Zhichao Zhou
About me
I am an Associate Professor and PI at Division of Cardiology in the
Department of Medicine Solna at Karolinska Institutet. I graduated from a Medical school in China in 2007 and obtained
my Ph.D. degree from the Department of Cardiology, Erasmus University Medical
Center Rotterdam in the Netherlands in 2013. I had my postdoc trainings at
West Virginia University and Karolinska Institutet, respectively (2014-2018). My research
focus is on the elucidation of novel disease mechanisms underlying
cardiovascular complications and identification of effective therapeutic
strategies for patients with cardiometabolic disease suffering from
cardiovascular complications.
My research has been supported by a series of grants from the following funders:
* Swedish Research Council (2023)
* EFSD/Novo Nordisk Foundation Future Leaders Award (2022)
* Swedish Heart and Lung Foundation (2019, 2020, 2022, 2023 and 2024)
* Karolinska Institutet KID Funding (2021 and 2023)
* Eva and Oscar Ahréns Foundation (2021)
* Loo and Hans Ostermans Foundation (2018 and 2020)
* Lars Hiertas Minne Foundation (2018)
* Karolinska Institutet Grant (2018, 2020, 2020 and
2022)
* Sigurt and Elsa Goljes Memorial Foundation (2017)
* Olaussons Fund 2016
Commission of trust:
* Editorial board: Front Cardiovasc Med- Front Pharmacol
- Purinergic
Signal - ATVB (early career editorial board)
* Coordinator of KIRCNET (2020-2023) [1]
* Committee member: KIRCNET (2023-present), KiiM (2021-2023) [2] and Cardiovascular Research Seminar Series (2022-present)
* Member of Swedish Cardiometabolic Research Network (SCAMN) (2023-present)
* The SRP Diabetes PI group (2022-present) [3]
* Guest editor: Front Cardiovasc Med 2022 - Int J Hypertens 2019
* Grant evaluation task for: UK Medical Research Council (MRC) - Polish National Science Center and Health Research Council of New Zealand
* Journal reviewer for: J Am Coll Cardiol - Eur Heart J
- Circ Res
- Cardiovasc Res
- Hypertension
- Atherosclerosis
- Br J Pharmacol
- J Appl Physiol
- Am J Hypertens
- JACC Asia
- Mol Cell Life Sci
- J Diabetes
- J Diabetes Res
- Front Cardiovasc Med
- Front Pharmacol
- Purinergic Signal etc.
[1] https://ki.se/en/research/kircnet-ki-respiration-and-circulation-network
[2] https://ki.se/en/research/kiim-ki-inflammation-and-immunology-network
[3] https://ki.se/en/srp-diabetes/strategic-research-programme-in-diabetes-srp-diabetes
Research
- Cardiovascular complications are major clinical problems in various
cardiometabolic diseases (e.g. diabetes and obesity) that leads to high
morbidity and mortality worldwide. The underlying mechanisms are poorly
understood, and specific therapy targeting cardiovascular injury is lacking.
In recent years, we have identified that red blood cells (RBCs) undergo
dysfunction which acts as disease mediator of development of vascular
dysfunction in diabetes and COVID-19, and targeting dysfunctional RBCs could
serve as a potential strategy for the treatment of vascular injury.
RBCs contain abundant and diverse non-coding (nc) RNAs. Using high throughput
profiling followed by functional validations in samples from
well-characterized clinical cohorts of patients and genetically modified and
disease animal models, my study explores the expression and function of
ncRNAs in RBCs and the implications of alteration of RBC-derived ncRNAs for
the development of cardiovascular complications. In addition, RBCs serve as
ATP pool and release of ATP from RBCs is impaired in several disease
conditions. Another research interest of mine is to investigate the
functional interaction between the RBC and cardiovascular wall through
activation of ATP-mediated purinergic signaling in cardiometabolic disease.
The ultimate research goal is to elucidate altered RBC-derived factors as
novel disease mechanisms of cardiovascular complications and identify key
RBC-derived factors as potential diagnostic markers and therapeutic
targets.
