Publikationer EIMS

Här finns länkar till våra forskningsresultat. Resultaten publiceras främst i vetenskapliga tidskrifter men ibland når de även ut i pressen, då ofta som bra och kortfattade populärvetenskapliga versioner av våra viktigaste fynd.

Kronologisk publiceringslista

2021

Higher body mass index at ages 16 to 20 years is associated with increased risk of a multiple sclerosis diagnosis in subsequent adulthood among men

Xu Y, Hiyoshi A, Brand JS, Smith KA, Bahmanyar S, Alfredsson L, Olsson T, Montgomery S.
Mult Scler. 2021 Jan;27(1):147-150. doi: 10.1177/1352458520928061. Epub 2020 Jun 8. PMID: 32507076.
 

DRB1-environment interactions in multiple sclerosis etiology: results from two Swedish case-control studies

Hedström AK, Hillert J, Brenner N, Butt J, Waterboer T, Strid P, Kockum I, Olsson T, Alfredsson L.
J Neurol Neurosurg Psychiatry. 2021 Mar 9:jnnp-2020-325676. doi: 10.1136/jnnp-2020-325676. Online ahead of print. PMID:33687974.

2020

Confounding effect of blood volume and body mass index on blood neurofilament light chain levels

Manouchehrinia A, Piehl F, Hillert J, Kuhle J, Alfredsson L, Olsson T, Kockum I.
Ann Clin Transl Neurol. 2020 Jan;7(1):139-143.  doi: 10.1002/acn3.50972. Epub 2020 Jan 1. PMID:31893563.

 

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

International Multiple Sclerosis Genetics Consortium. Electronic address: chris.cotsapas@yale.edu; International Multiple Sclerosis Genetics Consortium. Cell. 2020 Jan 23;180(2):403. doi: 10.1016/j.cell.2020.01.002. No abstract available. PMID:31978348.

High Levels of Epstein-Barr Virus Nuclear Antigen-1-Specific Antibodies and Infectious Mononucleosis Act Both Independently and Synergistically to Increase Multiple Sclerosis Risk

Hedström AK, Huang J, Michel A, Butt J, Brenner N, Hillert J, Waterboer T, Kockum I, Olsson T, Alfredsson L.
Front Neurol. 2020 Jan 24;10:1368. doi: 10.3389/fneur.2019.01368. eCollection 2019. PMID:32038456.

 

Blood neurofilament light levels segregate treatment effects in multiple sclerosis

Delcoigne B, Manouchehrinia A, Barro C, Benkert P, Michalak Z, Kappos L, Leppert D, Tsai JA, Plavina T, Kieseier BC, Lycke J, Alfredsson L, Kockum I, Kuhle J, Olsson T, Piehl F.
Neurology. 2020 Mar 17;94(11):e1201-e1212. doi: 10.1212/WNL.0000000000009097. Epub 2020 Feb 11. PMID:32047070.

 

Low fish consumption is associated with a small increased risk of MS

Hedström AK, Olsson T, Kockum I, Hillert J, Alfredsson L.
Neurol Neuroimmunol Neuroinflamm. 2020 Apr 10;7(3). pii: e717. doi: 10.1212/NXI.0000000000000717. Print 2020 May. PMID:32277017.

 

Low sun exposure increases multiple sclerosis risk both directly and indirectly

Hedström AK, Olsson T, Kockum I, Hillert J, Alfredsson L.
J Neurol. 2020 Apr;267(4):1045-1052. doi: 10.1007/s00415-019-09677-3. Epub 2019 Dec 17.PMID: 31844981.

 

Plasma neurofilament light levels are associated with risk of disability in multiple sclerosis

Manouchehrinia A, Stridh P, Khademi M, Leppert D, Barro C, Michalak Z, Benkert P, Lycke J, Alfredsson L, Kappos L, Piehl F, Olsson T, Kuhle J, Kockum I. Neurology. 2020 May 20:10.1212/WNL.0000000000009571. doi: 10.1212/WNL.0000000000009571.

 

Breastfeeding is associated with reduced risk of multiple sclerosis in males, predominantly among HLA-DRB1*15:01 carriers

Hedström AK, Adams C, Shao X, Schaefer C, Olsson T, Barcellos LF, Alfredsson L.
Mult Scler J Exp Transl Clin. 2020 Jun 1;6(2):2055217320928101. doi: 10.1177/2055217320928101. eCollection 2020 Apr-Jun. PMID: 32728476. 

 

Hospital diagnosed pneumonia before age 20 years and multiple sclerosis risk

Smith KA, Hiyoshi A, Burkill S, Bahmanyar S, Öckinger J, Alfredsson L, Olsson T, Montgomery S.
BMJ Neurol Open. 2020 Jun 16;2(1):e000044. doi: 10.1136/bmjno-2020-000044. eCollection 2020. PMID: 33681783. 

 

Smoking and Epstein-Barr virus infection in multiple sclerosis development

Hedström AK, Huang J, Brenner N, Butt J, Hillert J, Waterboer T, Kockum I, Olsson T, Alfredsson .
Sci Rep. 2020 Jul 3;10(1):10960. doi: 10.1038/s41598-020-67883-w. PMID: 32620875.

 

Stressful life events are associated with the risk of multiple sclerosis

Jiang X, Olsson T, Hillert J, Kockum I, Alfredsson L.
Eur J Neurol. 2020 Dec;27(12):2539-2548. doi:10.1111/ene.14458. Epub 2020 Aug 23. PMID: 32741033.

 

The DQB1*03:02 genotype and treatment for pain in people with and without Multiple Sclerosis

Burkill S, Smith KA, Stridh P, Kockum I, Hillert J, Lindahl H, Alfredsson L, Olsson T, Piehl F, Montgomery S, Bahmanyar S.
Front Neurol. 2020 Sep 4;11:993. doi: 10.3389/fneur.2020.00993. eCollection 2020.PMID: 33013655.

 

Perceived cognitive impairment is associated with sexual dysfunction in people with multiple sclerosis: A 2.5-year follow-up study of a large international cohort

Wu J, Jelinek GA, Weiland T, Hedström AK, Alfredsson L, Neate S, De Livera A, Nag N, Simpson-Yap S.
Mult Scler Relat Disord. 2020 Oct;45:102410. doi: 10.1016/j.msard.2020.102410. Epub 2020 Jul 17. PMID: 32736213.

 

Pregnancy does not modify risk of multiple sclerosis in genetically susceptible women

Adams CJ, Wu SL, Shao X, Bradshaw PT, Gonzales E, Smith JB, Xiang AH, Bellesis KH, Chinn T, Bos SD, Wendel-Haga M, Olsson T, Kockum I, Langer-Gould AM, Schaefer C, Alfredsson L, Barcellos LF.
Neurol Neuroimmunol Neuroinflamm. 2020 Oct 9;7(6):e898. doi: 10.1212/NXI.0000000000000898. Print 2020 Nov. PMID: 33037103.

