Sven Erik Dahlén

Sven Erik Dahlén

Professor, Senior
Telephone: +46852487092
Visiting address: M 52, Karolinska Universitetssjukhuset Huddinge, 14186 Stockholm
Postal address: H7 Medicin, Huddinge, H7 CIM Mjösberg KLA, 171 77 Stockholm

Research

  • Leukotrienes and prostanoids as mast cell mediators and modulators of asthmatic airway obstruction.

    The aim of this project is to increase the understanding of mechanisms behind the development of asthma and other inflammatory airway diseases. Acknowledged internationally, our research group has over the years gathered experience and knowledge in leukotrienes, prostanoids and other inflammatory mediators. We have shown earlier that leukotrienes, together with histamine, cause some of the cardinal symptoms of asthma. The mechanisms through which leukotrienes exert their cellular effects are presently not well understood. Like leukotrienes, prostanoids are derived from the poly-unsaturated, essential fatty acid, arachidonic acid. The mechanisms and the location of prostanoid generation and effects differ importantly from those of the leukotrienes. The prostanoid family contains members that mediate asthma augmentation and airway inflammation. On the other hand, relief of asthma symptoms by other members of the family has also been described. Again, understanding how prostanoids mediate their cellular effects, particularly in the lung is presently only sketchily understood, at best. The main drive of this project is to elucidate the beneficial and malign mechanisms by which leukotrienes and prostanoids exert their effects on the different cellular structures of the lung. As this is very much and experimental undertaking, our set up consists of a network of co-operating basic researchers and clinicians and aims to provide comprehensive answers using animal models and human tissues. Implicit in our research is the aim for new discoveries which can lead to improved diagnosis and treatment of all airway inflammatory diseases, including asthma.

    Financing
    Swedish Research Council
    Swedish Heart-Lung Foundation

    Co-workers
    Yvonne Nygren, secreterary
    Mikael Adner, Associated Professor
    Maria Kumlin, Associated Professor
    Anita Sydbom, Associated Professor
    Roelinde Middelveld, Project leader, PhD
    Katarina Stark, Postdoc
    Cecilia Kemi, Postdoc
    Maciek Kupczyk, Postdoc
    Ingrid Delin, BMA
    Susanna Kumlien-Georén, BMA, PhD
    Stina Gustavsson, assistant
    Linda Swedin, PhD student
    Jesper Säfholm, PhD student