Articles
- Article: CLINICAL SCIENCE. 2024;138(15):975-985
- Journal article: CARDIOVASCULAR RESEARCH (CVR). 2024;120:cvae088.035
- Article: PURINERGIC SIGNALLING. 2024;20(1):5-8
- Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.3099
- Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.3096
- Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.3066
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2023;133(17):e167693
- Article: JACC: BASIC TO TRANSLATIONAL SCIENCE. 2023;8(8):907-918
- Article: JCI INSIGHT. 2023;8(6):e160745
- Article: PHARMACOLOGICAL RESEARCH. 2023;188:106677
- Article: JOURNAL OF INTERNAL MEDICINE. 2023;293(2):228-245
- Article: BASIC RESEARCH IN CARDIOLOGY. 2022;117(1):46
- Article: JACC: BASIC TO TRANSLATIONAL SCIENCE. 2022;7(3):193-204
- Article: DIABETES. 2022;71(2):285-297
- Article: MEDICAL PRINCIPLES AND PRACTICE. 2022;31(2):187-194
- Article: PHARMACOLOGY. 2022;107(3-4):160-166
- Journal article: EUROPEAN HEART JOURNAL. 2021;42(Supplement_1):ehab724.3364
- Article: CURRENT OPINION IN PHARMACOLOGY. 2021;60:183-192
- Article: JOURNAL OF THROMBOSIS AND THROMBOLYSIS. 2021;51(1):226-231
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY. 2021;320(1):H90-H94
- Article: CELLS. 2020;9(7):E1712-1712
- Article: STEM CELL RESEARCH AND THERAPY. 2020;11(1):284
- Article: WORLD JOURNAL OF SURGICAL ONCOLOGY. 2020;18(1):88
- Article: FRONTIERS IN PHARMACOLOGY. 2020;11:603226
- Journal article: EUROPEAN HEART JOURNAL. 2019;40(Supplement_1):ehz746.0897
- Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2019;23(9):6085-6097
- Article: JOURNAL OF PHARMACOLOGICAL SCIENCES. 2019;141(1):64-69
- Journal article: THE FASEB JOURNAL. 2019;33:512.4
- Article: FRONTIERS IN PHARMACOLOGY. 2019;10:861
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2018;19(12):E3942-3942
- Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2018;72(7):769-780
- Article: JACC: BASIC TO TRANSLATIONAL SCIENCE. 2018;3(4):450-463
- Article: FRONTIERS IN PHARMACOLOGY. 2018;9:255
- Article: PURINERGIC SIGNALLING. 2017;13(4):591-600
- Article: PURINERGIC SIGNALLING. 2017;13(3):319-329
- Journal article: EUROPEAN HEART JOURNAL. 2017;38(suppl_1):ehx501.280
- Journal article: EUROPEAN HEART JOURNAL. 2017;38(suppl_1):ehx493.p5386
- Journal article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2017;37(suppl_1)
- Article: AMERICAN JOURNAL OF HYPERTENSION. 2017;30(3):304-312
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY. 2016;311(6):H1339-H1351
- Journal article: HYPERTENSION. 2016;68(suppl_1)
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY. 2016;311(1):H299-H309
- Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2016;90:30-37
- Journal article: CIRCULATION. 2015;132(suppl_3)
- Article: VASCULAR PHARMACOLOGY. 2015;73:78-85
- Article: PURINERGIC SIGNALLING. 2015;11(2):263-273
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY. 2014;306(6):H918-H927
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2014;306(5):L442-L452
- Article: PHARMACOLOGICAL RESEARCH. 2013;77:22-29
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY. 2013;304(10):H1370-H1381
- Article: PHARMACOLOGICAL RESEARCH. 2013;67(1):10-17
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY. 2012;302(8):H1747-H1755
- Article: HYPERTENSION. 2012;59(1):151-157
- Article: LIFE SCIENCES. 2011;89(13-14):491-497
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All other publications
