Sven-Christian Pawelzik

Sven-Christian Pawelzik

Adjunct Lecturer
Visiting address: BioClinicum, Plan 8,Karolinska Universitetssjukhuset Solna, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Kardiov m Bäck M, 171 77 Stockholm
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About me

  • I am a team leader in the Translational Cardiology group at the Department of
    Medicine, Solna (MedS), driven to learn about new aspects of human health and
    apply this knowledge to contribute to innovative therapeutic approaches. My
    focus of interest is inflammation as basis of cardiovascular diseases.

    2011 - 2016 Postdoctoral Researcher, University of Pennsylvania, Philadelphia, PA, USA
    2010 PhD in Medical Science, Karolinska Institutet, Sweden
    2006 MSc, Human Biology, University of Marburg, Germany
    2001 BSc, Human Biology, University of Marburg, Germany

Teaching

  • Main supervisor for two PhD students
    Co-supervisor for two PhD students
    Main supervisor for several BSc and MSc students (Biomedicine, Biochemistry,
    Molecular Biology)

    PhD course: Lipid Metabolism and Inflammation in Cardiovascular Disease (https://kiwas.ki.se/katalog/kursplan/show/9584)

    PhD course: Bioactive Lipid Mediators in Human Disease, University of Modena and Reggio Emilia, 2025

Articles

All other publications

Grants

  • VINNOVA
    21 November 2022 - 31 December 2025
    Purpose and goal: This project aims to introduce personalized medicine for an optimized omega-3 fatty acid treatment in cardiovascular prevention. More specifically, the goal is to develop a personalized medicine CVD prevention decision tool to determine if omega-3 treatment is likely to be beneficial in individual patients, and determine what PUFA, dose, and formulation to use for an optimized response towards cardiovascular health. Expected results and effects: The anticipated outcome of the project is the digital decision support system (DSS) OmegaPerMed Prevention Tool that can identify responders and non-responders to omega-3 treatment. This could hence be the first personalized medicine tool to be widely implemented in international CVD treatment guidelines for secondary prevention to the benefit of large patient population in Europe and world-wide. In addition, it has the potential to be expanded towards personalized dietary PUFA recommendations for primary CVD prevention and other non-CVD associated with chronic inflammation. Approach and implementation: This multidisciplinary project will explore well characterized cohorts and clinical trials for interactions between genes, polyunsaturated fatty acid (PUFA) exposure, cardiovascular disease risk and lipidomic markers towards beneficial effects of omega-3 PUFA. Complimentary lipidomic methods will be employed for mapping PUFA, PUFA sources, and PUFA-derived mediators as biomarkers. All available data will be integrated using artificial intelligence to develop the OmegaPerMed Prevention Tool, which will be continuously tested in a feasibility trial.
  • European Commission
    1 November 2022
    CArdiovascular REsolution of INflammation to promote HEALTH (CARE-IN-HEALTH), responds to an unmet medical need by addressing one of the critical hallmarks of the phenotypic and functional cardiovascular during the transition from health to Cardiovascular disease (CVD) : Chronic Inflammation.  Identifying the resolution of the chronic lipid-driven/-regulated vascular inflammation allows to develop and test, in a real-life setting, tools for use in health care and by citizens to stay healthy.
  • Swedish Research Council
    1 January 2013 - 31 December 2015

Employments

  • Adjunct Lecturer, Department of Medicine, Karolinska Institutet, 2023-2027

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2010

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