PSF related publications

(172 Publications 2012-2022)

To support Protein Science Facility (PSF) in future evaluations and applications all users are required to acknowledge experimentation or services performed at PSF in manuscripts submitted for publication e.g.

Part of this work was facilitated by the Protein Science Facility at Karolinska Institutet/SciLifeLab (

Part of this work was performed at the Karolinska Institutet/SciLifeLab Protein Science Core Facility (

Protein Science Facility has been a member of SciLifeLab 2012-2020 so PSF related publications number 1-146 are also listed at the SciLifeLab pages.


172. MYC assembles and stimulates topoisomerases 1 and 2 in a "topoisome".
Das SK, Kuzin V, Cameron DP, Sanford S, Jha RK, Nie Z, Rosello MT, Holewinski R, Andresson T, Wisniewski J, Natsume T, Price DH, Lewis BA, Kouzine F, Levens D, Baranello L
Mol Cell 2022 01;82(1):140-158.e12

171. Antibodies to cartilage oligomeric matrix protein are pathogenic in mice and may be clinically relevant in rheumatoid arthritis.
Ge C, Tong D, Lönnblom E, Liang B, Cai W, Fahlquist-Hagert C, Li T, Kastbom A, Gjertsson I, Dobritzsch D, Holmdahl R
Arthritis Rheumatol 2022 Jan;():

170. Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses.
Luttens A, Gullberg H, Abdurakhmanov E, Vo DD, Akaberi D, Talibov VO, Nekhotiaeva N, Vangeel L, De Jonghe S, Jochmans D, Krambrich J, Tas A, Lundgren B, Gravenfors Y, Craig AJ, Atilaw Y, Sandström A, Moodie LWK, Lundkvist Å, van Hemert MJ, Neyts J, Lennerstrand J, Kihlberg J, Sandberg K, Danielson UH, Carlsson J
J Am Chem Soc 2022 Feb;():

169. Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile Aquifex aeolicus.
Rehling D, Scaletti ER, Rozman Grinberg I, Lundin D, Sahlin M, Hofer A, Sjöberg BM, Stenmark P
Biochemistry 2022 01;61(2):92-106

168. A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo.
Hanke L, Das H, Sheward DJ, Perez Vidakovics L, Urgard E, Moliner-Morro A, Kim C, Karl V, Pankow A, Smith NL, Porebski B, Fernandez-Capetillo O, Sezgin E, Pedersen GK, Coquet JM, Hällberg BM, Murrell B, McInerney GM
Nat Commun 2022 01;13(1):155


167. Genome-wide mapping of G-quadruplex structures with CUT&Tag.
Lyu J, Shao R, Kwong Yung PY, Elsässer SJ
Nucleic Acids Res 2021 Nov;():

166. A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens.
Vella P, Rudraraju RS, Lundbäck T, Axelsson H, Almqvist H, Vallin M, Schneider G, Schnell R
Bioorg Med Chem 2021 01;30():115898

165. Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase.
Schriever K, Saenz-Mendez P, Rudraraju RS, Hendrikse NM, Hudson EP, Biundo A, Schnell R, Syrén PO
J Am Chem Soc 2021 03;143(10):3794-3807

164. N-Thio-β-lactams targeting L,D-transpeptidase-2, with activity against drug-resistant strains of Mycobacterium tuberculosis.
Martelli G, Pessatti TB, Steiner EM, Cirillo M, Caso C, Bisognin F, Landreh M, Monte PD, Giacomini D, Schnell R
Cell Chem Biol 2021 Mar;():

163. Crystal structure of a homotrimeric verrucomicrobial exo-β-1,4-mannosidase active in the hindgut of the wood-feeding termite Reticulitermes flavipes. Kalyani DC, Reichenbach T, Keskitalo MM, Conrad J, Aspeborg H, Divne C
J Struct Biol X 2021 ;5():100048

162. Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
Rehling D, Zhang SM, Jemth AS, Koolmeister T, Throup A, Wallner O, Scaletti E, Moriyama T, Nishii R, Davies J, Desroses M, Rudd SG, Scobie M, Homan E, Berglund UW, Yang JJ, Helleday T, Stenmark P
J Biol Chem ;296():100568

161. NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir. Zhang SM, Rehling D, Jemth AS, Throup A, Landázuri N, Almlöf I, Göttmann M, Valerie NCK, Borhade SR, Wakchaure P, Page BDG, Desroses M, Homan EJ, Scobie M, Rudd SG, Berglund UW, Söderberg-Nauclér C, Stenmark P, Helleday T
Cell Chem Biol 2021 Jun;():

160. Mechanism of Ganglioside Receptor Recognition by Botulinum Neurotoxin Serotype E.
Masuyer G, Davies JR, Stenmark P
Int J Mol Sci 2021 Aug;22(15):

159. FragMAXapp: crystallographic fragment-screening data-analysis and project-management system. Lima, G. M. A., Jagudin, E., Talibov, V. O., Benz, L. S., Marullo, C., Barthel, T., Wollenhaupt, J., Weiss, M. S. & Mueller, U. Acta Cryst. 2021 D77. 

158. Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors.
Akaberi D, Båhlström A, Chinthakindi PK, Nyman T, Sandström A, Järhult JD, Palanisamy N, Lundkvist Å, Lennerstrand J
Antiviral Res 2021 Apr;190():105074

157. Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase.
Schriever K, Saenz-Mendez P, Rudraraju RS, Hendrikse NM, Hudson EP, Biundo A, Schnell R, Syrén PO
J Am Chem Soc 2021 Jan;():

156. A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens.
Vella P, Rudraraju RS, Lundbäck T, Axelsson H, Almqvist H, Vallin M, Schneider G, Schnell R
Bioorg Med Chem 2021 Jan;30():115898

155. A DNA-nanoassembly-based approach to map membrane protein nanoenvironments.
Ambrosetti E, Bernardinelli G, Hoffecker I, Hartmanis L, Kiriako G, de Marco A, Sandberg R, Högberg B, Teixeira AI
Nat Nanotechnol 2021 Jan;16(1):85-95

