Sven-Erik Dahlén

Sven-Erik Dahlén

Professor
Telephone: +46852487092
Visiting address: M 52, Karolinska Universitetssjukhuset Huddinge, 14186 Stockholm
Postal address: H7 Medicin, Huddinge, H7 Hjärt och lungsjukdomar Mjösberg, 171 77 Stockholm
Part of:

Research

  • Leukotrienes and prostanoids as mast cell mediators and modulators of asthmatic airway obstruction.

    The aim of this project is to increase the understanding of mechanisms behind the development of asthma and other inflammatory airway diseases. Acknowledged internationally, our research group has over the years gathered experience and knowledge in leukotrienes, prostanoids and other inflammatory mediators. We have shown earlier that leukotrienes, together with histamine, cause some of the cardinal symptoms of asthma. The mechanisms through which leukotrienes exert their cellular effects are presently not well understood. Like leukotrienes, prostanoids are derived from the poly-unsaturated, essential fatty acid, arachidonic acid. The mechanisms and the location of prostanoid generation and effects differ importantly from those of the leukotrienes. The prostanoid family contains members that mediate asthma augmentation and airway inflammation. On the other hand, relief of asthma symptoms by other members of the family has also been described. Again, understanding how prostanoids mediate their cellular effects, particularly in the lung is presently only sketchily understood, at best. The main drive of this project is to elucidate the beneficial and malign mechanisms by which leukotrienes and prostanoids exert their effects on the different cellular structures of the lung. As this is very much and experimental undertaking, our set up consists of a network of co-operating basic researchers and clinicians and aims to provide comprehensive answers using animal models and human tissues. Implicit in our research is the aim for new discoveries which can lead to improved diagnosis and treatment of all airway inflammatory diseases, including asthma.

    Financing
    Swedish Research Council
    Swedish Heart-Lung Foundation

    Co-workers
    Yvonne Nygren, secreterary
    Mikael Adner, Associated Professor
    Maria Kumlin, Associated Professor
    Anita Sydbom, Associated Professor
    Roelinde Middelveld, Project leader, PhD
    Katarina Stark, Postdoc
    Cecilia Kemi, Postdoc
    Maciek Kupczyk, Postdoc
    Ingrid Delin, BMA
    Susanna Kumlien-Georén, BMA, PhD
    Stina Gustavsson, assistant
    Linda Swedin, PhD student
    Jesper Säfholm, PhD student