- Review: BRITISH JOURNAL OF PHARMACOLOGY. 2024
- Review: JOURNAL OF PHYSIOLOGY. 2023;601(22):4989-5009
- Review: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2023;43(5):628-636
- Conference publication: EUROPEAN HEART JOURNAL. 2022;43:2917
- Conference publication: EUROPEAN HEART JOURNAL. 2022;43:2921
- Conference publication: EUROPEAN HEART JOURNAL. 2022;43:2910
- Conference publication: EUROPEAN HEART JOURNAL. 2022;43:3074
- Editorial comment: PURINERGIC SIGNALLING. 2022;18(2):161-163
- Conference publication: DIABETOLOGIA. 2022;65(SUPPL 1):S25
- Review: PURINERGIC SIGNALLING. 2021;17(4):705-712
- Conference publication: EUROPEAN HEART JOURNAL. 2021;42:3259
- Editorial comment: DRUG DISCOVERY TODAY. 2021;26(8):1773-1775
- Review: HELLENIC JOURNAL OF CARDIOLOGY. 2021;62(3):190-200
- Review: BASIC RESEARCH IN CARDIOLOGY. 2021;116(1):22
- Review: FRONTIERS IN PHARMACOLOGY. 2021;12:654425
- Preprint: SSRN. 2021
- Conference publication: EUROPEAN HEART JOURNAL. 2021;42:3364
- Preprint: SSRN ELECTRONIC JOURNAL. 2021
- Review: AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY. 2020;319(4):H723-H729
- Review: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2020;9(18):e017404
- Review: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2020;140:1-9
- Conference publication: WIENER KLINISCHE WOCHENSCHRIFT. 2020;132:S217
- Editorial comment: FRONTIERS IN PHARMACOLOGY. 2020;11:1200
- Review: CARDIOVASCULAR RESEARCH (CVR). 2019;115(11):1596-1605
- Review: PHARMACOLOGICAL RESEARCH. 2019;141:32-45
- Conference publication: EUROPEAN HEART JOURNAL. 2019;40:3903
- Editorial comment: AGING. 2018;10(12):3643-3644
- Conference publication: HYPERTENSION. 2018;68:715.2
- Conference publication: CARDIOVASCULAR RESEARCH (CVR). 2018;114:S42
- Conference publication: CARDIOVASCULAR RESEARCH (CVR). 2018;114:S26-S27
- Conference publication: CARDIOVASCULAR RESEARCH (CVR). 2018;114:S42
- Conference publication: THE FASEB JOURNAL. 2018;32(1)
- Conference publication: EUROPEAN HEART JOURNAL. 2017;38:1140
- Conference publication: EUROPEAN HEART JOURNAL. 2017;38:51-52
- Conference publication: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2017;37
- Conference publication: THE FASEB JOURNAL. 2016;30
- Conference publication: CIRCULATION. 2015;132
- Conference publication: THE FASEB JOURNAL. 2013;27:1185.5
- Conference publication: THE FASEB JOURNAL. 2013;27:898.1
- Conference publication: JOURNAL OF VASCULAR RESEARCH. 2013;50:15
- Conference publication: THE FASEB JOURNAL. 2012;26:1055.5
- Conference publication: CIRCULATION. 2012;126(21)
- Conference publication: CIRCULATION. 2011;124(21)
- Letter: JOURNAL OF APPLIED PHYSIOLOGY. 2011;110(1):289-294
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Grants
- Swedish Research Council1 December 2023 - 30 November 2026
- 2022 EFSD - NNF Future Leaders Award - Functional role of erythrocyte-derived non-coding RNAs in diabetes-associated vascular complicationsNovo Nordisk Foundation1 January 2023 - 31 December 2027
- Swedish Heart-Lung Foundation1 January 2021 - 31 December 2023
- Swedish Heart-Lung Foundation1 January 2020 - 31 December 2022
- Swedish Research Council1 January 2017 - 31 December 2020
- EFSD/Novo Nordic Foundation Future Leaders Awards
Employments
- Principal Researcher, Department of Medicine, Karolinska Institutet, 2022-
Degrees and Education
- Docent, Karolinska Institutet, 2024