Olav Rooijackers
Professor | Docent
E-mail: olav.rooyackers@ki.se
Visiting address: Universitetssjukhuset Huddinge Hälsovägen, Enheten för anestesi K32, 14186 Stockholm
Postal address: H9 Klinisk vetenskap, intervention och teknik, H9 CLINTEC Anestesi, 141 52 Huddinge
About me
- I am a trained biologist, or more accurate animal physiologist from the Agricultural University in Wageningen (NL). I have a PhD in clinical nutrition from the University of Maastricht (NL). After that I did 2 postdoc fellowships
- one at the Endocrine Research Unit at the Mayo Clinic in Rochester, Minnesota (USA) and one at the Department of Medicine at the University of Edinburgh (UK).
In January 2000 I joined the current research group at Karolinska Institutet (KI) and located at the Department of Perioperative Medicine and Intensive Care (PMI) at Karolinska Unversity Hospital in Flemingsberg. I started here as a assistent professor and head of the analytical lab. Presently I am a professor in experimental anesthesiology and intensive care and together with Professor Jan Wernerman run the ICU metabolism research group (see www.icu.metabolism.se). In addition, I am head of the Division of Anaesthesia and Intensive Care at the Department of Clinical Research, Intervention and Technology (CLINTEC) at KI, director of doctoral studies at CLINTEC, treasurer of the Swedish Society of Clinical Nutrition and Metabolism (SWESPEN) and head of the Clinical Research Facility at the function PMI at Karolinska University Hospital in Flemingsberg.
Research
- The research me and the research group are involved in is to study the metabolic and nutritional problems of critically ill patients. We mainly perform smaller mechanistic physiological studies, but also perfrom smaller intervention studies to elucidate how interventions actually work. The research group is run by me Associate Professor Åke Norberg and Senior Professor Jan Wernerman and includes clinical researchers (from students up to consultants), basic researchers (from exchange students to associate professors) technical staff and research nurses. Part of metabolism we focus on are:
- Why do critically ill patients waste muscle mass and function so fast?
- Why are plasma glutamine levels sometime high and sometime low in critically ill patients and how do they handle extra glutamine?
- How much nutritional protein is beneficial for critically ill patients?
- What is causing high lactate levels during sepsis and is this a problem?
- Were does plasma albumin go when we are ill and especially when we are critically ill?
- Can we use metabolomics to predict the development of organ failure in patients with an acute severe insult?
- Can agressive early nutrition prolong organ failure by inhibiting autophagy?
Details on projects and links to publications can be found on our research group's website.
Teaching
- My teaching activities are mainly at the postgraduate level. I am involved in a local course in researcher and research ethics and my main interest in this course is the researcher ethics
- how should be behave us as researchers? Ocassionally I organise a course in Clinical Techniques in the study of Endocrine and Metabolic Disorders
- a course that teaches different techniques and approaches to study human subjects and patients.