Selected publications

Articles

All other publications

  • Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2024;153(5):1181-1193
    Bradding P; Porsbjerg C; Cote A; Dahlen S-E; Hallstrand TS; Brightling CE
  • Letter: CLINICAL AND EXPERIMENTAL ALLERGY. 2023;53(10):1062-1066
    Belikova M; Safholm J; Al-Ameri M; Orre A-C; Dahlen S-E; Adner M
  • Review: ERJ OPEN RESEARCH. 2023;9(3):444-2022
    Khaleva E; Rattu A; Brightling C; Bush A; Bourdin A; Bossios A; Chung KF; Chaudhuri R; Coleman C; Djukanovic R; Dahlen S-E; Exley A; Fleming L; Fowler SJ; Gupta A; Hamelmann E; Koppelman GH; Melen E; Mahler V; Seddon P; Singer F; Porsbjerg C; Ramiconi V; Rusconi F; Yasinska V; Roberts G
  • Review: EUROPEAN RESPIRATORY JOURNAL. 2023;61(4):2200606
    Khaleva E; Rattu A; Brightling C; Bush A; Bossios A; Bourdin A; Chung KF; Chaudhuri R; Coleman C; Dahlen S-E; Djukanovic R; Deschildre A; Fleming L; Fowler SJ; Gupta A; Hamelmann E; Hashimoto S; Hedlin G; Koppelman GH; Melen E; Murray CS; Pilette C; Porsbjerg C; Pike KC; Rusconi F; Williams C; Ahrens B; Alter P; Anckers F; van den Berge M; Blumchen K; Brusselle G; Clarke GW; Cunoosamy D; Dahlen B; Dixey P; Exley A; Frey U; Gaillard EA; Giovannini-Chami L; Grigg J; Hartenstein D; Heaney LG; Karadag B; Kaul S; Kull I; Licari A; Maitland-van der Zee AH; Mahler V; Schoos A-MM; Nagakumar P; Negus J; Nielsen H; Paton J; Pijnenburg M; Ramiconi V; Vilarnau SR; Principe S; Rutjes N; Saglani S; Seddon P; Singer F; Staudinger H; Turner S; Vijverberg S; Winders T; Yasinska V; Roberts G
  • Review: EUROPEAN RESPIRATORY JOURNAL. 2023;61(4):2201231
    Rattu A; Khaleva E; Brightling C; Dahlen S-E; Bossios A; Fleming L; Chung KF; Melen E; Djukanovic R; Chaudhuri R; Exley A; Koppelman GH; Bourdin A; Rusconi F; Porsbjerg C; Coleman C; Williams C; Nielsen H; Davin E; Taverner P; Vilarnau SR; Roberts G
  • Letter: EUROPEAN RESPIRATORY JOURNAL. 2022;60(6):2201795
    Mikus MS; Kolmert J; Andersson LI; Dahlen S-E; James A
  • Corrigendum: CLINICAL PROTEOMICS. 2022;19(1):29
    Ostling J; Van Geest M; Olsson HK; Dahlen S-E; Viklund E; Gustafsson PM; Mirgorodskaya E; Olin A-C
  • Editorial comment: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;148(5):1157-1160
    Mullol J; Boyce J; Dahl S-E; Dahlen B; Picado C; Bobolea I
  • Editorial comment: EUROPEAN RESPIRATORY JOURNAL. 2021;58(4):2102168
    Porsbjerg C; Maitland-van der Zee AH; Brusselle G; Canonica GW; Agusti A; Faner R; Vogelmeier CF; Nawijn M; van den Berge M; Rusconi F; Pilette C; Ramiconi V; Coleman C; Chaudhuri R; Chung KF; Wedzicha J; Saglani S; Van der Schee MP; Heaney L; Bourdin A; Roberts G; Djukanovic R; Kuna P; Kupczyk M; Axmann J; Staudinger H; Clarke GW; Dahlen SE; Brightling C
  • Review: CLINICAL AND EXPERIMENTAL ALLERGY. 2021;51(8):992-1005
    Principe S; Porsbjerg C; Bolm Ditlev S; Klein DK; Golebski K; Dyhre-Petersen N; van Dijk YE; van Bragt JJMH; Dankelman LLH; Dahlen S-E; Brightling CE; Vijverberg SJH; Maitland-van der Zee AH
  • Letter: ALLERGY. 2021;76(7):2270-2273
