Xinsong Chen
About me
A researcher with years of experience and verifiable achievements in oncology, experimental pathology, cell and molecular biology, tumor biology, and virology from leading laboratories at Karolinska Institutet (KI). Currently, I am working as a research specialist (senior scientist) at the Oncology-Pathology department of KI and Karolinska University Hospital, with the main focus on studying breast cancer biomarkers, establishing novel diagnostic approaches for improving patient segmentation, precision oncology using various sequencing base tools, and developing various cancer patient biopsies-based IVD assays for better prediction of treatment response and facilitate drug development. I also participated in the preparation and management of several clinical trial translational studies.
Research
My primary research interests are studying intra-tumoral heterogeneity using multi-omics datasets and multi-modality approaches, integration of computational pathology image analysis approaches with spatial transcriptomic and proteomic analysis, precision medicine & diagnostics for breast cancer patients, as well as translational medicine studies from clinical trials or patient cohorts.
Teaching
Course supervisor and thesis examiner for eight bachelor's and master’s students at the Biomedicine program KI.
Co-supervisor for 3 Ph.D. students at Dept. Oncology-Pathology, KI.
Lecturing undergraduate to Ph.D. level courses at KI, including Basic Tumor Biology, Basic Tumor Histopathology, Molecular Pathology, Molecular Medicine - Oncology, etc.
Articles
- Article: NPJ PRECISION ONCOLOGY. 2025;9(1):310Li T; Yang Q; Acs B; Sifakis EG; Toosi H; Engblom C; Thrane K; Lin Q; Mold JE; Sun W; Boyaci C; Steen S; Frisen J; Lagergren J; Lundeberg J; Chen X; Hartman J
- Journal article: CLINICAL CANCER RESEARCH. 2025;31(12):p5-06-12-p5-06-12-P50612Yang Q; Chen X; Hartman J; Sifakis EG
- Journal article: NATURE COMMUNICATIONS. 2025;16(1):2801Shafighi S; Geras A; Jurzysta B; Naeini AS; Filipiuk I; Raczkowska A; Toosi H; Koperski L; Thrane K; Engblom C; Mold JE; Chen X; Hartman J; Nowis D; Carbone A; Lagergren J; Szczurek E
- Article: NATURE COMMUNICATIONS. 2024;15(1):9343Shafighi S; Geras A; Jurzysta B; Sahaf Naeini A; Filipiuk I; Raczkowska A; Toosi H; Koperski L; Thrane K; Engblom C; Mold JE; Chen X; Hartman J; Nowis D; Carbone A; Lagergren J; Szczurek E
- Article: GENOME BIOLOGY. 2024;25(1):214Demirci I; Larsson AJM; Chen X; Hartman J; Sandberg R; Frisen J
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2024;16(747):eadi2952Neo SY; Tong L; Chong J; Liu Y; Jing X; Oliveira MMS; Chen Y; Chen Z; Lee K; Burduli N; Chen X; Gao J; Ma R; Lim JP; Huo J; Xu S; Alici E; Wickstrom SL; Haglund F; Hartman J; Wagner AK; Cao Y; Kiessling R; Lam KP; Westerberg LS; Lundqvist A
- Article: BIOINFORMATICS. 2024;40(5):btae284Kurt S; Chen M; Toosi H; Chen X; Engblom C; Mold J; Hartman J; Lagergren J
- Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2024;43(1):107Fonseca P; Cui W; Struyf N; Tong L; Chaurasiya A; Casagrande F; Zhao H; Fernando D; Chen X; Tobin NP; Seashore-Ludlow B; Lundqvist A; Hartman J; Gondor A; Ostling P; Holmgren L
- Article: BREAST CANCER RESEARCH. 2024;26(1):24Ronnlund C; Sifakis EG; Schagerholm C; Yang Q; Karlsson E; Chen X; Foukakis T; Weidler J; Bates M; Fredriksson I; Robertson S; Hartman J
- Article: SCIENCE. 2023;382(6675):eadf8486Engblom C; Thrane K; Lin Q; Andersson A; Toosi H; Chen X; Steiner E; Lu C; Mantovani G; Hagemann-Jensen M; Saarenpaa S; Jangard M; Saez-Rodriguez J; Michaelsson J; Hartman J; Lagergren J; Mold JE; Lundeberg J; Frisen J
- Article: BIOENGINEERING & TRANSLATIONAL MEDICINE. 2023;8(5):e10537Collodet C; Blust K; Gkouma S; Stahl E; Chen X; Hartman J; Hedhammar M
- Article: NATURE BIOTECHNOLOGY. 2023;41(8):1085-1088Llorens-Bobadilla E; Zamboni M; Marklund M; Bhalla N; Chen X; Hartman J; Frisen J; Stahl PL
- Journal article: CANCER COMMUNICATIONS. 2023;43(7):855-859Tong L; Kremer V; Neo SY; Liu Y; Chen Y; Wagner AK; Yang Y; Chen Z; Seitz C; Tobin NP; Ligtenberg MA; Alici E; Chen X; Haglund F; Seliger B; Harmenberg U; Colon E; Plogell A-HS; Liu LL; Lundqvist A
- Article: NATURE COMMUNICATIONS. 2023;14(1):982Jun S-H; Toosi H; Mold J; Engblom C; Chen X; O'Flanagan C; Hagemann-Jensen M; Sandberg R; Aparicio S; Hartman J; Roth A; Lagergren J