 

The influence of human leukocyte antigen-DRB1*15:01 and its interaction with smoking in MS development is dependent on DQA1*01:01 status

Hedström AK, Hössjer O, Hillert J, Stridh P, Kockum I, Olsson T, Alfredsson L.
Mult Scler. 2020 Nov;26(13):1638-1646. doi: 10.1177/1352458519877685. Epub 2019 Oct 1. PMID:31573825.

 

Cotinine as a measure of smoking in observational studies of multiple sclerosis

Hedström AK, Olsson T, Alfredsson L.
Mult Scler. 2020 Nov 10:1352458520968803. doi: 10.1177/1352458520968803. Online ahead of print. PMID: 33170069.

 

Overweight/obesity in young adulthood interacts with aspects of EBV infection in MS etiology

Hedström AK, Brenner N, Butt J, Hillert J, Waterboer T, Olsson T, Alfredsson L.
Neurol Neuroimmunol Neuroinflamm. 2020 Dec 15;8(1):e912. doi: 10.1212/NXI.0000000000000912. Print 2021 Jan. PMID: 33465039.

2019

Lifestyle and Environmental Factors in Multiple Sclerosis

Alfredsson L, Olsson T. Lifestyle and Environmental Factors in Multiple Sclerosis. Cold Spring Harb Perspect Med. 2019 Apr 1;9(4). pii: a028944. doi: 10.1101/cshperspect.a028944.
 

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

International Multiple Sclerosis Genetics Consortium. Electronic address: chris.cotsapas@yale.edu; International Multiple Sclerosis Genetics Consortium.
Cell. 2019 Jun 27;178(1):262. doi: 10.1016/j.cell.2019.06.016. Erratum for: Cell. 2018 Nov 29;175(6):1679-1687.e7. Erratum in: Cell. 2020 Jan 23;180(2):403.

 

IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis

Lindahl H, Guerreiro-Cacais AO, Bedri SK, Linnerbauer M, Lindén M, Abdelmagid N, Tandre K, Hollins C, Irving L, Glover C, Jones C, Alfredsson L, Rönnblom L, Kockum I, Khademi M, Jagodic M, Olsson T. J Immunol. 2019 Aug 15;203(4):888-898. doi: 10.4049/jimmunol.1900400. Epub 2019 Jul 10.

 

Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk

Tengvall K, Huang J, Hellström C, Kammer P, Biström M, Ayoglu B, Lima Bomfim I, Stridh P, Butt J, Brenner N, Michel A, Lundberg K, Padyukov L, Lundberg IE, Svenungsson E, Ernberg I, Olafsson S, Dilthey AT, Hillert J, Alfredsson L, Sundström P, Nilsson P, Waterboer T, Olsson T, Kockum I.
Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16955-16960. doi: 10.1073/pnas.1902623116. Epub 2019 Aug 2.

 

Different epigenetic clocks reflect distinct pathophysiological features of multiple sclerosis

Theodoropoulou E, Alfredsson L, Piehl F, Marabita F, Jagodic M.
Epigenomics. 2019 Sep;11(12):1429-1439. doi: 10.2217/epi-2019-0102. Epub 2019 Oct 8.

 

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

International Multiple Sclerosis Genetics Consortium.
Science. 2019 Sep 27;365(6460). pii: eaav7188. doi: 10.1126/science.aav7188.

 

Environmental and genetic risk factors for MS: an integrated review

Waubant E, Lucas R, Mowry E, Graves J, Olsson T, Alfredsson L, Langer-Gould A. Ann Clin Transl Neurol. 2019 Sep;6(9):1905-1922. doi: 10.1002/acn3.50862. Epub 2019 Aug 7. Review. PMID:31392849. 

 

Increased serological response against human herpesvirus 6A is associated with risk for multiple sclerosis

Engdahl E, Gustafsson R,  Huang J,  Biström M, Bomfim IL, Stridh P, Khademi M, Brenner N, Butt J, Michel A, Jonsdottir I, Stefánsson K, Jons D, Hortlund M, Alonso-Magdalena L, Flamand L, Ihira M, Yoshikawa T, Andersen O, Hillert J, Alfredsson L, Waterboer T, Sundström P, Olsson T, Kockum I, Fogdell-Hahn A. Frontiers in Immunology. 2019 Nov 26;10:2715. doi: 10.3389/fimmu.2019.02715. eCollection 2019. PMID:32038605.

 

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Cross-Disorder Group of the Psychiatric Genomics Consortium. Electronic address: plee0@mgh.harvard.edu; Cross-Disorder Group of the Psychiatric Genomics Consortium.
Cell. 2019 Dec 12;179(7):1469-1482.e11. doi: 10.1016/j.cell.2019.11.020.

2018

The association between multiple sclerosis and pain medications.

Burkill S, Montgomery S, Kockum I, Piehl F, Strid P, Hillert J, Alfredsson L, Olsson T, Bahmanyar S.

Pain. 2018 Oct 29. doi: 10.1097/j.pain.0000000000001429. [Epub ahead of print]

Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis.

Mowry EM, Hedström AK, Gianfrancesco MA, Shao X, Schaefer CA, Shen L, Bellesis KH, Briggs FBS, Olsson T, Alfredsson L, Barcellos LF.

Mult Scler Relat Disord. 2018 Aug;24:135-141. doi: 10.1016/j.msard.2018.06.009. Epub 2018 Jun 23.

Organic solvents and MS susceptibility: Interaction with MS risk HLA genes.

Hedström AK, Hössjer O, Katsoulis M, Kockum I, Olsson T, Alfredsson L.

Neurology. 2018 Jul 31;91(5):e455-e462. doi: 10.1212/WNL.0000000000005906. Epub 2018 Jul 3.

Association of Pre-Disease Body Mass Index With Multiple Sclerosis Prognosis.

Manouchehrinia A, Hedström AK, Alfredsson L, Olsson T, Hillert J, Ramanujam R. Front Neurol. 2018 May 11;9:232. doi: 10.3389/fneur.2018.00232. eCollection 2018.

Lifestyle and Environmental Factors in Multiple Sclerosis.

Alfredsson L, Olsson T.