    Liu J; Kolmert J; Safholm J; Johnsson A-K; Zurita J; Wheelock CE; Dahlen S-E; Nilsson G; Adner M
  • Letter: ALLERGY. 2021;76(6):1917-1921
    Abdel-Aziz MI; Kermani NZ; Neerincx AH; Vijverberg SJH; Guo Y; Howarth P; Dahlen S-E; Djukanovic R; Sterk PJ; Kraneveld AD; van der Zee AH; Chung KF; Adcock IM
  • Letter: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021;203(9):1204-1205
    Kolmert J; Dahlen S-E; Wheelock CE
  • Editorial comment: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;147(3):853-856
    Mazein A; Ivanova O; Balaur I; Ostaszewski M; Berzhitskaya V; Serebriyskaya T; Ligon T; Hasenauer J; De Meulder B; Overall RW; Roy L; Knowles RG; Wheelock CE; Dahlen S-E; Chung KF; Adcock IM; Roberts G; Djukanovic R; Pellet J; Gawron P; Balling R; Maitland-van der Zee AH; Schneider R; Sterk PJ; Auffray C
  • Corrigendum: RESPIRATORY RESEARCH. 2021;22(1):47
    Kermani NZ; Song W-J; Badi Y; Versi A; Guo Y; Sun K; Bhavsar P; Howarth P; Dahlen S-E; Sterk PJ; Djukanovic R; Adcock IM; Chung KF
  • Editorial comment: ACTA PAEDIATRICA. 2021;110(2):641-642
    James AJ; Nordlund B; Konradsen JR; Ebersjo C; Dahlen S-E; Berggren Brostrom E; Hedlin G
  • Letter: ALLERGY. 2021;76(1):380-383
    Zounemat Kermani N; Saqi M; Agapow P; Pavlidis S; Kuo C; Tan KS; Mumby S; Sun K; Loza M; Baribaud F; Sousa AR; Riley J; Wheelock AM; Wheelock CE; De Meulder B; Schofield J; Sanchez-Ovando S; Simpson JL; Baines KJ; Wark PA; Auffray C; Dahlen S-E; Sterk PJ; Djukanovic R; Adcock IM; Guo Y-K; Chung KF
  • Review: CLINICAL SCIENCE. 2020;134(11):1219-1242
    Adner M; Canning BJ; Meurs H; Ford W; Ramos Ramírez P; van den Berg MPM; Birrell MA; Stoffels E; Lundblad LKA; Nilsson GP; Olsson HK; Belvisi MG; Dahlén S-E
  • Letter: EUROPEAN RESPIRATORY JOURNAL. 2019;53(6):1900453
    Perotin J-M; Schofield JPR; Wilson SJ; Ward J; Brandsma J; Strazzeri F; Bansal A; Yang X; Rowe A; Corfield J; Lutter R; Shaw DE; Bakke PS; Caruso M; Dahlen B; Fowler SJ; Horvath I; Howarth P; Krug N; Montuschi P; Sanak M; Sandstrom T; Sun K; Pandis I; Auffray C; De Meulder B; Lefaudeux D; Riley JH; Sousa AR; Dahlen S-E; Adcock IM; Chung KF; Sterk PJ; Skipp PJ; Collins JE; Davies DE; Djukanovic R; Adcock IM; Ahmed H; Auffray C; Bakke P; Banssal AT; Baribaud F; Bates S; Bel EH; Bigler J; Bisgaard H; Boedigheimer MJ; Bonnelykke K; Brandsma J; Brinkman P; Bucchioni E; Burg D; Bush A; Caruso M; Chaiboonchoe A; Chanez P; Chung KF; Compton CH; Corfield J; D'Amico A; Dahlen SE; De Meulder B; Djukanovic R; Erpenbeck VJ; Erzen D; Fichtner K; Fitch N; Fleming LJ; Formaggio E; Fowler SJ; Frey U; Gahlemann M; Geiser T; Guo Y; Hashimoto S; Haughney J; Hedlin G; Hekking PW; Higenbottam T; Hohlfeld JM; Holweg C; Horvath I; Howarth P; James AJ; Knowles R; Knox AJ; Krug N; Lefaudeux D; Loza MJ; Lutter R; Manta A; Masefield S; Matthews JG; Mazein A; Meiser A; Middelveld RJM; Miralpeix M; Montuschi P; Mores N; Murray CS; Musial J; Myles D; Pahus L; Pandis I; Pavlidis S; Powell P; Pratico G; Puig Valls M; Rao N; Riley J; Roberts A; Roberts