Project: Gender differences in carcinogenesis
In this project we investigate sex differences in response to carcinogens. A main objective is to identify chemicals exhibiting sexual dimorphism in their response. Another objective is to identify mode of action for these chemicals. Of special interest is oxidative stress and male susceptibility to carcinogens.
- The Swedish research Council for Environment Agricultural Sciences and Spatial Planning (FORMAS)
TGF beta promotes repair of bulky DNA damage through increased ERCC1/XPF and ERCC1/XPA interaction.
Zheng H, Jarvis IWH, Bottai M, Dreij K, Stenius U
Carcinogenesis 2019 Jun;40(4):580-591
Gender differences in cancer susceptibility: role of oxidative stress.
Ali I, Högberg J, Hsieh J, Auerbach S, Korhonen A, Stenius U, et al
Carcinogenesis 2016 Oct;37(10):985-992
Gender differences in chemical carcinogenesis in National Toxicology Program 2-year bioassays.
Kadekar S, Peddada S, Silins I, French J, Högberg J, Stenius U
Toxicol Pathol 2012 Dec;40(8):1160-8