Selected publications

Articles

All other publications

  • Letter: EUROPEAN RESPIRATORY JOURNAL. 2024;64(3):2400428
    Versi A; Azim A; Ivan FX; Abdel-Aziz MI; Bates S; Riley J; Zee AHM-VD; Dahlen S-E; Djukanovic R; Chotirmall SH; Howarth P; Kermani NZ; Chung KF; Adcock IM
  • Conference publication: ALLERGY. 2023;78:262
    Khaleva E; Brightling C; Djukanovic R; Dahlen SE; Coleman C; Henderson M; Roberts G
  • Letter: CLINICAL AND EXPERIMENTAL ALLERGY. 2023;53(10):1062-1066
    Belikova M; Safholm J; Al-Ameri M; Orre A-C; Dahlen S-E; Adner M
  • Letter: EUROPEAN RESPIRATORY JOURNAL. 2022;60(6):2201795
    Mikus MS; Kolmert J; Andersson LI; Dahlen S-E; James A
  • Corrigendum: CLINICAL PROTEOMICS. 2022;19(1):29
    Ostling J; Van Geest M; Olsson HK; Dahlen S-E; Viklund E; Gustafsson PM; Mirgorodskaya E; Olin A-C
  • Editorial: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;148(5):1157-1160
    Mullol J; Boyce J; Dahl S-E; Dahlen B; Picado C; Bobolea I
  • Editorial: EUROPEAN RESPIRATORY JOURNAL. 2021;58(4):2102168
    Porsbjerg C; Maitland-van der Zee AH; Brusselle G; Canonica GW; Agusti A; Faner R; Vogelmeier CF; Nawijn M; van den Berge M; Rusconi F; Pilette C; Ramiconi V; Coleman C; Chaudhuri R; Chung KF; Wedzicha J; Saglani S; Van der Schee MP; Heaney L; Bourdin A; Roberts G; Djukanovic R; Kuna P; Kupczyk M; Axmann J; Staudinger H; Clarke GW; Dahlen SE; Brightling C
  • Letter: ALLERGY. 2021;76(7):2270-2273
    Liu J; Kolmert J; Safholm J; Johnsson A-K; Zurita J; Wheelock CE; Dahlen S-E; Nilsson G; Adner M
  • Letter: ALLERGY. 2021;76(6):1917-1921
    Abdel-Aziz MI; Kermani NZ; Neerincx AH; Vijverberg SJH; Guo Y; Howarth P; Dahlen S-E; Djukanovic R; Sterk PJ; Kraneveld AD; van der Zee AH; Chung KF; Adcock IM
  • Letter: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021;203(9):1204-1205
    Kolmert J; Dahlen S-E; Wheelock CE
  • Editorial: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;147(3):853-856
    Mazein A; Ivanova O; Balaur I; Ostaszewski M; Berzhitskaya V; Serebriyskaya T; Ligon T; Hasenauer J; De Meulder B; Overall RW; Roy L; Knowles RG; Wheelock CE; Dahlen S-E; Chung KF; Adcock IM; Roberts G; Djukanovic R; Pellet J; Gawron P; Balling R; Maitland-van der Zee AH; Schneider R; Sterk PJ; Auffray C
  • Corrigendum: RESPIRATORY RESEARCH. 2021;22(1):47
    Kermani NZ; Song W-J; Badi Y; Versi A; Guo Y; Sun K; Bhavsar P; Howarth P; Dahlen S-E; Sterk PJ; Djukanovic R; Adcock IM; Chung KF
  • Editorial: ACTA PAEDIATRICA. 2021;110(2):641-642
    James AJ; Nordlund B; Konradsen JR; Ebersjo C; Dahlen S-E; Berggren Brostrom E; Hedlin G
  • Letter: ALLERGY. 2021;76(1):380-383
    Zounemat Kermani N; Saqi M; Agapow P; Pavlidis S; Kuo C; Tan KS; Mumby S; Sun K; Loza M; Baribaud F; Sousa AR; Riley J; Wheelock AM; Wheelock CE; De Meulder B; Schofield J; Sanchez-Ovando S; Simpson JL; Baines KJ; Wark PA; Auffray C; Dahlen S-E; Sterk PJ; Djukanovic R; Adcock IM; Guo Y-K; Chung KF
  • Letter: EUROPEAN RESPIRATORY JOURNAL. 2019;53(6):1900453