I am the co-organiser of a International course in Tracer Methodology in Clinical Nutrition and Metabolism. This is an intensive course taking place ones a year in a weekend to teach on the usage of stable isotope labelled metabolites to quantify metabolic fluxes in vivo in humans. For more information look at our website (http://icu-metabolism.se/tracers.html)
Articles
- Article: JOURNAL OF INFECTIOUS DISEASES. 2024;230(2):e318-e326
- Article: DIABETES TECHNOLOGY & THERAPEUTICS. 2024
- Article: JOURNAL OF PARENTERAL AND ENTERAL NUTRITION. 2024;48(4):421-428
- Article: INTENSIVE CARE MEDICINE. 2024;50(5):678-686
- Article: JOURNAL OF IMMUNOLOGY. 2024;212(3):389-396
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 2023;325(5):G391-G397
- Article: RESPIRATORY RESEARCH. 2023;24(1):62
- Article: JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 2022;13(5):2551-2561
- Article: NUTRIENTS. 2022;14(18):3733
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(1):e13195
- Article: CRITICAL CARE. 2022;26(1):143
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(3):503-510
- Article: PLOS ONE. 2022;17(10):e0276775
- Article: LAKARTIDNINGEN. 2021;118:21163
- Journal article: CLINICAL NUTRITION ESPEN. 2021;46:s644
- Journal article: CLINICAL NUTRITION ESPEN. 2021;46:s642
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118
- Article: CLINICAL NUTRITION ESPEN. 2021;45:322-332
- Article: CLINICAL NUTRITION. 2021;40(8):4932-4940
- Article: CRITICAL CARE. 2021;25(1):240
- Article: CLINICAL NUTRITION. 2021;40(7):4526-4534
- Article: CLINICAL NUTRITION ESPEN. 2021;43:104-110
- Article: MOLECULAR THERAPY. 2021;29(5):1903-1917
- Article: CLINICAL NUTRITION. 2021;40(3):912-918
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(3):1217
- Article: TRANSPLANTATION PROCEEDINGS. 2021;53(1):130-135
- Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306
- Article: CLINICAL NUTRITION ESPEN. 2020;40:226-230
- Article: CELL. 2020;183(1):158-168.e14
- Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670
- Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832
- Article: CRITICAL CARE. 2020;24(1):46
- Article: CELL METABOLISM. 2020;31(2):375-390.e11
- Article: PLOS ONE. 2020;15(10):e0240045
- Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2020;9(12):e1224
- Article: TRANSPLANTATION DIRECT. 2019;5(12):e505
- Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2019;63(7):885-894
- Article: SCIENTIFIC REPORTS. 2019;9(1):10762
- Article: CLINICAL NUTRITION. 2018;37(4):1399-1405
- Article: CRITICAL CARE. 2018;22(1):152
- Article: CRITICAL CARE. 2018;22(1):13
- Article: CRITICAL CARE. 2017;21(1):298
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2017;123(6):1501-1515
- Article: JOURNAL OF PARENTERAL AND ENTERAL NUTRITION. 2017;41(6):976-980
- Article: CLINICAL NUTRITION. 2017;36(2):429-437
- Article: CLINICAL NUTRITION. 2017;36(1):186-190
- Article: FRONTIERS IN ENDOCRINOLOGY. 2017;8:229
- Article: PLOS ONE. 2017;12(3):e0174611
- Article: INTENSIVE CARE MEDICINE EXPERIMENTAL. 2016;4(1):20
- Article: CRITICAL CARE. 2016;20(1):370
- Journal article: INTENSIVE CARE MEDICINE EXPERIMENTAL. 2016;4(Suppl 1):27
- Journal article: INTENSIVE CARE MEDICINE EXPERIMENTAL. 2016;4(Suppl 1):30
- Article: OBESITY SURGERY. 2016;26(7):1391-1397
- Article: CRITICAL CARE. 2016;20(1):113
- Article: PLOS ONE. 2016;11(3):e0150440
- Journal article: INTENSIVE CARE MEDICINE EXPERIMENTAL. 2015;3(Suppl 1):a623
- Journal article: INTENSIVE CARE MEDICINE EXPERIMENTAL. 2015;3(Suppl 1):a190
- Journal article: INTENSIVE CARE MEDICINE EXPERIMENTAL. 2015;3(Suppl 1):a179