G; Rowe A; Sandstrom T; Seibold W; Selby A; Shaw DE; Sigmund R; Singer F; Skipp PJ; Sousa AR; Sterk PJ; Sun K; Thornton B; van Aalderen WM; van Geest M; Vestbo J; Vissing NH; Wagener AH; Wagers SS; Weiszhart Z; Wheelock CE; Wilson SJ; Aliprantis A; Allen D; Alving K; Badorrek P; Balgoma D; Ballereau S; Barber C; Batuwitage MK; Bautmans A; Bedding A; Behndig AF; Beleta J; Berglind A; Berton A; Bochenek G; Braun A; Campagna D; Carayannopoulos L; Casaulta C; Chaleckis R; Dahlen B; Davison T; De Alba J; De Lepeleire I; Dekker T; Delin I; Dennison P; Dijkhuis A; Dodson P; Dyson K; Edwards J; El Hadjam L; Emma R; Ericsson M; Faulenbach C; Flood B; Galffy G; Gallart H; Garissi D; Gent J; de Verdier MG; Gibeon D; Gomez C; Gove K; Guillmant-Farry E; Henriksson E; Hewitt L; Hoda U; Hu R; Hu S; Hu X; Jeyasingham E; Johnson K; Jullian N; Kamphuis J; Kennington EJ; Kerry D; Kerry G; Klueglich M; Knobel H; Kolmert J; Konradsen JR; Kots M; Kretsos K; Krueger L; Kuo S; Kupczyk M; Lambrecht B; Lantz A-S; Larminie C; Larsson LX; Latzin P; Lazarinis N; Lemonnier N; Lone-Latif S; Lowe LA; Manta A; Marouzet L; Martin J; Mathon C; McEvoy L; Meah S; Menzies-Gow A; Metcalf L; Mikus M; Monk P; Naz S; Nething K; Nicholas B; Nihlen U; Nilsson P; Niven R; Nordlund B; Nsubuga S; Ostling J; Pacino A; Palkonen S; Pellet J; Pennazza G; Petren A; Pink S; Pison C; Postle A; Rahman-Amin M; Ravanetti L; Ray E; Reinke S; Reynolds L; Riemann K; Robberechts M; Rocha JP; Rossios C; Russell K; Rutgers M; Santini G; Santoninco M; Saqi M; Schoelch C; Schofield JPR; Scott S; Sehgal N; Sjodin M; Smids B; Smith C; Smith J; Smith KM; Soderman P; Sogbessan A; Spycher F; Staykova D; Stephan S; Stokholm J; Strandberg K; Sunther M; Szentkereszty M; Tamasi L; Tariq K; Thorngren J-O; Thorsen J; Valente S; van de Pol M; van Drunen CM; Van Eyll J; Versnel J; Vink A; von Garnier C; Vyas A; Wald F; Walker S; Ward J; Wetzel K; Wiegman C; Williams S; Yang X; Yeyasingham E; Yu W; Zetterquist W; Zolkipli Z; Zwinderman AH; Prins J-B; Gahlemann M; Visintin L; Evans H; Puhl M; Buzermaniene L; Hudson V; Bond L; de Boer P; Widdershoven G; Sigmund R; Roberts A; Supple D; Hamerlijnck D; Negus J; Kamphuis J; Sergison L; Visintin L; de Boer P; Onstein S; MacNee W; Bernardini R; Bont L; Wecksell P-A; de Boer P; Gahlemann M; Sigmund R; Draper A; Gozzard N
  • Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;143(3):864-879
    Bousquet J; Hellings PW; Agache I; Amat F; Annesi-Maesano I; Ansotegui IJ; Anto JM; Bachert C; Bateman ED; Bedbrook A; Bennoor K; Bewick M; Bindslev-Jensen C; Bosnic-Anticevich S; Bosse I; Brozek J; Brussino L; Canonica GW; Cardona V; Casale T; Sarabia AMC; Chavannes NH; Cecchi L; de Sousa JC; Costa E; Cruz AA; Czarlewski W; De Carlo G; De Feo G; Demoly P; Devillier P; Dykewicz MS; El-Gamal Y; Eller EE; Fonseca JA; Fontaine J-F; Fokkens WJ; Guzman M-A; Haahtela T; Illario M; Ivancevich J-C; Just J; Kaidashev I; Khaitov M; Kalayci O; Keil T; Klimek L; Kowalski ML; Kuna P; Kvedariene V; Larenas-Linnemann D; Laune D; Le LTT; Carlsen