Sven-Christian Pawelzik

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(6):5392
Helicobacter Pylori Virulence Factor Cytotoxin-Associated Gene A (CagA) Induces Vascular Calcification in Coronary Artery Smooth Muscle Cells
Sundqvist MOO; Warme J; Hofmann R; Pawelzik S-C; Back M
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2023;194:308-315
Decreased oxidative stress and altered urinary oxylipidome by intravenous omega-3 fatty acid emulsion in a randomized controlled trial of older subjects hospitalized for COVID-19
Pawelzik S-C; Arnardottir H; Sarajlic P; Mahdi A; Vigor C; Zurita J; Zhou B; Kolmert J; Galano J-M; Religa D; Durand T; Wheelock CE; Back M
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2022;179(19):4709-4721
The tyrosine kinase inhibitor nilotinib targets the discoidin domain receptor DDR2 in calcific aortic valve stenosis
Carracedo M; Pawelzik S-C; Artiach G; Pouwer MG; Plunde O; Saliba-Gustafsson P; Ehrenborg E; Eriksson P; Pieterman E; Stenke L; Princen HMG; Franco-Cereceda A; Back M
Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(9):e895
Immunomodulation by intravenous omega-3 fatty acid treatment in older subjects hospitalized for COVID-19: A single-blind randomized controlled trial
Arnardottir H; Pawelzik S-C; Sarajlic P; Quaranta A; Kolmert J; Religa D; Wheelock CE; Back M
Article: BIOCHEMICAL PHARMACOLOGY. 2022;201:115075
The resolvin D2-GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice
Bardin M; Pawelzik S-C; Lagrange J; Mahdi A; Arnardottir H; Feve B; Regnault V; Lacolley P; Michel J-B; Mercier N; Back M
Journal article: CARDIOLOGY PLUS. 2022;7(1):3-11
Calcific aortic valve stenosis and COVID-19: clinical management, valvular damage, and pathophysiological mechanisms
Bäck M; Hashem M; Giani A; Pawelzik S-C; Franco-Cereceda A
Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(24):e142883
The resolvin D1 receptor GPR32 transduces inflammation resolution and atheroprotection
Arnardottir H; Thul S; Pawelzik S-C; Karadimou G; Artiach G; Gallina AL; Mysdotter V; Carracedo M; Tarnawski L; Caravaca AS; Baumgartner R; Ketelhuth DF; Olofsson PS; Paulsson-Berne G; Hansson GK; Back M
Article: CIRCULATION. 2021;144(20):1629-1645
Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium
Franco Cereceda A; Bäck M; Plunde O; Pawelzik S-C
Journal article: CIRCULATION. 2021;144(20):1629-1645
Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium
Sainz-Jaspeado M; Smith RO; Plunde O; Pawelzik S-C; Jin Y; Nordling S; Ding Y; Aspenstrom P; Hedlund M; Bastianello G; Ascione F; Li Q; Demir CS; Fernando D; Daniel G; Franco-Cereceda A; Kroon J; Foiani M; Petrova TV; Kilimann MW; Back M; Claesson-Welsh L
Article: AMERICAN HEART JOURNAL. 2021;231:105-109
Helicobacter pylori screening in clinical routine during hospitalization for acute myocardial infarction
Waerme J; Sundqvist M; Mars K; Aladellie L; Pawelzik S-C; Erlinge D; Jernberg T; James S; Hofmann R; Baeck M
Article: CELLS. 2020;9(7):E1710-1710
TLR7 Expression Is Associated with M2 Macrophage Subset in Calcific Aortic Valve Stenosis
Karadimou G; Plunde O; Pawelzik S-C; Carracedo M; Eriksson P; Franco-Cereceda A; Paulsson-Berne G; Back M
Article: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2020;2020:5197376-9
Semicarbazide-Sensitive Amine Oxidase Increases in Calcific Aortic Valve Stenosis and Contributes to Valvular Interstitial Cell Calcification
Mercier N; Pawelzik S-C; Pirault J; Carracedo M; Persson O; Wollensack B; Franco-Cereceda A; Back M
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(24):4625-4638
Biological characterization of new inhibitors of microsomal PGE synthase-1 in preclinical models of inflammation and vascular tone
Larsson K; Steinmetz J; Bergqvist F; Arefin S; Spahiu L; Wannberg J; Pawelzik S-C; Morgenstern R; Stenberg P; Kublickiene K; Korotkova M; Jakobsson P-J
Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2019;145:106361
Urinary prostaglandin D₂ and E₂ metabolites associate with abdominal obesity, glucose metabolism, and triglycerides in obese subjects
Pawelzik S-C; Avignon A; Idborg H; Boegner C; Stanke-Labesque F; Jakobsson P-J; Sultan A; Back M
Article: JOURNAL OF IMMUNOLOGY. 2018;200(12):4004-4011
Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms
Ocana JA; Romer E; Sahu R; Pawelzik S-C; FitzGerald GA; Kaplan MH; Travers JB
Article: CIRCULATION. 2016;134(4):328-338
Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1-Deficient Hyperlipidemic Mice
Tang SY; Monslow J; Grant GR; Todd L; Pawelzik S-C; Chen L; Lawson J; Pure E; FitzGerald GA
Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2014;91(6):269-275
Evaluation of urinary prostaglandin E₂ metabolite as a biomarker in infants with fever due to viral infection
Idborg H; Pawelzik S-C; Perez-Manso M; Bjork L; Hamrin J; Herlenius E; Jakobsson P-J
Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2013;102:1-12
Characterization of a new mPGES-1 inhibitor in rat models of inflammation
Leclerc P; Pawelzik S-C; Idborg H; Spahiu L; Larsson C; Stenberg P; Korotkova M; Jakobsson P-J
Article: BIOCHEMISTRY. 2011;50(35):7684-7693
Location of Inhibitor Binding Sites in the Human Inducible Prostaglandin E Synthase, MPGES1
Prage EB; Pawelzik S-C; Busenlehner LS; Kim K; Morgenstern R; Jakobsson P-J; Armstrong RN
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(38):29254-29261
Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1
Pawelzik S-C; Uda NR; Spahiu L; Jegerschold C; Stenberg P; Hebert H; Morgenstern R; Jakobsson P-J
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2010;1801(4):462-472
Hyperforin induces Ca²⁺-Andependent arachidonic acid release in human platelets by facilitating cytosolic phospholipase A₂ activation through select phospholipid interactions
Hoffmann M; Lopez JJ; Pergola C; Feisst C; Pawelczik S; Jakobsson P-J; Sorg BL; Glaubitz C; Steinhilber D; Werz O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(44):18757-18762
Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells
Hanaka H; Pawelzik S-C; Johnsen JI; Rakonjac M; Terawaki K; Rasmuson A; Sveinbjornsson B; Schumacher MC; Hamberg M; Samuelsson B; Jakobsson P-J; Kogner P; Radmark O
Article: LEUKEMIA AND LYMPHOMA. 2009;50(7):1198-1203
Lymphoblastic T-cell lymphoma in mice is unaffected by Celecoxib as single agent or in combination with cyclophosphamide
Johansson A-S; Pawelzik S-C; Larefalk A; Jakobsson P-J; Holmberg D; Lindskog M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(32):11110-11115
Structural basis for induced formation of the inflammatory mediator prostaglandin E₂
Jegerschold C; Paweizik S-C; Purhonen P; Bhakat P; Gheorghe KR; Gyobu N; Mitsuoka K; Morgenstern R; Jakobsson P-J; Hebert H
Article: CIRCULATION. 2008;117(13):1701-1710
Microsomal prostaglandin E₂ synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction
Degousee N; Fazel S; Angoulvant D; Stefanski E; Pawelzik S-C; Korotkova M; Arab S; Liu P; Lindsay TF; Zhuo S; Butany J; Li R-K; Audoly L; Schmidt R; Angioni C; Geisslinger G; Jakobsson P-J; Rubin BB
Journal article: GBM ANNUAL SPRING MEETING MOSBACH 2006. 2006;2006(Spring)
Mutational Analysis of human glutathione-dependent microsomal Prostaglandin E synthase-1 (mPGES-1)
Pawelzik S-C; Jegerschöld C; Pettersson PL; Morgenstern R; Hebert H; Jakobsson P-J
Journal article: VALUE IN HEALTH. 2004;7(2):144-152
Resource utilization and costs of stroke unit care in Germany
Dodel RC; Haacke C; Zamzow K; Pawelzik S; Spottke A; Rethfeldt M; Siebert U; Oertel WH; Schöffski O; Back T
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Alla övriga publikationer