    Perotin J-M; Schofield JPR; Wilson SJ; Ward J; Brandsma J; Strazzeri F; Bansal A; Yang X; Rowe A; Corfield J; Lutter R; Shaw DE; Bakke PS; Caruso M; Dahlen B; Fowler SJ; Horvath I; Howarth P; Krug N; Montuschi P; Sanak M; Sandstrom T; Sun K; Pandis I; Auffray C; De Meulder B; Lefaudeux D; Riley JH; Sousa AR; Dahlen S-E; Adcock IM; Chung KF; Sterk PJ; Skipp PJ; Collins JE; Davies DE; Djukanovic R; Adcock IM; Ahmed H; Auffray C; Bakke P; Banssal AT; Baribaud F; Bates S; Bel EH; Bigler J; Bisgaard H; Boedigheimer MJ; Bonnelykke K; Brandsma J; Brinkman P; Bucchioni E; Burg D; Bush A; Caruso M; Chaiboonchoe A; Chanez P; Chung KF; Compton CH; Corfield J; D'Amico A; Dahlen SE; De Meulder B; Djukanovic R; Erpenbeck VJ; Erzen D; Fichtner K; Fitch N; Fleming LJ; Formaggio E; Fowler SJ; Frey U; Gahlemann M; Geiser T; Guo Y; Hashimoto S; Haughney J; Hedlin G; Hekking PW; Higenbottam T; Hohlfeld JM; Holweg C; Horvath I; Howarth P; James AJ; Knowles R; Knox AJ; Krug N; Lefaudeux D; Loza MJ; Lutter R; Manta A; Masefield S; Matthews JG; Mazein A; Meiser A; Middelveld RJM; Miralpeix M; Montuschi P; Mores N; Murray CS; Musial J; Myles D; Pahus L; Pandis I; Pavlidis S; Powell P; Pratico G; Puig Valls M; Rao N; Riley J; Roberts A; Roberts G; Rowe A; Sandstrom T; Seibold W; Selby A; Shaw DE; Sigmund R; Singer F; Skipp PJ; Sousa AR; Sterk PJ; Sun K; Thornton B; van Aalderen WM; van Geest M; Vestbo J; Vissing NH; Wagener AH; Wagers SS; Weiszhart Z; Wheelock CE; Wilson SJ; Aliprantis A; Allen D; Alving K; Badorrek P; Balgoma D; Ballereau S; Barber C; Batuwitage MK; Bautmans A; Bedding A; Behndig AF; Beleta J; Berglind A; Berton A; Bochenek G; Braun A; Campagna D; Carayannopoulos L; Casaulta C; Chaleckis R; Dahlen B; Davison T; De Alba J; De Lepeleire I; Dekker T; Delin I; Dennison P; Dijkhuis A; Dodson P; Dyson K; Edwards J; El Hadjam L; Emma R; Ericsson M; Faulenbach C; Flood B; Galffy G; Gallart H; Garissi D; Gent J; de Verdier MG; Gibeon D; Gomez C; Gove K; Guillmant-Farry E; Henriksson E; Hewitt L; Hoda U; Hu R; Hu S; Hu X; Jeyasingham E; Johnson K; Jullian N; Kamphuis J; Kennington EJ; Kerry D; Kerry G; Klueglich M; Knobel H; Kolmert J; Konradsen JR; Kots M; Kretsos K; Krueger L; Kuo S; Kupczyk M; Lambrecht B; Lantz A-S; Larminie C; Larsson LX; Latzin P; Lazarinis N; Lemonnier N; Lone-Latif S; Lowe LA; Manta A; Marouzet L; Martin J; Mathon C; McEvoy L; Meah S; Menzies-Gow A; Metcalf L; Mikus M; Monk P; Naz S; Nething K; Nicholas B; Nihlen U; Nilsson P; Niven R; Nordlund B; Nsubuga S; Ostling J; Pacino A; Palkonen S; Pellet J; Pennazza G; Petren A; Pink S; Pison C; Postle A; Rahman-Amin M; Ravanetti L; Ray E; Reinke S; Reynolds L; Riemann K; Robberechts M; Rocha JP; Rossios C; Russell K; Rutgers M; Santini G; Santoninco M; Saqi M; Schoelch C; Schofield JPR; Scott S; Sehgal N; Sjodin M; Smids B; Smith C; Smith J; Smith KM; Soderman P; Sogbessan A; Spycher F; Staykova D; Stephan S; Stokholm J; Strandberg K; Sunther M; Szentkereszty M; Tamasi L; Tariq K; Thorngren J-O; Thorsen J; Valente S; van de Pol M; van Drunen CM; Van Eyll J; Versnel J; Vink A; von Garnier C; Vyas A; Wald F; Walker S; Ward J; Wetzel K; Wiegman C; Williams S; Yang X; Yeyasingham E; Yu W; Zetterquist W; Zolkipli Z; Zwinderman AH; Prins J-B; Gahlemann M; Visintin L; Evans H; Puhl M; Buzermaniene L; Hudson V; Bond L; de Boer P; Widdershoven G; Sigmund R; Roberts A; Supple D; Hamerlijnck D; Negus J; Kamphuis J; Sergison L; Visintin L; de Boer P; Onstein S; MacNee W; Bernardini R; Bont L; Wecksell P-A; de Boer P; Gahlemann M; Sigmund R; Draper A; Gozzard N