Cold Spring Harb Perspect Med. 2018 May 7. pii: a028944. doi: 10.1101/cshperspect.a028944. [Epub ahead of print]

 

Ancient genomes from Iceland reveal the making of a human population

Ebenesersdóttir SS, Sandoval-Velasco M, Gunnarsdóttir ED, Jagadeesan A, Guðmundsdóttir VB, Thordardóttir EL, Einarsdóttir MS, Moore KHS, Sigurðsson Á, Magnúsdóttir DN, Jónsson H, Snorradóttir S, Hovig E, Møller P, Kockum I, Olsson T, Alfredsson L, Hansen TF, Werge T, Cavalleri GL, Gilbert E, Lalueza-Fox C, Walser JW 3rd, Kristjánsdóttir S, Gopalakrishnan S, Árnadóttir L, Magnússon ÓÞ, Gilbert MTP, Stefánsson K, Helgason A.
Science. 2018 Jun 1;360(6392):1028-1032. doi: 10.1126/science.aar2625.

Analysis of shared heritability in common disorders of the brain

Brainstorm Consortium, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nöthen MM, Rossor M, Lupton MK, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis JC, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee SJ, De Jager PL, Geschwind DH, Riemenschneider M, Riedel-Heller S, Rotter JI, Ransmayr G, Hyman BT, Cruchaga C, Alegret M, Winsvold B, Palta P, Farh KH, Cuenca-Leon E, Furlotte N, Kurth T, Ligthart L, Terwindt GM, Freilinger T, Ran C, Gordon SD, Borck G, Adams HHH, Lehtimäki T, Wedenoja J, Buring JE, Schürks M, Hrafnsdottir M, Hottenga JJ, Penninx B, Artto V, Kaunisto M, Vepsäläinen S, Martin NG, Montgomery GW, Kurki MI, Hämäläinen E, Huang H, Huang J, Sandor C, Webber C, Muller-Myhsok B, Schreiber S, Salomaa V, Loehrer E, Göbel H, Macaya A, Pozo-Rosich P, Hansen T, Werge T, Kaprio J, Metspalu A, Kubisch C, Ferrari MD, Belin AC, van den Maagdenberg AMJM, Zwart JA, Boomsma D, Eriksson N, Olesen J, Chasman DI, Nyholt DR, Avbersek A, Baum L, Berkovic S, Bradfield J, Buono RJ, Catarino CB, Cossette P, De Jonghe P, Depondt C, Dlugos D, Ferraro TN, French J, Hjalgrim H, Jamnadas-Khoda J, Kälviäinen R, Kunz WS, Lerche H, Leu C, Lindhout D, Lo W, Lowenstein D, McCormack M, Møller RS, Molloy A, Ng PW, Oliver K, Privitera M, Radtke R, Ruppert AK, Sander T, Schachter S, Schankin C, Scheffer I, Schoch S, Sisodiya SM, Smith P, Sperling M, Striano P, Surges R, Thomas GN, Visscher F, Whelan CD, Zara F, Heinzen EL, Marson A, Becker F, Stroink H, Zimprich F, Gasser T, Gibbs R, Heutink P, Martinez M, Morris HR, Sharma M, Ryten M, Mok KY, Pulit S, Bevan S, Holliday E, Attia J, Battey T, Boncoraglio G, Thijs V, Chen WM, Mitchell B, Rothwell P, Sharma P, Sudlow C, Vicente A, Markus H, Kourkoulis C, Pera J, Raffeld M, Silliman S, Boraska Perica V, Thornton LM, Huckins LM, William Rayner N, Lewis CM, Gratacos M, Rybakowski F, Keski-Rahkonen A, Raevuori A, Hudson JI, Reichborn-Kjennerud T, Monteleone P, Karwautz A, Mannik K, Baker JH, O'Toole JK, Trace SE, Davis OSP, Helder SG, Ehrlich S, Herpertz-Dahlmann B, Danner UN, van Elburg AA, Clementi M, Forzan M, Docampo E, Lissowska J, Hauser J, Tortorella A, Maj M, Gonidakis F, Tziouvas K, Papezova H, Yilmaz Z, Wagner G, Cohen-Woods S, Herms S, Julià A, Rabionet R, Dick DM, Ripatti S, Andreassen OA, Espeseth T, Lundervold AJ, Steen VM, Pinto D, Scherer SW, Aschauer H, Schosser A, Alfredsson L, Padyukov L, Halmi KA, Mitchell J, Strober M, Bergen AW, Kaye W, Szatkiewicz JP, Cormand B, Ramos-Quiroga JA, Sánchez-Mora C, Ribasés M, Casas M, Hervas A, Arranz MJ, Haavik J, Zayats T, Johansson S, Williams N, Dempfle A, Rothenberger A, Kuntsi J, Oades RD, Banaschewski T, Franke B, Buitelaar JK, Arias Vasquez A, Doyle AE, Reif A, Lesch KP, Freitag C, Rivero O, Palmason H, Romanos M, Langley K, Rietschel M, Witt SH, Dalsgaard S, Børglum AD, Waldman I, Wilmot B, Molly N, Bau CHD, Crosbie J, Schachar R, Loo SK, McGough JJ, Grevet EH, Medland SE, Robinson E, Weiss LA, Bacchelli E, Bailey A, Bal V, Battaglia A, Betancur C, Bolton P, Cantor R, Celestino-Soper P, Dawson G, De Rubeis S, Duque F, Green A, Klauck SM, Leboyer M, Levitt P, Maestrini E, Mane S, De-Luca DM, Parr J, Regan R, Reichenberg A, Sandin S, Vorstman J, Wassink T, Wijsman E, Cook E, Santangelo S, Delorme R, Rogé B, Magalhaes T, Arking D, Schulze TG, Thompson RC, Strohmaier J, Matthews K, Melle I, Morris D, Blackwood D, McIntosh A, Bergen SE, Schalling M, Jamain S, Maaser A, Fischer SB, Reinbold CS, Fullerton JM, Guzman-Parra J, Mayoral F, Schofield PR, Cichon S, Mühleisen TW, Degenhardt F, Schumacher J, Bauer M, Mitchell PB, Gershon ES, Rice J, Potash JB, Zandi PP, Craddock N, Ferrier IN, Alda M, Rouleau GA, Turecki G, Ophoff R, Pato C, Anjorin A, Stahl E, Leber M, Czerski PM, Cruceanu C, Jones IR, Posthuma D, Andlauer TFM, Forstner AJ, Streit F, Baune BT, Air T, Sinnamon G, Wray NR, MacIntyre DJ, Porteous D, Homuth G, Rivera M, Grove J, Middeldorp CM, Hickie I, Pergadia M, Mehta D, Smit JH, Jansen R, de Geus E, Dunn E, Li QS, Nauck M, Schoevers RA, Beekman AT, Knowles JA, Viktorin A, Arnold P, Barr CL, Bedoya-Berrio G, Bienvenu OJ, Brentani H, Burton C, Camarena B, Cappi C, Cath D, Cavallini M, Cusi D, Darrow S, Denys D, Derks EM, Dietrich A, Fernandez T, Figee M, Freimer N, Gerber G, Grados M, Greenberg E, Hanna GL, Hartmann A, Hirschtritt ME, Hoekstra PJ, Huang A, Huyser C, Illmann C, Jenike M, Kuperman S, Leventhal B, Lochner C, Lyon GJ, Macciardi F, Madruga-Garrido M, Malaty IA, Maras A, McGrath L, Miguel EC, Mir P, Nestadt G, Nicolini H, Okun MS, Pakstis A, Paschou P, Piacentini J, Pittenger C, Plessen K, Ramensky V, Ramos EM, Reus V, Richter MA, Riddle MA, Robertson MM, Roessner V, Rosário M, Samuels JF, Sandor P, Stein DJ, Tsetsos F, Van Nieuwerburgh F, Weatherall S, Wendland JR, Wolanczyk T, Worbe Y, Zai G, Goes FS, McLaughlin N, Nestadt PS, Grabe HJ, Depienne C, Konkashbaev A, Lanzagorta N, Valencia-Duarte A, Bramon E, Buccola N, Cahn W, Cairns M, Chong SA, Cohen D, Crespo-Facorro B, Crowley J, Davidson M, DeLisi L, Dinan T, Donohoe G, Drapeau E, Duan J, Haan L, Hougaard D, Karachanak-Yankova S, Khrunin A, Klovins J, Kučinskas V, Lee Chee Keong J, Limborska S, Loughland C, Lönnqvist J, Maher B, Mattheisen M, McDonald C, Murphy KC, Nenadic I, van Os J, Pantelis C, Pato M, Petryshen T, Quested D, Roussos P, Sanders AR, Schall U, Schwab SG, Sim K, So HC, Stögmann E, Subramaniam M, Toncheva D, Waddington J, Walters J, Weiser M, Cheng W, Cloninger R, Curtis D, Gejman PV, Henskens F, Mattingsdal M, Oh SY, Scott R, Webb B, Breen G, Churchhouse C, Bulik CM, Daly M, Dichgans M, Faraone SV, Guerreiro R, Holmans P, Kendler KS, Koeleman B, Mathews CA, Price A, Scharf J, Sklar P, Williams J, Wood NW, Cotsapas C, Palotie A, Smoller JW, Sullivan P, Rosand J, Corvin A, Neale BM, Schott JM, Anney R, Elia J, Grigoroiu-Serbanescu M, Edenberg HJ, Murray R.
Science. 2018 Jun 22;360(6395):eaap8757. doi: 10.1126/science.aap8757. 