154. Direct detection of SARS-CoV-2 using non-commercial RT-LAMP reagents on heat-inactivated samples.
Alekseenko A, Barrett D, Pareja-Sanchez Y, Howard RJ, Strandback E, Ampah-Korsah H, et al
Sci Rep 2021 01;11(1):1820

153. A homodimeric bacterial exo-β-1,3-glucanase derived from moose rumen microbiome shows a structural framework similar to yeast exo-β-1,3-glucanases.
Kalyani DC, Reichenbach T, Aspeborg H, Divne C
Enzyme Microb Technol 2021 Feb;143():109723


152. An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility.
Navarro C, Lyu J, Katsori AM, Caridha R, Elsässer SJ
Nat Commun 2020 10;11(1):5095

151. Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease.
Akaberi D, Chinthakindi PK, Båhlström A, Palanisamy N, Sandström A, Lundkvist Å, et al
J Biomol Struct Dyn 2020 Nov;38(18):5526-5536

150. Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins.
Nowak K, Rosenthal F, Karlberg T, Bütepage M, Thorsell AG, Dreier B, et al
Nat Commun 2020 10;11(1):5199

149. One-Pot Production of RNA in High Yield and Purity Through Cleaving Tandem Transcripts.
Feyrer H, Munteanu R, Baronti L, Petzold K
Molecules 2020 Mar;25(5):

148. A robust and versatile method for production and purification of large-scale RNA samples for structural biology.
Karlsson H, Baronti L, Petzold K
RNA 2020 08;26(8):1023-1037

147. A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes.
Yuen LH, Dana S, Liu Y, Bloom SI, Thorsell AG, Neri D, Donato AJ, Kireev D, Schüler H, Franzini RM
J Am Chem Soc 2019 04;141(13):5169-5181


146. Development of a chemical probe against NUDT15.
Zhang SM, Desroses M, Hagenkort A, Valerie NCK, Rehling D, Carter M, Wallner O, Koolmeister T, Throup A, Jemth AS, Almlöf I, Loseva O, Lundbäck T, Axelsson H, Regmi S, Sarno A, Krämer A, Pudelko L, Bräutigam L, Rasti A, Göttmann M, Wiita E, Kutzner J, Schaller T, Kalderén C, Cázares-Körner A, Page BDG, Krimpenfort R, Eshtad S, Altun M, Rudd SG, Knapp S, Scobie M, Homan EJ, Berglund UW, Stenmark P, Helleday T
Nat Chem Biol 2020 10;16(10):1120-1128

145. An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.
Hanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, Corcoran M, Achour A, Karlsson Hedestam GB, Hällberg BM, Murrell B, McInerney GM
Nat Commun 2020 09;11(1):4420

144. A ribonucleotide reductase from Clostridium botulinum reveals distinct evolutionary pathways to regulation via the overall activity site.
Martínez-Carranza M, Jonna VR, Lundin D, Sahlin M, Carlson LA, Jemal N, Högbom M, Sjöberg BM, Stenmark P, Hofer A
J Biol Chem 2020 Nov;295(46):15576-15587

143. Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
Škerlová J, Unterlass J, Göttmann M, Marttila P, Homan E, Helleday T, Jemth AS, Stenmark P
J Biol Chem 2020 08;295(33):11656-11668

142. A Transmembrane Crenarchaeal Mannosyltransferase Is Involved in N-Glycan Biosynthesis and Displays an Unexpected Minimal Cellulose-Synthase-like Fold.
Gandini R, Reichenbach T, Spadiut O, Tan TC, Kalyani DC, Divne C
J Mol Biol 2020 07;432(16):4658-4672

141. Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA.
Baronti L, Guzzetti I, Ebrahimi P, Friebe Sandoz S, Steiner E, Schlagnitweit J, Fromm B, Silva L, Fontana C, Chen AA, Petzold K
Nature 2020 07;583(7814):139-144

140. In silico Druggability Assessment of the NUDIX Hydrolase Protein Family as a Workflow for Target Prioritization.
Michel M, Homan EJ, Wiita E, Pedersen K, Almlöf I, Gustavsson AL, Lundbäck T, Helleday T, Warpman Berglund U
Front Chem 2020 ;8():443

139. MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
Scaletti ER, Vallin KS, Bräutigam L, Sarno A, Warpman Berglund U, Helleday T, Stenmark P, Jemth AS
J Biol Chem 2020 04;295(15):4761-4772

138, The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products.
Scaletti E, Claesson M, Helleday T, Jemth AS, Stenmark P
J Mol Biol 2020 02;432(4):1126-1142

137. Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease.
Akaberi D, Chinthakindi PK, Båhlström A, Palanisamy N, Sandström A, Lundkvist Å, Lennerstrand J
J Biomol Struct Dyn 2020 Nov;38(18):5526-5536


136. Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.
Nicholls TJ, Spåhr H, Jiang S, Siira SJ, Koolmeister C, Sharma S, Kauppila JHK, Jiang M, Kaever V, Rackham O, Chabes A, Falkenberg M, Filipovska A, Larsson NG, Gustafsson CM
Mol Cell 2019 12;76(5):784-796.e6

135. E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2.
Anandapadamanaban M, Kyriakidis NC, Csizmók V, Wallenhammar A, Espinosa AC, Ahlner A, Round AR, Trewhella J, Moche M, Wahren-Herlenius M, Sunnerhagen M
J Biol Chem 2019 07;294(30):11404-11419

134. Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs.
Scaletti E, Jemth AS, Helleday T, Stenmark P
FEBS Lett 2019 07;593(14):1863-1873

133. Crystal structure of the catalytic domain of the Weissella oryzae botulinum-like toxin.
Košenina S, Masuyer G, Zhang S, Dong M, Stenmark P
FEBS Lett 2019 06;593(12):1403-1410

132. Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana.
Jemth AS, Scaletti E, Carter M, Helleday T, Stenmark P
Biochemistry 2019 02;58(7):887-899

131. Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Ge C, Xu B, Liang B, Lönnblom E, Lundström SL, Zubarev RA, Ayoglu B, Nilsson P, Skogh T, Kastbom A, Malmström V, Klareskog L, Toes REM, Rispens T, Dobritzsch D, Holmdahl R
Arthritis Rheumatol 2019 02;71(2):210-221

130. Cotranslational Folding of a Pentarepeat β-Helix Protein.
Notari L, Martínez-Carranza M, Farías-Rico JA, Stenmark P, von Heijne G
J Mol Biol 2018 12;430(24):5196-5206



129. 14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface.
Karlberg T, Hornyak P, Pinto AF, Milanova S, Ebrahimi M, Lindberg M, Püllen N, Nordström A, Löverli E, Caraballo R, Wong EV, Näreoja K, Thorsell AG, Elofsson M, De La Cruz EM, Björkegren C, Schüler H
Nat Commun 2018 09;9(1):3785

128. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Page BDG, Valerie NCK, Wright RHG, Wallner O, Isaksson R, Carter M, Rudd SG, Loseva O, Jemth AS, Almlöf I, Font-Mateu J, Llona-Minguez S, Baranczewski P, Jeppsson F, Homan E, Almqvist H, Axelsson H, Regmi S, Gustavsson AL, Lundbäck T, Scobie M, Strömberg K, Stenmark P, Beato M, Helleday T
Nat Commun 2018 01;9(1):250

127. Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins.
Spåhr H, Chia T, Lingford JP, Siira SJ, Cohen SB, Filipovska A, Rackham O
Nat Commun 2018 06;9(1):2212

126. A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.
Ladds MJGW, van Leeuwen IMM, Drummond CJ, Chu S, Healy AR, Popova G, Pastor Fernández A, Mollick T, Darekar S, Sedimbi SK, Nekulova M, Sachweh MCC, Campbell J, Higgins M, Tuck C, Popa M, Safont MM, Gelebart P, Fandalyuk Z, Thompson AM, Svensson R, Gustavsson AL, Johansson L, Färnegårdh K, Yngve U, Saleh A, Haraldsson M, D'Hollander ACA, Franco M, Zhao Y, Håkansson M, Walse B, Larsson K, Peat EM, Pelechano V, Lunec J, Vojtesek B, Carmena M, Earnshaw WC, McCarthy AR, Westwood NJ, Arsenian-Henriksson M, Lane DP, Bhatia R, McCormack E, Laín S
Nat Commun 2018 03;9(1):1107

125. Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.
Visnes T, Cázares-Körner A, Hao W, Wallner O, Masuyer G, Loseva O, Mortusewicz O, Wiita E, Sarno A, Manoilov A, Astorga-Wells J, Jemth AS, Pan L, Sanjiv K, Karsten S, Gokturk C, Grube M, Homan EJ, Hanna BMF, Paulin CBJ, Pham T, Rasti A, Berglund UW, von Nicolai C, Benitez-Buelga C, Koolmeister T, Ivanic D, Iliev P, Scobie M, Krokan HE, Baranczewski P, Artursson P, Altun M, Jensen AJ, Kalderén C, Ba X, Zubarev RA, Stenmark P, Boldogh I, Helleday T
Science 2018 11;362(6416):834-839

124. MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.
Jemth AS, Gustafsson R, Bräutigam L, Henriksson L, Vallin KSA, Sarno A, Almlöf I, Homan E, Rasti A, Warpman Berglund U, Stenmark P, Helleday T
Nucleic Acids Res 2018 11;46(20):10888-10904
123. STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions.
Desroses M, Busker S, Astorga-Wells J, Attarha S, Kolosenko I, Zubarev RA, Helleday T, Grandér D, Page BDG
J Pharm Biomed Anal 2018 Oct;160():80-88

122. Structural and biochemical characterization of the Cutibacterium acnes exo-β-1,4-mannosidase that targets the N-glycan core of host glycoproteins.
Reichenbach T, Kalyani D, Gandini R, Svartström O, Aspeborg H, Divne C
PLoS One 2018 ;13(9):e0204703

121. Structural and Functional Characterization of the BcsG Subunit of the Cellulose Synthase in Salmonella typhimurium.
Sun L, Vella P, Schnell R, Polyakova A, Bourenkov G, Li F, Cimdins A, Schneider TR, Lindqvist Y, Galperin MY, Schneider G, Römling U
J Mol Biol 2018 09;430(18 Pt B):3170-3189

120. A glutaredoxin domain fused to the radical-generating subunit of ribonucleotide reductase (RNR) functions as an efficient RNR reductant.
Rozman Grinberg I, Lundin D, Sahlin M, Crona M, Berggren G, Hofer A, Sjöberg BM
J Biol Chem 2018 10;293(41):15889-15900

119. BtsCI and BseGI display sequence preference in the nucleotides flanking the recognition sequence.
Rosa J, Fernandez-Gonzalez E, Ducani C, Högberg B
PLoS One 2018 ;13(8):e0202057

118. CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response.
Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J
Nat Med 2018 07;24(7):927-930

117. Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14.
Holechek J, Lease R, Thorsell AG, Karlberg T, McCadden C, Grant R, Keen A, Callahan E, Schüler H, Ferraris D
Bioorg Med Chem Lett 2018 06;28(11):2050-2054

116. The structure of the N-terminal module of the cell wall hydrolase RipA and its role in regulating catalytic activity.
Steiner EM, Lyngsø J, Guy JE, Bourenkov G, Lindqvist Y, Schneider TR, Pedersen JS, Schneider G, Schnell R
Proteins 2018 09;86(9):912-923

115. Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding.
Gustafsson R, Zhang S, Masuyer G, Dong M, Stenmark P
Toxins (Basel) 2018 04;10(4):

114. Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima.
Morgunova E, Yin Y, Das PK, Jolma A, Zhu F, Popov A, Xu Y, Nilsson L, Taipale J
Elife 2018 04;7():

113. Structural and functional studies of Spr1654: an essential aminotransferase in teichoic acid biosynthesis in Streptococcus pneumoniae.
Han X, Sun R, Sandalova T, Achour A
Open Biol 2018 04;8(4):