  • Letter: ALLERGY. 2019;74(2):406-411
    Simpson AJ; Hekking P-P; Shaw DE; Fleming LJ; Roberts G; Riley JH; Bates S; Sousa AR; Bansal AT; Pandis I; Sun K; Bakke PS; Caruso M; Dahlen B; Dahlen S-E; Horvath I; Krug N; Montuschi P; Sandstrom T; Singer F; Adcock IM; Wagers SS; Djukanovic R; Chung KF; Sterk PJ; Fowler SJ; Adcock IM; Ahmed H; Auffray C; Bakke P; Bansal AT; Baribaud F; Bates S; Bel EH; Bigler J; Bisgaard H; Boedigheimer MJ; Bonnelykke K; Brandsma J; Brinkman P; Bucchioni E; Burg D; Bush A; Caruso M; Chaiboonchoe A; Chanez P; Chung FK; Compton CH; Corfield J; D'Amico A; Dahlen B; Dahlen SE; De Meulder B; Djukanovic R; Erpenbeck VJ; Erzen D; Fichtner K; Fitch N; Fleming LJ; Formaggio E; Fowler SJ; Frey U; Gahlemann M; Geiser T; Goss V; Guo Y; Hashimoto S; Haughney J; Hedlin G; Hekking PW; Higenbottam T; Hohlfeld JM; Holweg C; Horvath I; Howarth P; James AJ; Knowles R; Knox AJ; Krug N; Lefaudeux D; Loza MJ; Lutter R; Manta A; Masefield S; Matthews JG; Mazein A; Meiser A; Middelveld RJM; Miralpeix M; Montuschi P; Mores N; Murray CS; Musial J; Myles D; Pahus L; Pandis I; Pavlidis S; Postle A; Powel P; Pratico G; Puig Valls M; Rao N; Riley J; Roberts A; Roberts G; Rowe A; Sandstrom T; Schofield JPR; Seibold W; Selby A; Shaw DE; Sigmund R; Singer F; Skipp PJ; Sousa AR; Sterk PJ; Sun K; van Aalderen WM; van Geest M; Vestbo J; Vissing NH; Wagener AH; Wagers SS; Weiszhart Z; Wheelock CE; Wilson SJ
  • Editorial: RESPIROLOGY. 2018;23(7):654-655
    Chotirmall SH; Dahlen S-E; Carlsten C; Wong WSF; Chung KF; Gosens R; Knight DA
  • Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(5):1459-1461.e2
    Sanchez-Vidaurre S; Eldh M; Larssen P; Daham K; Martinez-Bravo M-J; Dahlen S-E; Dahlen B; van Hage M; Gabrielsson S
  • Corrigendum: CLINICAL AND TRANSLATIONAL ALLERGY. 2017;7:5
    Bousquet J; Farrell J; Crooks G; Hellings P; Bel EH; Bewick M; Chavannes NH; de Sousa JC; Cruz AA; Haahtela T; Joos G; Khaltaev N; Malva J; Muraro A; Nogues M; Palkonen S; Pedersen S; Robalo-Cordeiro C; Samolinski B; Strandberg T; Valiulis A; Yorgancioglu A; Zuberbier T; Bedbrook A; Aberer W; Adachi M; Agusti A; Akdis CA; Akdis M; Ankri J; Alonso A; Annesi-Maesano I; Ansotegui IJ; Anto JM; Arnavielhe S; Arshad H; Bai C; Baiardini I; Bachert C; Baigenzhin AK; Barbara C; Bateman ED; Beghe B; Ben Kheder A; Bennoor KS; Benson M; Bergmann KC; Bieber T; Bindslev-Jensen C; Bjermer L; Blain H; Blasi F; Boner AL; Bonini M; Bonini S; Bosnic-Anticevitch S; Boulet LP; Bourret R; Bousquet PJ; Braido F; Briggs AH; Brightling CE; Brozek J; Buhl R; Burney PG; Bush A; Caballero-Fonseca F; Caimmi D; Calderon MA; Calverley PM; Camargos PAM; Canonica GW; Camuzat T; Carlsen KH; Carr W; Carriazo A; Casale T; Sarabia AMC; Chatzi L; Chen YZ; Chiron R; Chkhartishvili E; Chuchalin AG; Chung KF; Ciprandi G; Cirule I; Cox L; Costa DJ; Custovic A; Dahl R; Dahlen SE; Darsow U; De Carlo G; De Blay F; Dedeu T; Deleanu D; Keenoy EDM; Demoly P; Denburg JA; Devillier P; Didier A; Dinh-Xuan AT; Djukanovic R; Dokic D; Douagui H; Dray G; Dubakiene