Xiuming Liang

Publikationer
Forskningsbidrag
Populärvetenskap och samverkan

Artiklar

Article: JOURNAL OF CONTROLLED RELEASE. 2025;384:113882
Screening scaffold proteins for improved functional delivery of luminal proteins using engineered extracellular vesicles
Niu Z; Zhou H; Zheng W; Hayes OG; Hou VWQ; Gorgens A; Roudi S; Zhou G; Wiklander RJ; Sych T; Sezgin E; Nordin JZ; Zhao Y; Liang X; Andaloussi SEL
Journal article: PHARMACOLOGICAL RESEARCH. 2025;217:107800
Extracellular vesicles as a promising platform of precision medicine in liver cancer
Xu K; Wu Q; Zhao L; Nguyen R; Safri F; Yang W; Xu Y; Ye Y; Kwan HY; Wang Q; Liang X; Shiddiky MJA; Warkiani ME; George J; Qiao L; Bao J
Article: JOURNAL OF CONTROLLED RELEASE. 2025;386:114038
Advanced peptide nanoparticles enable robust and efficient delivery of gene editors across cell types.
Gustafsson O; Krishna S; Borate S; Ghaeidamini M; Liang X; Saher O; Cuellar R; Birdsong BK; Roudi S; Estupiñán HY; Alici E; Smith CIE; Esbjörner EK; Spuler S; de Jong OG; Escobar H; Nordin JZ; Andaloussi SEL
Journal article: CELL DEATH & DISEASE. 2025;16(1):452
Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis
Tang G; Cao X; Chen J; Hui F; Xu N; Jiang Y; Lu H; Xiao H; Liang X; Ma M; Qian Y; Liu D; Wang Z; Liu S; Yu G; Sun L
Article: NATURE COMMUNICATIONS. 2025;16(1):4028
Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors
Liang X; Gupta D; Xie J; Van Wonterghem E; Van Hoecke L; Hean J; Niu Z; Ghaeidamini M; Wiklander OPB; Zheng W; Wiklander RJ; He R; Mamand DR; Bost J; Zhou G; Zhou H; Roudi S; Estupinan HY; Radler J; Zickler AM; Gorgens A; Hou VWQ; Slovak R; Hagey DW; de Jong OG; Uy AG; Zong Y; Mager I; Perez CM; Roberts TC; Carter D; Vader P; Esbjorner EK; de Fougerolles A; Wood MJA; Vandenbroucke RE; Nordin JZ; EL Andaloussi S
Article: EXTRACELLULAR VESICLE. 2024;4:100054
An extracellular vesicle delivery platform based on the PTTG1IP protein.
Martin Perez C; Liang X; Gupta D; Haughton ER; Conceição M; Mäger I; El Andaloussi S; Wood MJA; Roberts TC
Article: NATURE BIOMEDICAL ENGINEERING. 2024;8(11):1453-1468
Antibody-displaying extracellular vesicles for targeted cancer therapy
Wiklander OPB; Mamand DR; Mohammad DK; Zheng W; Jawad Wiklander R; Sych T; Zickler AM; Liang X; Sharma H; Lavado A; Bost J; Roudi S; Corso G; Lennaard AJ; Abedi-Valugerdi M; Maeger I; Alici E; Sezgin E; Nordin JZ; Gupta D; Goergens A; EL Andaloussi S
Article: ADVANCED SCIENCE. 2024;11(42):e2407619
Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles
Zickler AM; Liang X; Gupta D; Mamand DR; De Luca M; Corso G; Errichelli L; Hean J; Sen T; Elsharkasy OM; Kamei N; Niu Z; Zhou G; Zhou H; Roudi S; Wiklander OPB; Gorgens A; Nordin JZ; Castilla-Llorente V; EL Andaloussi S
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2024;13(7):e12471
Extracellular vesicles originating from melanoma cells promote dysregulation in haematopoiesis as a component of cancer immunoediting
