PreMOF: predicting organ failure using metabolomics

Aim

To use metabolomics to predict the development of organ failure.

Description

In this project we used several large cohorts (sepsis, trauma, ICU and pediatric IVA) to identify a metabolite finger print that can predict in the early stages whether patients are likely to develop organ failure. We are collaborating with the Swedih Metabolomics Center in Umeå for the analyses.

Main results and publications

It is very early days for this project, but preliminary analyses on 100 ICU patients show promising results that there might be a cluster of metabolites that predicts the worsening of organ failure. More to follow in the coming years

Collaborators

Olav Rooyackers (KI),
Johan Helleberg (SLL),
Swedish Metabolomics Core (LINK),
Anders Oldner (KI),
Kristofer Strålin (KI),
Anna Norrby-Tegelund (KI),
Eric Rullman (KI)

Funding

Region Stockholm (ALF project funding)