Urban Ekman
Anknuten till Forskning | Docent
E-postadress: urban.ekman@ki.se
Besöksadress: Blickagången 16, 14152 Huddinge
Postadress: H1 Neurobiologi, vårdvetenskap och samhälle, H1 Klinisk geriatrik Westman, 171 77 Stockholm
Om mig
- Docent. Med. Dr. Leg. Psykolog.
Forskningsbeskrivning
- Kognitiva nedsättningar kan orsakas av ett brett spektrum av medicinska
tillstånd och medför ofta svåra konsekvenser för den drabbade i form av
minskat oberoende och funktionalitet. Det finns ett stort behov
av effektivare metoder, både gällande tidig diagnostik men även gällande
psykologiska behandlingsmetoder för att öka självständighet och
förbättra välmåendet.
Min forskningsinriktning har två huvudspår:
1. Det första spåret syftar till att skapa en innovativ
forskningsplattform för utveckling och utvärdering av psykologiska
behandlingsmetoder och kognitiva rehabilitering för personer med kognitiv
svikt. Vi kommer att utvärdera både feasibility och effekter av
behandling/rehabilitering. Målet är att förbättra prevention
och psykiskt mående för en patientgrupp som många gånger saknar
verksamma stödinsatser.
2. Det andra spåret är att vidareutveckla och utvärdera det pågående
MemClin-projektet (se webbadress nedan). MemClin-projektets storskalighet
och populationsbaserade karaktär gör det till en viktig plattform för
klinisk relevant forskning under många år framöver. I nuläget består
databasen av kliniska data från ungefär 3000 personer, med en förväntad
tillströmning av cirka 1000 nya individer per år. Projektet är inriktat
på att öka kunskapen om tidiga kliniska manifestationer av olika
neurodegenerativa sjukdomar och andra kognitiv tillstånd. Etableringen av
MemClin gör det möjligt att bygga robusta modeller för att förbättra
den diagnostiska precisionen och stärka den longitudinella prediktionen.
Artiklar
- Article: SPINAL CORD. 2025;63(9):514-521Bendt M; Butler Forslund E; Hagman G; Ekman U; Bezuidenhout L; Johansson H; Rydström A; Hultling C; Seiger Å; Franzén E
- Article: SCIENTIFIC REPORTS. 2025;15(1):23071Almkvist O; Gyllenhammar M; Norberg S; Roeseler ML; Westman E; Ekman U
- Article: CLINICAL NEUROPSYCHOLOGIST. 2025;39(2):424-438Almkvist O; Rennie A; Westman E; Wallert J; Ekman U
- Article: BRAIN COMMUNICATIONS. 2024;6(5):fcae290Rennie A; Ekman U; Shams S; Ryden L; Samuelsson J; Zettergren A; Kern S; Oppedal K; Blanc F; Hort J; Garcia-Ptacek S; Antonini A; Lemstra AW; Padovani A; Kramberger MG; Rektorova I; Walker Z; Snaedal J; Pardini M; Taylor J-P; Bonanni L; Granberg T; Aarsland D; Skoog I; Wahlund L-O; Kivipelto M; Westman E; Ferreira D
- Article: SCIENTIFIC REPORTS. 2024;14(1):9513Albrecht F; Johansson H; Ekman U; Poulakis K; Bezuidenhout L; Pereira JB; Franzen E
- Article: JOURNAL OF ORAL REHABILITATION. 2023;50(12):1422-1431Hedberg L; Kumar A; Skott P; Smedberg J-I; Seiger A; Sandborgh-Englund G; Nordin LE; Kareholt I; Tzortzakakis A; Westman E; Trulsson M; Ekman U
- Article: NEUROBIOLOGY OF AGING. 2023;129:41-49Rennie A; Ekman U; Wallert J; Muehlboeck J-S; Eriksdotter M; Wahlund L-O; Ferreira D; Westman E
- Article: PHYSICAL THERAPY. 2023;103(8):pzad065Wallin A; Franzen E; Ekman U; Johansson S
- Article: BRAIN AND BEHAVIOR. 2023;13(4):e2948Kvist A; Bezuidenhout L; Johansson H; Albrecht F; Ekman U; Conradsson DM; Franzen E
