Sven-Erik Dahlén
Professor, Senior
E-postadress: sven-erik.dahlen@ki.se
Telefon: +46852487092
Besöksadress: M 52, Karolinska Universitetssjukhuset Huddinge, 14186 Stockholm
Postadress: H7 Medicin, Huddinge, H7 CIM Mjösberg KLA, 171 77 Stockholm
Forskningsbeskrivning
- Forskningsbeskrivning
Leukotriener och prostanoider som mastcellsmediatorer och modulatorer av astmatisk luftvägsobstruktion
Projektet syftar till att öka förståelsen av mekanismer vid astma och andra inflammatoriska luftvägssjukdomar. Forskargruppen har specifik erfarenhet och kompetens att undersöka betydelsen av leukotriener, prostanoider och andra inflammationsmediatorer. Tidigare forskning i projektet har visat att vissa leukotriener tillsammans med histamin orsakar flera av kardinalsymptomen vid astma. Kunskap om grundläggande mekanismer inom leukotriensystemet är dock fortfarande begränsad. Prostaglandiner bildas också från arakidonsyra men via andra mekanismer och i andra kompartment. Nu vet man att prostaglandinfamiljen innehåller både en del föreningar som kan förvärra astma och inflammation i luftvägarna medan andra har potential att kunna bli läkemedel för att lindra symtomen. Men innan vi når dit måste kunskapen om prostaglandinernas verkan i lungan ökas. Med ett brett och integrerat angrepp undersöks alltså betydelse och verkningsmekanismer för leukotriener och prostaglandiner. Det här projektet är av grundforskningsnatur och utreder förhållanden med hjälp av flera olika experimentella modeller som innefattar både human vävnad och djursförsök. Projektet ingår i ett nätverk där grundforskare och kliniska forskare samarbetar för att med olika infallsvinklar försöka lösa gemensamma övergripande frågeställningar. Ett övergripande mål med vår forskning är att upptäcka nya molekyler eller andra förhållanden som leder till att ny och bättre diagnostik och behandling mot astma och andra inflammatoriska luftvägssjukdomar kan utvecklas.
Finansiering
Vetenskapsrådet
Hjärt-Lungfonden
Medarbetare
Yvonne Nygren, sekreterare
Mikael Adner, docent
Maria Kumlin, docent
Anita Sydbom, docent
Roelinde Middelveld, projektledare, PhD
Katarina Stark, postdoc
Cecilia Kemi, postdoc
Maciek Kupczyk, postdoc
Ingrid Delin, BMA
Susanna Kumlien-Georén, BMA, PhD
Stina Gustavsson, assistent
Linda Swedin, doktorand
Jesper Säfholm, doktorand
Artiklar
- Article: MUCOSAL IMMUNOLOGY. 2025;18(3):656-667
- Article: LANCET RESPIRATORY MEDICINE. 2025;13(1):35-46
- Article: HEALTH AND QUALITY OF LIFE OUTCOMES. 2024;22(1):109
- Article: EUROPEAN RESPIRATORY JOURNAL. 2024;65(3):2400691
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2024;155(4):1310-1320
- Article: EUROPEAN RESPIRATORY JOURNAL. 2024;64(5):2400207
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2024;210(9):1091-1100
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2024;210(9):1101-1112
- Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2024;14(9):e70007
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2024;210(3):288-297
- Article: ALLERGY ASTHMA & IMMUNOLOGY RESEARCH. 2024;16(4):338-352
- Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2024;14(7):e1771
- Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2024;170:106789
- Article: EBIOMEDICINE. 2024;99:104936
- Article: ALLERGY. 2023;78(11):2906-2920
- Article: ERJ OPEN RESEARCH. 2023;9(5):00269-02023
- Article: BRAIN BEHAVIOR AND IMMUNITY. 2023;111:249-258
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2023;152(1):117-125
- Article: LANCET RESPIRATORY MEDICINE. 2023;11(1):55-64
- Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1151754
- Article: ALLERGY. 2023;78(1):156-167
- Article: PLOS ONE. 2023;18(2):e0281356
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2022;934:175257
- Article: ALLERGY. 2022;77(9):2677-2687
- Article: CLINICAL PROTEOMICS. 2022;19(1):20
- Article: EUROPEAN RESPIRATORY JOURNAL. 2022;59(6):2101733
- Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(4):e816
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022;205(4):397-411
- Article: EUROPEAN RESPIRATORY JOURNAL. 2022;59(2):2100142
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;149(1):89-101
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2021;907:174282
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;148(3):889-894
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;148(2):407-419
- Article: CHEST. 2021;160(1):53-64
- Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2021;1866(5):158886
- Article: CELL RESEARCH. 2021;31(5):554-568
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2021;51(4):594-603
- Article: RESPIRATORY RESEARCH. 2021;22(1):10
- Article: ALLERGY. 2021;76(1):114-130
- Article: FRONTIERS IN IMMUNOLOGY. 2021;12:804812
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021;203(1):37-53
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;147(1):123-134
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2020;146(5):1045-1055
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2020;50(10):1184-1195
- Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2020;149:106428
- Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2020;1865(4):158611
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2020;145(3):808-817.e2
- Article: EUROPEAN RESPIRATORY JOURNAL. 2020;55(2):1900544
- Article: EUROPEAN RESPIRATORY JOURNAL. 2020;55(1):1901163
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;144(5):1198-1213
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;144(4):984-992
- Article: ALLERGY. 2019;74(10):1835-1851
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;144(1):70-82
- Article: JOURNAL OF LIPID RESEARCH. 2019;60(6):1164-1173
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;143(6):2202-2214.e5
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;143(5):1811-1820.e7
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2019;49(4):442-460
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2019;49(2):155-162
- Article: ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY. 2019;15(1):54
- Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1361
- Article: RESPIRATORY RESEARCH. 2018;19(1):236
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;142(4):1080-1089
- Article: METABOLOMICS. 2018;14(10):123
- Article: ANALYTICAL CHEMISTRY. 2018;90(17):10239-10248
- Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2018;137:20-29
- Article: JOURNAL OF PROTEOME RESEARCH. 2018;17(6):2072-2091
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;141(5):1761-1773.e6
- Article: EUROPEAN RESPIRATORY JOURNAL. 2018;51(5):1702173
- Article: THORAX. 2018;73(2):107-115
- Article: PLOS ONE. 2018;13(9):e0203874
- Article: FRONTIERS IN IMMUNOLOGY. 2018;9:2193
- Article: ALLERGY. 2017;72(11):1753-1760
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2017;47(7):909-917
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(6):1797-1807
- Article: EUROPEAN RESPIRATORY JOURNAL. 2017;49(5):1602294
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(4):1321-1330.e4
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2017;195(4):443-455
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2017;28(1):79-85
- Article: JOURNAL OF NUTRITION HEALTH & AGING. 2017;21(1):92-104
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2016;46(12):1540-1548
- Article: ALLERGY. 2016;71(11):1603-1611
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2016;46(9):1185-1193
- Article: EUROPEAN RESPIRATORY JOURNAL. 2016;47(6):1645-1656
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2016;120(9):1011-1017
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2016;137(3):833-843
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2016;193(2):131-142
- Article: CLINICAL AND TRANSLATIONAL ALLERGY. 2016;6:37
- Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2016;170(1):57-61
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2015;26(8):772-779
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2015;136(5):1232-9.e1
- Article: EUROPEAN RESPIRATORY JOURNAL. 2015;46(5):1308-1321
- Article: ALLERGY. 2015;70(11):1372-1392
- Article: RESPIRATORY RESEARCH. 2015;16:129
- Article: ACTA PAEDIATRICA. 2015;104(10):1047-1054
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2015;119(3):272-279
- Article: THORAX. 2015;70(7):695-697
- Article: ALLERGY. 2015;70(5):514-521
- Article: RESPIRATORY MEDICINE. 2015;109(3):312-319
- Article: CHEST. 2015;147(2):397-405
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2015;3(1):68-75
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2014;740:302-311
- Article: ALLERGY. 2014;69(9):1198-1204
- Article: ALLERGY. 2014;69(9):1241-1247
- Article: ALLERGY. 2014;69(9):1205-1214
- Article: EUROPEAN RESPIRATORY JOURNAL. 2014;44(2):304-323
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2014;134(2):306-313
- Article: ALLERGY. 2014;69(5):643-651
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2014;44(2):212-221
- Article: EUROPEAN RESPIRATORY JOURNAL. 2014;43(2):343-373
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2014;44(2):250-260
- Article: BMJ OPEN RESPIRATORY RESEARCH. 2014;1(1):e000039
- Article: PEPTIDES. 2014;51:100-109
- Article: CLINICAL SCIENCE. 2013;125(11-12):533-542
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2013;718(1-3):544-551
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2013;718(1-3):277-282
- Article: RESPIRATORY MEDICINE. 2013;107(10):1521-1530
- Article: ALLERGY. 2013;68(10):1314-1321
- Article: ANALYTICAL CHEMISTRY. 2013;85(16):7866-7874
- Article: MOLECULAR NUTRITION & FOOD RESEARCH. 2013;57(8):1378-1389
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2013;132(2):328-35.e5
- Article: EUROPEAN RESPIRATORY JOURNAL. 2013;42(1):65-78
- Article: THORAX. 2013;68(7):611-618
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2013;168(4):794-806
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2013;699(1-3):141-149
- Article: CLINICAL AND TRANSLATIONAL ALLERGY. 2013;3:21
