Inositide Signalling

Insulin secretion

Inositides contribute to vital cell processes

Inositides take an active part in regulating many vital processes in all cells in the organism. Depending on its primary function, every cell has a specific footprint of what inositides it contains.

Beta-cells contain unusually high amounts of the inositolpyrophosphate IP7

One of the inositides is an inositol pyrophosphate with a common name IP7. It is an active molecule and as soon as it is formed with assistance of the IP6K1 enzyme, it is degraded back to the more stable IP6 under the control of DIPP enzyme. In insulin producing beta-cells the amount of IP7 is unusually high compared to other cells in mammals. IP7 in beta-cells controls insulin release.

For efficient glucose metabolism insulinis released in two phases

As levels of blood glucose rise, it is taken up by beta-cells. This initiates a series of molecular events leading to insulin being released into the blood. Insulin is released in two phases, an initial and a second phase. This enables a more efficient regulation of blood glucose levels.

High levels of IP7 in beta-cells guarantee efficient insulin release

We have shown that IP7 increases the size of the pool of insulin granules that are available for the first phase of secretion. This is known as the readily-releasable pool. Therefore maintaining a high level of IP7 in beta cells is vital for an initial quick and

Project leader

Christopher Barker

Senior Research Specialist

People working on Inositide Signalling

Elisabetta Dare

Senior Research Specialist