Mamand DR; Bazaz S; Mohammad DK; Liang X; Pavlova S; Mim C; Gabrielsson S; Nordin JZ; Wiklander OPB; Abedi-Valugerdi M; EL-Andaloussi S
Article: NATURE COMMUNICATIONS. 2023;14(1):4734
Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles
Zheng W; Raedler J; Sork H; Niu Z; Roudi S; Bost JPP; Goergens A; Zhao Y; Mamand DRR; Liang X; Wiklander OPB; Lehto T; Gupta D; Nordin JZZ; EL Andaloussi S
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2022;11(12):e12290
Cell-specific targeting of extracellular vesicles though engineering the glycocalyx
Zheng W; He R; Liang X; Roudi S; Bost J; Pierre-Michael C; van Niel G; Andaloussi SEL
Article: CELL DEATH AND DIFFERENTIATION. 2022;29(11):2190-2202
Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer
Wang Y; Zheng L; Shang W; Yang Z; Li T; Liu F; Shao W; Lv L; Chai L; Qu L; Xu Q; Du J; Liang X; Zeng J; Jia J
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2022;11(7):e12248
Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models
Liang X; Niu Z; Galli V; Howe N; Zhao Y; Wiklander OPB; Zheng W; Wiklander RJ; Corso G; Davies C; Hean J; Kyriakopoulou E; Mamand DR; Amin R; Nordin JZ; Gupta D; Andaloussi SEL
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2022;11(6):e12238
Identification of storage conditions stabilizing extracellular vesicles preparations
Gorgens A; Corso G; Hagey DW; Wiklander RJ; Gustafsson MO; Felldin U; Lee Y; Bostancioglu RB; Sork H; Liang X; Zheng W; Mohammad DK; van DWSI; Vader P; Zickler AM; Mamand DR; Ma L; Holme MN; Stevens MM; Wiklander OPB; El Andaloussi S
Article: ADVANCED HEALTHCARE MATERIALS. 2022;11(5):e2101658
Growth Media Conditions Influence the Secretion Route and Release Levels of Engineered Extracellular Vesicles
Bost JP; Saher O; Hagey D; Mamand DR; Liang X; Zheng W; Corso G; Gustafsson O; Gorgens A; Smith CIE; Zain R; El Andaloussi S; Gupta D
Article: JCI INSIGHT. 2021;6(24):e146362
CPVL promotes glioma progression via STAT1 pathway inhibition through interactions with the BTK/p300 axis
Yang H; Liu X; Zhu X; Li X; Jiang L; Zhong M; Zhang M; Chen T; Ma M; Liang X; Lv K
Article: NATURE BIOMEDICAL ENGINEERING. 2021;5(9):1084-1098
Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles.
Gupta D; Wiklander OPB; Görgens A; Conceição M; Corso G; Liang X; Seow Y; Balusu S; Feldin U; Bostancioglu B; Jawad R; Mamand DR; Lee YXF; Hean J; Mäger I; Roberts TC; Gustafsson M; Mohammad DK; Sork H; Backlund A; Lundin P; de Fougerolles A; Smith CIE; Wood MJA; Vandenbroucke RE; Nordin JZ; El-Andaloussi S
Article: JOURNAL OF PATHOLOGY. 2021;253(2):148-159
SETDB1 promotes gastric carcinogenesis and metastasis via upregulation of CCND1 and MMP9 expression
Shang W; Wang Y; Liang X; Li T; Shao W; Liu F; Cui X; Wang Y; Lv L; Chai L; Qu L; Zheng L; Jia J
Article: FRONTIERS IN ONCOLOGY. 2021;11:757497
Mechanisms of JARID1B Up-Regulation and Its Role in Helicobacter pylori-Induced Gastric Carcinogenesis.
Zheng L; Wu Y; Shen L; Liang X; Yang Z; Li S; Li T; Shang W; Shao W; Wang Y; Liu F; Ma L; Jia J
Article: MOLECULAR CANCER RESEARCH. 2021;19(1):74-85
