Zhichao Zhou
Senior Forskare | Docent
E-postadress: zhichao.zhou@ki.se
Besöksadress: Norrbacka S1:02, Karolinska Universitetssjukhuset Solna, 17176 Stockholm
Postadress: K2 Medicin, Solna, K2 Kardio Pernow J Zhou Z, 171 77 Stockholm
Artiklar
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2025;135(10):e180900Collado A; Humoud R; Kontidou E; Eldh M; Swaich J; Zhao A; Yang J; Jiao T; Domingo E; Carlestal E; Mahdi A; Tengbom J; Vegvari A; Deng Q; Alvarsson M; Gabrielsson S; Eriksson P; Zhou Z; Pernow J
- Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2025;45(Suppl_1):atu0045Kontidou E; Collado A; Humoud R; Manickam K; Jiao T; Alvarsson M; Yang J; Mahdi A; Pernow J; Zhichao Z
- Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2025;45(Suppl_1):atu0046aCollado A; Humoud R; Kontidou E; Yang J; Mahdi A; Tengbom J; Zhichao Z; Pernow J
- Article: PURINERGIC SIGNALLING. 2025;:1-3Collado A; Zhou Z
- Article: PURINERGIC SIGNALLING. 2025;:1-3Jiao T; Zhou Z
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2025;182(2):417-431Collado A; Jiao T; Kontidou E; Carvalho LRRA; Chernogubova E; Yang J; Zaccagnini G; Zhao A; Tengbom J; Zheng X; Rethi B; Alvarsson M; Catrina S-B; Mahdi A; Carlstroem M; Martelli F; Pernow J; Zhou Z
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2024;327(6):H1431-H1441Tengbom J; Humoud R; Kontidou E; Jiao T; Yang J; Hedin U; Zhou Z; Jurga J; Collado A; Mahdi A; Pernow J
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2024;327(5):H1296-H1302Kontidou E; Humoud R; Chernogubova E; Alvarsson M; Maegdefessel L; Collado A; Pernow J; Zhou Z
- Journal article: EUROPEAN HEART JOURNAL. 2024;45:ehae666.3685Collado A; Humoud R; Kontidou E; Swaich J; Yang J; Mahdi A; Tengbom J; Zhou Z; Pernow J
- Article: CLINICAL SCIENCE. 2024;138(15):975-985Tengbom J; Kontidou E; Collado A; Yang J; Alvarsson M; Brinck J; Rossner S; Zhou Z; Pernow J; Mahdi A
- Journal article: CARDIOVASCULAR RESEARCH. 2024;120:cvae088.035Collado A; Humoud R; Kontidou E; Eldh M; Yang J; Jiao T; Domingo E; Mahdi A; Gabrielsson S; Eriksson P; Zhou Z; Pernow J
- Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2024;44(Suppl_1):a1127Collado A; Humoud R; Kontidou E; Yang J; Jiao T; Mahdi A; Zhou Z; Pernow J
- Article: PURINERGIC SIGNALLING. 2024;20(1):5-8He X; Zhou Z
- Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.3099Yang JN; Sundqvist M; Zheng X; Jiao T; Collado A; Mahdi A; Tengbom J; Mergia E; Zhou Z; Carlstrom M; Akaike T; Cortese-Krott M; Weitzberg E; Lundberg JO; Pernow J
- Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.3096Jiao T; Collado A; Mahdi A; Tengbom J; Tratsiakovich Y; Milne G; Alvarsson M; Lundberg J; Zhou Z; Yang J; Pernow J
- Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.3066Collado A; Humoud R; Eldh M; Jiao T; Domingo E; Kontidou E; Yang J; Mahdi A; Gabrielsson S; Eriksson P; Zhou Z; Pernow J
