Sven-Christian Pawelzik

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About me

I am a team leader in the Translational Cardiology group at the Department of
Medicine, Solna (MedS), driven to learn about new aspects of human health and
apply this knowledge to contribute to innovative therapeutic approaches. My
focus of interest is inflammation as basis of cardiovascular diseases.

2011 - 2016 Postdoctoral Researcher, University of Pennsylvania, Philadelphia, PA, USA
2010 PhD in Medical Science, Karolinska Institutet, Sweden
2006 MSc, Human Biology, University of Marburg, Germany
2001 BSc, Human Biology, University of Marburg, Germany

Teaching

Main supervisor for two PhD students
Co-supervisor for two PhD students
Main supervisor for several BSc and MSc students (Biomedicine, Biochemistry,
Molecular Biology)
PhD course organiser for Lipid Metabolism and Inflammation in Cardiovascular
Disease (https://kiwas.ki.se/katalog/kursplan/show/9584)

Articles

Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(6):5392
Helicobacter Pylori Virulence Factor Cytotoxin-Associated Gene A (CagA) Induces Vascular Calcification in Coronary Artery Smooth Muscle Cells
Sundqvist MOO; Warme J; Hofmann R; Pawelzik S-C; Back M
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2023;194:308-315
Decreased oxidative stress and altered urinary oxylipidome by intravenous omega-3 fatty acid emulsion in a randomized controlled trial of older subjects hospitalized for COVID-19
Pawelzik S-C; Arnardottir H; Sarajlic P; Mahdi A; Vigor C; Zurita J; Zhou B; Kolmert J; Galano J-M; Religa D; Durand T; Wheelock CE; Back M
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2022;179(19):4709-4721
The tyrosine kinase inhibitor nilotinib targets the discoidin domain receptor DDR2 in calcific aortic valve stenosis
Carracedo M; Pawelzik S-C; Artiach G; Pouwer MG; Plunde O; Saliba-Gustafsson P; Ehrenborg E; Eriksson P; Pieterman E; Stenke L; Princen HMG; Franco-Cereceda A; Back M
Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(9):e895
Immunomodulation by intravenous omega-3 fatty acid treatment in older subjects hospitalized for COVID-19: A single-blind randomized controlled trial
Arnardottir H; Pawelzik S-C; Sarajlic P; Quaranta A; Kolmert J; Religa D; Wheelock CE; Back M
Article: BIOCHEMICAL PHARMACOLOGY. 2022;201:115075
The resolvin D2-GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice
Bardin M; Pawelzik S-C; Lagrange J; Mahdi A; Arnardottir H; Feve B; Regnault V; Lacolley P; Michel J-B; Mercier N; Back M
Journal article: CARDIOLOGY PLUS. 2022;7(1):3-11
Calcific aortic valve stenosis and COVID-19: clinical management, valvular damage, and pathophysiological mechanisms
Bäck M; Hashem M; Giani A; Pawelzik S-C; Franco-Cereceda A
Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(24):e142883
The resolvin D1 receptor GPR32 transduces inflammation resolution and atheroprotection
Arnardottir H; Thul S; Pawelzik S-C; Karadimou G; Artiach G; Gallina AL; Mysdotter V; Carracedo M; Tarnawski L; Caravaca AS; Baumgartner R; Ketelhuth DF; Olofsson PS; Paulsson-Berne G; Hansson GK; Back M
Article: CIRCULATION. 2021;144(20):1629-1645
Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium
Franco Cereceda A; Bäck M; Plunde O; Pawelzik S-C
Journal article: CIRCULATION. 2021;144(20):1629-1645
Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium
Sainz-Jaspeado M; Smith RO; Plunde O; Pawelzik S-C; Jin Y; Nordling S; Ding Y; Aspenstrom P; Hedlund M; Bastianello G; Ascione F; Li Q; Demir CS; Fernando D; Daniel G; Franco-Cereceda A; Kroon J; Foiani M; Petrova TV; Kilimann MW; Back M; Claesson-Welsh L
Article: AMERICAN HEART JOURNAL. 2021;231:105-109
Helicobacter pylori screening in clinical routine during hospitalization for acute myocardial infarction
Waerme J; Sundqvist M; Mars K; Aladellie L; Pawelzik S-C; Erlinge D; Jernberg T; James S; Hofmann R; Baeck M
Article: CELLS. 2020;9(7):E1710-1710
TLR7 Expression Is Associated with M2 Macrophage Subset in Calcific Aortic Valve Stenosis
Karadimou G; Plunde O; Pawelzik S-C; Carracedo M; Eriksson P; Franco-Cereceda A; Paulsson-Berne G; Back M
Article: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2020;2020:5197376-9