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(1):e2209856120Chen X; Sifakis EG; Robertson S; Neo SY; Jun S-H; Tong L; Min ATH; Lovrot J; Hellgren R; Margolin S; Bergh J; Foukakis T; Lagergren J; Lundqvist A; Ma R; Hartman J
- Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(5):e004592Tay AHM; Prieto-Diaz R; Neo S; Tong L; Chen X; Carannante V; Onfelt B; Hartman J; Haglund F; Majellaro M; Azuaje J; Garcia-Mera X; Brea JM; Loza MI; Jespers W; Gutierrez-de-Teran H; Sotelo E; Lundqvist A
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(3):1354Hases L; Ibrahim A; Chen X; Liu Y; Hartman J; Williams C
- Article: BREAST CANCER RESEARCH. 2020;22(1):80Singh M; Zhou X; Chen X; Santos GS; Peuget S; Cheng Q; Rihani A; Arner ESJ; Hartman J; Selivanova G
- Article: CANCER RESEARCH. 2020;80(7):1538-1550Peuget S; Zhu J; Sanz G; Singh M; Gaetani M; Chen X; Shi Y; Saei AA; Visnes T; Lindstrom MS; Rihani A; Moyano-Galceran L; Carlson JW; Hjerpe E; Joneborg U; Lehti K; Hartman J; Helleday T; Zubarev R; Selivanova G
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(3):1185-1198Neo SY; Yang Y; Record J; Ma R; Chen X; Chen Z; Tobin NP; Blake E; Seitz C; Thomas R; Wagner AK; Andersson J; de Boniface J; Bergh J; Murray S; Alici E; Childs R; Johansson M; Westerberg LS; Haglund F; Hartman J; Lundqvist A
- Article: ONCOGENE. 2016;35(29):3807-3816Chen X; Kamranvar SA; Masucci MG
- Article: ONCOGENE. 2013;32(49):5522-5530Kamranvar SA; Chen X; Masucci MG
- Article: PLOS PATHOGENS. 2013;9(10):e1003664Gastaldello S; Chen X; Callegari S; Masucci MG
- Show more
All other publications
- Conference publication: VIRCHOWS ARCHIV. 2024;485:S206Steen S; Karlsson E; Chen X; Acs B; Hartman J
- Conference publication: CANCER RESEARCH. 2024;84(9):po4-01-05-po4-01-05Ronnlund C; Yang Q; Schagerholm C; Foukakis T; Fredriksson I; Chen X; Robertson S; Sifakis E; Hartman J
- Conference publication: CANCER RESEARCH. 2023;83(5):p2-21-02-p2-21-02Zerdes I; Salgkamis D; Matikas A; Selander L; Wang K; Tzoras E; Sifakis E; Agartz S; Chen X; Hellstrom M; Hartman J; Bergh J; Foukakis T; Hatschek T
- Preprint: BIORXIV. 2022Collodet C; Blust K; Gkouma S; Ståhl E; Chen X; Hartman J; Hedhammar M
- Preprint: BIORXIV. 2022Engblom C; Thrane K; Lin Q; Andersson A; Toosi H; Chen X; Steiner E; Mantovani G; Hagemann-Jensen M; Saarenpää S; Jangard M; Michaëlsson J; Hartman J; Lagergren J; Mold J; Lundeberg J; Frisén J
- Preprint: BIORXIV. 2022Shafighi SD; Geras A; Jurzysta B; Naeini AS; Filipiuk I; Rączkowski Ł; Toosi H; Koperski Ł; Thrane K; Engblom C; Mold J; Chen X; Hartman J; Nowis D; Carbone A; Lagergren J; Szczurek E
- Conference publication: ANNALS OF ONCOLOGY. 2022;33(7):S1306Chen X; Sifakis EG; Robertson S; Neo SY; Jun S-H; Tong L; Lovrot J; Tay A; Hellgren R; Margolin S; Bergh J; Foukakis T; Lagergren J; Lundqvist A; Ma R; Hartman J
- Preprint: BIORXIV. 2022Llorens-Bobadilla E; Zamboni M; Marklund M; Bhalla N; Chen X; Hartman J; Frisén J; Ståhl P
- Preprint: BIORXIV. 2021Jun S-H; Toosi H; Mold J; Engblom C; Chen X; O’Flanagan C; Hagemann-Jensen M; Sandberg R; Aparicio S; Hartman J; Roth A; Lagergren J
- Conference publication: VIRCHOWS ARCHIV. 2018;473:S30Schagerholm C; Robertson S; Govindasamy-Muralidharan K; Lovrot J; Chen X; Hartman J
- Doctoral thesis: 2015Chen X
- Review: SEMINARS IN CANCER BIOLOGY. 2014;26:43-51Chen X; Kamranvar SA; Masucci MG
Selected grants
- Multimodal analysis of breast tumors during ongoing neoadjuvant therapyKarolinska Institutet Foundations1 January 2025 - 31 December 2026
- Investigating intratumoral heterogeneity to improve treatment outcomeCancerfonden1 January 2024 - 31 December 2026
- Precision pathology - prediction of patient specific drug responseRegion Stockholm (Health, Medicine and Technic)1 January 2022 - 31 December 2024
- Treatment Prediction and heterogeneity studies on breast cancer using ex vivo modelsKarolinska Institutet Foundations20 October 2020 - 20 October 2022
Employments
- Research Specialist, Department of Oncology-Pathology, Karolinska Institutet, 2022-
Degrees and Education
- PhD Of Medical Science, Department of Cell and Molecular Biology, Karolinska Institutet, 2015
Journal reviewing
- npj Precision Oncology, Nature Portfolio, Anonymous peer review
- Advanced Science, Wiley, Anonymous peer review