Sven Erik Dahlén
Professor, Senior
E-mail: sven-erik.dahlen@ki.se
Telephone: +46852487092
Visiting address: M 52, Karolinska Universitetssjukhuset Huddinge, 14186 Stockholm
Postal address: H7 Medicin, Huddinge, H7 CIM Mjösberg KLA, 171 77 Stockholm
Part of:
Research
- Leukotrienes and prostanoids as mast cell mediators and modulators of asthmatic airway obstruction.
The aim of this project is to increase the understanding of mechanisms behind the development of asthma and other inflammatory airway diseases. Acknowledged internationally, our research group has over the years gathered experience and knowledge in leukotrienes, prostanoids and other inflammatory mediators. We have shown earlier that leukotrienes, together with histamine, cause some of the cardinal symptoms of asthma. The mechanisms through which leukotrienes exert their cellular effects are presently not well understood. Like leukotrienes, prostanoids are derived from the poly-unsaturated, essential fatty acid, arachidonic acid. The mechanisms and the location of prostanoid generation and effects differ importantly from those of the leukotrienes. The prostanoid family contains members that mediate asthma augmentation and airway inflammation. On the other hand, relief of asthma symptoms by other members of the family has also been described. Again, understanding how prostanoids mediate their cellular effects, particularly in the lung is presently only sketchily understood, at best. The main drive of this project is to elucidate the beneficial and malign mechanisms by which leukotrienes and prostanoids exert their effects on the different cellular structures of the lung. As this is very much and experimental undertaking, our set up consists of a network of co-operating basic researchers and clinicians and aims to provide comprehensive answers using animal models and human tissues. Implicit in our research is the aim for new discoveries which can lead to improved diagnosis and treatment of all airway inflammatory diseases, including asthma.
Financing
Swedish Research Council
Swedish Heart-Lung Foundation
Co-workers
Yvonne Nygren, secreterary
Mikael Adner, Associated Professor
Maria Kumlin, Associated Professor
Anita Sydbom, Associated Professor
Roelinde Middelveld, Project leader, PhD
Katarina Stark, Postdoc
Cecilia Kemi, Postdoc
Maciek Kupczyk, Postdoc
Ingrid Delin, BMA
Susanna Kumlien-Georén, BMA, PhD
Stina Gustavsson, assistant
Linda Swedin, PhD student
Jesper Säfholm, PhD student
Selected publications
- Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2008;78(2):89-97Selg E; Lastbom L; Ryrfeldt A; Kumlin M; Dahlen S-E
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2007;152(8):1185-1195Selg E; Buccellati C; Andersson M; Rovati GE; Ezinga M; Sala A; Larsson A-K; Ambrosio E; Låstbom L; Capra V; Dahlen B; Ryrfeldt A; Folco GC; Dahlen S-E
- Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2007;119(5):1267-1268Gaber F; James A; Delin I; Wetterholm A; Sampson AP; Dahlen B; Dahlen S-E; Kumlin M
- Article: EUROPEAN RESPIRATORY JOURNAL. 2006;28(3):603-611Ressmeyer AR; Larsson AK; Vollmer E; Dahlen SE; Uhlig S; Martin C