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2023;133(17):e167693Yang J; Sundqvist ML; Zheng X; Jiao T; Collado A; Tratsiakovich Y; Mahdi A; Tengbom J; Mergia E; Catrina S-B; Zhou Z; Carlstroem M; Akaike T; Cortese-Krott MM; Weitzberg E; Lundberg JO; Pernow J
- Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2023;8(8):907-918Jiao T; Collado A; Mahdi A; Tengbom J; Tratsiakovich Y; Milne GT; Alvarsson M; Lundberg JO; Zhou Z; Yang J; Pernow J
- Article: JCI INSIGHT. 2023;8(6):e160745Zhou J; Tian G; Quan Y; Kong Q; Huang F; Li J; Wu W; Tang Y; Zhou Z; Liu X
- Article: PHARMACOLOGICAL RESEARCH. 2023;188:106677Kong Q; Zhou J; Ma C; Wei Z; Chen Y; Cheng Y; Wu W; Zhou Z; Tang Y; Liu X
- Article: JOURNAL OF INTERNAL MEDICINE. 2023;293(2):228-245Mahdi A; Wodaje T; Kovamees O; Tengbom J; Zhao A; Jiao T; Henricsson M; Yang J; Zhou Z; Nieminen AI; Levin M; Collado A; Brinck J; Pernow J
- Article: BASIC RESEARCH IN CARDIOLOGY. 2022;117(1):46Jiao T; Collado A; Mahdi A; Jurga J; Tengbom J; Saleh N; Verouhis D; Bohm F; Zhou Z; Yang J; Pernow J
- Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2022;7(3):193-204Mahdi A; Collado A; Tengbom J; Jiao T; Wodaje T; Johansson N; Farnebo F; Farnert A; Yang J; Lundberg JO; Zhou Z; Pernow J
- Article: DIABETES. 2022;71(2):285-297Zhou Z; Collado A; Sun C; Tratsiakovich Y; Mahdi A; Winter H; Chernogubova E; Seime T; Narayanan S; Jiao T; Jin H; Alvarsson M; Zheng X; Yang J; Hedin U; Catrina S-B; Maegdefessel L; Pernow J
- Article: MEDICAL PRINCIPLES AND PRACTICE. 2022;31(2):187-194Dankl D; Rezar R; Mamandipoor B; Zhou Z; Wernly S; Wernly B; Osmani V
- Article: PHARMACOLOGY. 2022;107(3-4):160-166Mahdi A; Jiao T; Tratsiakovich Y; Wernly B; Yang J; Ostenson C-G; Danser AHJ; Pernow J; Zhou Z
- Journal article: EUROPEAN HEART JOURNAL. 2021;42(Supplement_1):ehab724.3364Mahdi A; Collado A; Tengbom J; Jiao T; Wodaje T; Yang J; Lundberg JO; Zhou Z; Pernow J
- Article: CURRENT OPINION IN PHARMACOLOGY. 2021;60:183-192Collado A; Jin H; Pernow J; Zhou Z
- Article: JOURNAL OF THROMBOSIS AND THROMBOLYSIS. 2021;51(1):226-231Paar V; Wernly B; Zhou Z; Motloch LJ; Hoppe UC; Egle A; Lichtenauer M
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2021;320(1):H90-H94Wernly B; Erlinge D; Pernow J; Zhou Z
- Article: FRONTIERS IN PHARMACOLOGY. 2020;11:603226Mahdi A; Tratsiakovich Y; Tengbom J; Jiao T; Garib L; Alvarsson M; Yang J; Pernow J; Zhou Z
- Article: STEM CELL RESEARCH & THERAPY. 2020;11(1):284Liu F; Fang Y; Hou X; Yan Y; Xiao H; Zuo D; Wen J; Wang L; Zhou Z; Dang X; Zhou R; Liao B
- Article: CELLS. 2020;9(7):E1712-1712Red Blood Cell Peroxynitrite Causes Endothelial Dysfunction in Type 2 Diabetes Mellitus via ArginaseMahdi A; Tengbom J; Alvarsson M; Wernly B; Zhou Z; Pernow J
- Article: WORLD JOURNAL OF SURGICAL ONCOLOGY. 2020;18(1):88Shen C; Wang C; He T; Cai Z; Yin X; Yin Y; Lu D; Zhang B; Zhou Z
- Journal article: EUROPEAN HEART JOURNAL. 2019;40(Supplement_1):ehz746.0897Yang JN; Jiao T; Tratsiakovich Y; Mahdi A; Zhou Z; Lundberg JO; Pernow J