 

Age at Menarche and Risk of Multiple Sclerosis: Current Progress From Epidemiological Investigations

Jiang X, Olsson T, Alfredsson L.
Front Immunol. 2018 Nov 13;9:2600. doi: 10.3389/fimmu.2018.02600. eCollection 2018.

2017

Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship.

Marabita F, Almgren M, Sjöholm LK, Kular L, Liu Y, James T, Kiss NB, Feinberg AP, Olsson T, Kockum I, Alfredsson L, Ekström TJ, Jagodic M.

Sci Rep. 2017 Nov 6;7(1):14589. doi: 10.1038/s41598-017-14788-w. Erratum in: Sci Rep. 2018 Mar 7;8(1):4340.

 

​Genetic risk factors for pediatric-onset multiple sclerosis.

Gianfrancesco MA, Stridh P, Shao X, Rhead B, Graves JS, Chitnis T, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Mar S, Kahn I, Rose J, Roalstad S, Casper TC, Shen L, Quach H, Quach D, Hillert J, Hedstrom A, Olsson T, Kockum I, Alfredsson L, Schaefer C, Barcellos LF, Waubant E; Network of Pediatric Multiple Sclerosis Centers.

Mult Scler. 2017 Oct 1:1352458517733551. doi: 10.1177/1352458517733551. [Epub ahead of print]

Environmental modifiable risk factors for multiple sclerosis: Report from the 2016 ECTRIMS focused workshop.

Amato MP, Derfuss T, Hemmer B, Liblau R, Montalban X, Soelberg Sørensen P, Miller DH; 2016 ECTRIMS Focused Workshop Group.

Mult Scler. 2017 Jan 6:1352458516686847. doi: 10.1177/1352458516686847. [Epub ahead of print]

The interaction between smoking and HLA genes in multiple sclerosis: replication and refinement.

Hedström AK, Katsoulis M, Hössjer O, Bomfim IL, Oturai A, Sondergaard HB, Sellebjerg F, Ullum H, Thørner LW, Gustavsen MW, Harbo HF, Obradovic D, Gianfrancesco MA, Barcellos LF, Schaefer CA, Hillert J, Kockum I, Olsson T, Alfredsson L.

Eur J Epidemiol. 2017 Oct;32(10):909-919. doi: 10.1007/s10654-017-0250-2. Epub 2017 Jun 8.

Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS.

Gianfrancesco MA, Stridh P, Rhead B, Shao X, Xu E, Graves JS, Chitnis T, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Mar S, Kahn I, Rose J, Roalstad S, Casper TC, Shen L, Quach H, Quach D, Hillert J, Bäärnhielm M, Hedstrom A, Olsson T, Kockum I, Alfredsson L, Metayer C, Schaefer C, Barcellos LF, Waubant E; Network of Pediatric Multiple Sclerosis Centers.

Neurology. 2017 Apr 25;88(17):1623-1629. doi: 10.1212/WNL.0000000000003849. Epub 2017 Mar 29.

Causal Effect of Genetic Variants Associated With Body Mass Index on Multiple Sclerosis Susceptibility.

Gianfrancesco MA, Glymour MM, Walter S, Rhead B, Shao X, Shen L, Quach H, Hubbard A, Jónsdóttir I, Stefánsson K, Strid P, Hillert J, Hedström A, Olsson T, Kockum I, Schaefer C, Alfredsson L, Barcellos LF.

Am J Epidemiol. 2017 Feb 1;185(3):162-171. doi: 10.1093/aje/kww120.

Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis.

Olsson T, Barcellos LF, Alfredsson L.

Nat Rev Neurol. 2017 Jan;13(1):25-36. doi: 10.1038/nrneurol.2016.187. Epub 2016 Dec 9. Review.

