Srustidhar Das

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: NATURE. 2024;:1-9
Liver X receptor unlinks intestinal regeneration and tumorigenesis
Das S; Parigi SM; Luo X; Fransson J; Kern BC; Okhovat A; Diaz OE; Sorini C; Czarnewski P; Webb AT; Morales RA; Lebon S; Monasterio G; Castillo F; Tripathi KP; He N; Pelczar P; Schaltenberg N; De la Fuente M; Lopez-Kostner F; Nylen S; Larsen HL; Kuiper R; Antonson P; Hermoso MA; Huber S; Biton M; Scharaw S; Gustafsson J-A; Katajisto P; Villablanca EJ
Journal article: NATURE PROTOCOLS. 2024;19(10):3085-3137
A versatile tissue-rolling technique for spatial-omics analyses of the entire murine gastrointestinal tract
Monasterio G; Morales RA; Bejarano DA; Abalo XM; Fransson J; Larsson L; Schlitzer A; Lundeberg J; Das S; Villablanca EJ
Article: IMMUNITY. 2022;55(12):2336-2351.e12
B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing
Frede A; Czarnewski P; Monasterio G; Tripathi KP; Bejarano DA; Flores ROR; Sorini C; Larsson L; Luo X; Geerlings L; Novella-Rausell C; Zagami C; Kuiper R; Morales RA; Castillo F; Hunt M; Mariano LL; Hu YOO; Engblom C; Lennon-Dumenil A-M; Mittenzwei R; Westendorf AM; Hoevelmeyer N; Lundeberg J; Saez-Rodriguez J; Schlitzer A; Das S; Villablanca EJ
Article: MUCOSAL IMMUNOLOGY. 2022;15(5):940-951
Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine
Morales RA; Rabahi S; Diaz OE; Salloum Y; Kern BC; Westling M; Luo X; Parigi SM; Monasterio G; Das S; Hernandez PP; Villablanca EJ
Article: NATURE COMMUNICATIONS. 2022;13(1):828
The spatial transcriptomic landscape of the healing mouse intestine following damage
Parigi SM; Larsson L; Das S; Flores ROR; Frede A; Tripathi KP; Diaz OE; Selin K; Morales RA; Luo X; Monasterio G; Engblom C; Gagliani N; Saez-Rodriguez J; Lundeberg J; Villablanca EJ
Article: DISEASE MODELS & MECHANISMS. 2021;14(12):dmm049104
Perfluorooctanesulfonic acid modulates barrier function and systemic T-cell homeostasis during intestinal inflammation
Diaz OE; Sorini C; Morales RA; Luo X; Frede A; Krais AM; Chavez MN; Wincent E; Das S; Villablanca EJ
Article: MUCOSAL IMMUNOLOGY. 2021;14(2):411-419
Liver X receptor regulates Th17 and RORγt⁺Treg cells by distinct mechanisms
Parigi SM; Das S; Frede A; Cardoso RF; Tripathi KP; Donas C; Hu YOO; Antonson P; Engstrand L; Gustafsson J-A; Villablanca EJ
Article: CELL REPORTS. 2020;32(5):107979
Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1⁺ Macrophages Regulates Intestinal Homeostasis
Kaya B; Donas C; Wuggenig P; Diaz OE; Morales RA; Melhem H; Hernandez PP; Kaymak T; Das S; Hruz P; Franc Y; Geier F; Ayata CK; Villablanca EJ; Niess JH
Article: REPRODUCTIVE TOXICOLOGY. 2020;93:163-168
Retinoic acid induced cytokines are selectively modulated by liver X receptor activation in zebrafish
Diaz OE; Xue S; Luo X; Nava J; Appelblom A; Morales RA; Das S; Villablanca EJ
Article: NATURE COMMUNICATIONS. 2019;10(1):2892
Conserved transcriptomic profile between mouse and human colitis allows unsupervised patient stratification
Czarnewski P; Parigi SM; Sorini C; Diaz OE; Das S; Gagliani N; Villablanca EJ
Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2018;1864(8):2538-2549
Axed MUC4 (MUC4/X) aggravates pancreatic malignant phenotype by activating integrin-β1/FAK/ERK pathway
