Xinsong Chen

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: SCIENCE TRANSLATIONAL MEDICINE. 2024;16(747):eadi2952

Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axis.

Neo SY; Tong L; Chong J; Liu Y; Jing X; Oliveira MMS; Chen Y; Chen Z; Lee K; Burduli N; Chen X; Gao J; Ma R; Lim JP; Huo J; Xu S; Alici E; Wickström SL; Haglund F; Hartman J; Wagner AK; Cao Y; Kiessling R; Lam KP; Westerberg LS; Lundqvist A
Journal article: CANCER RESEARCH. 2024;84(9_Supplement):po4-01-05-po4-01-05

Abstract PO4-01-05: The prognostic importance of biological pathway enrichment patterns in trastuzumab-treated early HER2-positive breast cancer

Rönnlund C; Yang Q; Schagerholm C; Foukakis T; Fredriksson I; Chen X; Robertson S; Sifakis E; Hartman J
Article: BIOINFORMATICS. 2024;40(5):btae284

CopyVAE: a variational autoencoder-based approach for copy number variation inference using single-cell transcriptomics.

Kurt S; Chen M; Toosi H; Chen X; Engblom C; Mold J; Hartman J; Lagergren J
Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2024;43(1):107

A phenotypic screening approach to target p60AmotL2-expressing invasive cancer cells.

Fonseca P; Cui W; Struyf N; Tong L; Chaurasiya A; Casagrande F; Zhao H; Fernando D; Chen X; Tobin NP; Seashore-Ludlow B; Lundqvist A; Hartman J; Göndör A; Östling P; Holmgren L
Article: BREAST CANCER RESEARCH. 2024;26(1):24

Prognostic impact of HER2 biomarker levels in trastuzumab-treated early HER2-positive breast cancer.

Rönnlund C; Sifakis EG; Schagerholm C; Yang Q; Karlsson E; Chen X; Foukakis T; Weidler J; Bates M; Fredriksson I; Robertson S; Hartman J
Article: SCIENCE. 2023;382(6675):eadf8486

Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics.

Engblom C; Thrane K; Lin Q; Andersson A; Toosi H; Chen X; Steiner E; Lu C; Mantovani G; Hagemann-Jensen M; Saarenpää S; Jangard M; Saez-Rodriguez J; Michaëlsson J; Hartman J; Lagergren J; Mold JE; Lundeberg J; Frisén J
Article: BIOENGINEERING & TRANSLATIONAL MEDICINE. 2023;8(5):e10537

Development and characterization of a recombinant silk network for 3D culture of immortalized and fresh tumor-derived breast cancer cells.

Collodet C; Blust K; Gkouma S; Ståhl E; Chen X; Hartman J; Hedhammar M
Article: NATURE BIOTECHNOLOGY. 2023;41(8):1085-1088

Solid-phase capture and profiling of open chromatin by spatial ATAC.

Llorens-Bobadilla E; Zamboni M; Marklund M; Bhalla N; Chen X; Hartman J; Frisén J; Ståhl PL
Article: NATURE COMMUNICATIONS. 2023;14(1):982

Reconstructing clonal tree for phylo-phenotypic characterization of cancer using single-cell transcriptomics.

Jun S-H; Toosi H; Mold J; Engblom C; Chen X; O'Flanagan C; Hagemann-Jensen M; Sandberg R; Aparicio S; Hartman J; Roth A; Lagergren J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(1):e2209856120

Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction.

Chen X; Sifakis EG; Robertson S; Neo SY; Jun S-H; Tong L; Hui Min AT; Lövrot J; Hellgren R; Margolin S; Bergh J; Foukakis T; Lagergren J; Lundqvist A; Ma R; Hartman J
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(5):e004592

A2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models.

Tay AHM; Prieto-Díaz R; Neo S; Tong L; Chen X; Carannante V; Önfelt B; Hartman J; Haglund F; Majellaro M; Azuaje J; Garcia-Mera X; Brea JM; Loza MI; Jespers W; Gutierrez-de-Teran H; Sotelo E; Lundqvist A
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(3):1354

The Importance of Sex in the Discovery of Colorectal Cancer Prognostic Biomarkers.

Hases L; Ibrahim A; Chen X; Liu Y; Hartman J; Williams C
Article: BREAST CANCER RESEARCH. 2020;22(1):80

Identification and targeting of selective vulnerability rendered by tamoxifen resistance.

Singh M; Zhou X; Chen X; Santos GS; Peuget S; Cheng Q; Rihani A; Arnér ESJ; Hartman J; Selivanova G
Article: CANCER RESEARCH. 2020;80(7):1538-1550

Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds.

Peuget S; Zhu J; Sanz G; Singh M; Gaetani M; Chen X; Shi Y; Saei AA; Visnes T; Lindström MS; Rihani A; Moyano-Galceran L; Carlson JW; Hjerpe E; Joneborg U; Lehti K; Hartman J; Helleday T; Zubarev R; Selivanova G
Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(3):1185-1198

CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment.

Neo SY; Yang Y; Record J; Ma R; Chen X; Chen Z; Tobin NP; Blake E; Seitz C; Thomas R; Wagner AK; Andersson J; de Boniface J; Bergh J; Murray S; Alici E; Childs R; Johansson M; Westerberg LS; Haglund F; Hartman J; Lundqvist A
Article: ONCOGENE. 2016;35(29):3807-3816

Oxidative stress enables Epstein-Barr virus-induced B-cell transformation by posttranscriptional regulation of viral and cellular growth-promoting factors.