 

Overexpression of the Cytokine BAFF and Autoimmunity Risk

Steri M, Orrù V, Idda ML, Pitzalis M, Pala M, Zara I, Sidore C, Faà V, Floris M, Deiana M, Asunis I, Porcu E, Mulas A, Piras MG, Lobina M, Lai S, Marongiu M, Serra V, Marongiu M, Sole G, Busonero F, Maschio A, Cusano R, Cuccuru G, Deidda F, Poddie F, Farina G, Dei M, Virdis F, Olla S, Satta MA, Pani M, Delitala A, Cocco E, Frau J, Coghe G, Lorefice L, Fenu G, Ferrigno P, Ban M, Barizzone N, Leone M, Guerini FR, Piga M, Firinu D, Kockum I, Lima Bomfim I, Olsson T, Alfredsson L, Suarez A, Carreira PE, Castillo-Palma MJ, Marcus JH, Congia M, Angius A, Melis M, Gonzalez A, Alarcón Riquelme ME, da Silva BM, Marchini M, Danieli MG, Del Giacco S, Mathieu A, Pani A, Montgomery SB, Rosati G, Hillert J, Sawcer S, D'Alfonso S, Todd JA, Novembre J, Abecasis GR, Whalen MB, Marrosu MG, Meloni A, Sanna S, Gorospe M, Schlessinger D, Fiorillo E, Zoledziewska M, Cucca F.
N Engl J Med. 2017 Apr 27;376(17):1615-1626. doi: 10.1056/NEJMoa1610528.

 

Identification of a Genetic Variation in ERAP1 Aminopeptidase that Prevents Human Cytomegalovirus miR-UL112-5p-Mediated Immunoevasion

Romania P, Cifaldi L, Pignoloni B, Starc N, D'Alicandro V, Melaiu O, Pira GL, Giorda E, Carrozzo R, Bergvall M, Bergström T, Alfredsson L, Olsson T, Kockum I, Seppälä I, Lehtimäki T, Hurme MA, Hengel H, Santoni A, Cerboni C, Locatelli F, D'Amato M, Fruci D.
Cell Rep. 2017 Jul 25;20(4):846-853. doi: 10.1016/j.celrep.2017.06.084.

 

Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations

Olafsson S, Stridh P, Bos SD, Ingason A, Euesden J, Sulem P, Thorleifsson G, Gustafsson O, Johannesson A, Geirsson AJ, Thorsson AV, Sigurgeirsson B, Ludviksson BR, Olafsson E, Kristjansdottir H, Jonasson JG, Olafsson JH, Orvar KB, Benediktsson R, Bjarnason R, Kristjansdottir S, Gislason T, Valdimarsson T, Mikaelsdottir E, Sigurdsson S, Jonsson S, Rafnar T, Aarsland D, Djurovic S, Fladby T, Knudsen GP, Celius EG, Myhr KM, Grondal G, Steinsson K, Valdimarsson H, Bjornsson S, Bjornsdottir US, Bjornsson ES, Nilsson B, Andreassen OA, Alfredsson L, Hillert J, Kockum IS, Masson G, Thorsteinsdottir U, Gudbjartsson DF, Stefansson H, Hjaltason H, Harbo HF, Olsson T, Jonsdottir I, Stefansson K.
NPJ Genom Med. 2017 Aug 8;2:24. doi: 10.1038/s41525-017-0027-2. eCollection 2017.

 

Concussion in adolescence and risk of multiple sclerosis

Montgomery S, Hiyoshi A, Burkill S, Alfredsson L, Bahmanyar S, Olsson T.
Ann Neurol. 2017 Oct;82(4):554-561. doi: 10.1002/ana.25036. Epub 2017 Sep 25.

 

Reply to "concussion may not cause multiple sclerosis"

Montgomery S, Hiyoshi A, Burkill S, Alfredsson L, Bahmanyar S, Olsson T..
Ann Neurol. 2017 Oct;82(4):652-653. doi: 10.1002/ana.25062.

2016

TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cells.

Parsa R, Lund H, Tosevski I, Zhang XM, Malipiero U, Beckervordersandforth J, Merkler D, Prinz M, Gyllenberg A, James T, Warnecke A, Hillert J, Alfredsson L, Kockum I, Olsson T, Fontana A, Suter T, Harris RA.

Glia. 2016 Nov;64(11):1925-37. doi: 10.1002/glia.23033. Epub 2016 Aug 1.

Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk.

Rhead B, Bäärnhielm M, Gianfrancesco M, Mok A, Shao X, Quach H, Shen L, Schaefer C, Link J, Gyllenberg A, Hedström AK, Olsson T, Hillert J, Kockum I, Glymour MM, Alfredsson L, Barcellos LF.

Neurol Genet. 2016 Sep 13;2(5):e97. doi: 10.1212/NXG.0000000000000097. eCollection 2016 Oct.

Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies.

George MF, Briggs FB, Shao X, Gianfrancesco MA, Kockum I, Harbo HF, Celius EG, Bos SD, Hedström A, Shen L, Bernstein A, Alfredsson L, Hillert J, Olsson T, Patsopoulos NA, De Jager PL, Oturai AB, Søndergaard HB, Sellebjerg F, Sorensen PS, Gomez R, Caillier SJ, Cree BA, Oksenberg JR, Hauser SL, D'Alfonso S, Leone MA, Martinelli Boneschi F, Sorosina M, van der Mei I, Taylor BV, Zhou Y, Schaefer C, Barcellos LF.

Neurol Genet. 2016 Aug 4;2(4):e87. doi: 10.1212/NXG.0000000000000087. eCollection 2016 Aug.

Environmental factors and their interactions with risk genotypes in MS susceptibility.

Hedström AK, Alfredsson L, Olsson T.

Curr Opin Neurol. 2016 Jun;29(3):293-8. doi: 10.1097/WCO.0000000000000329. Review.

High consumption of coffee is associated with decreased multiple sclerosis risk; results from two independent studies.

Hedström AK, Mowry EM, Gianfrancesco MA, Shao X, Schaefer CA, Shen L, Olsson T, Barcellos LF, Alfredsson L.

J Neurol Neurosurg Psychiatry. 2016 May;87(5):454-60. doi: 10.1136/jnnp-2015-312176. Epub 2016 Mar 3.

Smoking is a major preventable risk factor for multiple sclerosis.

Hedström AK, Olsson T, Alfredsson L.

Mult Scler. 2016 Jul;22(8):1021-6. doi: 10.1177/1352458515609794. Epub 2015 Oct 12

Body mass index during adolescence, rather than childhood, is critical in determining MS risk.

Hedström AK, Olsson T, Alfredsson L.

Mult Scler. 2016 Jun;22(7):878-83. doi: 10.1177/1352458515603798. Epub 2015 Sep 11.

 

Anoctamin 2 identified as an autoimmune target in multiple sclerosis.