112. Identification of Poly(ADP-Ribose) Polymerase Macrodomain Inhibitors Using an AlphaScreen Protocol.
Ekblad T, Verheugd P, Lindgren AE, Nyman T, Elofsson M, Schüler H
SLAS Discov 2018 04;23(4):353-362

111. The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability.
Hafstrand I, Doorduijn EM, Sun R, Talyzina A, Sluijter M, Pellegrino S, Sandalova T, Duru AD, van Hall T, Achour A
J Immunol 2018 04;200(8):2860-2868

110. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.
Stafford WC, Peng X, Olofsson MH, Zhang X, Luci DK, Lu L, Cheng Q, Trésaugues L, Dexheimer TS, Coussens NP, Augsten M, Ahlzén HM, Orwar O, Östman A, Stone-Elander S, Maloney DJ, Jadhav A, Simeonov A, Linder S, Arnér ESJ
Sci Transl Med 2018 02;10(428):

109. Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit.
Rozman Grinberg I, Lundin D, Hasan M, Crona M, Jonna VR, Loderer C, Sahlin M, Markova N, Borovok I, Berggren G, Hofer A, Logan DT, Sjöberg BM
Elife 2018 02;7():

108. Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold.
Carter M, Jemth AS, Carreras-Puigvert J, Herr P, Martínez Carranza M, Vallin KSA, Throup A, Helleday T, Stenmark P
Structure 2018 02;26(2):295-303.e6

107. Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
Narwal M, Jemth AS, Gustafsson R, Almlöf I, Warpman Berglund U, Helleday T, Stenmark P
Biochemistry 2018 02;57(5):593-603



106. Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1.
Lehmann LC, Hewitt G, Aibara S, Leitner A, Marklund E, Maslen SL, Maturi V, Chen Y, van der Spoel D, Skehel JM, Moustakas A, Boulton SJ, Deindl S
Mol Cell 2017 Dec;68(5):847-859.e7

105. A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family.
Carreras-Puigvert J, Zitnik M, Jemth AS, Carter M, Unterlass JE, Hallström B, Loseva O, Karem Z, Calderón-Montaño JM, Lindskog C, Edqvist PH, Matuszewski DJ, Ait Blal H, Berntsson RPA, Häggblad M, Martens U, Studham M, Lundgren B, Wählby C, Sonnhammer ELL, Lundberg E, Stenmark P, Zupan B, Helleday T
Nat Commun 2017 11;8(1):1541

104. Structural basis for dolichylphosphate mannose biosynthesis.
Gandini R, Reichenbach T, Tan TC, Divne C
Nat Commun 2017 07;8(1):120

103. Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance.
Petrus P, Bialesova L, Checa A, Kerr A, Naz S, Bäckdahl J, Gracia A, Toft S, Dahlman-Wright K, Hedén P, Dahlman I, Wheelock CE, Arner P, Mejhert N, Gao H, Rydén M
J Clin Endocrinol Metab 2018 02;103(2):710-721

102. Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51.
Kumar R, Moche M, Winblad B, Pavlov PF
Sci Rep 2017 10;7(1):14288

101. Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX-type gene cluster.
Gustafsson R, Berntsson RP, Martínez-Carranza M, El Tekle G, Odegrip R, Johnson EA, Stenmark P
FEBS Lett 2017 11;591(22):3781-3792

100. Entirely enzymatic nanofabrication of DNA-protein conjugates.
Bernardinelli G, Högberg B
Nucleic Acids Res 2017 Oct;45(18):e160

99. Profiling of in vitro activities of urea-based inhibitors against cysteine synthases from Mycobacterium tuberculosis.
Brunner K, Steiner EM, Reshma RS, Sriram D, Schnell R, Schneider G
Bioorg Med Chem Lett 2017 10;27(19):4582-4587

98. Capturing LTA4 hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB4 synthesis.
Stsiapanava A, Samuelsson B, Haeggström JZ
Proc Natl Acad Sci U S A 2017 09;114(36):9689-9694

97. Mucin-Inspired Lubrication on Hydrophobic Surfaces.
Käsdorf BT, Weber F, Petrou G, Srivastava V, Crouzier T, Lieleg O
Biomacromolecules 2017 Aug;18(8):2454-2462

96. Investigation of calcium-dependent activity and conformational dynamics of zebra fish 12-lipoxygenase.
Mittal M, Hasan M, Balagunaseelan N, Fauland A, Wheelock C, Rådmark O, Haeggström JZ, Rinaldo-Matthis A
Biochim Biophys Acta Gen Subj 2017 Aug;1861(8):2099-2111

95. Biophysical characterization of the calmodulin-like domain of Plasmodium falciparum calcium dependent protein kinase 3.
Andresen C, Niklasson M, Cassman Eklöf S, Wallner B, Lundström P
PLoS One 2017 ;12(7):e0181721

94. Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Dobritzsch D, Holmdahl R
JCI Insight 2017 Jul;2(13):

93. Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14.
Upton K, Meyers M, Thorsell AG, Karlberg T, Holechek J, Lease R, Schey G, Wolf E, Lucente A, Schüler H, Ferraris D
Bioorg Med Chem Lett 2017 07;27(13):2907-2911

92. Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J
Science 2017 05;356(6337):

91. SnoN Stabilizes the SMAD3/SMAD4 Protein Complex.
Walldén K, Nyman T, Hällberg BM
Sci Rep 2017 04;7():46370

90. Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy.
B Kumar R, Zhu L, Hebert H, Jegerschöld C
J Vis Exp 2017 03;(121):

89. Binding and processing of β-lactam antibiotics by the transpeptidase LdtMt2 from Mycobacterium tuberculosis.
Steiner EM, Schneider G, Schnell R
FEBS J 2017 03;284(5):725-741

88. Characterization of the Ruler Protein Interaction Interface on the Substrate Specificity Switch Protein in the Yersinia Type III Secretion System.
Ho O, Rogne P, Edgren T, Wolf-Watz H, Login FH, Wolf-Watz M
J Biol Chem 2017 02;292(8):3299-3311

87. Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.
Thorsell AG, Ekblad T, Karlberg T, Löw M, Pinto AF, Trésaugues L, Moche M, Cohen MS, Schüler H
J Med Chem 2017 02;60(4):1262-1271

86. Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
Herold N, Rudd SG, Ljungblad L, Sanjiv K, Myrberg IH, Paulin CB, Heshmati Y, Hagenkort A, Kutzner J, Page BD, Calderón-Montaño JM, Loseva O, Jemth AS, Bulli L, Axelsson H, Tesi B, Valerie NC, Höglund A, Bladh J, Wiita E, Sundin M, Uhlin M, Rassidakis G, Heyman M, Tamm KP, Warpman-Berglund U, Walfridsson J, Lehmann S, Grandér D, Lundbäck T, Kogner P, Henter JI, Helleday T, Schaller T
Nat Med 2017 Feb;23(2):256-263

85, Small Molecule Microarray Based Discovery of PARP14 Inhibitors.
Peng B, Thorsell AG, Karlberg T, Schüler H, Yao SQ
Angew Chem Int Ed Engl 2017 01;56(1):248-253



84. A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice.
Lundbäck P, Lea JD, Sowinska A, Ottosson L, Fürst CM, Steen J, Aulin C, Clarke JI, Kipar A, Klevenvall L, Yang H, Palmblad K, Park BK, Tracey KJ, Blom AM, Andersson U, Antoine DJ, Erlandsson Harris H
Hepatology 2016 11;64(5):1699-1710

83. A ribonucleotide reductase inhibitor with deoxyribonucleoside-reversible cytotoxicity.
Crona M, Codó P, Jonna VR, Hofer A, Fernandes AP, Tholander F
Mol Oncol 2016 11;10(9):1375-1386

82. Generation and analyses of human synthetic antibody libraries and their application for protein microarrays.
Säll A, Walle M, Wingren C, Müller S, Nyman T, Vala A, Ohlin M, Borrebaeck CAK, Persson H
Protein Eng Des Sel 2016 10;29(10):427-437

81. Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD.
Quistgaard EM, Weininger U, Ural-Blimke Y, Modig K, Nordlund P, Akke M, Löw C
BMC Biol 2016 Sep;14(1):82

80. NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.
Valerie NC, Hagenkort A, Page BD, Masuyer G, Rehling D, Carter M, Bevc L, Herr P, Homan E, Sheppard NG, Stenmark P, Jemth AS, Helleday T
Cancer Res 2016 09;76(18):5501-11

79. The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation.
Schulte T, Mikaelsson C, Beaussart A, Kikhney A, Deshmukh M, Wolniak S, Pathak A, Ebel C, Löfling J, Fogolari F, Henriques-Normark B, Dufrêne YF, Svergun D, Nygren PÅ, Achour A
Sci Rep 2016 09;6():32371

78. The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity.
Sandalova T, Lee M, Henriques-Normark B, Hesek D, Mobashery S, Mellroth P, Achour A
Mol Microbiol 2016 09;101(6):954-67

77. Mutation-Induced Population Shift in the MexR Conformational Ensemble Disengages DNA Binding: A Novel Mechanism for MarR Family Derepression.
Anandapadamanaban M, Pilstål R, Andresen C, Trewhella J, Moche M, Wallner B, Sunnerhagen M
Structure 2016 08;24(8):1311-1321

76. Kinetic investigation of human 5-lipoxygenase with arachidonic acid.
Mittal M, Kumar RB, Balagunaseelan N, Hamberg M, Jegerschöld C, Rådmark O, Haeggström JZ, Rinaldo-Matthis A
Bioorg Med Chem Lett 2016 08;26(15):3547-51

75. Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.
Brunner K, Maric S, Reshma RS, Almqvist H, Seashore-Ludlow B, Gustavsson AL, Poyraz Ö, Yogeeswari P, Lundbäck T, Vallin M, Sriram D, Schnell R, Schneider G
J Med Chem 2016 07;59(14):6848-59

74. Identification of Inhibitors of Pseudomonas aeruginosa Exotoxin-S ADP-Ribosyltransferase Activity.
Pinto AF, Ebrahimi M, Saleeb M, Forsberg Å, Elofsson M, Schüler H
J Biomol Screen 2016 Jul;21(6):590-5

73. Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication.
Schulte T, Liu L, Panas MD, Thaa B, Dickson N, Götte B, Achour A, McInerney GM
Open Biol 2016 Jul;6(7):

72. Coxsackievirus counters the host innate immune response by blocking type III interferon expression.
Lind K, Svedin E, Domsgen E, Kapell S, Laitinen OH, Moll M, Flodström-Tullberg M
J Gen Virol 2016 06;97(6):1368-1380

71. Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Siitonen V, Selvaraj B, Niiranen L, Lindqvist Y, Schneider G, Metsä-Ketelä M
Proc Natl Acad Sci U S A 2016 May;113(19):5251-6

70. Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis.
Kouznetsova E, Kanno T, Karlberg T, Thorsell AG, Wisniewska M, Kursula P, Sjögren C, Schüler H
Structure 2016 05;24(5):789-796

69. Engineering a thermostable Halothermothrix orenii β-glucosidase for improved galacto-oligosaccharide synthesis.
Hassan N, Geiger B, Gandini R, Patel BK, Kittl R, Haltrich D, Nguyen TH, Divne C, Tan TC
Appl Microbiol Biotechnol 2016 Apr;100(8):3533-43

68. Novel mode of inhibition by D-tagatose 6-phosphate through a Heyns rearrangement in the active site of transaldolase B variants.
Stellmacher L, Sandalova T, Schneider S, Schneider G, Sprenger GA, Samland AK
Acta Crystallogr D Struct Biol 2016 Apr;72(Pt 4):467-76

67. A saposin-lipoprotein nanoparticle system for membrane proteins.
Frauenfeld J, Löving R, Armache JP, Sonnen AF, Guettou F, Moberg P, Zhu L, Jegerschöld C, Flayhan A, Briggs JA, Garoff H, Löw C, Cheng Y, Nordlund P
Nat Methods 2016 Apr;13(4):345-51

66. CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.
Almqvist H, Axelsson H, Jafari R, Dan C, Mateus A, Haraldsson M, Larsson A, Martinez Molina D, Artursson P, Lundbäck T, Nordlund P
Nat Commun 2016 Mar;7():11040

65. Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
Mills SJ, Silvander C, Cozier G, Trésaugues L, Nordlund P, Potter BV
Biochemistry 2016 Mar;55(9):1384-97

64. The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer.
Hafstrand I, Doorduijn EM, Duru AD, Buratto J, Oliveira CC, Sandalova T, van Hall T, Achour A
J Immunol 2016 Mar;196(5):2327-34

63. The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a--an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity.
Lim SM, Yeung K, Trésaugues L, Ling TH, Nordlund P
FEBS J 2016 Mar;283(6):1107-23

62. Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.
Llona-Minguez S, Höglund A, Jacques SA, Johansson L, Calderón-Montaño JM, Claesson M, Loseva O, Valerie NCK, Lundbäck T, Piedrafita J, Maga G, Crespan E, Meijer L, Morón EB, Baranczewski P, Hagbjörk AL, Svensson R, Wiita E, Almlöf I, Visnes T, Jeppsson F, Sigmundsson K, Jensen AJ, Artursson P, Jemth AS, Stenmark P, Berglund UW, Scobie M, Helleday T
J Med Chem 2016 Feb;59(3):1140-1148

61. Crystal structure of the flavoenzyme PA4991 from Pseudomonas aeruginosa.
Jacewicz A, Schnell R, Lindqvist Y, Schneider G
Acta Crystallogr F Struct Biol Commun 2016 Feb;72(Pt 2):105-11

60. A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E2 synthase.
Brock JS, Hamberg M, Balagunaseelan N, Goodman M, Morgenstern R, Strandback E, Samuelsson B, Rinaldo-Matthis A, Haeggström JZ
Proc Natl Acad Sci U S A 2016 Jan;113(4):972-7


59. Exploring water as building bricks in enzyme engineering.
Hendil-Forssell P, Martinelle M, Syrén PO
Chem Commun (Camb) 2015 Dec;51(97):17221-4

58. Structural insights into the DNA-binding specificity of E2F family transcription factors.
Morgunova E, Yin Y, Jolma A, Dave K, Schmierer B, Popov A, Eremina N, Nilsson L, Taipale J
Nat Commun 2015 Dec;6():10050

57. DNA-dependent formation of transcription factor pairs alters their binding specificity.
Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J
Nature 2015 Nov;527(7578):384-8

56. Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity.
Ahmad S, Thulasingam M, Palombo I, Daley DO, Johnson KA, Morgenstern R, Haeggström JZ, Rinaldo-Matthis A
Biochim Biophys Acta 2015 Oct;1854(10 Pt A):1365-71

55. Acid–Base Catalyst Discriminates between a Fructose 6‐Phosphate Aldolase and a Transaldolase. Stellmacher L, Sandalova T, Leptihn S, Schneider G, Sprenger GA, Samland AK, ChemCatChem 2015, 7, 3140
54. Half-of-the-Sites Reactivity of the Castor Δ9-18:0-Acyl Carrier Protein Desaturase.
Liu Q, Chai J, Moche M, Guy J, Lindqvist Y, Shanklin J
Plant Physiol 2015 Sep;169(1):432-41

53. Structure of the Glycosyltransferase Ktr4p from Saccharomyces cerevisiae.
Possner DD, Claesson M, Guy JE
PLoS One 2015 ;10(8):e0136239
52. Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.
Carter M, Jemth AS, Hagenkort A, Page BD, Gustafsson R, Griese JJ, Gad H, Valerie NC, Desroses M, Boström J, Warpman Berglund U, Helleday T, Stenmark P
Nat Commun 2015 Aug;6():7871

51Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation.
Tan TC, Kracher D, Gandini R, Sygmund C, Kittl R, Haltrich D, Hällberg BM, Ludwig R, Divne C
Nat Commun 2015 Jul;6():7542

50. Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate.
Trésaugues L, Lundbäck T, Welin M, Flodin S, Nyman T, Silvander C, Gräslund S, Nordlund P
PLoS One 2015 ;10(6):e0131507

49. Structure of the nuclease subunit of human mitochondrial RNase P.
Reinhard L, Sridhara S, Hällberg BM
Nucleic Acids Res 2015 Jun;43(11):5664-72

48. Crystal structures of the kinase domain of the sulfate-activating complex in Mycobacterium tuberculosis.
Poyraz Ö, Brunner K, Lohkamp B, Axelsson H, Hammarström LG, Schnell R, Schneider G
PLoS One 2015 ;10(3):e0121494

47. Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein.
Karlberg T, Klepsch M, Thorsell AG, Andersson CD, Linusson A, Schüler H
J Biol Chem 2015 Mar;290(12):7336-44

46. Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa.
Schmidberger JW, Schnell R, Schneider G
Acta Crystallogr D Biol Crystallogr 2015 Mar;71(Pt 3):721-31

45. High-resolution crystal structure of a polyextreme GH43 glycosidase from Halothermothrix orenii with α-L-arabinofuranosidase activity.
Hassan N, Kori LD, Gandini R, Patel BK, Divne C, Tan TC
Acta Crystallogr F Struct Biol Commun 2015 Mar;71(Pt 3):338-45

44. Biochemical and structural characterization of a thermostable β-glucosidase from Halothermothrix orenii for galacto-oligosaccharide synthesis.
Hassan N, Nguyen TH, Intanon M, Kori LD, Patel BK, Haltrich D, Divne C, Tan TC
Appl Microbiol Biotechnol 2015 Feb;99(4):1731-44


43. A novel cytosolic NADH:quinone oxidoreductase from Methanothermobacter marburgensis.
Ullmann E, Tan TC, Gundinger T, Herwig C, Divne C, Spadiut O
Biosci Rep 2014 Dec;34(6):e00167

42. Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme.
Dobritzsch D, Wang H, Schneider G, Yu S
Biochem J 2014 Sep;462(3):441-52

41. Structural basis for regulation of the human acetyl-CoA thioesterase 12 and interactions with the steroidogenic acute regulatory protein-related lipid transfer (START) domain.
Swarbrick CM, Roman N, Cowieson N, Patterson EI, Nanson J, Siponen MI, Berglund H, Lehtiö L, Forwood JK
J Biol Chem 2014 Aug;289(35):24263-74

40. Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.
Guettou F, Quistgaard EM, Raba M, Moberg P, Löw C, Nordlund P
Nat Struct Mol Biol 2014 Aug;21(8):728-31

39. Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family.
Pinto AF, Schüler H
Curr Top Microbiol Immunol 2015 ;384():153-66

38. Structural and biochemical characterization of human PR70 in isolation and in complex with the scaffolding subunit of protein phosphatase 2A.
Dovega R, Tsutakawa S, Quistgaard EM, Anandapadamanaban M, Löw C, Nordlund P
PLoS One 2014 ;9(7):e101846

37. Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.
Löw C, Quistgaard EM, Kovermann M, Anandapadamanaban M, Balbach J, Nordlund P
Biol Chem 2014 Jul;395(7-8):881-9

36. Crystal structure of human CRMP-4: correction of intensities for lattice-translocation disorder.
Ponnusamy R, Lebedev AA, Pahlow S, Lohkamp B
Acta Crystallogr D Biol Crystallogr 2014 Jun;70(Pt 6):1680-94

35. Structure and inhibition of mouse leukotriene C4 synthase.
Niegowski D, Kleinschmidt T, Ahmad S, Qureshi AA, Mårback M, Rinaldo-Matthis A, Haeggström JZ
PLoS One 2014 ;9(5):e96763

34. Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.
Trésaugues L, Silvander C, Flodin S, Welin M, Nyman T, Gräslund S, Hammarström M, Berglund H, Nordlund P
Structure 2014 May;22(5):744-55

33. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Gad H, Koolmeister T, Jemth AS, Eshtad S, Jacques SA, Ström CE, Svensson LM, Schultz N, Lundbäck T, Einarsdottir BO, Saleh A, Göktürk C, Baranczewski P, Svensson R, Berntsson RP, Gustafsson R, Strömberg K, Sanjiv K, Jacques-Cordonnier MC, Desroses M, Gustavsson AL, Olofsson R, Johansson F, Homan EJ, Loseva O, Bräutigam L, Johansson L, Höglund A, Hagenkort A, Pham T, Altun M, Gaugaz FZ, Vikingsson S, Evers B, Henriksson M, Vallin KS, Wallner OA, Hammarström LG, Wiita E, Almlöf I, Kalderén C, Axelsson H, Djureinovic T, Puigvert JC, Häggblad M, Jeppsson F, Martens U, Lundin C, Lundgren B, Granelli I, Jensen AJ, Artursson P, Nilsson JA, Stenmark P, Scobie M, Berglund UW, Helleday T
Nature 2014 Apr;508(7495):215-21

32. Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors.
Liscio P, Carotti A, Asciutti S, Karlberg T, Bellocchi D, Llacuna L, Macchiarulo A, Aaronson SA, Schüler H, Pellicciari R, Camaioni E
J Med Chem 2014 Mar;57(6):2807-12

31. Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.
Stsiapanava A, Olsson U, Wan M, Kleinschmidt T, Rutishauser D, Zubarev RA, Samuelsson B, Rinaldo-Matthis A, Haeggström JZ
Proc Natl Acad Sci U S A 2014 Mar;111(11):4227-32

30. Epitope-specific antibody response is controlled by immunoglobulin V(H) polymorphisms.
Raposo B, Dobritzsch D, Ge C, Ekman D, Xu B, Lindh I, Förster M, Uysal H, Nandakumar KS, Schneider G, Holmdahl R
J Exp Med 2014 Mar;211(3):405-11

29. ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics.
Marteyn BS, Karimova G, Fenton AK, Gazi AD, West N, Touqui L, Prevost MC, Betton JM, Poyraz O, Ladant D, Gerdes K, Sansonetti PJ, Tang CM
mBio 2014 Mar;5(2):e00022-14

28. Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism.
Niegowski D, Kleinschmidt T, Olsson U, Ahmad S, Rinaldo-Matthis A, Haeggström JZ
J Biol Chem 2014 Feb;289(8):5199-207

27. Structural and functional insights into peptidoglycan access for the lytic amidase LytA of Streptococcus pneumoniae.
Mellroth P, Sandalova T, Kikhney A, Vilaplana F, Hesek D, Lee M, Mobashery S, Normark S, Svergun D, Henriques-Normark B, Achour A
mBio 2014 Feb;5(1):e01120-13

26. Product formation controlled by substrate dynamics in leukotriene A4 hydrolase.
Stsiapanava A, Tholander F, Kumar RB, Qureshi AA, Niegowski D, Hasan M, Thunnissen M, Haeggström JZ, Rinaldo-Matthis A
Biochim Biophys Acta 2014 Feb;1844(2):439-46

25. Structural basis for binding of fluorinated glucose and galactose to Trametes multicolor pyranose 2-oxidase variants with improved galactose conversion.
Tan TC, Spadiut O, Gandini R, Haltrich D, Divne C
PLoS One 2014 ;9(1):e86736

24. The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold.
Schulte T, Löfling J, Mikaelsson C, Kikhney A, Hentrich K, Diamante A, Ebel C, Normark S, Svergun D, Henriques-Normark B, Achour A
Open Biol 2014 Jan;4():130090

23. RipD (Rv1566c) from Mycobacterium tuberculosis: adaptation of an NlpC/p60 domain to a non-catalytic peptidoglycan-binding function.
Böth D, Steiner EM, Izumi A, Schneider G, Schnell R
Biochem J 2014 Jan;457(1):33-41


22. Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3.
Lindgren AE, Karlberg T, Ekblad T, Spjut S, Thorsell AG, Andersson CD, Nhan TT, Hellsten V, Weigelt J, Linusson A, Schüler H, Elofsson M
J Med Chem 2013 Dec;56(23):9556-68

21. Discovery of an allosteric inhibitor binding site in 3-Oxo-acyl-ACP reductase from Pseudomonas aeruginosa.
Cukier CD, Hope AG, Elamin AA, Moynie L, Schnell R, Schach S, Kneuper H, Singh M, Naismith JH, Lindqvist Y, Gray DW, Schneider G
ACS Chem Biol 2013 Nov;8(11):2518-27

20. Substrate specificity and oligomerization of human GMP synthetase.
Welin M, Lehtiö L, Johansson A, Flodin S, Nyman T, Trésaugues L, Hammarström M, Gräslund S, Nordlund P
J Mol Biol 2013 Nov;425(22):4323-33

19. Metal-mediated crystallization of the xylose transporter XylE from Escherichia coli in three different crystal forms.
Quistgaard EM, Löw C, Moberg P, Nordlund P
J Struct Biol 2013 Nov;184(2):375-8

18. Nanobody mediated crystallization of an archeal mechanosensitive channel.
Löw C, Yau YH, Pardon E, Jegerschöld C, Wåhlin L, Quistgaard EM, Moberg P, Geifman-Shochat S, Steyaert J, Nordlund P
PLoS One 2013 ;8(10):e77984

17. Structural insights into substrate recognition in proton-dependent oligopeptide transporters.
Guettou F, Quistgaard EM, Trésaugues L, Moberg P, Jegerschöld C, Zhu L, Jong AJ, Nordlund P, Löw C
EMBO Rep 2013 Sep;14(9):804-10

16. PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.
Lindgren AE, Karlberg T, Thorsell AG, Hesse M, Spjut S, Ekblad T, Andersson CD, Pinto AF, Weigelt J, Hottiger MO, Linusson A, Elofsson M, Schüler H
ACS Chem Biol 2013 Aug;8(8):1698-703

15. Structural and biophysical characterization of the cytoplasmic domains of human BAP29 and BAP31.
Quistgaard EM, Löw C, Moberg P, Guettou F, Maddi K, Nordlund P
PLoS One 2013 ;8(8):e71111

14. High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation.
Anandapadamanaban M, Andresen C, Helander S, Ohyama Y, Siponen MI, Lundström P, Kokubo T, Ikura M, Moche M, Sunnerhagen M
Nat Struct Mol Biol 2013 Aug;20(8):1008-14

13. Enzymatic production of 'monoclonal stoichiometric' single-stranded DNA oligonucleotides.
Ducani C, Kaul C, Moche M, Shih WM, Högberg B
Nat Methods 2013 Jul;10(7):647-52

12. The crystal structure of the lumenal domain of Erv41p, a protein involved in transport between the endoplasmic reticulum and Golgi apparatus.
Biterova EI, Svärd M, Possner DD, Guy JE
J Mol Biol 2013 Jun;425(12):2208-18

11. Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct Substrates.
Chen MW, Lohkamp B, Schnell R, Lescar J, Schneider G
PLoS One 2013 ;8(6):e66936

10. Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters.
Quistgaard EM, Löw C, Moberg P, Trésaugues L, Nordlund P
Nat Struct Mol Biol 2013 Jun;20(6):766-8

9. Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase.
Lim SM, Chen D, Teo H, Roos A, Jansson AE, Nyman T, Trésaugues L, Pervushin K, Nordlund P
J Lipid Res 2013 Jun;54(6):1630-43

8. Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains.
Forst AH, Karlberg T, Herzog N, Thorsell AG, Gross A, Feijs KL, Verheugd P, Kursula P, Nijmeijer B, Kremmer E, Kleine H, Ladurner AG, Schüler H, Lüscher B
Structure 2013 Mar;21(3):462-75

7. Structure of LdtMt2, an L,D-transpeptidase from Mycobacterium tuberculosis.
Böth D, Steiner EM, Stadler D, Lindqvist Y, Schnell R, Schneider G
Acta Crystallogr D Biol Crystallogr 2013 Mar;69(Pt 3):432-41


6. Unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics.
Allerbring EB, Duru AD, Uchtenhagen H, Madhurantakam C, Tomek MB, Grimm S, Mazumdar PA, Friemann R, Uhlin M, Sandalova T, Nygren PÅ, Achour A
Eur J Immunol 2012 Nov;42(11):2990-3000

5. High-resolution insights into binding of unfolded polypeptides by the PPIase chaperone SlpA.
Quistgaard EM, Nordlund P, Löw C
FASEB J 2012 Oct;26(10):4003-13

4. Discovery of ligands for ADP-ribosyltransferases via docking-based virtual screening.
Andersson CD, Karlberg T, Ekblad T, Lindgren AE, Thorsell AG, Spjut S, Uciechowska U, Niemiec MS, Wittung-Stafshede P, Weigelt J, Elofsson M, Schüler H, Linusson A
J Med Chem 2012 Sep;55(17):7706-18

3. Inflammation-associated nitrotyrosination affects TCR recognition through reduced stability and alteration of the molecular surface of the MHC complex.
Madhurantakam C, Duru AD, Sandalova T, Webb JR, Achour A
PLoS One 2012 ;7(3):e32805

2. Tetrahydrodipicolinate N-succinyltransferase and dihydrodipicolinate synthase from Pseudomonas aeruginosa: structure analysis and gene deletion.
Schnell R, Oehlmann W, Sandalova T, Braun Y, Huck C, Maringer M, Singh M, Schneider G
PLoS One 2012 ;7(2):e31133

1. High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C.
Willander H, Askarieh G, Landreh M, Westermark P, Nordling K, Keränen H, Hermansson E, Hamvas A, Nogee LM, Bergman T, Saenz A, Casals C, Åqvistg J, Jörnvall H, Berglund H, Presto J, Knight SD, Johansson J
Proc Natl Acad Sci U S A 2012 Feb;109(7):2325-9