Review: METABOLITES. 2022;12(8):721
Prostanoid Metabolites as Biomarkers in Human Disease
Idborg H; Pawelzik S-C
Editorial comment: CARDIOVASCULAR RESEARCH (CVR). 2022;118(2):353-354
von Willebrand factor's vascular crossroad
Pawelzik S-C; Back M
Preprint: MEDRXIV. 2021
Immunomodulation by intravenous omega-3 fatty acid treatment in older subjects hospitalized for COVID-19: a single-blind randomized controlled trial
Arnardottir H; Pawelzik S-C; Sarajlic P; Quaranta A; Kolmert J; Religa D; Wheelock C; Bäck M
Conference publication: ATHEROSCLEROSIS. 2021;331:E9
THE RESOLVIN D1 RECEPTOR GPR32 TRANSDUCES INFLAMMATION-RESOLUTION AND ATHEROPROTECTION
Arnardottir H; Thul S; Karadimou G; Pawelzik S-C; Artiach G; Mysdotter V; Carracedo M; Tarnawski L; Caravaca AS; Baumgartner R; Ketelhuth DF; Olofsson PS; Paulsson-Berne G; Hansson GK; Back M
Review: TOXINS. 2020;12(4):E227-227
Inflammation and Premature Ageing in Chronic Kidney Disease
Ebert T; Pawelzik S-C; Witasp A; Arefin S; Hobson S; Kublickiene K; Shiels PG; Back M; Stenvinkel P
Editorial comment: ANNALS OF TRANSLATIONAL MEDICINE. 2020;8(6):258
Eastern Remedies for Western-type diet induced atherosclerosis
Pawelzik S-C; Back M
Review: FRONTIERS IN PHYSIOLOGY. 2020;11:624657
Stimulating the Resolution of Inflammation Through Omega-3 Polyunsaturated Fatty Acids in COVID-19: Rationale for the COVID-Omega-F Trial
Arnardottir H; Pawelzik S-C; ohlund Wistbacka U; Artiach G; Hofmann R; Reinholdsson I; Braunschweig F; Tornvall P; Religa D; Back M
Thesis / dissertation: 2010
Structure and function of microsomal prostaglandin E synthase-1
Pawelzik, Sven-Christian
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;71(6):508
Characterization of mPGES-1 Inhibition in Rat Models of Inflammation
Leclerc P; Larsson C; Spahiu L; Pawelzik S-C; Idborg H; Stenberg P; Korotkova M; Jakobsson P-J
Conference publication: ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES. 2009;65:S77
Structure of Microsomal Prostaglandin E Synthase 1 as Determined by Electron Crystallography
Hebert H; Jegerschoeld C; Purhonen P; Bhakat P; Gheorghe K; Gyobu N; Mitsuoka K; Pawelzik S; Jakobsson P-J; Morgenstern R

Forskningsbidrag

Optimizing omega-3 supplementation to resolve inflammation in a personalized medicine CVD prevention
VINNOVA
21 November 2022 - 31 December 2025
Personalised blueprint of chronic inflammation in health-to-disease transition
European Commission
1 November 2022
Mast cell derived lipid mediators in atherogenesis
Swedish Research Council
1 January 2013 - 31 December 2015

Anställningar

Adjungerad Adjunkt, Medicin, Solna, Karolinska Institutet, 2023-2025

Examina och utbildning

Medicine Doktorsexamen, Institutionen för medicin, Solna, Karolinska Institutet, 2010

Artiklar

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Anställningar

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Nyheter från KI

Kalenderhändelser från KI