KL; Lourenco O; Mahboub B; Mair A; Menditto E; Milenkovic B; Morais-Almeida M; Mosges R; Mullol J; Murray R; Naclerio R; Namazova-Baranova L; Novellino E; O'Hehir RE; Ohta K; Okamoto Y; Okubo K; Onorato GL; Palkonen S; Panzner P; Papadopoulos NG; Park H-S; Paulino E; Pawankar R; Pfaar O; Plavec D; Popov TA; Potter P; Prokopakis EP; Rottem M; Ryan D; Salimaki J; Samolinski B; Sanchez-Borges M; Schunemann HJ; Sheikh A; Sisul J-C; Rajabian-Soderlund R; Sooronbaev T; Stellato C; To T; Todo-Bom A-M; Tomazic P-V; Toppila-Salmi S; Valero A; Valiulis A; Valovirta E; Ventura M-T; Wagenmann M; Wang DY; Wallace D; Waserman S; Wickman M; Yorgancioglu A; Zhang L; Zhong N; Zidarn M; Zuberbier T; Bousquet J; Hellings PW; Aberer W; Agache I; Akdis CA; Akdis M; Alberti MR; Almeida R; Amat F; Angles R; Annesi-Maesano I; Ansotegui IJ; Anto JM; Arnavielle S; Asayag E; Asarnoj A; Arshad H; Avolio F; Bacci E; Bachert C; Baiardini I; Barbara C; Barbagallo M; Baroni I; Barreto BA; Basagana X; Bateman ED; Bedolla-Barajas M; Bedbrook A; Bewick M; Beghe B; Bel EH; Bergmann KC; Bennoor KS; Benson M; Bertorello L; Biaoszewski AZ; Bieber T; Bialek S; Bindslev-Jensen C; Bjermer L; Blain H; Blasi F; Blua A; Marciniak MB; Bogus-Buczynska I; Boner AL; Bonini M; Bonini S; Bosnic-Anticevich CS; Bosse I; Bouchard J; Boulet LP; Bourret R; Bousquet PJ; Braido F; Briedis V; Brightling CE; Brozek J; Bucca C; Buhl R; Buonaiuto R; Panaitescu C; Cabanas MTB; Burte E; Bush A; Caballero-Fonseca F; Caillot D; Caimmi D; Calderon MA; Camargos PAM; Camuzat T; Canfora G; Canonica GW; Cardona V; Carlsen KH; Carreiro-Martins P; Carriazo AM; Carr W; Cartier C; Casale T; Castellano G; Cecchi L; Sarabia AMC; Chavannes NH; Chen Y; Chiron R; Chivato T; Chkhartishvili E; Chuchalin AG; Chung KF; Ciaravolo MM; Ciceran A; Cingi C; Ciprandi G; Coehlo ACC; Colas L; Colgan E; Coll J; Conforti D; de Sousa JC; Cortes-Grimaldo RM; Corti F; Costa E; Costa-Dominguez C; Courbis AL; Cox L; Crescenzo M; Cruz AA; Custovic A; Czarlewski W; Dahlen SE; Dario C; da Silva J; Dauvilliers Y; Darsow U; De Blay F; De Carlo G; Dedeu T; Emerson MDF; De Feo G; De Vries G; De Martino B; Rubini NDPM; Deleanu D; Demoly P; Denburg JA; Devillier P; Ercolano SDC; Di Carluccio N; Didier A; Dokic D; Dominguez-Silva MG; Douagui H; Dray G; Dubakiene R; Durham SR; Du Toit G; Dykewicz MS; El-Gamal Y; Eklund P; Eller E; Emuzyte R; Farrell J; Farsi A; de MJFJ; Ferrero J; Fink-Wagner A; Fiocchi A; Fokkens WJ; Fonseca JA; Fontaine JF; Forti S; Fuentes-Perez JM; Galvez-Romero JL; Gamkrelidze A; Garcia-Aymerich J; Garcia-Cobas CY; Garcia-Cruz MH; Gemicioglu B; Genova S; Christoff G; Gereda JE; van Wijk RG; Gomez RM; Gomez-Vera J; Diaz SG; Gotua M; Grisle I; Guidacci M; Guldemond NA; Gutter Z; Guzman MA; Haahtela T; Hajjam J; Hernandez L; Hourihane JO; Huerta-Villalobos YR; Humbert M; Iaccarino G; Illario M; Ivancevich JC; Jares EJ; Jassem E; Johnston SL; Joos G; Jung KS; Jutel M; Kaidashev I; Kalayci O; Kalyoncu AF; Karjalainen J; Kardas P; Keil T; Keith PK; Khaitov M; Khaltaev