- Article: JOURNAL OF ALZHEIMERS DISEASE. 2023;92(2):605-614Gyllenhammar M; Rennie A; Padilla DF; Wallert J; Rydstrom A; Wahlund L-O; Eriksdotter M; Westman E; Ekman U
- Article: PILOT AND FEASIBILITY STUDIES. 2023;9(1):41Wallin A; Franzen E; Ekman U; Piehl F; Johansson S
- Article: MULTIPLE SCLEROSIS AND RELATED DISORDERS. 2022;67:104181Wallin A; Franz E; Bezuidenhout L; Ekman U; Piehl F; Johansson S
- Article: PARKINSONISM & RELATED DISORDERS. 2022;102:19-29Albrecht F; Poulakis K; Freidle M; Johansson H; Ekman U; Volpe G; Westman E; Pereira JB; Franz E
- Article: NPJ PARKINSONS DISEASE. 2022;8(1):12Freidle M; Johansson H; Ekman U; Lebedev AV; Schalling E; Thompson WH; Svenningsson P; Lovden M; Abney A; Albrecht F; Steurer H; Leavy B; Holmin S; Hagstromer M; Franzen E
- Article: JOURNAL OF PARKINSONS DISEASE. 2021;11(4):2057-2071Albrecht F; Pereira JB; Mijalkov M; Freidle M; Johansson H; Ekman U; Westman E; Franzen E
- Article: BMC SPORTS SCIENCE MEDICINE AND REHABILITATION. 2021;13(1):70Rydwik E; Anmyr L; Regardt M; McAllister A; Zarenoe R; Akerman E; Orrevall Y; Bragesjo M; Dahl O; Kemani MK; Nordstrand L; Ekman U; Holmstrom L; Nygren-Bonnier M
- Article: BMC ORAL HEALTH. 2021;21(1):297Hedberg L; Ekman U; Nordin LE; Smedberg J-I; Skott P; Seiger A; Sandborgh-Englund G; Westman E; Kumar A; Trulsson M
- Article: AGING-US. 2021;13(10):13430-13442Wallert J; Rennie A; Ferreira D; Muehlboeck J-S; Wahlund L-O; Westman E; Ekman U
- Article: PLOS ONE. 2021;16(5):e0251849Freidle M; Johansson H; Lebedev AV; Ekman U; Lovden M; Franzen E
- Article: NEUROREHABILITATION AND NEURAL REPAIR. 2021;35(4):356-366Johansson H; Ekman U; Rennie L; Peterson DS; Leavy B; Franzen E
- Article: FRONTIERS IN PSYCHOLOGY. 2020;11:600841Ekman U; Kemani MK; Wallert J; Wicksell RK; Holmstrom L; Ngandu T; Rennie A; Akenine U; Westman E; Kivipelto M
- Journal article: ALZHEIMERS & DEMENTIA. 2020;16(S4)Cedres N; Ekman U; Ferreira D; Westman E
- Article: PARKINSONS DISEASE. 2020;2020:2410863-12Johansson H; Freidle M; Ekman U; Schalling E; Leavy B; Svenningsson P; Hagstromer M; Franzen E
- Article: BMC GERIATRICS. 2020;20(1):93Ekman U; Ferreira D; Muehlboeck J-S; Wallert J; Rennie A; Eriksdotter M; Wahlund L-O; Westman E
- Article: NEURODEGENERATIVE DISEASES. 2020;20(4):153-164Cedres N; Ekman U; Poulakis K; Shams S; Cavallin L; Muehlboeck S; Granberg T; Wahlund L-O; Ferreira D; Westman E
- Article: BMC NEUROLOGY. 2019;19(1):280Franzen E; Johansson H; Freidle M; Ekman U; Wallen MB; Schalling E; Lebedev A; Lovden M; Holmin S; Svenningsson P; Hagstromer M
- Article: JOURNAL OF HEAD TRAUMA REHABILITATION. 2019;34(3):189-198Berginstrom N; Nordstrom P; Ekman U; Eriksson J; Nyberg L; Nordstrom A
- Article: ACTA NEUROLOGICA SCANDINAVICA. 2019;139(3):254-259Wahlin A; Fordell H; Ekman U; Lenfeldt N; Malm J
- Journal article: ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION. 2018;99(10):e10Fordell H; Wåhlin A; Ekman U; Malm J; Lenfeldt N
- Article: ACTA NEUROLOGICA SCANDINAVICA. 2018;138(4):284-292Ekman U; Fordell H; Eriksson J; Lenfeldt N; Wahlin A; Eklund A; Malm J
- Article: JOURNAL OF HEAD TRAUMA REHABILITATION. 2018;33(4):266-274Berginstrom N; Nordstroem P; Ekman U; Eriksson J; Andersson M; Nyberg L; Nordstrom A
