Endocrinology Unit with the Lipid laboratory
At the unit we study the role of lipid metabolism in cardiometabolic diseases, in order to develop treatments for common national diseases such as obesity and lipid disorders. The unit is comprised of one wet laboratory and one clinical research center with four independent research groups. The groups lead their own projects but with a continuous collaboration within the unit.
As an integral part of the Department of Medicine, Huddinge, the Endocrinology unit is studying the role of lipid metabolism in cardiometabolic diseases. Professor Mikael Rydén is heading the Unit of Endocrinology with the Lipid laboratory and Clinical Research Center.
Lipid Laboratory and Clinical Research Center
The unit is comprised by one fully equipped wet laboratory, called the Lipid laboratory, located in the Neo research building at KI Campus Flemingsberg and a Clinical Research Center at the adjacent Karolinska University Hospital, Huddinge. The Clinical Research Center is part of a core facility within the Strategic Research Programme in Diabetes.
The Unit of Endocrinology with the Lipid laboratory is world leading in the studies of human white adipose tissue, with ongoing local, national and international collaborations with research groups conducting metabolic research.
Studies of white adipose tissue
Our scientific mission is to study role of human white adipose tissue in common cardiometabolic diseases. We have a long-standing record as one of the world-leading groups in the field of human adipose tissue research. Altogether, the unit consists of four independent groups led by principal investigators with specific areas of interest, senior researchers, post-doctoral fellows, PhD students and technical staff.
For more information about the research conducted at the Endocrinology unit and the Lipid Laboratory and Clinical Research Center, please visit the respective group page found below.
Cardio Metabolic Unit (CMU)
The Cardio Metabolic Unit (CMU) is a research constellation, driving innovative and implementable research and education, closely integrated with specialized health care. In line with its translational approach, CMU is linked to the Department of Medicine in Huddinge and Department of Laboratory Medicine at Campus Flemingsberg, Karolinska Institutet.
ANOVA is academic specialist center for clinical investigation and treatment in the areas of andrology, sexual medicine and trans medicine. The center belongs to Karolinska University Hospital, but the research is conducted in a variety of fields in collaboration with the Endocrinology unit at the Department of Medicine, Huddinge at Karolinska Institutet, among other partners.
Head of Unit
Mikael Rydén is Head of the Endocrinology unit and Co-lead of the research group Rydén & Mejhert lab together with Niklas Mejhert.
Mikael is a senior consultant in endocrinology and Professor of adipose tissue research. He has spent the last 25 years of his career focusing on studies of white adipose tissue.
Lipid Laboratory, Medicinaren 25, NEO, 7th Floor, Hälsovägen 7 C, Campus Flemingsberg, Huddinge.
Clinical research, ongoing studies
1). LOSHAT (inclusion 2018-ongoing)
2). Adipo-SCAPIS (inclusion 2017-ongoing)
3). GETS (inclusion 2015-ongoing)
4). NEFA (inclusion 2011-2014)
5). SOWOT (inclusion 2014-2016)
6). Bone marrow transplant trial (inclusion 2010-2012)
8). Cancer cachexi (inclusion 2004-2005)
- Adipose lipid turnover and long-term changes in body weight.
Arner P, Bernard S, Appelsved L, Fu KY, Andersson DP, Salehpour M, et al. Nat. Med. 2019 09;25(9):1385-1389
- Insulin action is severely impaired in adipocytes of apparently healthy overweight and obese subjects.
Rydén M, Petrus P, Andersson DP, Medina-Gómez G, Escasany E, Corrales Cordón P, et al
J. Intern. Med. 2019 May;285(5):578-588
- Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue. Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, et al. Cell Rep 2018 10;25(3):551-560.e5
- Improved metabolism and body composition beyond normal levels following gastric bypass surgery: a longitudinal study.
Andersson DP, Dahlman I, Eriksson Hogling D, Bäckdahl J, Toft E, Qvisth V, Näslund E, Thorell A, Rydén M, Arner P
J Intern Med 2019 01;285(1):92-101
- Weight Gain and Impaired Glucose Metabolism in Women Are Predicted by Inefficient Subcutaneous Fat Cell Lipolysis.
Arner P, Andersson DP, Bäckdahl J, Dahlman I, Rydén M. Cell Metab. 2018 Jul;28(1):45-54.e3
- Long Non-Coding RNAs Associated with Metabolic Traits in Human White Adipose Tissue.
Gao H, Kerr A, Jiao H, Hon CC, Rydén M, Dahlman I, et al. EBioMedicine 2018 Apr;30():248-260
- Impact of fat mass and distribution on lipid turnover in human adipose tissue.
Spalding KL, Bernard S, Näslund E, Salehpour M, Possnert G, Appelsved L, et al. Nat Commun 2017 05;8():15253
- The Adipose Transcriptional Response to Insulin Is Determined by Obesity, Not Insulin Sensitivity.
Rydén M, Hrydziuszko O, Mileti E, Raman A, Bornholdt J, Boyd M, et al. Cell Rep 2016 08;16(9):2317-26
- Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis.
Rydén M, Uzunel M, Hård JL, Borgström E, Mold JE, Arner E, et al. Cell Metab. 2015 Sep;22(3):408-1
- Early B cell factor 1 regulates adipocyte morphology and lipolysis in white adipose tissue.
Gao H, Mejhert N, Fretz JA, Arner E, Lorente-Cebrián S, Ehrlund A, et al. Cell Metab. 2014 Jun;19(6):981-92