Helicobacter pylori Induces a Novel NF-kB/LIN28A/let-7a/hTERT Axis to Promote Gastric Carcinogenesis
Shen L; Zeng J; Ma L; Li S; Chen C; Jia J; Liang X
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2020;9(1):1800222
Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging
Gupta D; Liang X; Pavlova S; Wiklander OPB; Corso G; Zhao Y; Saher O; Bost J; Zickler AM; Piffko A; Maire CL; Ricklefs FL; Gustafsson O; Llorente VC; Gustafsson MO; Bostancioglu RB; Mamand DR; Hagey DW; Goergens A; Nordin JZ; EL Andaloussi S
Article: EBIOMEDICINE. 2020;53:102672
Orphan nuclear receptor Nurr1 promotes Helicobacter pylori-associated gastric carcinogenesis by directly enhancing CDK4 expression
Shang W; Liang X; Li S; Li T; Zheng L; Shao W; Wang Y; Liu F; Ma L; Jia J
Article: EBIOMEDICINE. 2019;47:44-57
Identification of AUNIP as a candidate diagnostic and prognostic biomarker for oral squamous cell carcinoma
Yang Z; Liang X; Fu Y; Liu Y; Zheng L; Liu F; Li T; Yin X; Qiao X; Xu X
Article: CANCER MEDICINE. 2019;8(8):3965-3980
Helicobacter pylori-induced YAP1 nuclear translocation promotes gastric carcinogenesis by enhancing IL-1β expression.
Wu Y; Shen L; Liang X; Li S; Ma L; Zheng L; Li T; Yu H; Chan H; Chen C; Yu J; Jia J
Article: EBIOMEDICINE. 2019;39:301-314
H. pylori infection induced BMAL1 expression and rhythm disorder aggravate gastric inflammation
Li T; Shao W; Li S; Ma L; Zheng L; Shang W; Jia X; Sun P; Liang X; Jia J
Article: EBIOMEDICINE. 2018;38:69-78
CHAF1A interacts with TCF4 to promote gastric carcinogenesis via upregulation of c-MYC and CCND1 expression
Zheng L; Liang X; Li S; Li T; Shang W; Jia X; Shao W; Sun P; Chen C; Jia J
Article: ONCOGENE. 2018;37(7):884-896
MiR-22 sustains NLRP3 expression and attenuates H. pylori-induced gastric carcinogenesis.
Li S; Liang X; Ma L; Shen L; Li T; Zheng L; Sun A; Shang W; Chen C; Zhao W; Jia J
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:1326
Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures
Wiklander OPB; Bostancioglu RB; Welsh JA; Zickler AM; Murke F; Corso G; Felldin U; Hagey DW; Evertsson B; Liang X-M; Gustafsson MO; Mohammad DK; Wiek C; Hanenberg H; Bremer M; Gupta D; Bjornstedt M; Giebel B; Nordin JZ; Jones JC; EL Andaloussi S; Goergens A
Article: EBIOMEDICINE. 2017;21:104-116
Histone Chaperone ASF1A Predicts Poor Outcomes for Patients With Gastrointestinal Cancer and Drives Cancer Progression by Stimulating Transcription of β-Catenin Target Genes
Liang X; Yuan X; Yu J; Wu Y; Li K; Sun C; Li S; Shen L; Kong F; Jia J; Bjorkholm M; Xu D
Article: FASEB JOURNAL. 2017;31(2):491-504
Human 15-lipoxygenase-1 is a regulator of dendritic-cell spreading and podosome formation
Han H; Liang X; Ekberg M; Kritikou JS; Brunnstrom A; Pelcman B; Matl M; Miao X; Andersson M; Yuan X; Schain F; Parvin S; Melin E; Sjoberg J; Xu D; Westerberg LS; Bjorkholm M; Claesson H-E
Article: AMERICAN JOURNAL OF CANCER RESEARCH. 2017;7(3):448-461
Histone demethylase PHF8 promotes progression and metastasis of gastric cancer.