- Article: SCIENTIFIC REPORTS. 2018;8(1):8431Ekman U; Ferreira D; Westman E
- Article: FRONTIERS IN AGING NEUROSCIENCE. 2018;10:144Wallert J; Westman E; Ulinder J; Annerstedt M; Terzis B; Ekman U
- Article: INTELLIGENCE. 2017;64:9-17Wallert J; Ekman U; Westman E; Madison G
- Article: SCIENTIFIC REPORTS. 2017;7:46263Ferreira D; Verhagen C; Andres Hernandez-Cabrera J; Cavallin L; Guo C-J; Ekman U; Muehlboeck J-S; Simmons A; Barroso J; Wahlund L-O; Westman E
- Article: ACTA NEUROLOGICA SCANDINAVICA. 2015;132(2):79-88Domellof ME; Ekman U; Forsgren L; Elgh E
- Article: FRONTIERS IN NEUROSCIENCE. 2014;8:207Ekman U; Eriksson J; Forsgren L; Domellof ME; Elgh E; Lundquist A; Nyberg L
- Article: LANCET NEUROLOGY. 2012;11(8):679-687Ekman U; Eriksson J; Forsgren L; Mo SJ; Riklund K; Nyberg L
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Alla övriga publikationer
- Preprint: RESEARCH SQUARE. 2020Cedres N; Ekman U; Poulakis K; Shams S; Cavallin L; muehlboeck S; Granberg T; Wahlund L-O; Ferreira D; Westman E
- Conference publication: INTERNATIONAL JOURNAL OF STROKE. 2018;13:42Fordell H; Wahlin A; Ekman U; Lenfeldt N; Malm J
- Conference publication: INTERNATIONAL JOURNAL OF STROKE. 2018;13:50Fordell H; Wahlin A; Ekman U; Lenfeldt N; Malm J
- Conference publication: BRAIN INJURY. 2017;31(6-7):755Berginstrom N; Nordstrom P; Ekman U; Eriksson J; Andersson M; Nyberg L; Nordstrom A
- Conference publication: JOURNAL OF PSYCHOPHYSIOLOGY. 2013;27:69-70Neely AS; Sehlstedt I; Ekman U; Eriksson J; Sandberg P; Qwillbard T; Nyberg L
Forskningsbidrag
- Utvärdering av en ny psykologisk behandling med syfte att förbättra den psykologiska hälsan för personer med kognitiv sviktALF (Region Stockholm)1 January 2024 - 31 December 2026Cognitive impairments often make it difficult to act independently and can cause significant psycho-social suffering. People with early cognitive impairment frequently suffer from existential anxiety, health problems (such as stress symptoms, anxiety, and depression), and social avoidance. There is a great need for improved treatment and rehabilitation methods to alleviate these negative consequences. This project aims to evaluate a newly developed psychological treatment for individuals with cognitive impairments and to study which underlying mechanisms predict positive treatment effects. Adequate support to adapt to the changed living conditions can help the individual with cognitive impairment to preserve functionality and maintain good health. The benefit of the upcoming research is significant as it has the potential to improve the care of a large proportion of patients with cognitive impairment, who currently lack effective psychological treatment/rehabilitation. We expect that the project will provide improved support to those suffering from psychological symptoms in relation to their cognitive impairments. In addition, we expect the method to be useful for those who struggle with adherence to lifestyle changes (ie, increasing the patient's motivation to adhere to lifestyle changes that may benefit their cognitive impairment). Thus, the current project may provide a new path towards improved prevention/manageability of cognitive decline.