Chen X; Kamranvar SA; Masucci MG
Article: ONCOGENE. 2013;32(49):5522-5530

Telomere dysfunction and activation of alternative lengthening of telomeres in B-lymphocytes infected by Epstein-Barr virus.

Kamranvar SA; Chen X; Masucci MG
Article: PLOS PATHOGENS. 2013;9(10):e1003664

Caspase-1 promotes Epstein-Barr virus replication by targeting the large tegument protein deneddylase to the nucleus of productively infected cells.

Gastaldello S; Chen X; Callegari S; Masucci MG

Alla övriga publikationer

Letter: CANCER COMMUNICATIONS. 2023;43(7):855-859

Renal cell carcinoma escapes NK cell-mediated immune surveillance through the downregulation of DNAM-1.

Tong L; Kremer V; Neo SY; Liu Y; Chen Y; Wagner AK; Yang Y; Chen Z; Seitz C; Tobin NP; Ligtenberg MA; Alici E; Chen X; Haglund F; Seliger B; Harmenberg U; Colón E; Plogell A-HS; Liu LL; Lundqvist A
Conference publication: CANCER RESEARCH. 2023;83(5):p2-21-02-p2-21-02

Longitudinal tumor-immune microenvironment changes in patients with clinical luminal A early breast cancer treated with neoadjuvant palbociclib and endocrine therapy: results from the Swedish randomized PREDIX Luminal A trial

Zerdes I; Salgkamis D; Matikas A; Selander L; Wang K; Tzoras E; Sifakis E; Agartz S; Chen X; Hellstrom M; Hartman J; Bergh J; Foukakis T; Hatschek T
Preprint: BIORXIV. 2022

Development and characterization of a recombinant silk network for 3D culture of immortalized and fresh tumor-derived breast cancer cells

Collodet C; Blust K; Gkouma S; Ståhl E; Chen X; Hartman J; Hedhammar M
Preprint: BIORXIV. 2022

Spatial transcriptomics of T and B cell receptors uncovers lymphocyte clonal dynamics in human tissue

Engblom C; Thrane K; Lin Q; Andersson A; Toosi H; Chen X; Steiner E; Mantovani G; Hagemann-Jensen M; Saarenpää S; Jangard M; Michaëlsson J; Hartman J; Lagergren J; Mold J; Lundeberg J; Frisén J
Preprint: BIORXIV. 2022

Tumoroscope: a probabilistic model for mapping cancer clones in tumor tissues

Shafighi SD; Geras A; Jurzysta B; Naeini AS; Filipiuk I; Rączkowski Ł; Toosi H; Koperski Ł; Thrane K; Engblom C; Mold J; Chen X; Hartman J; Nowis D; Carbone A; Lagergren J; Szczurek E
Meeting abstract: ANNALS OF ONCOLOGY. 2022;33(7):S1306

Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction

Chen X; Sifakis EG; Robertson S; Neo SY; Jun S-H; Tong L; Lovrot J; Tay A; Hellgren R; Margolin S; Bergh J; Foukakis T; Lagergren J; Lundqvist A; Ma R; Hartman J
Preprint: BIORXIV. 2022

Chromatin accessibility profiling in tissue sections by spatial ATAC

Llorens-Bobadilla E; Zamboni M; Marklund M; Bhalla N; Chen X; Hartman J; Frisén J; Ståhl PL
Preprint: BIORXIV. 2021

PhylEx: Accurate reconstruction of clonal structure via integrated analysis of bulk DNA-seq and single cell RNA-seq data

Jun S-H; Toosi H; Mold J; Engblom C; Chen X; O’Flanagan C; Hagemann-Jensen M; Sandberg R; Aparicio S; Hartman J; Roth A; Lagergren J
Conference publication: VIRCHOWS ARCHIV. 2018;473:S30

Transcriptional profiling of endocrine resistant versus sensitive breast cancer uncovers gene expression programmes associated with therapeutic response

Schagerholm C; Robertson S; Govindasamy-Muralidharan K; Lovrot J; Chen X; Hartman J
Thesis / dissertation: 2015

Studies on early cellular responses during Epstein-Barr virus infection

Chen, Xinsong
Review: SEMINARS IN CANCER BIOLOGY. 2014;26:43-51

Tumor viruses and replicative immortality--avoiding the telomere hurdle.

Chen X; Kamranvar SA; Masucci MG

Forskningsbidrag

Investigating intratumoral heterogeneity to improve treatment outcome

Cancerfonden

1 January 2024 - 31 December 2026
Precision pathology - prediction of patient specific drug response

Region Stockholm (Hälsa, Medicin och Teknik)

1 January 2022 - 31 December 2024
Behandlingsprediktion och heterogenitetsstudier på bröstcancer med ex vivo modeller

Karolinska Institutet Foundations

20 October 2020 - 20 October 2022

Anställningar

Forskningsspecialist, Onkologi-Patologi, Karolinska Institutet, 2022-
Postdoktor, Onkologi-Patologi, Karolinska Institutet, 2018-2022
Research Engineer, Clinical Pathology and Cancer Diagnostics, Södersjukhuset, 2016-2018
Doktorand, Cell- och molekylärbiologi, Karolinska Institutet, 2013-2016

Examina och utbildning

Medicine Doktorsexamen, Institutionen för cell- och molekylärbiologi, Karolinska Institutet, 2015

Sakkunniggranskning för vetenskaplig tidskrift

npj Precision Oncology, Anonymous peer review

Artiklar

Alla övriga publikationer

Forskningsbidrag

Anställningar

Examina och utbildning

Sakkunniggranskning för vetenskaplig tidskrift

Nyheter från KI

Kalenderhändelser från KI