R; Durham SR; Dykewicz MS; El-Gamal Y; Emuzyte R; Fabbri LM; Fletcher M; Fiocchi A; Wagner AF; Fonseca J; Fokkens WJ; Forastiere F; Frith P; Gaga M; Gamkrelidze A; Garces J; Garcia-Aymerich J; Gemicioglu B; Gereda JE; Diaz SG; Gotua M; Grisle I; Grouse L; Gutter Z; Guzman MA; Heaney LG; Hellquist-Dahl B; Henderson D; Hendry A; Heinrich J; Heve D; Horak F; Hourihane JOB; Howarth P; Humbert M; Hyland ME; Illario M; Ivancevich JC; Jardim JR; Jares EJ; Jeandel C; Jenkins C; Johnston SL; Jonquet O; Julge K; Jung KS; Just J; Kaidashev I; Khaitov MR; Kalayci O; Kalyoncu AF; Keil T; Keith PK; Klimek L; N'Goran BK; Kolek V; Koppelman GH; Kowalski ML; Kull I; Kuna P; Kvedariene V; Lambrecht B; Lau S; Larenas-Linnemann D; Laune D; Le LTT; Lieberman P; Lipworth B; Li J; Carlsen KL; Louis R; MacNee W; Magard Y; Magnan A; Mahboub B; Mair A; Majer I; Makela MJ; Manning P; Mara S; Marshall GD; Masjedi MR; Matignon P; Maurer M; Mavale-Manuel S; Melen E; Melo-Gomes E; Meltzer EO; Menzies-Gow A; Merk H; Michel JP; Miculinic N; Mihaltan F; Milenkovic B; Mohammad GMY; Molimard M; Momas I; Montilla-Santana A; Morais-Almeida M; Morgan M; Mosges R; Mullol J; Nafti S; Namazova-Baranova L; Naclerio R; Neou A; Neffen H; Nekam K; Niggemann B; Ninot G; Nyembue TD; O'Hehir RE; Ohta K; Okamoto Y; Okubo K; Ouedraogo S; Paggiaro P; Pali-Scholl I; Panzner P; Papadopoulos N; Papi A; Park HS; Passalacqua G; Pavord I; Pawankar R; Pengelly R; Pfaar O; Picard R; Pigearias B; Pin I; Plavec D; Poethig D; Pohl W; Popov TA; Portejoie F; Potter P; Postma D; Price D; Rabe KF; Raciborski F; Pontal FR; Repka-Ramirez S; Reitamo S; Rennard S; Rodenas F; Roberts J; Roca J; Manas LR; Rolland C; Rodriguez MR; Romano A; Rosado-Pinto J; Rosario N; Rosenwasser L; Rottem M; Ryan D; Sanchez-Borges M; Scadding GK; Schunemann HJ; Serrano E; Schmid-Grendelmeier P; Schulz H; Sheikh A; Shields M; Siafakas N; Sibille Y; Similowski T; Simons FER; Sisul JC; Skrindo I; Smit HA; Sole D; Sooronbaev T; Spranger O; Stelmach R; Sterk PJ; Sunyer J; Thijs C; To T; Todo-Bom A; Triggiani M; Valenta R; Valero AL; Valia E; Valovirta E; Van Ganse E; van Hage M; Vandenplas O; Vasankari T; Vellas B; Vestbo J; Vezzani G; Vichyanond P; Viegi G; Vogelmeier C; Vontetsianos T; Wagenmann M; Wallaert B; Walker S; Wang DY; Wahn U; Wickman M; Williams DM; Williams S; Wright J; Yawn BP; Yiallouros PK; Yusuf OM; Zaidi A; Zar HJ; Zernotti ME; Zhang L; Zhong N; Zidarn M; Mercier J
  • Editorial: CLINICAL AND EXPERIMENTAL ALLERGY. 2016;46(9):1136-1138
    Walker SM; Akdis C; Dahlen SE; Djukanovic R; Edwards J; Garcia-Marcos L; Johnston S; Kupczyk M; Martin T; Myles D; Palkonen S; Papadopoulos N; Powell P; Riley J
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Employments

  • Professor, Senior, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2026
  • Professor, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2024
  • Professor, Institute of Environmental Medicine, Karolinska Institutet, 2020-2024
  • Professor, Senior, Institute of Environmental Medicine, Karolinska Institutet, 2019-2020
  • Professor, Institute of Environmental Medicine, Karolinska Institutet, 1996-2019

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