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Health effects of air pollution

Projects at the Unit of Environmental Epidemiology, Institute of Environmental Medicine (IMM)

Traffic-related air pollution in relation to respiratory and other health effects from infancy to adulthood

The main objective of the project is to study adverse health effects in children, adolescents and young adults related to exposure to air pollution from traffic. A particular aim is to try to disentangle effects of exposure to exhaust emissions, such as ultrafine particles, from those related to coarse particles resulting from road and tire wear. Health effects of interest include wheezing, asthma, allergic sensitization, disturbances of lung function and psychiatric disorders. It is based on several birth cohorts, including BAMSE, EMIL and Born-into-Life. A special feature of the study is the longitudinal prospective follow-up of the study subjects from birth with repeated questionnaires and clinical tests, including blood samples and lung function measurements. Furthermore, a methodology has been developed for detailed individual assessment of exposure to various air pollution components based on longitudinal information regarding addresses of homes, day care centers and schools as well as on emission data bases and dispersion modeling. The combination of longitudinal information on exposure and various health outcomes from birth until adulthood and detailed air pollution exposure assessment based on residential as well as other relevant addresses makes this project unique in the world.

Financing

  • Swedish Research Council
  • Swedish Research Council FORMAS

Contact person

Professor/överläkare

Göran Pershagen

Telefon: 08-524 874 60
Enhet: Miljömedicinsk epidemiologi
E-post: Goran.Pershagen@ki.se

Docent

Erik Melén

Telefon: 08-524 875 08
Enhet: Miljömedicinsk epidemiologi
E-post: Erik.Melen@ki.se

Forskarassistent

Olena Gruzieva

Enhet: Institutet för miljömedicin (IMM), C6
E-post: olena.gruzieva@ki.se

Publications

25061921

24948353

25229653

24094547

25036432

24149084

27057569

26011717

25323237

27494442

26068947

26397124

27297996


Health effects of air pollution from different sources in relation to cardiovascular and metabolic diseases as well as cancer

Large parts of the population are exposed to increased levels of ambient air pollution, particularly in urban areas. Long-term exposure to air pollution can cause severe health effects, such as respiratory, cardiovascular and/or metabolic diseases. In this project we will significantly strengthen the basis for the risk assessment using data from a number of adult cohorts based in Stockholm county. Individual long-term exposure to air pollutants from different sources is estimated for the cohort members using models with high spatial resolution. Exposure-response relationships will then be assessed for several adverse health outcomes, including hypertension, ischemic heart disease, stroke, various types of cancer, overweight and type 2 diabetes. This will be combined with detailed data on population exposures to calculate the number of cases attributable to air pollution exposure. The role of gender and socioeconomic status is also assessed. It is expected that the results will provide important guidance for prioritization of preventive measures as well as for health sustainable urban development.

Financing

  • European Union
  • Swedish Environmental Protection Agency
  • US Health Effects Institute

Contact persons

Professor/överläkare

Göran Pershagen

Telefon: 08-524 874 60
Enhet: Miljömedicinsk epidemiologi
E-post: Goran.Pershagen@ki.se

Professor, senior

Tom Bellander

Telefon: 08-524 800 03
Enhet: Miljömedicinsk epidemiologi
E-post: Tom.Bellander@ki.se

Anknuten

Petter Ljungman

Enhet: Miljömedicinsk epidemiologi
E-post: Petter.Ljungman@ki.se

Publications

23849838

24452269

25233102

24835507

24598414

24835336

24561271

25712504

26057255

25827311

25816055

25625785

25643114

26342569

25978793

27485990

26046983

26641521


DANTE Device detected atrial fibrillation and environmental exposures

We investigate how short-term and long-term air pollution may trigger or increase the burden of paroxysmal atrial fibrillation in patient with pacemaker devices.

Financing

  • The Swedish Research Council for Health Working Life and Welfare

Contact person

Anknuten

Petter Ljungman

Enhet: Miljömedicinsk epidemiologi
E-post: Petter.Ljungman@ki.se

Airrest II Air polllution and cardiac arrest

We are investigating how short-term exposure to air pollution may trigger cardiac arrest using an ongoing cardiac arrest registry in Sweden. The potential effect modification by previous hospitalization will also be examined.

Financing

  • The Swedish Research Council for Health Working Life and Welfare

Contact person

Anknuten

Petter Ljungman

Enhet: Miljömedicinsk epidemiologi
E-post: Petter.Ljungman@ki.se


AIRFIB Air pollution and atrial fibrillation

Using a large-scale screening study for paroxysmal atrial fibrillation in 75 year olds in Stockholm, we are investigating associations between short-term air pollution exposure and onset of atrial fibrillation.

Financing

  • Swedish Society for Medical Research

Contact persons

Anknuten

Petter Ljungman

Enhet: Miljömedicinsk epidemiologi
E-post: Petter.Ljungman@ki.se

Forskarstuderande

Marcus Dahlquist

Enhet: Miljömedicinsk epidemiologi
E-post: marcus.dahlquist@ki.se