Jahan R; Macha MA; Rachagani S; Das S; Smith LM; Kaur S; Batra SK
Article: MUCOSAL IMMUNOLOGY. 2018;11(3):703-715
Intestinal epithelial cell-specific RARα depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system
Jijon HB; Suarez-Lopez L; Diaz OE; Das S; De Calisto J; Yaffe MB; Pittet MJ; Mora JR; Belkaid Y; Xavier RJ; Villablanca EJ
Article: BIOCHEMICAL PHARMACOLOGY. 2018;151:47-58
Cytochrome P4501-inhibiting chemicals amplify aryl hydrocarbon receptor activation and IL-22 production in T helper 17 cells
Schiering C; Vonk A; Das S; Stockinger B; Wincent E
Article: IMMUNITY. 2018;48(1):120-132.e8
Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation
Emgard J; Kammoun H; Garcia-Cassani B; Chesne J; Parigi SM; Jacob J-M; Cheng H-W; Evren E; Das S; Czarnewski P; Sleiers N; Melo-Gonzalez F; Kvedaraite E; Svensson M; Scandella E; Hepworth MR; Huber S; Ludewig B; Peduto L; Villablanca EJ; Veiga-Fernandes H; Pereira JOP; Flavell RA; Willinger T
Article: SCIENTIFIC REPORTS. 2018;8(1):154
Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo
Parigi SM; Czarnewski P; Das S; Steeg C; Brockmann L; Fernandez-Gaitero S; Yman V; Forkel M; Hoog C; Mjosberg J; Westerberg L; Farnert A; Huber S; Jacobs T; Villablanca EJ
Article: PLOS ONE. 2018;13(9):e0204181
β7 integrins contribute to intestinal tumor growth in mice
Das S; Donas C; Akeus P; Quiding-Jarbrink M; Mora JR; Villablanca EJ
Article: PLOS ONE. 2018;13(4):e0193907
Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer
Aithal A; Junker WM; Kshirsagar P; Das S; Kaur S; Orzechowski C; Gautam SK; Jahan R; Sheinin YM; Lakshmanan I; Ponnusamy MP; Batra SK; Jain M
Article: CLINICAL CANCER RESEARCH. 2017;23(14):3906-3917
MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53
Lakshmanan I; Salfity S; Seshacharyulu P; Rachagani S; Thomas A; Das S; Majhi PD; Nimmakayala RK; Vengoji R; Lele SM; Ponnusamy MP; Batra SK; Ganti AK
Article: MUCOSAL IMMUNOLOGY. 2017;10(4):884-886
Retinoic acid takes effector T cells to the gallows: P2X7, the molecular hangman
Das S; Villablanca EJ
Article: ONCOGENE. 2016;35(20):2645-2654
Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer
Das S; Rachagani S; Sheinin Y; Smith LM; Gurumurthy CB; Roy HK; Batra SK
Article: ONCOGENE. 2015;34(37):4879-4889
NCOA3-mediated upregulation of mucin expression via transcriptional and post-translational changes during the development of pancreatic cancer
Kumar S; Das S; Rachagani S; Kaur S; Joshi S; Johansson SL; Ponnusamy MP; Jain M; Batra SK
Article: SCIENTIFIC REPORTS. 2015;5:9759
Membrane proximal ectodomain cleavage of MUC16 occurs in the acidifying Golgi/post-Golgi compartments
Das S; Majhi PD; Al-Mugotir MH; Rachagani S; Sorgen P; Batra SK
Article: ONCOTARGET. 2015;6(8):5772-5787
Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells
Das S; Rachagani S; Torres-Gonzalez MP; Lakshmanan I; Majhi PD; Smith LM; Wagner K-U; Batra SK
Article: ONCOTARGET. 2015;6(4):2064-2075
Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis
Pandey P; Rachagani S; Das S; Seshacharyulu P; Sheinin Y; Naslavsky N; Pan Z; Smith BL; Peters HL; Radhakrishnan P; McKenna NR; Giridharan SSP; Haridas D; Kaur S; Hollingsworth MA; MacDonald RG; Meza JL; Caplan S; Batra SK; Solheim JC
Article: CURRENT PHARMACEUTICAL DESIGN. 2015;21(10):1249-1255
