, S., Yamaoka, Y., Martinez-Gonzalez, B., Karayiannis, I., Karamitros, T., Sgouras, D. N., Elamin, W., Pascoe Ben and Sheppard, S. K., Ronkainen, J., Aro, P., Engstrand, L., … Falush, D. (2022). Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations. NATURE COMMUNICATIONS, 13(1).

Brusselaers, N., Pereira, M., Alm, J., Engstrand, L., & Engstrand Lilja, H. (2022). Effect of proton pump inhibitors in infants with esophageal atresia on the gut microbiome: a pilot cohort. GUT PATHOGENS, 14(1).