- Article: JOURNAL OF PHARMACOLOGICAL SCIENCES. 2019;141(1):64-69Sun C; Jiao T; Merkus D; Duncker DJ; Mustafa SJ; Zhou Z
- Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2019;23(9):6085-6097Zhou R; Huang W; Fan X; Liu F; Luo L; Yuan H; Jiang Y; Xiao H; Zhou Z; Deng C; Dang X
- Article: FRONTIERS IN PHARMACOLOGY. 2019;10:861Mahdi A; Jiao T; Yang J; Kovamees O; Alvarsson M; von Heijne M; Zhou Z; Pernow J
- Journal article: FASEB JOURNAL. 2019;33:512.4Zhou Z; Mahdi A; Tratsiakovich Y; Jiao T; Yang J; Ostenson C-G; Danser AHJ; Pernow J
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2018;19(12):E3942-3942Mahdi A; Jiao T; Tratsiakovich Y; Yang J; Ostenson C-G; Pernow J; Zhou Z
- Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2018;72(7):769-780Zhou Z; Mahdi A; Tratsiakovich Y; Zahoran S; Kovamees O; Nordin F; Gonzalez AEU; Alvarsson M; Ostenson C-G; Andersson DC; Hedin U; Hermesz E; Lundberg JO; Yang J; Pernow J
- Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2018;3(4):450-463Yang J; Zheng X; Mahdi A; Zhou Z; Tratsiakovich Y; Jiao T; Kiss A; Kovamees O; Alvarsson M; Catrina S-B; Lundberg JO; Brismar K; Pernow J
- Article: FRONTIERS IN PHARMACOLOGY. 2018;9:255Zhou Z; Lankhuizen IM; van Beusekom HM; Cheng C; Duncker DJ; Merkus D
- Article: PURINERGIC SIGNALLING. 2017;13(4):591-600Teng B; Labazi H; Sun C; Yang Y; Zeng X; Mustafa SJ; Zhou Z
- Article: PURINERGIC SIGNALLING. 2017;13(3):319-329Zhou Z; Sorop O; de Beer VJ; Heinonen I; Cheng C; Danser AHJ; Duncker DJ; Merkus D
- Journal article: EUROPEAN HEART JOURNAL. 2017;38(suppl_1):ehx493.p5386Yang JN; Mahdi A; Zhou Z; Tratsiakovich Y; Kovamees O; Alvarsson M; Pernow J
- Journal article: EUROPEAN HEART JOURNAL. 2017;38(suppl_1):ehx501.280Zhou Z; Mahdi A; Tratsiakovich Y; Kovamees O; Alvarsson M; Yang J; Pernow J
- Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2017;37(suppl_1)Zhou Z; Mahdi A; Tratsiakovich Y; Kövamees O; Yang J; Pernow J
- Article: AMERICAN JOURNAL OF HYPERTENSION. 2017;30(3):304-312Zhou Z; Yadav VR; Sun C; Teng B; Mustafa JS
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2016;311(6):H1339-H1351Sorop O; van den Heuvel M; van Ditzhuijzen NS; de Beer VJ; Heinonen I; van Duin RWB; Zhou Z; Koopmans SJ; Merkus D; van der Giessen WJ; Danser AHJ; Duncker DJ
- Journal article: HYPERTENSION. 2016;68(suppl_1)Yadav VR; Zhou Z; Teng B; Mustafa SJ
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2016;311(1):H299-H309Zhou Z; Chrifi I; Xu Y; Pernow J; Duncker DJ; Merkus D; Cheng C
- Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2016;90:30-37Labazi H; Teng B; Zhou Z; Mustafa SJ
- Journal article: CIRCULATION. 2015;132(suppl_3)ZHOU Z; Teng B; Labazi H; Sun C; Yang Y; Zeng X; Mustafa SJ
- Article: VASCULAR PHARMACOLOGY. 2015;73:78-85Zhou Z; Sun C; Tilley SL; Mustafa SJ
- Article: PURINERGIC SIGNALLING. 2015;11(2):263-273Zhou Z; Rajamani U; Labazi H; Tilley SL; Ledent C; Teng B; Mustafa SJ
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2014;306(6):H918-H927Zhou Z; de Beer VJ; Bender SB; Danser AHJ; Merkus D; Laughlin MH; Duncker DJ