N; Kleine-Tebbe J; Klimek L; Kowalski ML; Kuitunen M; Kull I; Kuna P; Kupczyk M; Kvedariene V; Krzych-Fata E; Lacwik P; Larenas-Linnemann D; Laune D; Lauri D; Lavrut J; Le LTT; Lessa M; Levato G; Li J; Lieberman P; Lipiec A; Lipworth B; Carlsen KCL; Louis R; Lourenco O; Luna-Pech JA; Maciej K; Magnan A; Mahboub B; Maier D; Mair A; Majer I; Malva J; Mandajieva E; Manning P; Keenoy EDM; Marshall GD; Masjedi MR; Maspero JF; Mathieu-Dupas E; Campos JJM; Matos AL; Maurer M; Mavale-Manuel S; Mayora O; Medina-Avalos MA; Melen E; Melo-Gomes E; Meltzer EO; Menditto E; Mercier J; Miculinic N; Mihaltan F; Milenkovic B; Moda G; Mogica-Martinez MD; Mohammad Y; Momas I; Montefort S; Monti R; Bogado DM; Morais-Almeida M; Morato-Castro FF; Mosges R; Mota-Pinto A; Santo PM; Mullol J; Munter L; Muraro A; Murray R; Naclerio R; Nadif R; Nalin M; Napoli L; Namazova-Baranova L; Neffen H; Niedeberger V; Nekam K; Neou A; Nieto A; Nogueira-Silva L; Nogues M; Novellino E; Nyembue TD; O'Hehir RE; Odzhakova C; Ohta K; Okamoto Y; Okubo K; Onorato GL; Cisneros MO; Ouedraogo S; Pali-Scholl I; Palkonen S; Panzner P; Papadopoulos NG; Park HS; Papi A; Passalacqua G; Paulino E; Pawankar R; Pedersen S; Pepin JL; Pereira AM; Persico M; Pfaar O; Phillips J; Picard R; Pigearias B; Pin I; Pitsios C; Plavec D; Pohl W; Popov TA; Portejoie F; Potter P; Pozzi AC; Price D; Prokopakis EP; Puy R; Pugin B; Ross REP; Przemecka M; Rabe KF; Raciborski F; Rajabian-Soderlund R; Reitsma S; Ribeirinho I; Rimmer J; Rivero-Yeverino D; Rizzo JA; Rizzo MC; Robalo-Cordeiro C; Rodenas F; Rodo X; Gonzalez MR; Rodriguez-Manas L; Rolland C; Valle SR; Rodriguez MR; Romano A; Rodriguez-Zagal E; Rolla G; Roller-Wirnsberger RE; Romano M; Rosado-Pinto J; Rosario N; Rottem M; Ryan D; Sagara H; Salimaki J; Samolinski B; Sanchez-Borges M; Sastre-Dominguez J; Scadding GK; Schunemann HJ; Scichilone N; Schmid-Grendelmeier P; Serpa FS; Shamai S; Sheikh A; Sierra M; Simons FER; Siroux V; Sisul JC; Skrindo I; Sole D; Somekh D; Sondermann M; Sooronbaev T; Sova M; Sorensen M; Sorlini M; Spranger O; Stellato C; Stelmach R; Stukas R; Sunyer J; Strozek J; Szylling A; Tebyrica JN; Thibaudon M; To T; Todo-Bom A; Tomazic PV; Toppila-Salmi S; Trama U; Triggiani M; Ulrik CS; Urrutia-Pereira M; Valenta R; Valero A; Valiulis A; Valovirta E; van Eerd M; van Ganse E; van Hague M; Vandenplas O; Ventura MT; Vezzani G; Vasankari T; Vatrella A; Verissimo MT; Viart F; Viegi M; Vicheva D; Vontetsianos T; Wagenmann M; Walker S; Wallace D; Wang DY; Waserman S; Werfel T; Westman M; Wickman M; Williams DM; Williams S; Wilson N; Wright J; Wroczynski P; Yakovliev P; Yawn BP; Yiallouros PK; Yorgancioglu A; Yusuf OM; Zar HJ; Zhang L; Zhong N; Zernotti ME; Zidarn M; Zuberbier T; Zubrinich C; Zurkuhlen A
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Employments

  • Professor, Department of Medicine, Huddinge, Karolinska Institutet, 2024-
  • Professor, Institute of Environmental Medicine, Karolinska Institutet, 2024-2025

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