Li S; Sun A; Liang X; Ma L; Shen L; Li T; Zheng L; Shang W; Zhao W; Jia J
Article: ONCOTARGET. 2016;7(10):11349-11363
Mutual amplification of HNF4α and IL-1R1 composes an inflammatory circuit in Helicobacter pylori associated gastric carcinogenesis.
Ma L; Zeng J; Guo Q; Liang X; Shen L; Li S; Sun Y; Li W; Liu S; Yu H; Chen C; Jia J
Article: ONCOTARGET. 2015;6(19):17661-17674
Histone demethylase RBP2 promotes malignant progression of gastric cancer through TGF-β1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit.
Liang X; Zeng J; Wang L; Shen L; Ma X; Li S; Wu Y; Ma L; Ci X; Guo Q; Jia M; Shen H; Sun Y; Liu Z; Liu S; Li W; Yu H; Chen C; Jia J
Article: ONCOTARGET. 2014;5(14):5798-5807
Histone demethylase RBP2 induced by Helicobactor Pylori CagA participates in the malignant transformation of gastric epithelial cells.
Liang X; Zeng J; Wang L; Shen L; Li S; Ma L; Ci X; Yu J; Jia M; Sun Y; Liu Z; Liu S; Li W; Yu H; Chen C; Jia J
Article: MOLECULAR CANCER. 2014;13:81
Critical role of histone demethylase RBP2 in human gastric cancer angiogenesis.
Li L; Wang L; Song P; Geng X; Liang X; Zhou M; Wang Y; Chen C; Jia J; Zeng J
Article: PLOS ONE. 2014;9(8):e105306
Helicobacter pylori promotes epithelial-mesenchymal transition in gastric cancer by downregulating programmed cell death protein 4 (PDCD4).
Yu H; Zeng J; Liang X; Wang W; Zhou Y; Sun Y; Liu S; Li W; Chen C; Jia J
Article: JOURNAL OF CELLULAR BIOCHEMISTRY. 2013;114(12):2666-2672
MicroRNA-212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2.
Jiping Z; Ming F; Lixiang W; Xiuming L; Yuqun S; Han Y; Zhifang L; Yundong S; Shili L; Chunyan C; Jihui J
Article: BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH. 2013;46(9):739-745
Histone demethylase retinoblastoma binding protein 2 regulates the expression of α-smooth muscle actin and vimentin in cirrhotic livers.
Wang Q; Wang LX; Zeng JP; Liu XJ; Liang XM; Zhou YB
Article: MOLECULAR CANCER RESEARCH. 2013;11(8):834-844
FoxM1 is overexpressed in Helicobacter pylori-induced gastric carcinogenesis and is negatively regulated by miR-370.
Feng Y; Wang L; Zeng J; Shen L; Liang X; Yu H; Liu S; Liu Z; Sun Y; Li W; Chen C; Jia J
Article: BRITISH JOURNAL OF CANCER. 2013;108(11):2272-2280
Telomerase reverse transcriptase inhibition stimulates cyclooxygenase 2 expression in cancer cells and synergizes with celecoxib to exert anti-cancer effects
Liu T; Liang X; Li B; Bjorkholm M; Jia J; Xu D
Article: PLOS ONE. 2013;8(7):e69784
Histone demethylase retinoblastoma binding protein 2 is overexpressed in hepatocellular carcinoma and negatively regulated by hsa-miR-212.
Liang X; Zeng J; Wang L; Fang M; Wang Q; Zhao M; Xu X; Liu Z; Li W; Liu S; Yu H; Jia J; Chen C
Article: EXPERIMENTAL BIOLOGY AND MEDICINE. 2012;237(4):435-441
Helicobacter pylori CagA induces ornithine decarboxylase upregulation via Src/MEK/ERK/c-Myc pathway: implication for progression of gastric diseases.
Xu X; Liu Z; Fang M; Yu H; Liang X; Li X; Liu X; Chen C; Jia J
Visa fler