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2014;306(5):L442-L452Zhou Z; de Beer VJ; de Wijs-Meijler D; Bender SB; Hoekstra M; Laughlin MH; Duncker DJ; Merkus D
- Article: PHARMACOLOGICAL RESEARCH. 2013;77:22-29Zhou Z; de Wijs-Meijler D; Lankhuizen I; Jankowski J; Jankowski V; Danser AHJ; Duncker DJ; Merkus D
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2013;304(10):H1370-H1381Merkus D; Visser M; Houweling B; Zhou Z; Nelson J; Duncker DJ
- Article: PHARMACOLOGICAL RESEARCH. 2013;67(1):10-17Zhou Z; Merkus D; Cheng C; Duckers HJ; Danser AHJ; Duncker DJ
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2012;302(8):H1747-H1755Zhou Z; Hemradj V; de Beer VJ; Gao F; Hoekstra M; Merkus D; Duncker DJ
- Article: HYPERTENSION. 2012;59(1):151-157Kappers MHW; de Beer VJ; Zhou Z; Danser AHJ; Sleijfer S; Duncker DJ; van den Meiracker AH; Merkus D
- Article: LIFE SCIENCES. 2011;89(13-14):491-497Gan L; Jiang W; Xiao Y-F; Deng L; Gu L-D; Guo Z-Y; Zhou Z-C; Wu D; Xin H-B
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Alla övriga publikationer
- Review: BRITISH JOURNAL OF PHARMACOLOGY. 2025;182(2):316-339Bibi A; Bartekova M; Gandhi S; Greco S; Made A; Sarkar M; Stopa V; Tastsoglou S; de Gonzalo-Calvo D; Devaux Y; Emanueli C; Hatzigeorgiou AG; Nossent AY; Zhou Z; Martelli F
- Review: JOURNAL OF PHYSIOLOGY-LONDON. 2023;601(22):4989-5009Collado A; Gan L; Tengbom J; Kontidou E; Pernow J; Zhou Z
- Review: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2023;43(5):628-636Kontidou E; Collado A; Pernow J; Zhou Z
- Conference publication: EUROPEAN HEART JOURNAL. 2022;43:2917Tengbom J; Collado A; Jiao T; Yang J; Zhou Z; Mahdi A; Pernow J
- Conference publication: EUROPEAN HEART JOURNAL. 2022;43:2921Yang JN; Tratsiakovich YT; Jiao TJ; Mahdi AM; Tengbom JT; Zhou ZZ; Collado AC; Lundberg JL; Pernow JP
- Conference publication: EUROPEAN HEART JOURNAL. 2022;43:2910Jiao T; Mahdi A; Tengbom J; Collado A; Jurga J; Saleh N; Verouhis D; Bohm F; Zhou Z; Yang J; Pernow J
- Conference publication: EUROPEAN HEART JOURNAL. 2022;43:3074Collado A; Jiao T; Zaccagnini G; Yang J; Carstrom M; Martelli F; Pernow J; Zhou Z
- Conference publication: DIABETOLOGIA. 2022;65(SUPPL 1):S25Collado A; Jiao T; Zaccagnini G; Yang J; Carlstrom M; Martelli F; Pernow J; Zhou Z
- Editorial comment: PURINERGIC SIGNALLING. 2022;18(2):161-163Cao X; Zhou Z
- Review: PURINERGIC SIGNALLING. 2021;17(4):705-712Zhou Z
- Conference publication: EUROPEAN HEART JOURNAL. 2021;42:3259Jiao T; Zhou Z; Mahdi A; Tengbom J; Tratsiakovich Y; Yang J; Pernow J
- Conference publication: EUROPEAN HEART JOURNAL. 2021;42:3364Mahdi A; Collado A; Tengbom J; Jiao T; Wodaje T; Yang J; Lundberg JO; Zhou Z; Pernow J
- Editorial comment: DRUG DISCOVERY TODAY. 2021;26(8):1773-1775Mahdi A; Wernly B; Pernow J; Zhou Z
- Review: HELLENIC JOURNAL OF CARDIOLOGY. 2021;62(3):190-200Rezar R; Lichtenauer M; Haar M; Hoedl G; Kern JM; Zhou Z; Wuppinger T; Kraus J; Strohmer B; Hoppe UC; Wernly B