Articles
- Article: EUROPEAN CLINICAL RESPIRATORY JOURNAL. 2026;13(1):2661503Saers J; Sundh J; Andersson L; Ekerljung L; Modig L; Dahlen S-E; Westman M; Janson C
- Article: ALLERGY. 2026;81(7):2366-2380Antao J; Rodrigues G; Zounemat-Kermani N; Montuschi P; Deng Q; Franssen FME; Andersson LI; Adcock IM; Dahlen S-E; Wagers SS; Spruit MA; Marques A
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2026;157(6):1285-1294.e8Belikova M; Johnsson A-K; Kolmert J; Wheelock CE; Abma W; Al-Ameri M; Sachs E; Jalali KV; Adner M; Nilsson G; Dahl S-E; Safhom J
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2026;183(9):2049-2060Abma W; Dahlen S-E; Wheelock CE; Adner M; Al-Amerie M; Sachs E; Vali Jalali K; De Maria L; Olsson H; Safholm J
- Article: ALLERGY. 2026Andersson LI; Kupczyk M; Dahlen B; Izuhara K; Gaga M; Siafakas NM; Papi A; Beghe B; Joos G; Rabe KF; Bel EH; Johnston SL; Chanez P; Gjomarkaj M; Howarth PH; Nizankowska-Mogilnicka E; Middelveld R; Dahlen S-E; Bossios A; James A
- Article: ERJ OPEN RESEARCH. 2026;12(1):699-2025Labor M; Janson C; Palm A; Malinovschi A; Holm M; Ekerljung L; Dahlen S-E; Modig L; Emilsson OI
- Article: ALLERGY. 2026;81(2):413-426Shahbazi Khamas S; Brinkman P; Neerincx AH; Vijverberg SJH; Hashimoto S; Blankestijn JM; Duitman JW; Dekker T; Smids BS; Terheggen-Lagro SWJ; Lutter R; Metwally NKA; Sondaal F; Haarman EG; Sterk PJ; Adcock IM; Auffray C; Bang C; Bansal AT; Buntrock-Dopke H; Bonnelykke K; Bush A; Chawes BL; Chung KF; Corcuera-Elosegui P; Dahlen S-E; Djukanovic R; Fleming LJ; Fowler SJ; Franke A; Frey U; Gorenjak M; Brandstetter S; Harner S; Hedlin G; Kabesch M; Zounemat-Kermani N; Kheirolldein P; Kiefer A; Konradsen JR; Kraneveld AD; Lopez-Fernandez L; Murray CS; Nordlund B; Pino-Yanes M; Potocnik U; Roberts G; Stokholm J; Sorensen SJ; Sardon-Prado O; Shaw DE; Singer F; Sousa AR; Thorsen J; Toncheva AA; Vissing NH; Wolff C; Abdel-Aziz MI; van der Zee AH
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2025;156(6):1669-1678Johnsson A-K; Kolmert J; Ronnberg E; Safholm J; Al-Ameri M; Sachs E; Vali K; Wheelock CE; Dahl S-E; Nilsson GP
- Article: ALLERGY. 2025;80(9):2541-2556Wirth L; Weigel W; Stamper CT; Kolmert J; de Souza Ferreira S; Hammer Q; Sparreman Mikus M; Theorell J; Andersson L; Lantz A-S; Wallen-Nielsen E; Petren A; Wheelock CE; Bossios A; Lazarinis N; Malinovschi A; Janson C; Dahlen B; Hochdorfer T; Tibbitt CA; Dahlen S-E; Yasinska V; Mjosberg J
- Article: ERJ OPEN RESEARCH. 2025;11(4):01089-02024Eastwood MC; Busby J; Kolmert J; Zurita J; Dahlen S-E; Mcdowell PJ; Bradley J; Jackson D; Pavord I; Djukanovic R; Arron J; Bradding P; Brightling C; Chaudhuri R; Cowan D; Fowler S; Hardman TC; Holweg C; Lordan J; Mansur A; Robinson D; Wheelock CE; Heaney L; UK MRCRSP
- Article: MUCOSAL IMMUNOLOGY. 2025;18(3):656-667Brown AC; Carroll OR; Mayall JR; Zounemat-Kermani N; Vinzenz SLE; Gomez HM; Mills EF; Kim RY; Donovan C; Baines KJ; Williams EJ; Berthon BS; Wynne K; Scott HA; Pinkerton JW; Guo Y; Hansbro PM; Foster PS; Wark PAB; Dahlen S-E; Adcock IM; Wood LG; Horvat JC