- Journal article: INTENSIVE CARE MEDICINE EXPERIMENTAL. 2015;3(Suppl 1):a42
- Journal article: INTENSIVE CARE MEDICINE EXPERIMENTAL. 2015;3(Suppl 1):a286
- Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2015;59(10):1311-1318
- Journal article: CLINICAL NUTRITION. 2015;34:s35
- Article: CLINICAL SCIENCE. 2015;129(4):375-384
- Article: BRITISH JOURNAL OF SURGERY. 2015;102(7):767-775
- Article: CRITICAL CARE. 2015;19(1):106
- Article: AMINO ACIDS. 2015;47(3):535-542
- Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2015;101(3):549-557
- Article: CLINICAL NUTRITION. 2015;34(1):95-100
- Article: PLOS ONE. 2015;10(8):e0136371
- Article: CRITICAL CARE. 2014;18(6):677
- Article: CLINICAL NUTRITION. 2014;33(5):802-807
- Journal article: PEDIATRIC CRITICAL CARE MEDICINE. 2014;15(4_suppl):143
- Article: PEDIATRIC CRITICAL CARE MEDICINE. 2014;15(4):314-328
- Article: CRITICAL CARE. 2014;18(2):r72
- Article: PLOS ONE. 2014;9(5):e96601
- Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2013;98(6):1485-1492
- Article: PHYSIOLOGICAL REPORTS. 2013;1(5):e00076
- Article: CRITICAL CARE. 2013;17(4):R158
- Article: CRITICAL CARE. 2013;17(3):R87
- Journal article: CRITICAL CARE. 2013;17(Suppl 2):p243
- Journal article: CRITICAL CARE. 2013;17(Suppl 2):p251
- Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2013;57(2):214-219
- Article: CLINICAL NUTRITION. 2012;31(5):676-681
- Article: JOURNAL OF PARENTERAL AND ENTERAL NUTRITION. 2012;36(5):556-561
- Article: ACTA PHYSIOLOGICA. 2012;205(3):411-422
- Article: CLINICAL SCIENCE. 2012;122(11-12):591-597
- Article: SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS. 2012;22(3):399-409
- Journal article: CLINICAL NUTRITION ESPEN. 2012;7(1):e54-e55
- Article: CLINICAL SCIENCE. 2012;122(3-4):133-142
- Article: BRITISH JOURNAL OF ANAESTHESIA. 2012;108(2):254-261
- Article: ACTA PHYSIOLOGICA. 2011;202(2):175-184
- Article: OBESITY FACTS. 2010;3(6):371-375
- Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2010;54(7):841-847
- Article: GENOME MEDICINE. 2010;2(1):1
- Article: CLINICAL SCIENCE. 2009;118(5-6):421-427
- Article: JOURNAL OF LIPID RESEARCH. 2009;50(11):2258-2264
- Article: CLINICAL SCIENCE. 2009;117(9-10):339-344
- Article: CLINICAL SCIENCE. 2009;117(9-10):313-319
- Journal article: CLINICAL NUTRITION ESPEN. 2009;4(4):e206-e207
- Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2009;53(6):717-723
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2009;106(5):1479-1486
- Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2009;53(3):299-304
- Journal article: PLOS ONE. 2008;3(12):10.1371/annotation/68d951
- Article: CLINICAL NUTRITION. 2008;27(6):816-821
- Journal article: CLINICAL NUTRITION ESPEN. 2008;3(1):e29-e31
- Article: PLOS ONE. 2008;3(11):e3686
- Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2007;27(6):589-597
- Article: CLINICAL SCIENCE. 2007;113(7-8):313-318
- Article: CRITICAL CARE MEDICINE. 2007;35(9):S449-S453
- Article: CLINICAL SCIENCE. 2007;112(9-10):499-506
- Article: INTENSIVE CARE MEDICINE. 2007;33(4):660-666
- Article: JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY. 2007;14(2):183-188
- Article: BMC GENOMICS. 2007;8:74
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2006;101(6):1576-1580
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2006;291(5):E1044-E1050
- Article: INTENSIVE CARE MEDICINE. 2006;32(11):1741-1746
- Article: CLINICAL SCIENCE. 2006;110(1):93-99
- Article: AMINO ACIDS. 2005;29(3):221-228
- Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2005;49(8):1101-1107
- Article: INTENSIVE CARE MEDICINE. 2005;31(8):1072-1078