Pancreatic Cancer Metastasis: Are we being Pre-EMTed?
Das S; Batra SK
Article: BRITISH JOURNAL OF CANCER. 2013;108(12):2590-2600
Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway
Pandey P; Seshacharyulu P; Das S; Rachagani S; Ponnusamy MP; Yan Y; Johansson SL; Datta K; Lin MF; Batra SK
Article: JOURNAL OF THORACIC ONCOLOGY. 2013;8(4):398-407
Pathobiological Implications of MUC4 in Non-Small-Cell Lung Cancer
Majhi PD; Lakshmanan I; Ponnusamy MP; Jain M; Das S; Kaur S; Shimizu ST; West WW; Johansson SL; Smith LM; Yu F; Rolle CE; Sharma P; Carey GB; Batra SK; Ganti AK
Article: FRONTIERS IN PHARMACOLOGY. 2013;4:106
An Escherichia coli strain for expression of the connexin45 carboxyl terminus attached to the 4th transmembrane domain
Kopanic JL; Al-Mugotir M; Zach S; Das S; Grosely R; Sorgen PL
Article: ONCOGENE. 2012;31(7):805-817
MUC16 induced rapid G2/M transition via interactions with JAK2 for increased proliferation and anti-apoptosis in breast cancer cells
Lakshmanan I; Ponnusamy MP; Das S; Chakraborty S; Haridas D; Mukhopadhyay P; Lele SM; Batra SK
Article: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 2011;300(6):G1144-G1155
Muc17 protects intestinal epithelial cells from enteroinvasive E. coli infection by promoting epithelial barrier integrity
Resta-Lenert S; Das S; Batra SK; Ho SB
Article: PLOS ONE. 2011;6(10):e26839
Pathobiological Implications of MUC16 Expression in Pancreatic Cancer
Haridas D; Chakraborty S; Ponnusamy MP; Lakshmanan I; Rachagani S; Cruz E; Kumar S; Das S; Lele SM; Anderson JM; Wittel UA; Hollingsworth MA; Batra SK
Article: ONCOGENE. 2010;29(42):5741-5754
MUC4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells
Ponnusamy MP; Lakshmanan I; Jain M; Das S; Chakraborty S; Dey P; Batra SK
Article: JOURNAL OF CLINICAL PATHOLOGY. 2010;63(8):702-707
Expression of intestinal MUC17 membrane-bound mucin in inflammatory and neoplastic diseases of the colon
Senapati S; Ho SB; Sharma P; Das S; Chakraborty S; Kaur S; Niehans G; Batra SK
Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2010;42(6):996-1006
Human intestinal MUC17 mucin augments intestinal cell restitution and enhances healing of experimental colitis
Luu Y; Junker W; Rachagani S; Das S; Batra SK; Heinrikson RL; Shekels LL; Ho SB
Article: MOLECULAR CANCER THERAPEUTICS. 2010;9(5):1419-1431
Effects of Thymoquinone in the Expression of Mucin 4 in Pancreatic Cancer Cells: Implications for the Development of Novel Cancer Therapies
Torres MP; Ponnusamy MP; Chakraborty S; Smith LM; Das S; Arafat HA; Batra SK
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Alla övriga publikationer

Review: NUTRIENTS. 2017;9(1):E68-68
Retinoic Acid and Its Role in Modulating Intestinal Innate Immunity
Czarnewski P; Das S; Parigi SM; Villablanca EJ
Review: CANCER RESEARCH. 2015;75(22):4669-4674
Understanding the Unique Attributes of MUC16 (CA125): Potential Implications in Targeted Therapy
Das S; Batra SK
Review: TRENDS IN BIOCHEMICAL SCIENCES. 2010;35(4):236-245
Mucin-interacting proteins: from function to therapeutics
Senapati S; Das S; Batra SK

Anställningar

Anknuten till Forskning, Institutet för miljömedicin, Karolinska Institutet, 2025-2026
Forskningsspecialist, Medicin, Solna, Karolinska Institutet, 2022-2024

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