Christopher Barker

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Articles

Article: BIOMOLECULES. 2023;13(6):885
Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling
Yu J; Leibiger B; Yang S-N; Shears SBB; Leibiger IBB; Berggren P-O; Barker CJJ
Article: DIABETES. 2021;70(1):111-118
XPR1 Mediates the Pancreatic β-Cell Phosphate Flush
Barker CJ; Tessaro FHG; Ferreira SDS; Simas R; Ayala TS; Kohler M; Rajasekaran SS; Martins JO; Dare E; Berggren P-O
Article: CELLULAR SIGNALLING. 2019;58:131-136
Inositol pyrophosphates and Akt/PKB: Is the pancreatic β-cell the exception to the rule?
Kim J; Dare E; Rajasekaran SS; Ryu SH; Berggren P-O; Barker CJ
Article: CELLULAR SIGNALLING. 2018;46:120-128
Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells
Rajasekaran SS; Kim J; Gaboardi G-C; Gromada J; Shears SB; dos Santos KT; Nolasco EL; Ferreira SDS; Illies C; Kohler M; Gu C; Ryu SH; Martins JO; Dare E; Barker CJ; Berggren P-O
Article: CELLULAR SIGNALLING. 2018;42:127-133
Protein kinase- and lipase inhibitors of inositide metabolism deplete IP₇ indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity
Rajasekaran SS; Illies C; Shears SB; Wang H; Ayala TS; Martins JO; Dare E; Berggren P-O; Barker CJ
Article: ORGANIC AND BIOMOLECULAR CHEMISTRY. 2010;8(12):2850-2858
Conformational analysis of the natural iron chelator myo-inositol 1,2,3-trisphosphate using a pyrene-based fluorescent mimic
Mansell D; Rattray N; Etchells LL; Schwalbe CH; Blake AJ; Torres J; Kremer C; Bichenkova EV; Barker CJ; Freeman S
Article: THE FASEB JOURNAL. 2010;24(6):1824-1837
Insulin-feedback via PI3K-C2α activated PKBα/Akt1 is required for glucose-stimulated insulin secretion
Leibiger B; Moede T; Uhles S; Barker CJ; Creveaux M; Domin J; Berggren P-O; Leibiger IB
Article: METHODS IN MOLECULAR BIOLOGY. 2010;645:123-131
Diphosphosinositol polyphosphates and energy metabolism: assay for ATP/ADP ratio.
Nagel A; Barker CJ; Berggren P-O; Illies C
Article: METHODS IN MOLECULAR BIOLOGY. 2010;645:21-46
HPLC separation of inositol polyphosphates.
Barker CJ; Illies C; Berggren P-O
Article: JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2009;14(1):51-59
"Chelatable iron pool": inositol 1,2,3-trisphosphate fulfils the conditions required to be a safe cellular iron ligand
Veiga N; Torres J; Mansell D; Freeman S; Dominguez S; Barker CJ; Diaz A; Kremer C
Article: CHEMICAL COMMUNICATIONS. 2008;(41):5161-5163
Fluorescent probe: complexation of Fe³⁺ with the myo-inositol 1,2,3-trisphosphate motif
Mansell D; Rattray N; Etchells LL; Schwalbe CH; Blake AJ; Bichenkova EV; Bryce RA; Barker CJ; Diaz A; Kremer C; Freeman S
Article: SCIENCE. 2007;318(5854):1299-1302
Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic β cells
Illies C; Gromada J; Fiume R; Leibiger B; Yu J; Juhl K; Yang S-N; Barma DK; Falck JR; Saiardi A; Barker CJ; Berggren P-O
Article: MOLECULAR ENDOCRINOLOGY. 2007;21(11):2775-2784
An autocrine insulin feedback loop maintains pancreatic β-cell 3-phosphorylated inositol lipids
Yu J; Berggren P-O; Barker CJ
Article: CELL. 2004;119(2):273-284
Removal of Ca²⁺ channel β₃ Subunit enhances Ca²⁺ oscillation frequency and insulin exocytosis
Berggren PO; Yang SN; Murakami M; Efanov AM; Uhles S; Köhler M; Moede T; Fernström A; Appelskog LB; Aspinwall CA; Zaitsev SV; Larsson O; de Vargas LM; Fecher-Trost C; Weissgerber P; Ludwig A; Leibiger B; Juntti-Berggren L; Barker CJ; Gromada J; Freichel M; Leibiger IB; Flockerzi V
Article: BIOCHEMICAL JOURNAL. 2004;380(Pt 2):465-473
Complex changes in cellular inositol phosphate complement accompany transit through the cell cycle.
Barker CJ; Wright J; Hughes PJ; Kirk CJ; Michell RH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(47):46210-46218
Cytosolic multiple inositol polyphosphate phosphatase in the regulation of cytoplasmic free Ca²⁺ concentration
Yu J; Leibiger B; Yang SN; Caffery JJ; Shears SB; Leibiger IB; Barker CJ; Berggren PO
Article: DIABETES. 2000;49(9):1409-1412
Phosphatidylinositol 4,5-bisphosphate and ATP-sensitive potassium channel regulation - A word of caution
Larsson O; Barker CJ; Berggren PO
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(7):3242-3247
G protein-coupled receptors regulate Na⁺,K⁺-ATPase activity and endocytosis by modulating the recruitment of adaptor protein 2 and clathrin
Ogimoto G; Yudowski GA; Barker CJ; Köhler M; Katz AI; Féraille E; Pedemonte CH; Berggren PO; Bertorello AM
Article: SCIENCE. 1997;278(5337):471-474
Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate
Larsson O; Barker CJ; Sjoholm A; Carlqvist H; Michell RH; Bertorello A; Nilsson T; Honkanen RE; Mayr GW; Zwiller J; Berggren PO
Article: CARBOHYDRATE RESEARCH. 1996;282(1):81-99
Synthesis and iron binding studies of myo-inositol 1,2,3-trisphosphate and (+/-)-myo-inositol 1,2-bisphosphate, and iron binding studies of all myo-inositol tetrakisphosphates.
Spiers ID; Barker CJ; Chung SK; Chang YT; Freeman S; Gardiner JM; Hirst PH; Lambert PA; Michell RH; Poyner DR; Schwalbe CH; Smith AW; Solomons KR
Article: BIOCHEMICAL SOCIETY TRANSACTIONS. 1995;23(2):169S
Inositol 1,2,3-trisphosphate is a product of InsP6 dephosphorylation in WRK-1 rat mammary epithelial cells and exhibits transient concentration changes during the cell cycle.
Barker CJ; Wright J; Kirk CJ; Michell RH
Article: BIOCHEMICAL JOURNAL. 1995;306(Pt 2):557-564
INOSITOL 1,2,3-TRISPHOSPHATE AND INOSITOL 1,2-BISPHOSPHATE AND/OR 2,3-BISPHOSPHATE ARE NORMAL CONSTITUENTS OF MAMMALIAN-CELLS
BARKER CJ; FRENCH PJ; MOORE AJ; NILSSON T; BERGGREN PO; BUNCE CM; KIRK CJ; MICHELL RH
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All other publications