Ayoglu B, Mitsios N, Kockum I, Khademi M, Zandian A, Sjöberg R, Forsström B, Bredenberg J, Lima Bomfim I, Holmgren E, Grönlund H, Guerreiro-Cacais AO, Abdelmagid N, Uhlén M, Waterboer T, Alfredsson L, Mulder J, Schwenk JM, Olsson T, Nilsson P.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2188-93. doi: 10.1073/pnas.1518553113. Epub 2016 Feb 9.

2015

Effect of Smoking Cessation on Multiple Sclerosis Prognosis.

Ramanujam R, Hedström AK, Manouchehrinia A, Alfredsson L, Olsson T, Bottai M, Hillert J.

JAMA Neurol. 2015 Oct;72(10):1117-23. doi: 10.1001/jamaneurol.2015.1788

Class II HLA interactions modulate genetic risk for multiple sclerosis.

Moutsianas L, Jostins L, Beecham AH, Dilthey AT, Xifara DK, Ban M, Shah TS, Patsopoulos NA,Alfredsson L, Anderson CA, Attfield KE, Baranzini SE, Barrett J, Binder TM, Booth D, Buck D, Celius EG, Cotsapas C, D'Alfonso S, Dendrou CA, Donnelly P, Dubois B, Fontaine B, Lar Fugger L, Goris A, Gourraud PA, Graetz C, Hemmer B, Hillert J; International IBD Genetics Consortium (IIBDGC), Kockum I, Leslie S, Lill CM, Martinelli-Boneschi F, Oksenberg JR, Olsson T, Oturai A, Saarela J, Søndergaard HB, Spurkland A, Taylor B, Winkelmann J, Zipp F, Haines JL, Pericak-Vance MA, Spencer CC, Stewart G, Hafler DA, Ivinson AJ, Harbo HF, Hauser SL, De Jager PL, Compston A, McCauley JL, Sawcer S, McVean G; International Multiple Sclerosis Genetics Consortium. Nat Genet. 2015 Oct;47(10):1107-13. doi: 10.1038/ng.3395. Epub 2015 Sep 7.

Identity-by-descent mapping in a Scandinavian multiple sclerosis cohort.

Westerlind H, Imrell K, Ramanujam R, Myhr KM, Celius EG, Harbo HF, Oturai AB, Hamsten A,Alfredsson L, Olsson T, Kockum I, Koski T, Hillert J. Eur J Hum Genet. 2015 May;23(5):688-92. doi: 10.1038/ejhg.2014.155. Epub 2014 Aug 27

Comparative analysis of first-year fingolimod and natalizumab drug discontinuation among Swedish patients with multiple sclerosis.

Frisell T, Forsberg L, Nordin N, Kiesel C, Alfredsson L, Askling J,Hillert J, Olsson T, Piehl F.

Mult Scler. 2015 Apr 28. pii: 1352458515579216. [Epub ahead of print]

Genetic variants are major determinants of CSF antibody levels in multiple sclerosis.

Goris A, Pauwels I, Gustavsen MW, van Son B, Hilven K, Bos SD, Celius EG, Berg-Hansen P, Aarseth J, Myhr KM, D'Alfonso S, Barizzone N, Leone MA, Martinelli Boneschi F, Sorosina M, Liberatore G, Kockum I, Olsson T, Hillert J, Alfredsson L, Bedri SK, Hemmer B, Buck D, Berthele A, Knier B, Biberacher V, van Pesch V, Sindic C, Bang Oturai A, Søndergaard HB, Sellebjerg F, Jensen PE, Comabella M, Montalban X, Pérez-Boza J, Malhotra S, Lechner-Scott J, Broadley S, Slee M, Taylor B, Kermode AG, Gourraud PA; International Multiple Sclerosis Genetics Consortium, Sawcer SJ, Andreassen BK, Dubois B, Harbo HF.

Brain. 2015 Mar;138(Pt 3):632-43. doi: 10.1093/brain/awu405. Epub 2015 Jan 22

Obesity interacts with infectious mononucleosis in risk of multiple sclerosis.

Hedström AK, Lima Bomfim I, Hillert J, Olsson T, Alfredsson L.

Eur J Neurol. 2015 Mar;22(3):578-e38. doi: 10.1111/ene.12620. Epub 2014 Dec 20.

Identity-by-descent mapping in a Scandinavian multiple sclerosis cohort.

Westerlind H, Imrell K, Ramanujam R, Myhr KM, Celius EG, Harbo HF, Oturai AB, Hamsten A, Alfredsson L, Olsson T, Kockum I, Koski T, Hillert J.

Eur J Hum Genet. 2015 May;23(5):688-92. doi: 10.1038/ejhg.2014.155. Epub 2014 Aug 27.

 

Shift work influences multiple sclerosis risk

Hedström A, Åkerstedt T, Olsson T, Alfredsson L.
Mult Scler. 2015 Aug;21(9):1195-9. doi: 10.1177/1352458514563592. Epub 2015 Feb 19.

 

A validated gene regulatory network and GWAS identifies early regulators of T cell-associated diseases

Gustafsson M, Gawel DR, Alfredsson L, Baranzini S, Björkander J, Blomgran R, Hellberg S, Eklund D, Ernerudh J, Kockum I, Konstantinell A, Lahesmaa R, Lentini A, Liljenström HR, Mattson L, Matussek A, Mellergård J, Mendez M, Olsson T, Pujana MA, Rasool O, Serra-Musach J, Stenmarker M, Tripathi S, Viitala M, Wang H, Zhang H, Nestor CE, Benson M
Sci Transl Med. 2015 Nov 11;7(313):313ra178. doi: 10.1126/scitranslmed.aad2722.

 

The Role of Environment and Lifestyle in Determining the Risk of Multiple Sclerosis

Hedström AK, Olsson T, Alfredsson L.
Curr Top Behav Neurosci. 2015;26:87-104. doi: 10.1007/7854_2015_372.

2014 

Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general.

Gustavsen MW, Viken MK, Celius EG, Berge T, Mero IL, Berg-Hansen P, Aarseth JH, Myhr KM, Søndergaard HB, Sellebjerg F, Oturai AB, Hillert J, Alfredsson L, Olsson T, Kockum I, Lie BA, Harbo HF.

J Neuroimmunol. 2014 Sep 15;274(1-2):174-9. doi: 10.1016/j.jneuroim.2014.06.024. Epub 2014 Jul 6.

HLA-A(*)02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6.

Engdahl E, Gustavsson R, Ramanujam R, Sundqvist E, Olsson T, Hillert J, Alfredsson L, Kockum I, Fogdell-Hahn A.

Hum Immunol. 2014 Jun. Epub 2014 Mar 22.

Variability in the CIITA gene interacts with HLA in multiple sclerosis.

