Georgios Sotiriou Project

Our mission is to develop biomaterials, tools and methods for medicine using engineering sciences. Our key focus is on flame aerosol engineering of smart nanoscale materials and devices investigating the parameters that influence their performance in bioapplications.

Nanoscale Material and Device Engineering for Biomedicine

Our project directs the Bionanomaterial Technology Laboratory in the Department of Microbiology, Tumor and Cell Biology (MTC), located in the BioClinicum Research Building at the Karolinska University Hospital. We are promoting interdisciplinary collaborations and guaranteeing the clinical relevance of the medical challenges that our lab aims to address. The key expertise of our lab lies on flame aerosol engineering of smart nanoscale materials and devices aiming superior performance in biomedical applications. Ever since the setting up of Georgios Sotiriou's lab, we have been discussing with medical doctors and (micro)biologists to identify medical challenges where material and aerosol process engineering may offer innovative solutions. A specific focus of our lab is against infectious diseases, an understudied field in nanomedicine despite the fact that infections are the leading cause of human deaths globally.

The focus of Georgios Sotiriou's research program at KI lies on the development of functional particles, and particle-enabled devices, made by aerosol processes targeting biomedical applications. The three main research pillars of our lab regard the (i) production of responsive nanomaterials for diagnostics in bioimaging and biosensing, (ii) the fabrication of antibacterial medical devices capitalizing on aerosol nanoparticle deposition on surfaces combining particle production and particle film fabrication in a single-step, and (iii) the utilization of flame-made nanoparticles as drug nanocarriers.

Awards

Dr. Georgios Sotiriou is tenured faculty at the Associate Professor level at MTC at Karolinska Institutet. Georgios Sotiriou has been awarded an ERC Starting Grant in 2017 and appointed Future Research Leader from the Swedish Foundation for Strategic Research (SSF) in 2020. Georgios Sotiriou's research was recently highlighted by the magazine “Framtidens Forskning” (in Swedish).

Publications

Luminescent CeO2:Eu3+ nanocrystals for robust in situ H2O2 real-time detection in bacterial cell cultures.
Henning DF, Merkl P, Yun C, Iovino F, Xie L, Mouzourakis E, et al
Biosens Bioelectron 2019 May;132():286-293

Enzyme-Mimetic Antioxidant Luminescent Nanoparticles for Highly Sensitive Hydrogen Peroxide Biosensing.
Pratsinis A, Kelesidis GA, Zuercher S, Krumeich F, Bolisetty S, Mezzenga R, et al
ACS Nano 2017 12;11(12):12210-12218

Quantitative analysis of the deposited nanoparticle dose on cell cultures by optical absorption spectroscopy.
Spyrogianni A, Herrmann IK, Lucas MS, Leroux JC, Sotiriou GA
Nanomedicine (Lond) 2016 Oct;11(19):2483-96

Contact

 

Georgios Sotiriou

Researcher
C1 Department of Microbiology, Tumor and Cell Biology