Review: ADVANCES IN BIOLOGICAL REGULATION. 2023;87:100919
Novel aspects of intra-islet communication: Primary cilia and filopodia
Moruzzi N; Leibiger B; Barker CJ; Leibiger IB; Berggren P-O
Corrigendum: CELLULAR SIGNALLING. 2019;53:415
Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells (vol 46, pg 120, 2018)
Rajasekaran SS; Kim J; Gaboardi G-C; Gromada J; Shears SB; dos Santos KT; Nolasco EL; Ferreira SDS; Illies C; Kohler M; Gu C; Ryu SH; Martins JO; Dare E; Barker CJ; Berggren P-O
Review: ADVANCES IN BIOLOGICAL REGULATION. 2015;57:112-119
β-Cell Ca(2+) dynamics and function are compromised in aging.
Barker CJ; Li L; Köhler M; Berggren P-O
Review: PHARMACOLOGICAL REVIEWS. 2013;65(2):641-669
New Horizons in Cellular Regulation by Inositol Polyphosphates: Insights from the Pancreatic β-Cell
Barker CJ; Berggren P-O
Review: ADVANCES IN BIOLOGICAL REGULATION. 2013;53(1):156-163
The pancreatic islet as a signaling hub.
Barker CJ; Leibiger IB; Berggren P-O
Review: ADVANCES IN BIOLOGICAL REGULATION. 2012;52(3):361-368
The pancreatic beta cell as a paradigm for advances in inositide research.
Barker CJ; Berggren P-O
Review: METHODS IN MOLECULAR BIOLOGY. 2010;645:1-19
The role of inositol and the principles of labelling, extraction, and analysis of inositides in mammalian cells.
Barker CJ; Berggren P-O
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2009;66(24):3851-3871
Inositol pyrophosphates: structure, enzymology and function
Barker CJ; Illies C; Gaboardi GC; Berggren P-O
Review: ADVANCES IN ENZYME REGULATION. 2009;49(1):168-173
Diphosphoinositol pentakisphosphate as a novel mediator of insulin exocytosis.
Barker CJ; Illies C; Fiume R; Gaboardi GC; Yu J; Berggren P-O
Review: ADVANCES IN ENZYME REGULATION. 2008;48:276-294
A key role for phosphorylated inositol compounds in pancreatic beta-cell stimulus-secretion coupling.
Berggren P-O; Barker CJ
Review: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2002;283(6):E1113-E1122
Phosphorylated inositol compounds in β-cell stimulus-response coupling
Barker CJ; Leibiger IB; Leibiger B; Berggren PO
Published conference paper: ANTICANCER RESEARCH. 1999;19(5A):3737-3741
Inositol hexakisphosphate and β-cell stimulus-secretion coupling
Barker CJ; Berggren PO

Employments

Senior Research Specialist, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2004

Articles

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