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2025;155(4):1310-1320Alvarado-Vazquez PA; Mendez-Enriquez E; Salomonsson M; Kopac P; Koren A; Bidovec-Stojkovic U; Koren A; Bidovec-Stojkovic U; Skrgat S; Simonson OE; Yasinska V; Dahlen S-E; Pejler G; Janson C; Korosec P; Malinovschi A; Hallgren J
- Article: EUROPEAN RESPIRATORY JOURNAL. 2025;65(3):2400691Khaleva E; Brightling C; Eiwegger T; Altraja A; Begin P; Blumchen K; Bossios A; Bourdin A; Ten Brinke A; Brusselle G; Bumbacea RS; Bush A; Casale TB; Clarke GW; Chaudhuri R; Chung KF; Coleman C; Corren J; Dahlen S-E; Deschildre A; Djukanovic R; Eger K; Exley A; Fleming L; Fowler SJ; Gaillard EA; Gappa M; Gupta A; Haitchi HM; Hashimoto S; Heaney LG; Hedlin G; Henderson M; Hua W; Jackson DJ; Karadag B; Katelaris CH; Koh MS; Kopp MV; Koppelman GH; Kull I; Kurukulaaratchy RJ; Lee J-H; Mahler V; Makela M; Masoli M; Mathioudakis AG; Mazon A; Melen E; Milger K; Moeller A; Murray CS; Nagakumar P; Nair P; Negus J; Nieto A; Papadopoulos NG; Paton J; Pijnenburg MW; Pike KC; Porsbjerg C; Rattu A; Rupani H; Rusconi F; Rutjes NW; Saglani S; Seddon P; Siddiqui S; Singer F; Tajiri T; Turner S; Upham JW; Vijverberg SJH; Wark PAB; Wechsler ME; Yasinska V; Roberts G
- Article: LANCET RESPIRATORY MEDICINE. 2025;13(1):35-46Zein JG; Zounemat-Kerman N; Adcock IM; Hu B; Attaway A; Castro M; Dahlen S-E; Denlinger LC; Erzurum SC; Fahy JV; Gaston B; Hastie AT; Israel E; Jarjour NN; Levy BD; Mauger DT; Moore W; Peters MC; Sumino K; Townsend E; Woodruff P; Ortega VE; Wenzel SE; Meyers DA; Chung KF; Bleecker ER; Unbiased Biomarkers Prediction Respiratory Disease ER
- Article: HEALTH AND QUALITY OF LIFE OUTCOMES. 2024;22(1):109Meys R; Franssen FME; Van 't Hul AJ; Bakke PS; Caruso M; Dahlen B; Fowler SJ; Geiser T; Howarth PH; Horvath I; Krug N; Behndig AF; Singer F; Musial J; Shaw DE; Montuschi P; Zee AHM-VD; Sterk PJ; Roberts G; Kermani NZ; Incalzi RA; Louis R; Andersson LI; Wagers SS; Dahlen S-E; Chung KF; Adcock IM; Spruit MA; U-BIOPRED SG
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2024;210(9):1091-1100Khamas SS; Van Dijk Y; Abdel-Aziz MI; Neerincx AH; Blankestijn JM; Vijverberg SJH; Hashimoto S; Bush A; Kraneveld AD; Hedman AM; Toncheva AA; Almqvist C; Wolff C; Murray CS; Hedlin G; Roberts G; Adcock IM; Korta-Murua J; Bonnelykke K; Fleming LJ; Pino-Yanes M; Gorenjak M; Kabesch M; Sardon-Prado O; Montuschi P; Singer F; Elosegui PC; Fowler SJ; Brandstetter S; Harner S; Dahlen S-E; Potocnik U; Frey U; van Aalderen W; Brinkman P; Maitland-van der Zee A-H; Consortia UBIOPRE
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2024;210(9):1101-1112Peltrini R; Cordell RL; Wilde M; Abuhelal S; Quek E; Zounemat-Kermani N; Ibrahim W; Richardson M; Brinkman P; Schleich F; Stefanuto P-H; Aung H; Greening N; Dahlen SE; Djukanovic R; Adcock IM; Brightling C; Monks P; Siddiqui S
- Article: EUROPEAN RESPIRATORY JOURNAL. 2024;64(5):2400207Kermani NZ; Chung KF; Macis G; Santini G; Clemeno FAA; Versi A; Sun K; Abdel-Aziz MI; Andersson LI; Auffray C; Badi Y; Bakke P; Brightling C; Brinkman P; Caruso M; Chanez P; De Meulder B; Djukanovic R; Fabbri L; Fowler SJ; Horvath I; Howarth P; James AJ; Kolmert J; Kraft M; Li C-X; Zee AHM-VD; Malerba M; Papi A; Rabe K; Sanak M; Shaw DE; Singh D; Mikus MS; van den Berge M; Wheelock AM; Wheelock CE; Yasinska V; Guo Y-K; Wagers S; Barnes PJ; Bush A; Sterk PJ; Dahlen S-E; Adcock IM; Siddiqui S; Montuschi P
- Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2024;14(9):e70007Versi A; Azim A; Ivan FX; Abdel-Aziz MI; Bates S; Riley J; Uddin M; Kermani NZ; Maitland-van der Zee A-H; Dahlen S-E; Djukanovic R; Chotirmall SH; Howarth P; Adcock IM; Chung KF
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2024;210(3):288-297Djukanovic R; Brinkman P; Kolmert J; Gomez C; Schofield J; Brandsma J; Shapanis A; Skipp PJS; Postle A; Wheelock C; Dahlen S-E; Sterk PJ; Brown T; Jackson DJ; Mansur A; Pavord I; Patel M; Brightling C; Siddiqui S; Bradding P; Sabroe I; Saralaya D; Chishimba L; Porter J; Robinson D; Fowler S; Howarth PH; Little L; Oliver T; Hill K; Stanton L; Allen A; Ellis D; Griffiths G; Harrison T; Akenroye A; Lasky-Su J; Heaney L; Chaudhuri R; Kurukulaaratchy R
- Show more
All other publications
- Review: ALLERGY. 2026;81(1):24-55Rattu A; Dixey P; Charles D; Brightling C; Chung KF; Bossios A; Bourdin A; Djukanovic R; Dahlen S-E; Fleming L; Chaudhuri R; Melen E; Deschildre A; Pilette C; Koppelman GH; Exley A; Anckers F; Miller S; Nielsen H; Williams C; Khaleva E; Roberts G
- Review: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2024;210(9):1079-1090Brinkman P; Wilde M; Ahmed W; Wang R; van der Schee M; Abuhelal S; Schaber C; Cunoosamy D; Clarke GW; Maitland-van der Zee A-H; Dahlen S-E; Siddiqui S; Fowler SJ
- Letter: EUROPEAN RESPIRATORY JOURNAL. 2024;64(3):2400428Versi A; Azim A; Ivan FX; Abdel-Aziz MI; Bates S; Riley J; Zee AHM-VD; Dahlen S-E; Djukanovic R; Chotirmall SH; Howarth P; Kermani NZ; Chung KF; Adcock IM
- Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2024;153(5):1181-1193Bradding P; Porsbjerg C; Cote A; Dahlen S-E; Hallstrand TS; Brightling CE
- Conference publication: ALLERGY. 2023;78:262Khaleva E; Brightling C; Djukanovic R; Dahlen SE; Coleman C; Henderson M; Roberts G
- Letter: CLINICAL AND EXPERIMENTAL ALLERGY. 2023;53(10):1062-1066Belikova M; Safholm J; Al-Ameri M; Orre A-C; Dahlen S-E; Adner M
- Review: ERJ OPEN RESEARCH. 2023;9(3):444-2022Khaleva E; Rattu A; Brightling C; Bush A; Bourdin A; Bossios A; Chung KF; Chaudhuri R; Coleman C; Djukanovic R; Dahlen S-E; Exley A; Fleming L; Fowler SJ; Gupta A; Hamelmann E; Koppelman GH; Melen E; Mahler V; Seddon P; Singer F; Porsbjerg C; Ramiconi V; Rusconi F; Yasinska V; Roberts G
- Review: EUROPEAN RESPIRATORY JOURNAL. 2023;61(4):2201231Rattu A; Khaleva E; Brightling C; Dahlen S-E; Bossios A; Fleming L; Chung KF; Melen E; Djukanovic R; Chaudhuri R; Exley A; Koppelman GH; Bourdin A; Rusconi F; Porsbjerg C; Coleman C; Williams C; Nielsen H; Davin E; Taverner P; Vilarnau SR; Roberts G