- Article: CLINICAL SCIENCE. 2005;108(2):179-184
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2005;288(2):E360-E364
- Article: CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 2005;8(1):77-82
- Article: CLINICAL SCIENCE. 2004;107(6):601-607
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2004;89(11):5382-5386
- Article: CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 2004;7(5):515-521
- Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2004;53(8):1076-1080
- Article: CLINICAL NUTRITION. 2004;23(4):743-752
- Article: INTENSIVE CARE MEDICINE. 2004;30(2):266-275
- Article: INTENSIVE CARE MEDICINE. 2003;29(12):2193-2198
- Journal article: CLINICAL NUTRITION. 2003;22:s44
- Journal article: CLINICAL NUTRITION. 2003;22:s48
- Journal article: CLINICAL NUTRITION. 2003;22:s45
- Journal article: CLINICAL NUTRITION. 2003;22:s43
- Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2003;446(2):261-269
- Journal article: CLINICAL SCIENCE. 2003;104(3):275-282
- Article: CLINICAL SCIENCE. 2003;104(3):275-282
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2003;88(1):285-291
- Article: CLINICAL NUTRITION. 2002;21(6):505-514
- Article: JOURNAL OF INHERITED METABOLIC DISEASE. 2002;25(7):577-584
- Article: DIABETES. 2002;51(7):2074-2081
- Article: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY. 2000;82(5-6):493-498
- Article: JOURNAL OF PHYSIOLOGY-LONDON. 2000;525 Pt 1(Pt 1):271-281
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 1998;85(5):1744-1752
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1997;273(4):E790-E800
- Article: CLINICAL SCIENCE. 1997;92(2):189-195
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996;93(26):15364-15369
- Article: CLINICAL SCIENCE. 1996;91(4):475-481
- Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 1996;45(10):1279-1283
- Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1996;1315(1):55-60
- Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 1995;25(8):548-552
- Article: CLINICAL NUTRITION. 1995;14(2):105-115
- Journal article: CLINICAL SCIENCE. 1994;87(5):619-626
- Journal article: CLINICAL NUTRITION. 1994;13(1):54-55
- Journal article: CLINICAL NUTRITION. 1994;13:6
- Journal article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 1993;57(5):s824-824S
- Journal article: CLINICAL NUTRITION. 1993;12:5
- Journal article: CLINICAL NUTRITION. 1993;12:62-63
- Journal article: CLINICAL NUTRITION. 1993;12:20-21
- Journal article: CLINICAL NUTRITION. 1992;11:58-59
- Journal article: CLINICAL NUTRITION. 1992;11:58
- Journal article: CLINICAL NUTRITION. 1992;11:58
- Journal article: CLINICAL NUTRITION. 1992;11:2-3
- Journal article: CLINICAL NUTRITION. 1991;10:40
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All other publications
- Letter: NATURE. 2023;621(7977):E7-E26
- Review: CRITICAL CARE. 2023;27(1):258
- Conference publication: TRANSPLANTATION. 2023;107(9):108-109
- Editorial comment: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022;206(6):660-661
- Editorial comment: NATURE. 2022;608(7921):E1-E10
- Review: CURRENT OPINION IN CRITICAL CARE. 2022;28(4):367-373
- Editorial comment: NATURE IMMUNOLOGY. 2022;23(6):861-864
- Review: CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 2022;25(2):88-92
- Review: CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 2021;24(1):71-78
- Preprint: RESEARCH SQUARE. 2020
- Review: CRITICAL CARE. 2019;23(1):318
- Letter: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2019;317(3):E433-E434
- Meeting abstract: JOURNAL OF HEPATOLOGY. 2019;70(1):E593