- Swedish Research Council1 January 2023 - 31 December 2026Life means combining motor-cognitive skills, e.g., walking, talking and navigating. Aging or neurological diseases, e.g., Parkinson’s disease (PD) compromises these skills needed for an independent life. It is uncertain which brain alterations lead to these difficulties and how to target these heterogenous motor-cognitive difficulties. Current treatments apply a "one-size-fits-all" approach, which needs to evolve towards personalized rehabilitation, reaching beyond a simple adaption to disease severity.Our multimodal project combines physiotherapy, neurology, psychology and neuroimaging to characterize motor-cognitive skills during complex walking, identify underlying brain alterations and subtype PD to inform a novel exercise approach for people with PD. This 5 years proposal has 4 stages: 1) Exploring brain alterations and links to the motor-cognitive skills in healthy and PD 2) PD subtyping using neuroimaging, motor, cognitive and clinical data 3) Characterization of exercise responsiveness in PD and 4) Development and testing of a personalized motor-cognitive exercise program. We combine novel techniques for data collection with in-depth analysis of existing data (EXPANd trial). The results will have an immediate application and clinical relevance for personalized rehabilitation in older and PD. There is no cure for PD yet, thus positive findings would revolutionize treatment, giving new hope to patients for a life with improved health, independence and higher quality.
- A collected clinical approach aiming at improved diagnostic accuracy and development of novel effective psychosocial interventions in patients with early-phase cognitive impairmentsCentrum för innovativ medicin (CIMED)1 January 2022 - 31 December 2024
- Swedish Research Council1 December 2021 - 30 November 2024
- Familjen Kamprads stiftelse1 September 2021 - 30 November 2025The burden of cognitive impairment is severe, and often obstructs affected people to act independently, and their families frequently carry a large responsibility. A great challenge for our society is to support the maintenance of cognitive health to avoid cognitive disability and decrease health-economic costs. In an RCT, we will evaluate the efficacy of PIPCI in an RCT comparing the intervention with both an active control group condition (cognitive training), and a waiting list control group condition. The primary objective is to evaluate intervention-related changes in psychological flexibility (the ability to notice and accept interfering thoughts, emotions, and bodily sensations without acting on them, when this serves action in line with personal values). The secondary objectives are to further evaluate intervention-related changes with measures of psychological health, cognitive measures and biological markers. The usefulness of the forthcoming research is significant as it has the potential to improve the care of a substantial proportion of patients with cognitive impairment, which today lack effective psychological treatment/rehabilitation.
- Swedish Research Council1 January 2017 - 31 December 2019
- Swedish Research Council for Health Working Life and Welfare1 January 2016 - 31 December 2017
Anställningar
- Anknuten till Forskning, Neurobiologi, vårdvetenskap och samhälle, Karolinska Institutet, 2024-2027
- Biträdande Lektor, Neurobiologi, vårdvetenskap och samhälle, Karolinska Institutet, 2020-2024
Examina och utbildning
- Docent, Klinisk psykologi, Karolinska Institutet, 2022