Gyllenberg A, Piehl F, Alfredsson L, Hillert J, Bomfim IL, Padyukov L, Orho-Melander M, Lindholm E, Landin-Olsson M, Lernmark Å; Swedish Childhood Diabetes Study Group; Diabetes Incidence in Sweden Study Group, Olsson T, Kockum I.

Genes Immun. 2014 Apr-May;15(3):162-7. doi: 10.1038/gene.2013.71. Epub 2014 Jan 16.

JC polyomavirus infection is strongly controlled by human leucocyte antigen class II variants.

Sundqvist E, Buck D, Warnke C, Albrecht E, Gieger C, Khademi M, Lima Bomfim I, Fogdell-Hanh A, Link J, Alfredsson L, Sødergaard HB, Hillert J; International Multiple Sclerosis Genetics Consortium, Oturai AB, Hemme B, Kockum I, Olsson T.

PLoS Pathog. 2014 April 24.

Ladda ner PDF

Smoking and risk of treatment-induced neutralizing antibodies to interferon β-1a.

Hedström AK, Ryner M, Fink K, Fogdell-Hahn A, Alfredsson L, Olsson T, Hillert J.

Mult Scler. 2014 Apr. Epub Aug 7.

Smoking and risk of multiple sclerosis: Evidence of modification by NAT1 variants.

Briggs FB, Acuna B, Shen L, Ramsay P, Quach H, Bernstein A, Bellesis KH, Kockum I, Hedström AK, Alfredsson L, Olsson T, Schaefer C, Barcellos LF.

Epidemiology. 2014 Mar 12. [Epub ahead of print]

Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis.

Hedström AK, Lima Bomfim I, Barcellos L, Gianfrancesco M, Schaefer C, Kockum I, Olsson T, Alfredsson L.

Neurology. 2014 Mar 11. Epub 2014 Feb 5.

Ladda ner PDF

Alcohol as a modifiable lifestyle factor affecting multiple sclerosis risk.

Hedström AK, Hillert J, Olsson T, Alfredsson L.

JAMA Neurol. 2014 Mar. Epub 2014 Jan 6.

2013 

Smokers run increased risk of developing anti-natalizumab antibodies.

Hedström A, Alfredsson L, Lundkvist Ryner M, Fogdell-Hahn A, Hillert J, Olsson T.

Mult Scler. 2013 Dec 5. [Epub ahead of print]

                                                                                                                                

Smoking and multiple sclerosis susceptibility.

Hedström AK, Hillert J, Olsson T, Alfredsson L.

Eur J Epidemiol. 2013 Nov. Epub 2013 Oct 22.

Ladda ner PDF

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

International Multiple Sclerosis Genetics Consortium (IMSGC), Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, Oturai A, Saarela J, etal.

Nat Genet. 2013 Nov. Epub 2013 Sep 29.

Ladda ner PDF

Anti-JC virus antibody prevalence in a multinational multiple sclerosis cohort.

Olsson T, Achiron A, Alfredsson L, Berger T, Brassat D, Chan A, Comi G, Eraksoy M, Hegen H, Hillert J, Jensen PE, Mirola L, Myhr KM, Oturai A, Schippling S, Siva A, Sorensen PS, Trampe AK, Weber T, Potts J, Plavina T, Paes D, Subramanyam M, Wiendl H, Dib H, Uren D, Hemmer B, Buck D.

Mult Scler. 2013 Oct Epub 2013 Mar 4.

A "candidate-interactome" aggregate analysis of genome-wide association data in multiple sclerosis.

Mechelli R, Umeton R, Policano C, Annibali V, Coarelli G, Ricigliano VA, Vittori D, Fornasiero A, Buscarinu MC; International Multiple Sclerosis Genetics Consortium; Wellvome Trust Case Control Consortium,2, Romano S, Salvetti M, Ristori G.

PLoS One. 2013 May 16.

Ladda ner PDF

Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity.

Lundström W, Highfill S, Walsh ST, Beq S, Morse E, Kockum I, Alfredsson L, Olsson T; Hillert J, Mackall CL.

Proc Natl Acad Sci U S A. 2013 May 7. Epub 2013 Apr 22.

Fatty fish intake is associated with decreased occurrence of multiple sclerosis.

Bäärnhielm M, Olsson T, Alfredsson L.

Mult Scler. 2014 May. Epub 2013 Oct 24

Smoking and risk of treatment-induced neutralizing antibodies to interferon β-1a.

Hedström AK, Ryner M, Fink K, Fogdell-Hahn A, Alfredsson L, Olsson T, Hillert J.

Mult Scler. 2014 Apr. Epub Aug 7.

Reverse causality behind the association between reproductive history and MS.

Hedström A, Hillert J, Olsson T, Alfredsson L.

Mult Scler. 2013 Jul 25. [Epub ahead of print]

Nicotine might have a protective effect in the etiology of multiple sclerosis.

Hedström AK, Hillert J, Olsson T, Alfredsson L.

Mult Scler. 2013 Jul;19(8):1009-13. doi: 10.1177/1352458512471879. Epub 2013 Jan 14.

Exposure to anaesthetic agents does not affect multiple sclerosis risk.

Hedström AK, Hillert J, Olsson T, Alfredsson L.

Eur J Neurol. 2013 May;20(5):735-9. doi: 10.1111/ene.12098. Epub 2013 Jan 24.

Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles.

Mero IL, Gustavsen MW, Sæther HS, Flåm ST, Berg-Hansen P, Søndergaard HB, Jensen PE, Berge T, Bjølgerud A, Muggerud A, Aarseth JH; INternational Multiple Sclerosis Genetic Consortium, Myhr KM, Celius EG, Sellebjerg F, Hillert J, Alfredsson L, Olsson T, Oturai AB, Kockum I, Lie BA, Andreassen BK, Harbo HF.

PLoS One. 2013. Epub 2013 Mar 5.

Ladda ner PDF

2012

Serum levels of LIGHT in MS.

Malmeström C, Gillett A, Jernås M, Khademi M, Axelsson M, Kockum I, Mattsson N, Zetterberg H, Blennow K, Alfredsson L, Wadenvik H, Lycke J, Olsson T, Olsson B.

Mult Scler. 2013 Jun;19(7):871-6. doi: 10.1177/1352458512463766. Epub 2012 Oct 4.

Lack of replication of interaction between EBNA1 IgG and smoking in risk for multiple sclerosis.

Sundqvist E, Sundström P, Lindén M, Hedström AK, Aloisi F, Hillert J, Kockum I, Alfredsson L, Olsson T.

Neurology. 2012 Sep 25;79(13):1363-8. Epub 2012 Aug 29.