- Review: FRONTIERS IN PHARMACOLOGY. 2021;12:654425Zhou J; Zhou Z; Liu X; Yin H-Y; Tang Y; Cao X
- Review: BASIC RESEARCH IN CARDIOLOGY. 2021;116(1):22Zhang Y; Wernly B; Cao X; Mustafa SJ; Tang Y; Zhou Z
- Preprint: SSRN. 2021Mahdi A; Collado A; Tengbom J; Jiao T; Wodaje T; Johanssson N; Farnebo F; Färnert A; Yang J; Lundberg J; Zhou Z; Pernow J
- Preprint: SSRN ELECTRONIC JOURNAL. 2021Mahdi A; Collado A; Tengbom J; Jiao T; Wodaje T; Johanssson N; Farnebo F; Färnert A; Yang J; Lundberg JO; Zhou Z; Pernow J
- Conference publication: WIENER KLINISCHE WOCHENSCHRIFT. 2020;132:S217Paar V; Wernly B; Zhou Z; Motloch LJ; Hoppe UC; Egle A; Lichtenauer M
- Review: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2020;319(4):H723-H729Wernly B; Zhou Z
- Review: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2020;9(18):e017404Cai Z; Tu L; Guignabert C; Merkus D; Zhou Z
- Editorial comment: FRONTIERS IN PHARMACOLOGY. 2020;11:1200Zhou Z; Matsumoto T
- Preprint: RESEARCH SQUARE. 2020Liu F; Fang Y; Hou X; Yan Y; Xiao H; Zuo D; Wen J; Wang L; Zhou Z; Dang X; Zhou R; Liao B
- Preprint: RESEARCH SQUARE. 2020Liu F; Fang Y; Hou X; Yan Y; Xiao H; Zuo D; Wen J; Wang L; Zhou Z; Dang X; Zhou R; Liao B
- Review: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2020;140:1-9Zhou R; Dang X; Sprague RS; Mustafa SJ; Zhou Z
- Conference publication: EUROPEAN HEART JOURNAL. 2019;40:3903Yang JN; Jiao T; Tratsiakovich Y; Mahdi A; Zhou Z; Lundberg JO; Pernow J
- Review: CARDIOVASCULAR RESEARCH. 2019;115(11):1596-1605Pernow J; Mahdi A; Yang J; Zhou Z
- Review: PHARMACOLOGICAL RESEARCH. 2019;141:32-45Zhou Z; Matsumoto T; Jankowski V; Pernow J; Mustafa SJ; Duncker DJ; Merkus D
- Editorial comment: AGING-US. 2018;10(12):3643-3644Zhou Z; Yang J; Pernow J
- Conference publication: FASEB JOURNAL. 2018;32(1)Yadav VR; Zhou Z; Teng B; Mustafa SJS
- Conference publication: CARDIOVASCULAR RESEARCH. 2018;114:S26-S27Yang JN; Tratsiakovich Y; Mahdi A; Zhou Z; Lundberg JO; Pernow J
- Conference publication: CARDIOVASCULAR RESEARCH. 2018;114:S42Zhou Z; Mahdi A; Tratsiakovich Y; Yang J; Pernow J
- Conference publication: CARDIOVASCULAR RESEARCH. 2018;114:S42Mahdi A; Tratsiakovich Y; Yang J; Ostenson C-G; Danser JAH; Pernow J; Zhou Z
- Conference publication: EUROPEAN HEART JOURNAL. 2017;38:1140Yang JN; Mahdi A; Zhou Z; Tratsiakovich Y; Kovamees O; Alvarsson M; Pernow J
- Conference publication: EUROPEAN HEART JOURNAL. 2017;38:51-52Zhou Z; Mahdi A; Tratsiakovich Y; Kovamees O; Alvarsson M; Yang J; Pernow J
- Conference publication: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2017;37Zhou Z; Mahdi A; Tratsiakovich Y; Kovamees O; Yang J; Pernow J
- Conference publication: HYPERTENSION. 2016;68:715.2Yadav VR; Zhou Z; Teng B; Mustafa SJ
- Conference publication: FASEB JOURNAL. 2016;30Zhou Z; Yadav VR; Sun C; Teng B; Mustafa SJ
- Conference publication: CIRCULATION. 2015;132Zhou Z; Teng B; Labazi H; Sun C; Yang Y; Zeng X; Mustafa SJ