- Review: EUROPEAN RESPIRATORY JOURNAL. 2023;61(4):2200606Khaleva E; Rattu A; Brightling C; Bush A; Bossios A; Bourdin A; Chung KF; Chaudhuri R; Coleman C; Dahlen S-E; Djukanovic R; Deschildre A; Fleming L; Fowler SJ; Gupta A; Hamelmann E; Hashimoto S; Hedlin G; Koppelman GH; Melen E; Murray CS; Pilette C; Porsbjerg C; Pike KC; Rusconi F; Williams C; Ahrens B; Alter P; Anckers F; van den Berge M; Blumchen K; Brusselle G; Clarke GW; Cunoosamy D; Dahlen B; Dixey P; Exley A; Frey U; Gaillard EA; Giovannini-Chami L; Grigg J; Hartenstein D; Heaney LG; Karadag B; Kaul S; Kull I; Licari A; Maitland-van der Zee AH; Mahler V; Schoos A-MM; Nagakumar P; Negus J; Nielsen H; Paton J; Pijnenburg M; Ramiconi V; Vilarnau SR; Principe S; Rutjes N; Saglani S; Seddon P; Singer F; Staudinger H; Turner S; Vijverberg S; Winders T; Yasinska V; Roberts G
- Letter: EUROPEAN RESPIRATORY JOURNAL. 2022;60(6):2201795Mikus MS; Kolmert J; Andersson LI; Dahlen S-E; James A
- Corrigendum: CLINICAL PROTEOMICS. 2022;19(1):29Ostling J; Van Geest M; Olsson HK; Dahlen S-E; Viklund E; Gustafsson PM; Mirgorodskaya E; Olin A-C
- Editorial: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;148(5):1157-1160Mullol J; Boyce J; Dahl S-E; Dahlen B; Picado C; Bobolea I
- Editorial: EUROPEAN RESPIRATORY JOURNAL. 2021;58(4):2102168Porsbjerg C; Maitland-van der Zee AH; Brusselle G; Canonica GW; Agusti A; Faner R; Vogelmeier CF; Nawijn M; van den Berge M; Rusconi F; Pilette C; Ramiconi V; Coleman C; Chaudhuri R; Chung KF; Wedzicha J; Saglani S; Van der Schee MP; Heaney L; Bourdin A; Roberts G; Djukanovic R; Kuna P; Kupczyk M; Axmann J; Staudinger H; Clarke GW; Dahlen SE; Brightling C
- Review: CLINICAL AND EXPERIMENTAL ALLERGY. 2021;51(8):992-1005Principe S; Porsbjerg C; Bolm Ditlev S; Klein DK; Golebski K; Dyhre-Petersen N; van Dijk YE; van Bragt JJMH; Dankelman LLH; Dahlen S-E; Brightling CE; Vijverberg SJH; Maitland-van der Zee AH
- Letter: ALLERGY. 2021;76(7):2270-2273Liu J; Kolmert J; Safholm J; Johnsson A-K; Zurita J; Wheelock CE; Dahlen S-E; Nilsson G; Adner M
- Letter: ALLERGY. 2021;76(6):1917-1921Abdel-Aziz MI; Kermani NZ; Neerincx AH; Vijverberg SJH; Guo Y; Howarth P; Dahlen S-E; Djukanovic R; Sterk PJ; Kraneveld AD; van der Zee AH; Chung KF; Adcock IM
- Letter: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021;203(9):1204-1205Kolmert J; Dahlen S-E; Wheelock CE
- Editorial: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;147(3):853-856Mazein A; Ivanova O; Balaur I; Ostaszewski M; Berzhitskaya V; Serebriyskaya T; Ligon T; Hasenauer J; De Meulder B; Overall RW; Roy L; Knowles RG; Wheelock CE; Dahlen S-E; Chung KF; Adcock IM; Roberts G; Djukanovic R; Pellet J; Gawron P; Balling R; Maitland-van der Zee AH; Schneider R; Sterk PJ; Auffray C
- Corrigendum: RESPIRATORY RESEARCH. 2021;22(1):47Kermani NZ; Song W-J; Badi Y; Versi A; Guo Y; Sun K; Bhavsar P; Howarth P; Dahlen S-E; Sterk PJ; Djukanovic R; Adcock IM; Chung KF
- Editorial: ACTA PAEDIATRICA. 2021;110(2):641-642James AJ; Nordlund B; Konradsen JR; Ebersjo C; Dahlen S-E; Berggren Brostrom E; Hedlin G
- Show more
Employments
- Professor, Senior, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2026
- Professor, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2024
- Professor, Institute of Environmental Medicine, Karolinska Institutet, 2020-2024
- Professor, Senior, Institute of Environmental Medicine, Karolinska Institutet, 2019-2020
- Professor, Institute of Environmental Medicine, Karolinska Institutet, 1996-2019