Importance of human leukocyte antigen (HLA) class I and II alleles on the risk of multiple sclerosis.

Link J, Kockum I, Lorentzen AR, Lie BA, Celius EG, Westerlind H, Schaffer M, Alfredsson L, Olsson T, Brynedal B, Harbo HF, Hillert J.

PLoS One. 2012;7(5):e36779. Epub 2012 May 7

Ladda ner PDF

High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and women.

Hedström AK, Olsson T, Alfredsson L.

Mult Scler. 2012 Sep;18(9):1334-6. doi: 10.1177/1352458512436596. Epub 2012 Feb 10.

Sunlight is associated with decreased multiple sclerosis risk: no interaction with human leukocyte antigen-DRB1*15.

Bäärnhielm M, Hedström AK, Kockum I, Sundqvist E, Gustafsson SA, Hillert J, Olsson T, Alfredsson L.

Eur J Neurol. 2012 Jul;19(7):955-62. doi: 10.1111/j.1468-1331.2011.03650.x. Epub 2012 Jan 31.

2011

Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis.

Hedström AK, Sundqvist E, Bäärnhielm M, Nordin N, Hillert J, Kockum I, Olsson T, Alfredsson L.

Brain. 2011 Mar;134(Pt 3):653-64. Epub 2011 Feb 8

Ladda ner PDF

Exposure to environmental tobacco smoke is associated with increased risk for multiple sclerosis.

Hedström AK, Bäärnhielm M, Olsson T, Alfredsson L.

Mult Scler. 2011 Jul;17(7):788-93. Epub 2011 Mar 3.

The genetic association of variants in CD6, TNFRSF1A and IRF8 to multiple sclerosis: a multicenter case-control study.

International Multiple Sclerosis Genetics Consortium.

PLoS One. 2011 Apr 28;6(4):e18813.

Ladda ner PDF

Epstein-Barr virus and multiple sclerosis: interaction with HLA.

Sundqvist E, Sundström P, Lindén M, Hedström AK, Aloisi F, Hillert J, Kockum I, Alfredsson L, Olsson T.

Genes Immun. 2012 Jan;13(1):14-20. doi: 10.1038/gene.2011.42. Epub 2011 Jul 21.

Ladda ner PDF

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

International Multiple Sclerosis Genetics Consortium; Wellcome Trust Case Control Consortium 2,

Sawcer S, Hellenthal G, Pirinen M et al

Nature. 2011 Aug 10;476(7359):214-9. doi: 10.1038/nature102

Ladda ner PDF

No evidence of IL21 association with multiple sclerosis in a Swedish population.

Lindén M, Nohra R, Sundqvist E, Khademi M, Hillert J, Alfredsson L, Olsson T, Kockum I.

Tissue Antigens. 2011 Oct;78(4):271-4. doi: 10.1111/j.1399-0039.2011.01734.x. Epub 2011 Jul 8.

Shift work at young age is associated with increased risk for multiple sclerosis.

Hedström AK, Åkerstedt T, Hillert J, Olsson T, Alfredsson L.

Ann Neurol. 2011 Nov;70(5):733-41. doi: 10.1002/ana.22597. Epub 2011 Oct 17.

2010

RGMA and IL21R show association with experimental inflammation and multiple sclerosis.

Nohra R, Beyeen AD, Guo JP, Khademi M, Sundqvist E, Hedreul MT, Sellebjerg F, Smestad C, Oturai AB, Harbo HF, Wallström E, Hillert J, Alfredsson L, Kockum I, Jagodic M, Lorentzen J, Olsson T.

Genes Immun. 2010 Jun;11(4):279-93. Epub 2010 Jan 14.

IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci.

International Multiple Sclerosis Genetics Conssortium (IMSGC).

Genes Immun. 2010 Jul;11(5):397-405. Epub 2010 Jun 17.

Confirmation of association between multiple sclerosis and CYP27B1.

Sundqvist E, Bäärnhielm M, Alfredsson L, Hillert J, Olsson T, Kockum I.

Eur J Hum Genet. 2010 Dec;18(12):1349-52. Epub 2010 Jul 21.

Ladda ner PDF

2009

Tobacco smoking, but not Swedish snuff use, increases the risk of multiple sclerosis.

Hedström AK, Bäärnhielm M, Olsson T, Alfredsson L.

Neurology. 2009 Sep 1;73(9):696-701.

HLA-DRB1 and month of birth in multiple sclerosis.

Ramagopalan SV, Link J, Byrnes JK, Dyment DA, Giovannoni G, Hintzen RQ, Sundqvist E, Kockum I, Smestad C, Lie BA, Harbo HF, Padyukov L, Alfredsson L, Olsson T, Sadovnick AD, Hillert J, Ebers GC.

Neurology. 2009 Dec 15;73(24):2107-11.

Press

 

Här finner du artiklar, intervjuer och nyhetsinslag kopplade till EIMS-projektet och dess medarbetare.

Rökning

Rökare riskgrupp för sjukdomen MS, DN 2009-08-31

Rökning, men inte snus, ökar MS risk, Aftonbladet 2009-09-01

Rökning, men inte snus ökar risken för MS, Forskning och framsteg augusti 2009

Rökare drabbas oftare av MS, Dagens Medicin 2009-08-31

Rökning ökar risken för att utveckla MS, www.multipelskleros.nu 2012-02-03

Rökning ökar risken för MS, Expressen 2009-08-31

Skiftarbete

Skiftarbete i tonåren ökar risken för MS, pressmeddelande Karolinska Institutet 2011-10-18

Ungas skiftarbete tycks kunna öka risk för MS, Sveriges Radio 2011-10-18

Skiftarbete ökar risk för MS, DN 2011-10-18

Skiftarbete ökar risken för MS, SvD 2011-10-18

Skiftarbete kopplat till MS-risk, Dagens Medicin 2011-10-18

Skiftarbete ökar risk för MS bland unga, Sveriges Radio 2011-10-18

Skiftarbete ökar MS-risk, Sydsvenska Dagbladet 2011-10-18

Skiftarbete i tonåren ökar risken för MS, Läkemedelsvärlden 2011-10-18

Gener

Nya rön väcker hopp för MS-sjuka, DN 2011-08-10

Nya rön väcker hopp för MS-sjuka, SvD 2011-08-10

Genombrott i MS-forskningen, Aftonbladet 2011-08-10​

Vitamin D och solljus

Multiple sclerosis: Sunlight and vitamin D influence multiple sclerosis risk independently of HLA-DRB1*15 status,

Nature Reviews 2012-02-28

Herpesvirus

Kombinationen rökning och herpesvirus ökar MS-risk, Sveriges Radio 2010-04-09