Semicarbazide-Sensitive Amine Oxidase Increases in Calcific Aortic Valve Stenosis and Contributes to Valvular Interstitial Cell Calcification
Mercier N; Pawelzik S-C; Pirault J; Carracedo M; Persson O; Wollensack B; Franco-Cereceda A; Back M
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(24):4625-4638
Biological characterization of new inhibitors of microsomal PGE synthase-1 in preclinical models of inflammation and vascular tone
Larsson K; Steinmetz J; Bergqvist F; Arefin S; Spahiu L; Wannberg J; Pawelzik S-C; Morgenstern R; Stenberg P; Kublickiene K; Korotkova M; Jakobsson P-J
Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2019;145:106361
Urinary prostaglandin D₂ and E₂ metabolites associate with abdominal obesity, glucose metabolism, and triglycerides in obese subjects
Pawelzik S-C; Avignon A; Idborg H; Boegner C; Stanke-Labesque F; Jakobsson P-J; Sultan A; Back M
Article: JOURNAL OF IMMUNOLOGY. 2018;200(12):4004-4011
Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms
Ocana JA; Romer E; Sahu R; Pawelzik S-C; FitzGerald GA; Kaplan MH; Travers JB
Article: CIRCULATION. 2016;134(4):328-338
Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1-Deficient Hyperlipidemic Mice
Tang SY; Monslow J; Grant GR; Todd L; Pawelzik S-C; Chen L; Lawson J; Pure E; FitzGerald GA
Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2014;91(6):269-275
Evaluation of urinary prostaglandin E₂ metabolite as a biomarker in infants with fever due to viral infection
Idborg H; Pawelzik S-C; Perez-Manso M; Bjork L; Hamrin J; Herlenius E; Jakobsson P-J
Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2013;102:1-12
Characterization of a new mPGES-1 inhibitor in rat models of inflammation
Leclerc P; Pawelzik S-C; Idborg H; Spahiu L; Larsson C; Stenberg P; Korotkova M; Jakobsson P-J
Article: BIOCHEMISTRY. 2011;50(35):7684-7693
Location of Inhibitor Binding Sites in the Human Inducible Prostaglandin E Synthase, MPGES1
Prage EB; Pawelzik S-C; Busenlehner LS; Kim K; Morgenstern R; Jakobsson P-J; Armstrong RN
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(38):29254-29261
Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1
Pawelzik S-C; Uda NR; Spahiu L; Jegerschold C; Stenberg P; Hebert H; Morgenstern R; Jakobsson P-J
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2010;1801(4):462-472
Hyperforin induces Ca²⁺-Andependent arachidonic acid release in human platelets by facilitating cytosolic phospholipase A₂ activation through select phospholipid interactions
Hoffmann M; Lopez JJ; Pergola C; Feisst C; Pawelczik S; Jakobsson P-J; Sorg BL; Glaubitz C; Steinhilber D; Werz O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(44):18757-18762
Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells
Hanaka H; Pawelzik S-C; Johnsen JI; Rakonjac M; Terawaki K; Rasmuson A; Sveinbjornsson B; Schumacher MC; Hamberg M; Samuelsson B; Jakobsson P-J; Kogner P; Radmark O
Article: LEUKEMIA AND LYMPHOMA. 2009;50(7):1198-1203
Lymphoblastic T-cell lymphoma in mice is unaffected by Celecoxib as single agent or in combination with cyclophosphamide
Johansson A-S; Pawelzik S-C; Larefalk A; Jakobsson P-J; Holmberg D; Lindskog M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(32):11110-11115
Structural basis for induced formation of the inflammatory mediator prostaglandin E₂
Jegerschold C; Paweizik S-C; Purhonen P; Bhakat P; Gheorghe KR; Gyobu N; Mitsuoka K; Morgenstern R; Jakobsson P-J; Hebert H
Article: CIRCULATION. 2008;117(13):1701-1710
Microsomal prostaglandin E₂ synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction
Degousee N; Fazel S; Angoulvant D; Stefanski E; Pawelzik S-C; Korotkova M; Arab S; Liu P; Lindsay TF; Zhuo S; Butany J; Li R-K; Audoly L; Schmidt R; Angioni C; Geisslinger G; Jakobsson P-J; Rubin BB
Journal article: GBM ANNUAL SPRING MEETING MOSBACH 2006. 2006;2006(Spring)
Mutational Analysis of human glutathione-dependent microsomal Prostaglandin E synthase-1 (mPGES-1)
Pawelzik S-C; Jegerschöld C; Pettersson PL; Morgenstern R; Hebert H; Jakobsson P-J
Journal article: VALUE IN HEALTH. 2004;7(2):144-152
Resource utilization and costs of stroke unit care in Germany
Dodel RC; Haacke C; Zamzow K; Pawelzik S; Spottke A; Rethfeldt M; Siebert U; Oertel WH; Schöffski O; Back T
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All other publications