- Conference publication: FASEB JOURNAL. 2013;27:1185.5Duncker DJ; Zhou Z; de Beer VJ; Merkus D
- Conference publication: FASEB JOURNAL. 2013;27:898.1Zhou Z; de Beer VJ; Duncker DJ; Merkus D
- Conference publication: JOURNAL OF VASCULAR RESEARCH. 2013;50:15Zhou Z; Sorop O; De Beer VJ; Heinonen I; Danser AHJ; Merkus D; Duncker DJ
- Conference publication: CIRCULATION. 2012;126(21)Zhou Z; Jankowski J; Duncker D; Merkus D
- Conference publication: FASEB JOURNAL. 2012;26:1055.5Zhou Z; Duncker DJ; Merkus D
- Conference publication: CIRCULATION. 2011;124(21)de Beer VJ; Kappers MH; Zhou Z; van den Meiracker AH; Danser AHJ; Sleijfer S; Duncker DJ; Merkus D
- Letter: JOURNAL OF APPLIED PHYSIOLOGY. 2011;110(1):289-294Merkus D; Zhou Z
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Forskningsbidrag
- Swedish Research Council1 December 2023 - 30 November 2026BackgroundType 2 diabetes (T2D) is an important risk factor for cardiovascular complications. Endothelial dysfunction is a key factor of vascular complications in T2D. We found that erythrocytes (RBCs) undergo dysfunction in T2D which causes endothelial dysfunction. RBCs contain diverse and abundant non-coding (nc)RNAs, of which the expression and function are unknown. We hypothesize that altered function of RBC-derived ncRNAs induces endothelial dysfunction in T2D.AimTo characterize the function of RBC ncRNAs for endothelial dysfunctionTo elucidate how RBC ncRNAs transmit signal to endothelium in T2DTo explore the efficacy of modulating RBC ncRNA as a therapyWork planRBCs are isolated from patients and rodents with T2D as well as healthy controls. ncRNAs are identified via RNA-sequencing and qPCR. ncRNAs are also validated in extracellular vesicles (EVs) released from RBCs. The function of RBC ncRNAs in endothelial dysfunction is examined by co-incubations of RBCs with healthy artery/endothelial cell ex vivo and RBC transfusion rodent model in vivo. The RBC-derived EVs carrying ncRNAs and the signal to the vasculature are determined using molecular, pharmacological and genetic tools. The therapeutic effect of modulating RBC ncRNAs is addressed by determining endothelial function using both patient materials and gene-targeted animals.SignificanceThis study identifies RBC-derived ncRNAs as new disease mechanism and provides new therapy for vascular complication in T2D.
- 2022 EFSD - NNF Future Leaders Award - Functional role of erythrocyte-derived non-coding RNAs in diabetes-associated vascular complicationsNovo Nordisk Foundation1 January 2023 - 31 December 2027
- Swedish Heart-Lung Foundation1 January 2021 - 31 December 2023
- Swedish Heart-Lung Foundation1 January 2020 - 31 December 2022
- Swedish Research Council1 January 2017 - 31 December 2020
- EFSD/Novo Nordic Foundation Future Leaders Awards
Anställningar
- Senior Forskare, Medicin, Solna, Karolinska Institutet, 2022-
Examina och utbildning
- Docent, Fysiologi, Karolinska Institutet, 2024