- Review: CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 2019;22(2):146-151
- Corrigendum: CLINICAL NUTRITION. 2018;37(3):1091
- Review: CURRENT OPINION IN CRITICAL CARE. 2017;23(4):264-268
- Editorial comment: CRITICAL CARE. 2017;21(1):106
- Review: CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 2017;20(3):181-185
- Published conference paper: JOURNAL OF PARENTERAL AND ENTERAL NUTRITION. 2017;41(2):208-216
- Editorial comment: CLINICAL NUTRITION. 2016;35(3):543-544
- Review: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 2016;54:92-103
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2016;48(5):5
- Review: CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 2016;19(2):120-124
- Book chapter: THE STRESS RESPONSE OF CRITICAL ILLNESS: METABOLIC AND HORMONAL ASPECTS. 2016;p. 27-43
- Editorial comment: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2015;59(6):683-684
- Conference publication: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2015;59:51
- Book chapter: ANNUAL UPDATE IN INTENSIVE CARE AND EMERGENCY MEDICINE 2015: ANNUAL UPDATE IN INTENSIVE CARE AND EMERGENCY MEDICINE. 2015;p. 459-468
- Review: APPLIED PHYSIOLOGY NUTRITION AND METABOLISM. 2015;40(1):1-9
- Letter: PEDIATRIC CRITICAL CARE MEDICINE. 2014;15(8):793-794
- Review: CRITICAL CARE. 2014;18(3):226
- Editorial comment: CRITICAL CARE. 2014;18(3):144
- Conference publication: ACTA PHYSIOLOGICA. 2014;211:75
- Editorial comment: CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 2014;17(1):59-60
- Conference publication: FASEB JOURNAL. 2013;27:1073.6
- Published conference paper: CLINICAL NUTRITION. 2013;32(1):118-121
- Editorial comment: CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 2013;16(1):56
- Conference publication: INTENSIVE CARE MEDICINE. 2012;38:S19-S20
- Conference publication: INTENSIVE CARE MEDICINE. 2012;38:S130
- Editorial comment: CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 2012;15(1):47-48
- Conference publication: INTENSIVE CARE MEDICINE. 2011;37:S107
- Conference publication: INTENSIVE CARE MEDICINE. 2011;37:S169
- Conference publication: INTENSIVE CARE MEDICINE. 2011;37:S99
- Conference publication: FASEB JOURNAL. 2010;24:lb273
- Conference publication: BRITISH JOURNAL OF SURGERY. 2010;97:5
- Conference publication: INTENSIVE CARE MEDICINE. 2010;36:S407
- Conference publication: INTENSIVE CARE MEDICINE. 2009;35:121
- Conference publication: INTENSIVE CARE MEDICINE. 2009;35:167
- Book chapter: INTENSIVE CARE MEDICINE. 2009;p. 705-715
- Book chapter: YEARBOOK OF INTENSIVE CARE AND EMERGENCY MEDICINE. 2009;p. 705-715
- Review: BRITISH JOURNAL OF SURGERY. 2007;94(11):1342-1350
- Book chapter: MECHANISMS OF SEPSIS-INDUCED ORGAN DYSFUNCTION AND RECOVERY: UPDATE IN INTENSIVE CARE AND EMERGENCY MEDICINE. 2007;p. 311-320
- Conference publication: FASEB JOURNAL. 2006;20(4):A187
- Book chapter: INTENSIVE CARE MEDICINE. 2006;p. 52-67
- Book chapter: YEARBOOK OF INTENSIVE CARE AND EMERGENCY MEDICINE: ANNUAL UPDATE IN INTENSIVE CARE AND EMERGENCY MEDICINE. 2006;p. 52-67
- Other: CLINICAL NUTRITION. 2003;22(4):423
- Other: CLINICAL NUTRITION. 2002;21(3):265-266
- Other: CLINICAL NUTRITION. 2001;20(1):93
- Editorial comment: CLINICAL NUTRITION. 2000;19(3):145-146
- Review: ANNUAL REVIEW OF NUTRITION. 1997;17:457-485
- Published conference paper: MUSCLE & NERVE. 1997;5:S93-S96
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Grants
- Swedish Research Council1 January 2010 - 31 December 2012
Employments
- Professor, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2012-
Degrees and Education
- Docent, Karolinska Institutet, 2002