Review: METABOLITES. 2022;12(8):721
Prostanoid Metabolites as Biomarkers in Human Disease
Idborg H; Pawelzik S-C
Editorial comment: CARDIOVASCULAR RESEARCH (CVR). 2022;118(2):353-354
von Willebrand factor's vascular crossroad
Pawelzik S-C; Back M
Preprint: MEDRXIV. 2021
Immunomodulation by intravenous omega-3 fatty acid treatment in older subjects hospitalized for COVID-19: a single-blind randomized controlled trial
Arnardottir H; Pawelzik S-C; Sarajlic P; Quaranta A; Kolmert J; Religa D; Wheelock C; Bäck M
Conference publication: ATHEROSCLEROSIS. 2021;331:E9
THE RESOLVIN D1 RECEPTOR GPR32 TRANSDUCES INFLAMMATION-RESOLUTION AND ATHEROPROTECTION
Arnardottir H; Thul S; Karadimou G; Pawelzik S-C; Artiach G; Mysdotter V; Carracedo M; Tarnawski L; Caravaca AS; Baumgartner R; Ketelhuth DF; Olofsson PS; Paulsson-Berne G; Hansson GK; Back M
Review: TOXINS. 2020;12(4):E227-227
Inflammation and Premature Ageing in Chronic Kidney Disease
Ebert T; Pawelzik S-C; Witasp A; Arefin S; Hobson S; Kublickiene K; Shiels PG; Back M; Stenvinkel P
Editorial comment: ANNALS OF TRANSLATIONAL MEDICINE. 2020;8(6):258
Eastern Remedies for Western-type diet induced atherosclerosis
Pawelzik S-C; Back M
Review: FRONTIERS IN PHYSIOLOGY. 2020;11:624657
Stimulating the Resolution of Inflammation Through Omega-3 Polyunsaturated Fatty Acids in COVID-19: Rationale for the COVID-Omega-F Trial
Arnardottir H; Pawelzik S-C; ohlund Wistbacka U; Artiach G; Hofmann R; Reinholdsson I; Braunschweig F; Tornvall P; Religa D; Back M
Thesis / dissertation: 2010
Structure and function of microsomal prostaglandin E synthase-1
Pawelzik, Sven-Christian
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;71(6):508
Characterization of mPGES-1 Inhibition in Rat Models of Inflammation
Leclerc P; Larsson C; Spahiu L; Pawelzik S-C; Idborg H; Stenberg P; Korotkova M; Jakobsson P-J
Conference publication: ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES. 2009;65:S77
Structure of Microsomal Prostaglandin E Synthase 1 as Determined by Electron Crystallography
Hebert H; Jegerschoeld C; Purhonen P; Bhakat P; Gheorghe K; Gyobu N; Mitsuoka K; Pawelzik S; Jakobsson P-J; Morgenstern R

Grants

Optimizing omega-3 supplementation to resolve inflammation in a personalized medicine CVD prevention
VINNOVA
21 November 2022 - 31 December 2025
Personalised blueprint of chronic inflammation in health-to-disease transition
European Commission
1 November 2022
Mast cell derived lipid mediators in atherogenesis
Swedish Research Council
1 January 2013 - 31 December 2015

Employments

Adjunct Lecturer, Department of Medicine, Karolinska Institutet, 2023-2025

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2010

About me

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