Sven-Christian Pawelzik

Purpose and goal: This project aims to introduce personalized medicine for an optimized omega-3 fatty acid treatment in cardiovascular prevention. More specifically, the goal is to develop a personalized medicine CVD prevention decision tool to determine if omega-3 treatment is likely to be beneficial in individual patients, and determine what PUFA, dose, and formulation to use for an optimized response towards cardiovascular health. Expected results and effects: The anticipated outcome of the project is the digital decision support system (DSS) OmegaPerMed Prevention Tool that can identify responders and non-responders to omega-3 treatment. This could hence be the first personalized medicine tool to be widely implemented in international CVD treatment guidelines for secondary prevention to the benefit of large patient population in Europe and world-wide. In addition, it has the potential to be expanded towards personalized dietary PUFA recommendations for primary CVD prevention and other non-CVD associated with chronic inflammation. Approach and implementation: This multidisciplinary project will explore well characterized cohorts and clinical trials for interactions between genes, polyunsaturated fatty acid (PUFA) exposure, cardiovascular disease risk and lipidomic markers towards beneficial effects of omega-3 PUFA. Complimentary lipidomic methods will be employed for mapping PUFA, PUFA sources, and PUFA-derived mediators as biomarkers. All available data will be integrated using artificial intelligence to develop the OmegaPerMed Prevention Tool, which will be continuously tested in a feasibility trial.

CArdiovascular REsolution of INflammation to promote HEALTH (CARE-IN-HEALTH), responds to an unmet medical need by addressing one of the critical hallmarks of the phenotypic and functional cardiovascular during the transition from health to Cardiovascular disease (CVD) : Chronic Inflammation.  Identifying the resolution of the chronic lipid-driven/-regulated vascular inflammation allows to develop and test, in a real-life setting, tools for use in health care and by citizens to stay healthy.