- Article: PLOS ONE. 2013;8(1):e53877
- Article: PLOS ONE. 2013;8(1):e54137
- Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2013;162(2):135-142
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2012;303(12):L1027-L1036
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2012;303(11):L956-L966
- Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2012;68(10):1375-1383
- Article: CLINICAL RESPIRATORY JOURNAL. 2012;6(3):159-168
- Article: ALLERGY. 2012;67(7):958-961
- Article: EUROPEAN RESPIRATORY JOURNAL. 2012;39(6):1458-1467
- Article: LAKARTIDNINGEN. 2012;109(12):622-624
- Article: PLOS ONE. 2012;7(7):e41361
- Article: ALLERGY. 2012;67(1):91-98
- Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2012;158(3):299-306
- Article: PLOS ONE. 2012;7(2):e32110
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2011;669(1-3):136-142
- Article: ALLERGY. 2011;66(9):1216-1223
- Article: ACS NANO. 2011;5(7):5312-5324
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2011;110(4):1029-1035
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2011;41(1):36-45
- Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2010;42(10):1853-1860
- Article: LAKARTIDNINGEN. 2010;107(23):1541-1544
- Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2010;92(1-4):44-53
- Article: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE. 2010;14(6):764-771
- Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2010;42(2):273-280
- Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2010;153(3):249-258
- Article: EUROPEAN RESPIRATORY JOURNAL. 2009;34(1):200-208
- Article: RESPIRATORY RESEARCH. 2009;10(1):46
- Article: ALLERGY. 2009;64(6):919-926
- Article: EUROPEAN RESPIRATORY JOURNAL. 2009;33(4):747-753
- Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2009;88(3-4):101-110
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2009;179(7):549-558
- Article: RESPIRATORY MEDICINE. 2008;102(12):1730-1736
- Article: THORAX. 2008;63(12):1076-1082
- Article: LAKARTIDNINGEN. 2008;105(26-27):1946-1948
- Article: ALLERGY. 2008;63(5):518-526
- Article: RESPIRATORY RESEARCH. 2008;9(1):23
- Article: LAKARTIDNINGEN. 2007;104(51-52):3901
- Article: ENVIRONMENTAL RESEARCH. 2007;104(2):250-257
- Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2007;83(3):209-212
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2007;151(1):35-44
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2007;37(4):552-557
- Article: EUROPEAN RESPIRATORY JOURNAL. 2006;28(6):1229-1235
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2006;118(1):78-83
- Article: ENVIRONMENTAL RESEARCH. 2006;100(2):197-204
- Article: RESPIRATORY MEDICINE. 2006;100(2):226-237
- Article: THORAX. 2005;60(11):902-908
- Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2005;315(1):458-465
- Article: EUROPEAN RESPIRATORY JOURNAL. 2005;26(3):442-448
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2005;35(7):954-959
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2004;141(3):449-456
- Article: RESPIRATORY MEDICINE. 2003;97(11):1225-1229
- Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2003;307(1):408-418
- Article: EUROPEAN RESPIRATORY JOURNAL. 2003;22(3):470-477
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2003;111(5):1116-1121
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2002;137(8):1339-1345
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2002;109(5):789-793
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2002;165(1):9-14
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2001;133(7):1134-1144
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2001;164(2):202-206
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2001;31(3):400-408
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2000;401(3):389-395
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2000;401(3):381-388
- Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 1999;57(2-3):149-165
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 1999;10(1):45-52
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(4):1994-1999
- Article: THORAX. 1998;53(12):1041-1046
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 1998;28(11):1332-1339
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1998;357(2-3):203-211
- Article: EUROPEAN RESPIRATORY JOURNAL. 1998;12(2):345-350
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1996;317(1):107-113
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1996;98(2):421-432
- Article: FEBS JOURNAL. 1996;238(3):599-605
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1996;97(5):1151-1163
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1995;282(1-3):207-211
- Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 1995;273(3):1182-1189
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 1995;25(5):467-479
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Anställningar
- Professor, Senior, Medicin, Huddinge, Karolinska Institutet, 2024-2025
- Professor, Medicin, Huddinge, Karolinska Institutet, 2024-2024