Alla övriga publikationer

Preprint: BIORXIV. 2025
Systemic Inflammation Modulates Clearance and drives Extra-Hepatic Distribution of Extracellular Vesicles
Pavlova S; Mamand DR; Görgens A; Zickler AM; Zheng W; Liang X; Wiklander OPB; Abedi-Valugerdi M; Van Wonterghem E; Xie J; Niu Z; Roudi S; Yan D; Zhou G; Imami K; Wood MPA; Vanderbroucke RE; Andaloussi SE; Gupta D
Preprint: BIORXIV. 2024
Advanced Peptide Nanoparticles Enable Robust and Efficient delivery of gene editors across cell types
Gustafsson O; Krishna S; Borate S; Ghaeidamini M; Liang X; Saher O; Cuellar R; Birdsong B; Roudi S; Estupiñán Y; Alici E; Smith CIE; Esbjörner E; Spuler S; de Jong OG; Escobar H; Nordin J; Andaloussi SEL
Preprint: BIORXIV. 2024
A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release
Elsharkasy OM; Hegeman CV; Lansweers I; Cotugno OL; de Groot IY; de Wit ZEMNJ; Liang X; Garcia-Guerra A; Moorman NJA; Lefferts J; de Voogt WS; Gitz-Francois JJ; van Wesel ACW; Andaloussi SE; Schiffelers RM; Kooijmans SAA; Mastrobattista E; Vader P; de Jong OG
Preprint: RESEARCH SQUARE. 2023
Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors
Liang X; Gupta D; Xie J; Wonterghem E; Hoecke L; Hean J; Niu Z; Wiklander O; Zheng W; Wiklander R; He R; Mammad D; Bost J; Zhou G; Zhou H; Roudi S; Zickler A; Gorgens A; Hagey D; de Jong O; Uy A; Zong Y; Mager I; Perez C; Roberts T; Vader P; Fougerolles A; Wood M; Vandenbroucke R; Nordin J; El-Andaloussi S
Preprint: BIORXIV. 2023
An extracellular vesicle delivery platform based on the PTTG1IP protein
Perez CM; Liang X; Gupta D; Conceição M; Mäger I; Andaloussi SEL; Wood MJA; Roberts T
Preprint: BIORXIV. 2023
Identification of Novel Scaffold Proteins for Improved Endogenous Engineering of Extracellular Vesicles
Zheng W; Rädler J; Sork H; Niu Z; Roudi S; Bost J; Görgens A; Zhao Y; Mamand D; Liang X; Wiklander O; Lehto T; Gupta D; Nordin J; EL Andaloussi S
Preprint: BIORXIV. 2023
Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery
Liang X; Gupta D; Xie J; Wonterghem EV; Hoecke LV; Hean J; Niu Z; Wiklander O; Zheng W; Wiklander RJ; He R; Mamand D; Bost J; Zhou G; Zhou H; Roudi S; Zickler AM; Gorgens A; Hagey D; de Jong O; Uy AG; Zong Y; Mager I; Perez CM; Roberts T; Vader P; Fougerolles AD; Wood M; Vandenbroucke R; Nordin J; EL Andaloussi S
Letter: GENE. 2014;540(2):266-267
The absence of TERT promoter mutations in primary gastric cancer
Liu T; Liang X; Bjoerkholm M; Jia J; Xu D

Forskningsbidrag

Efficient gene editing by engineered extracellular vesicles
Karolinska Institutet’s Research Foundation Grants
1 January 2025 - 31 December 2025
Engineering extracellular vesicles for combination therapies of tumor
Region Stockholm (CIMED Junioransökan)
1 January 2024 - 31 December 2026
Högeffektiv intracellulär leverans av funktionella och terapeutiska proteiner genom konstruerade extracellulära vesiklar
Karolinska Institutet’s Research Foundation Grants
1 January 2023 - 31 December 2023
Targeted cancer immunotherapy by extracellular vesicles
Region Stockholm (CIMED Junioransökan)
1 January 2021 - 31 December 2022
Regulation mechanism of Helicobacter pylori-mediated biorhythm molecules to promote inflammation and cancer transformation
National Natural Science Foundation of China
1 January 2019 - 31 December 2022

Artiklar

Alla övriga publikationer

Forskningsbidrag

Nyheter från KI

Kalenderhändelser från KI